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| Number | Title | Issue Date |
| 8178579 | Dioxanes and uses thereof In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I): and pharmaceutically acceptable derivati... | 05/15/2012 |
| 8093009 | Mass spectrometric methods and products The invention involves assays, diagnostics, kits, and assay components for mass spectrometry and other methods to determine levels of glycated CD59 in subjects. ... | 01/10/2012 |
| 8076116 | Nucleic acids encoding class II human histone deacetylases, and uses related thereto The invention provides histone deacetylase class II nucleic acids and polypeptides, methods and reagents for their use, and related compounds including small molecule libraries containing class II histone deacetylase inhibitors. ... | 12/13/2011 |
| 8071082 | End-modified poly(beta-amino esters) and uses thereof Poly(beta-amino esters) are end-modified to form materials useful in the medical as well as non-medical field. An amine-terminated poly(beta-amino ester) is reacted with an electrophile, or an acrylate-terminated poly(beta-amino ester) is reacted with a nucleophile.... | 12/06/2011 |
| 8017755 | RNA-based transcriptional regulators RNA molecules have been shown to play a variety of functional roles in biological processes. RNA sequences can adopt 3-D conformations able to regulate transcription. RNA-based transcriptional regulators when recruited to a DNA template act to promote or suppress th... | 09/13/2011 |
| 8008502 | Thiazoline acid derivatives The present invention relates to novel thiazoline acids and derivatives thereof useful as chelators of trivalent metals in therapeutic applications. For example, the thiazoline acid derivatives are useful in diagnosing and treating pathological conditions associated... | 08/30/2011 |
| 8008024 | Methods, products and treatments for diabetes The invention involves assays, diagnostics, kits, and assay components for determining levels of K41-glycated CD59 in subjects. Treatments for subjects based upon levels of K41-glycated CD59 also are provided. ... | 08/30/2011 |
| 7994362 | Histone deacetylases, and uses related thereto The present invention concerns the discovery that proteins encoded by a family of genes, termed here HDx-related genes, which are involved in the control of chromatin structure and, thus in transcription and translation. The present invention makes available composi... | 08/09/2011 |
| 7960559 | Synthesis of enone intermediate The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously suscep... | 06/14/2011 |
| 7943179 | pH triggerable polymeric particles A drug delivery system comprising pH triggerable particles is described. The pH triggerable particles comprise and agent(s) to be delivered, which is encapsulated in a matrix comprising a pH trigger agent and a polymer. Agents including nucleic acids may be delivere... | 05/17/2011 |
| 7932213 | Small molecule printing The present invention provides compositions and methods to facilitate the identification of compounds that are capable of interacting with a biological macromolecule of interest. A composition is provided that comprises an array of chemical compounds attached to a s... | 04/26/2011 |
| 7906506 | Substituted chiral fused [1,2] imidazo [4,5-] ring compounds and methods Substituted fused [1,2]imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines, and imidazo[4,5-c]pyridines) with a —CH(—R2... | 03/15/2011 |
| 7897767 | Oxime substituted imidazoquinolines Imidazo ring compounds (e.g., imidazoquinolines, 6,7,8,9-tetrahydroimidazoquinolines, imidazonaphthyridines, and imidazopyridines) with an oxime substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of... | 03/01/2011 |
| 7897609 | Aryl substituted imidazonaphthyridines Imidazonaphthyridine ring systems substituted with an aryl substituent, pharmaceutical compositions containing the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases in... | 03/01/2011 |
| 7879849 | Pyrazolopyridines and analogs thereof Pyrazolopyridin-4-amines, pyrazoloquinolin-4-amines, pyrazolonaphthyridin-4-amines, and 6,7,8,9-tetrahydropyrazoloquinolin-4-amines, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immu... | 02/01/2011 |
| 7851658 | Palladium-catalyzed carbon-carbon bond forming reactions A novel palladium-mediated carbon-carbon bond forming reaction has been discovered using DNA-templated chemistry. The inventive reaction involves the palladium-mediated coupling of a terminal alkyne with an alkene to form an enone. A catalytic amount of palladium ma... | 12/14/2010 |
| 7833725 | Mass spectrometric methods and products The invention involves assays, diagnostics, kits, and assay components for mass spectrometry and other methods to determine levels of glycated CD59 in subjects. ... | 11/16/2010 |
| 7807842 | Synthesis of tetracyclines and analogues thereof The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously suscep... | 10/05/2010 |
| 7763735 | Synthesis of enone intermediate The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously suscep... | 07/27/2010 |
| 7747395 | Method of inhibitor design and identification using a 3-D structure of human peptide deformylase The present invention provides the three-dimensional structure of human mitochondrial Homo sapiens peptide deformylase (HsPDF) protein, and HsPDF complexed to a binding compound, such as a PDF inhibitor. This crystallographic information will aid in the ident... | 06/29/2010 |
