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| Number | Title | Issue Date |
| 7939626 | Chemoselective ligation The present invention features a chemoselective ligation reaction that can be carried out under physiological conditions. In general, the invention involves condensation of a specifically engineered phosphine, which can provide for formation of an amide bond between... | 05/10/2011 |
| 7939558 | Compounds having activity in increasing ion transport by mutant-CFTR and uses thereof The invention provides compositions, pharmaceutical preparations and methods for increasing activity (e.g., ion transport) of the mutant cystic fibrosis transmembrane conductance regulator protein (mutant-CFTR), e.g., ΔF508 CFTR, G551D-CFTR, G1349D-CFTR, or D1152H-... | 05/10/2011 |
| 7939278 | Methods and compositions for risk stratification The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, and... | 05/10/2011 |
| 7935345 | Monoclonal antibodies that specifically bind to and neutralize toxin, compositions, and methods of use The invention features compositions relating to antibodies that specifically bind to the protective antigen of Bacillus anthracis, fragments thereof, and nucleic acids encoding same. The invention further features methods of using such compositions. ... | 05/03/2011 |
| 7930104 | Predicting response to chemotherapy using gene expression markers The present invention provides gene expression information useful for predicting whether a cancer patient is likely to have a beneficial response to treatment with chemotherapy, comprising measuring, in a biological sample comprising a breast tumor sample obtained f... | 04/19/2011 |
| 7928056 | Enzyme treatment of foodstuffs for Celiac Sprue Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten. ... | 04/19/2011 |
| 7927794 | Methods for identifying a biosynthetic pathway gene product The present invention provides isolated, genetically modified host cells, where a host cell is genetically modified with a nucleic acid that includes a nucleotide sequence encoding a biosynthetic pathway enzyme. Synthesis of the enzyme in the host cell results in co... | 04/19/2011 |
| 7927616 | Pesticide compositions and methods for their use Pesticide compositions and methods for their use are provided. Embodiments of the subject pesticide compositions include a pesticide and an assimilable carbon skeleton energy component. Embodiments of the subject compositions may include a pesticide and one or more ... | 04/19/2011 |
| 7923582 | Chemoselective ligation The present invention features a chemoselective ligation reaction that can be carried out under physiological conditions. In general, the invention involves condensation of a specifically engineered phosphine, which can provide for formation of an amide bond between... | 04/12/2011 |
| 7923562 | Photocleavable linker methods and compositions Bifunctional linkers are provided that comprise a photocleavable moiety flanked by two different amine reactive moieties. In some embodiments the photocleavable moiety is a dimethoxynitrobenzyl moiety. In other embodiments the photocleavable moiety is 8-bromo-7-hydr... | 04/12/2011 |
| 7923532 | Methods for diagnosing celiac sprue and reagents useful therein Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten. ... | 04/12/2011 |
| 7923230 | Neurodegenerative protein aggregation inhibition methods and compounds Methods and compositions are provided for reducing aggregation of neurodegenerative proteins associated with neurotoxicity or other proteins. The compounds comprise a first domain or targeting element for binding to the target proteins linked to a second domain or r... | 04/12/2011 |
| 7922999 | Administration of growth factors for the treatment of CNS disorders A method and system that is directed to the local delivery of growth factors to the mammalian CNS to treat CNS disorders associated with neuronal death and/or dysfunction is described. ... | 04/12/2011 |
| 7922971 | Integrated meter for analyzing biological samples Analyte monitoring devices and methods therefore are provided. The devices integrate various functions of analyte monitoring, e.g., sample acquisition and testing. ... | 04/12/2011 |
| 7922883 | Biosensors and methods of using the same A biosensor strip having a low profile for reducing the volume of liquid sample needed to perform an assay. In one embodiment, the biosensor strip includes an electrode support; an electrode arrangement on the electrode support; a cover; a sample chamber; and an inc... | 04/12/2011 |
| 7919636 | Purifications of pomegranate ellagitannins and their uses thereof Compositions of purified and biologically active ellagitannins are provided by separation from pomegranate husk using a method of extraction and purification using a solid polymeric adsorbent and the uses of the said compounds. ... | 04/05/2011 |
