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Attorney: Baker; Gary


Number of patents: 68
Last date: April 24, 2012

1    
NumberTitleIssue Date
8163776Method of immunomodulation using thione-forming disulfides
The invention provides for the methods of modulating an immune response in an individual by administration of a thione-forming disulfide (TFD). Immunomodulatory responses include, but are not limited to, increased natural killer cell activity, expansion of NK cell p...
04/24/2012
8114654Site-specific incorporation of redox active amino acids into proteins
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate redox active amino acids into proteins are provided....
02/14/2012
8114629Site specific incorporation of keto amino acids into proteins
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate keto amino acids into proteins are provided. Methods...
02/14/2012
8105288Apparatus for peripheral vascular access
This invention provides devices and methods for insertion of a catheter into a vessel. The devices include coaxial slidably mounted needle, dilator and catheter components. The methods include piercing a vessel with the needle component, dilating the pierced hole wi...
01/31/2012
8076083Screening methods involving the detection of short-lived proteins
A method is provided for screening for agents that affect protein degradation rates, the method comprising: taking a library of cells, the cells expressing a fusion protein comprising a reporter protein and a protein encoded by a sequence from a cDNA library derived...
12/13/2011
8071344Site specific incorporation of keto amino acids into proteins
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate keto amino acids into proteins are provided. Methods...
12/06/2011
8067017Preservation of bioactive materials by freeze dried foam
This invention provides methods and compositions to preserve bioactive materials in a dried foam matrix. Methods provide non-boiling foam generation and penetration of preservative agents at temperatures near the phase transition temperature of the membranes. ...
11/29/2011
8042916Micromachined fluid ejector array
This invention relates to a micromachined fluid ejector array having a fluid reservoir bounded at one side by an elastic membrane having scalable arrays of orifices arranged between concentric piezoelectric transducers, and at another side by a top cover supported b...
10/25/2011
8037903Micromachined electrowetting microfluidic valve
This invention relates to a systems and methods of controlling the flow of a fluid in a capillary or microfluidic channel. A first pair of electrodes can influence the wetting of a fluid front at a relatively hydrophobic surface in the channel. A second pair of elec...
10/18/2011
8030028Compositions of orthogonal lysyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal lysyl-tRNAs, orthogonal lysyl-aminoacyl-tRNA synthetases, and orthogonal pairs of lysyl-tRNAs/synthetases, which incorporate homoglutamines into proteins are p...
10/04/2011
8012507Preservation of bioactive materials by spray drying
This invention provides methods and compositions to preserve bioactive materials in a matrix of powder particles. Methods provide high-pressure gas spraying and/or near supercritical spraying of formulations followed by drying in a stream of conditioned gas to form ...
09/06/2011
8008041Site-specific incorporation of redox active amino acids into proteins
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate redox active amino acids into proteins are provided....
08/30/2011
7968327Nucleic acid quantitation from tissue slides
This invention provides methods of quantitating nucleic acids from problematic samples, such as aged samples, formalin fixed samples, paraffin embedded samples, samples with aneuploid cells, and cells with fragmented nucleic acids. Methods include techniques to effi...
06/28/2011
7951539Two-stage nucleic acid amplification using an amplification oligomer
This invention provides methods, compositions and systems to detect a nucleic acid of interest in a two-stage amplification. The two-stage amplification begins with a first non-enzymatic accumulation of an amplification oligomer that is the target substrate for a se...
05/31/2011
7926123Fly pocket pants
This invention provides pants with vertical pocket openings at the pant front center. The pants can have a central vertical closure, such as a zipper, with the pocket opening optionally internally adjacent or externally adjacent to the closure. ...
04/19/2011
7923029Spray freeze dry of compositions for pulmonary administration
This invention provides methods and compositions to preserve bioactive materials, such as viruses, bacteria, cells, or liposomes, in freeze dried particles suitable for pulmonary administration. Methods provide spray freeze drying of formulations to form stable free...
04/12/2011
7910345Site specific incorporation of keto amino acids into proteins
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate keto amino acids into proteins are provided. Methods...
03/22/2011
7824893In vivo incorporation of alkynyl amino acids into proteins in eubacteria
The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate alkynyl amino acids such as para-propargyloxyphenylalanine into proteins produced in a eubacteria host such as E. coli. The invention provides novel orthogh...
11/02/2010
7811801Site-specific incorporation of redox active amino acids into proteins
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate redox active amino acids into proteins are provided....
10/12/2010
7790847Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine
The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the unnatural amino acid phenylselenocysteine into proteins produced in eubacterial host cells such as E. coli. The invention provides, for example but not ...
09/07/2010
7741071Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells
This invention provides methods and compositions for incorporation of an unnatural amino acid into a peptide using an orthogonal aminoacyl tRNA synthetase/tRNA pair. In particular, an orthogonal pair is provided to incorporate 5-hydroxy-L-tryptophan in a position en...
