Smoking Cessation Lighter and Method
A lighter for tobacco products suppresses the urge to smoke by operant conditioning.
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| Number | Title | Issue Date |
| 8173683 | Methods for treating cognitive disorders Disclosed herein are methods of treating a patient suffering a cognitive disorder. ... | 05/08/2012 |
| 8168631 | 3-(4-fluorophenyl)-3-hydroxy-2-amino-propionic acid amides and related compounds having analgesic activity Compounds according to the formula below are disclosed herein: Therapeutic methods, compositions, and medicaments related thereto are also disclosed. ... | 05/01/2012 |
| 8153666 | Compounds having analgesic and/or immunostimulant activity The compounds shown by their structural formulas in the specification have analgesic and or immunostimulant activity in mammals. ... | 04/10/2012 |
| 8153645 | Treating pain using selective antagonists of persistent sodium current The present invention provides methods of treating chronic pain in a mammal by administering to the mammal an effective amount of a selective persistent sodium channel antagonist that has at least 20-fold selectivity for persistent sodium current relative to transie... | 04/10/2012 |
| 8143410 | Kinase inhibitors The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation, in combination wit... | 03/27/2012 |
| 8124612 | Treating neurological disorders using selective antagonists of persistent sodium current The present invention provides methods of treating neurological disorders in a mammal by administering to the mammal an effective amount of a selective persistent sodium channel antagonist that has at least 20-fold selectivity for persistent sodium current relative ... | 02/28/2012 |
| 7910603 | 3-monosubstituted tropane derivatives as nociceptin receptor ligands Compounds of the formula or a pharmaceutically acceptable salt thereof, wherein R1 is aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl... | 03/22/2011 |
| 7902199 | Heterocyclic substituted piperazine compounds with CXCR3 antagonist activity The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general s... | 03/08/2011 |
| 7884107 | Substituted piperidines that increase P53 activity and the uses thereof In its many embodiments, the present invention discloses novel compounds, as inhibitors of HDM2 protein methods for preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of treatment, prevention, inhibition, of one or mo... | 02/08/2011 |
| 7879997 | Compounds for the treatment of inflammatory disorders This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, wherein n, M, V, T, W, X, U, R1 and R2 are as disclosed in the present specific... | 02/01/2011 |
| 7879890 | Compounds for the treatment of inflammatory disorders This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which can be useful for the treatment of diseases or conditions media... | 02/01/2011 |
| 7879838 | Heteroaryl substituted pyrazinyl-piperazine-piperidines with CXCR3 antagonist activity The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts or solvates of said compound, or of said prodrug, said compound having the general structure... | 02/01/2011 |
| 7868006 | Heterocyclic substituted piperazines with CXCR3 antagonist activity The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general s... | 01/11/2011 |
| 7868005 | Pyrazinyl substituted piperazine-piperidines with CXCR3 antagonist activity The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general s... | 01/11/2011 |
| 7825121 | Piperazine derivatives useful as CCR5 antagonists The use of CCR5 antagonists of the formula or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, pyridyl, thiophenyl or naphthyl; R | 11/02/2010 |
| 7786124 | Heterocyclic substituted pyridine compounds with CXCR3 antagonist activity The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general s... | 08/31/2010 |
| 7781437 | Substituted heterocyclic compounds with CXCR3 antagonist activity The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general s... | 08/24/2010 |
| 7776862 | Pyridyl and phenyl substituted piperazine-piperidines with CXCR3 antagonist activity The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general s... | 08/17/2010 |
| 7772263 | Compounds for the treatment of inflammatory disorders This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by ... | 08/10/2010 |
| 7763616 | Piperazine-piperidines with CXCR3 antagonist activity The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general s... | 07/27/2010 |
| 7741318 | Pyrazolo [1,5-A]pyrimidine adenosine Areceptor antagonists Compounds having the structural formula I are disclosed, wherein A is alkylene, or optionally substituted arylene, cycloalkylene or heteroaryldiyl; X is —C(O)— or —S... | 06/22/2010 |