| 7648739 | Switchable surfaces A substrate having a surface with reversibly switchable properties. The surface comprises a nanolayer of a material that switches from a first conformation state to a second conformation state when an external stimulus is applied. When the nanolayer is in the first ... | 01/19/2010 |
| 7550146 | Glycopeptide conjugates and uses thereof The present invention provides novel glycoconjugates such as glycopeptides, as well as convergent methods for the synthesis thereof. An exemplary preparative approach is exemplified by the synthesis of the mucin motif commonly found on epithelial tumor cell surfaces... | 06/23/2009 |
| 7541450 | Ligand-dependent protein splicing Ligand-dependent inteins allow for modulation of a protein's activity in vivo. Upon binding of the ligand to the ligand-dependent intein inserted into the protein of interest, the hybrid protein undergoes protein splicing removing the intein. The activity of the spl... | 06/02/2009 |
| 7462483 | p27 and p21 in gene therapies The expansion of a population of stem cells or progenitor cells, or precursors thereof, may be accomplished by disrupting or inhibiting p21cip1/waf1 and/or p27, cyclin dependent kinase inhibitors. In the absence of p27 activity, progenitor cells move into... | 12/09/2008 |
| 7445892 | Method of testing anticancer agent-sensitivity of tumor cells Susceptibility of a tumor cell to an anticancer agent is tested by measuring an expression level or levels of a gene or genes selected from the group consisting of the genes listed in Tables 3 and 4 in a tumor cell collected from a cancer patient treated with an ant... | 11/04/2008 |
| 7384964 | Synthesis of epothilones, intermediates thereto, analogues and uses thereof The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (... | 06/10/2008 |
| 7291345 | Formable and settable polymer bone composite and method of production thereof A composite osteoimplant. The osteoimplant includes a polymer and bone-derived particles. The composite is adapted and constructed to be formable during or immediately prior to implantation and to be set after final surgical placement. ... | 11/06/2007 |
| 7270813 | Coupling agents for orthopedic biomaterials The invention provides a method for the preparation of bone-polymer composites wherein the mineral portion of the bone is treated with a coupling agent before being incorporated into a biocompatible polymeric matrix. The resulting composites may be used as such or b... | 09/18/2007 |
| 7244853 | Dioxanes and uses thereof In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I): and pharmaceutically acceptable... | 07/17/2007 |
| 7244572 | One-dimensional arrays on optical fibers Linear arrays of chemosensors or chemical compounds are supported by an optical fiber that allows one to rapidly assay the entire array using changes in optical properties such as fluorescence. The location of the agent along the fiber determines the identity of the... | 07/17/2007 |
| 7230074 | Inhibitors of dipeptidyl-aminopeptidase type IV Peptide inhibitors of dipeptidyl-aminopeptidase type IV (DP-IV) are provided. The peptide inhibitors have an isomeric purity of about 96–99 percent. The peptide inhibitors include one or more amino acids covalently coupled to boroproline moiety. The compounds are ... | 06/12/2007 |
| 7192739 | Ligand-dependent protein splicing Ligand-dependent inteins allow for modulation of a protein's activity in vivo. Upon binding of the ligand to the ligand-dependent intein inserted into the protein of interest, the hybrid protein undergoes protein splicing removing the intein. The activity of the spl... | 03/20/2007 |
| 7183054 | Assay for identifying biological targets of polynucleotide-binding compounds The present invention provides methods and systems for the identification of a biological target of a chemical compound, such as saframycin A, known to bind a polynucleotide. The invention also provides methods of screening chemical compounds for those which act in ... | 02/27/2007 |
| 7122549 | Saframycins, analogues and uses thereof In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I), and methods for the synthesis thereof. ... | 10/17/2006 |
| 7115651 | Macrocycles and uses thereof The present invention relates to compounds having the structure (and pharmaceutically acceptable derivatives thereof) wherein R0–R4, Z, X, A—B, D—E, G—J, and... | 10/03/2006 |
| 7097855 | Transdermal thermal polymerization An invention for polymerizing or crosslinking a prepolymer using a water soluble, thermal polymerization initiator is disclosed. The prepolymer mixed with the initiator is injected or placed into an animal's body, and heat is applied over the site of the injection t... | 08/29/2006 |
| 7091324 | Prevention and treatment of HCV infection employing antibodies directed against conformational epitopes Conformational epitopes of the envelope protein E2 of the Hepatitis C virus (HCV) have been identified and characterized using a panel of monoclonal antibodies derived from patients infected with HCV. These conformational epitopes have been determined to be importan... | 08/15/2006 |
| 6998115 | Biodegradable poly(β-amino esters) and uses thereof Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-c... | 02/14/2006 |
| 6972335 | Synthesis of epothilones, intermediates thereto, analogues and uses thereof The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention furth... | 12/06/2005 |
| 6965034 | Synthesis of epothilones, intermediates thereto and analogues thereof The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof, useful in the treatment of cancer and cancer which has developed a multidrug-resistant phenotype. Also provided are intermediates ... | 11/15/2005 |