06/22/2010
7718410In vivo incorporation of alkynyl amino acids into proteins in eubacteria
The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate alkynyl amino acids such as para-propargyloxyphenylalanine into proteins produced in a eubacteria host such as E. coli. The invention provides novel orthogo...
05/18/2010
7709604Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells
This invention provides methods and compositions for incorporation of an unnatural amino acid into a peptide using an orthogonal aminoacyl tRNA synthetase/tRNA pair. In particular, an orthogonal pair is provided to incorporate 5-hydroxy-L-tryptophan in a position en...
05/04/2010
7703646Carrying bag adapted for accommodating a wheeled foldable article of furniture
A carrying bag includes a flexible bag body that defines an accommodation space therein and that has a lower peripheral edge defining a lower access opening. A rigid base member has a periphery configured to matingly engage the lower peripheral edge, and is displace...
04/27/2010
7700130Preservation of bioactive materials by spray drying
This invention provides methods and compositions to preserve bioactive materials in a matrix of powder particles. Methods provide high-pressure gas spraying and/or near supercritical spraying of formulations followed by drying in a stream of conditioned gas to form ...
04/20/2010
7700127Method and compositions for preparing and delivering rumen protected lipids, other nutrients and medicaments
This invention provides composite gels to, e.g., efficiently deliver unmodified amino acids, lipids, and/or feed supplements through the rumen of a ruminant animal. The invention also provides methods to make and use composite gels. ...
04/20/2010
7690229Station for alternate locks
Locking devices are provided that can be opened by alternate users with different keys. The devices generally include a lock slider anchored to an anchor tab through one or more link sliders. The sliders can be slidably mounted to a slide mount, such as, e.g., a sli...
04/06/2010
7662313Oriented nanostructures and methods of preparing
This invention provides compositions and devices having structurally ordered nanostructures, as well as methods for producing structurally ordered nanostructures. ...
02/16/2010
7655157Doped cadmium tungstate scintillator with improved radiation hardness
This invention provides novel cadmium tungstate scintillator materials that show improved radiation hardness. In particular, it was discovered that doping of cadmium tungstate (CdWO4) with trivalent metal ions or monovalent metal ions is particularly effe...
02/02/2010
7642085Protein arrays
The invention provides proteins attached to solid supports, and methods of preparing such solid support-bound proteins are provided. The proteins are attached to solid supports by means of an unnatural amino acid incorporated into the protein, which unnatural amino ...
01/05/2010
7638297Compositions of orthogonal lysyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal lysyl-tRNAs, orthogonal lysyl-aminoacyl-tRNA synthetases, and orthogonal pairs of lysyl-tRNAs/synthetases, which incorporate homoglutamines into proteins are p...
12/29/2009
7615351Two stage nucleic acid amplification using an amplification oligomer
This invention provides methods, compositions and systems to detect a nucleic acid of interest in a two-stage amplification. The two-stage amplification begins with a first non-enzymatic accumulation of an amplification oligomer that is the target substrate for a se...
11/10/2009
7611913Ferroelectric rare-earth manganese-titanium oxides
Ferroelectric rare-earth manganese-titanium oxides and methods of their manufacture. The ferroelectric materials can provide nonvolatile data storage in rapid access memory devices. ...
11/03/2009
7598091Micromachined diagnostic device with controlled flow of fluid and reaction
This invention relates to a micromachined microfluidics diagnostic device that comprises one or multiple assaying channels each of which is comprised a sample port, a first valve, a reaction chamber, a second valve, a fluid ejector array, a third valve, a buffer cha...
10/06/2009
7572393Organic species that facilitate charge transfer to or from nanostructures
The present invention provides polymeric compositions that can be used to modify charge transport across a nanocrystal surface or within a nanocrystal-containing matrix, as well as methods for making and using the novel compositions. ...
08/11/2009
7569764Solar modules with tracking and concentrating features
Disclosed are fixed solar-electric modules having arrays of solar concentrator assemblies capable of separately tracking movements through one or two degrees of rotational freedom to follow the movement of the sun daily and/or seasonally. The concentrators can inclu...
08/04/2009
7527943Compositions of orthogonal glutamyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof
Compositions and methods of producing components of protein biosynthetic machinery that include glutamyl orthogonal tRNAs, glutamyl orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of glutamyl tRNAs/synthetases are provided. Methods for identifying these ...
05/05/2009
7524647Site specific incorporation of keto amino acids into proteins
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate keto amino acids into proteins are provided. Methods...
04/28/2009
7494796Site-specific incorporation of redox active amino acids into proteins
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate redox active amino acids into proteins are provided....
02/24/2009
7485071Fabric yoga straps
Composite yoga mats and straps comprising a fabric sheet and loop holes and/or filament loops functioning as hand grips or appendage supports useful in the practice of yoga positions. The yoga straps or mats can to provide support, a stable surface, and moisture abs...
02/03/2009
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