| 7713985 | Adenosine Areceptor antagonists Compounds having the structural formula I or a pharmaceutically acceptable salt thereof, wherein: X1 and X2 are 1-3 substituents independently selected from the group... | 05/11/2010 |
| 7709492 | Pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine A receptor antagonists Compounds having the structural formula I or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, furanyl, thienyl, pyridyl, pyridyl N-oxide, oxazolyl or... | 05/04/2010 |
| 7705019 | Piperidinyl piperidine derivatives useful as inhibitors of chemokine receptors In its many embodiments, the present invention provides a novel class of compounds of structural formula IA or IB where R1-R8 are as disclosed herein as inhibitors of the CCR5 receptors, methods of pre... | 04/27/2010 |
| 7687527 | Compounds for the treatment of inflammatory disorders This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which can be useful for the treatment of diseases or conditions media... | 03/30/2010 |
| 7683088 | Compounds for the treatment of inflammatory disorders This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by ... | 03/23/2010 |
| 7683085 | Compounds for the treatment of inflammatory disorders This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by ... | 03/23/2010 |
| 7659275 | Piperidinyl piperazine derivatives useful as inhibitors of chemokine receptors In its many embodiments, the present invention provides a novel class of compounds of structural formula IA or IB where R1-R8 are as disclosed herein as inhibitors of the CCR5 receptors, methods of pre... | 02/09/2010 |
| 7652142 | Bipiperidinyl derivatives useful as inhibitors of chemokine receptors In its many embodiments, the present invention provides a novel class of bipiperidinyl compounds as inhibitors of the CCR5 receptors, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmac... | 01/26/2010 |
| 7652020 | Compounds for the treatment of inflammatory disorders This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF-α... | 01/26/2010 |
| 7638513 | Compounds for the treatment of inflammatory disorders This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, aggrecanase, ADMP, ... | 12/29/2009 |
| 7608643 | Compounds for inhibiting KSP kinesin activity The present invention relates to compounds of Formula I or pharmaceutically acceptable salts or solvates thereof: The present invention provides compositions comprising these compounds that are useful for treating cellular ... | 10/27/2009 |
| 7598259 | mGluR1 antagonists as therapeutic agents In its many embodiments, the present invention provides tricyclic compounds of formula I (wherein J1-J4, X, and R1-R5 are as defined herein) useful as metabotropic glutamate receptor (mGluR) antagonists, particularly as se... | 10/06/2009 |
| 7572802 | 7-[2-[4-(6-fluoro-3-methyl-1,2-benzisoxazol-5-yl)-1-piperazinyl]ethyl]-2-(1-propynyl)-7H-pyrazolo-[4,3-e]-[1,2,4]-triazolo-[1,5-C]-pyrimidin-5-amine The compound having the structural formula I or a pharmaceutically acceptable salt thereof, is disclosed, as well as its use in the treatment of central nervous system diseases, in particular Parkinson's disease, Extra Pyra... | 08/11/2009 |
| 7566718 | Amine-linked pyridyl and phenyl substituted piperazine-piperidines with CXCR3 antagonist activity The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general s... | 07/28/2009 |
| 7553864 | Compounds for the treatment of inflammatory disorders and microbial diseases This invention relates to compounds of the Formulae (I)-(IX): or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which can be useful for the treatment of diseases or condition... | 06/30/2009 |
| 7528132 | Kinase inhibitors A compound having the general structure of Formula (I): or a pharmaceutically acceptable salt, solvate, or ester thereof, are useful in treating diseases, disorders, or conditions such as immunodeficiencies, cancers, cardio... | 05/05/2009 |
| 7504424 | Compounds for the treatment of inflammatory disorders This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which can be useful for the treatment of diseases or conditions media... | 03/17/2009 |
| 7488745 | Compounds for the treatment of inflammatory disorders This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which can be useful for the treatment of diseases or conditions media... | 02/10/2009 |
| 7485650 | High affinity ligands for nociceptin receptor ORL-1 The compound of the formula or a pharmaceutically acceptable salt or solvate thereof, pharmaceutical compositions therefore, and the use of said compounds as nociceptin receptor inhibitors useful in the treatment of anxiety... | 02/03/2009 |