| 7919279 | Methods and compositions for KIR genotyping The present invention provides methods for single nucleotide polymorphism (SNP)-based killer cell immunoglobulin-like receptor (KIR) gene cluster genotyping using the matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometer. In genera... | 04/05/2011 |
| 7918988 | Biosensor A biosensor comprises a space part for sucking and housing a sample formed of two upper and lower plates, the two plates being stuck together by an adhesive layer, the space part for sucking and housing the sample being constituted so as to be partially opened in th... | 04/05/2011 |
| 7918976 | Transition metal complexes with bidentate ligand having an imidazole ring Novel transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators in enzyme based electrochemical sensors. In such instances, transition metal complexes accept electrons fro... | 04/05/2011 |
| 7918975 | Analytical sensors for biological fluid The subject invention provides devices and methods for the analysis of a body fluid. Embodiments include sensors that are sample-fillable by contacting a corner of the sensor to a sample. ... | 04/05/2011 |
| 7918012 | Method of making calibration-adjusted analyte sensors A sensor, and methods of making, for determining the concentration of an analyte, such as glucose, in a biological fluid such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. The sensor includes a working electrode and a counte... | 04/05/2011 |
| 7915026 | Host cells for production of isoprenoid compounds Methods for synthesizing isopentenyl pyrophosphate are provided. A first method comprises introducing into a host microorganism a plurality of heterologous nucleic acid sequences, each coding for a different enzyme in the mevalonate pathway for producing isopentenyl... | 03/29/2011 |
| 7914987 | Methods and compositions for use in analyte detection using proximity probes Methods and compositions for detecting an analyte in a sample are provided. In practicing the subject methods, a sample is combined with at least a pair of proximity probes that each include an analyte binding domain and a nucleic acid domain. The resultant mixture ... | 03/29/2011 |
| 7914742 | Analyte meter protectors and methods Analyte meter protectors, meters that include the same, and methods. ... | 03/29/2011 |
| 7914335 | Strip connectors for measurement devices Devices including strip connectors in measurement devices are provided. Also provided are systems, kits and methods. ... | 03/29/2011 |
| 7912654 | Crystal structure βadrenoreceptor A computer readable medium comprising atomic coordinates for the human β2 adrenoreceptor is provided. The computer readable medium programming for displaying a molecular model of the human β2 adrenoreceptor, programming for identifying a comp... | 03/22/2011 |
| 7912651 | Function homology screening A method of screening biologically active agent based on the analysis of complex biological responses in culture. Methods for selecting cells and culture conditions for such screens are provided, as well as the identification of an optimized set of discrete paramete... | 03/22/2011 |
| 7910541 | Enzyme treatment of foodstuffs for celiac sprue Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten. ... | 03/22/2011 |
| 7910374 | Volumetric induction phase shift detection system for determining tissue water content properties A method of determining the condition of a bulk tissue sample, by: positioning a bulk tissue sample between a pair of induction coils (or antennae); passing a spectrum of alternating current (or voltage) through a first of the induction coils (or antennae); measurin... | 03/22/2011 |
| 7910369 | Culture systems for ex vivo development The present invention provides methods for the culture of animal pluripotent stem cells and their differentiated progeny cells, tissues, and organs, and nonhuman animal embryos and fetuses. ... | 03/22/2011 |
| 7909984 | Small volume in vitro analyte sensor A sensor designed to determine the amount and concentration of analyte in a sample having a volume of less than about 1 μL. The sensor has a working electrode coated with a non-leachable redox mediator. The redox mediator acts as an electron transfer agent between ... | 03/22/2011 |
| 7908090 | Signatures for human aging Age and related conditions are assessed with a gene expression test that determines the expression levels of a panel of genetic markers. Each age signature contains expression information for genes in at least one functional group that is identified herein as having... | 03/15/2011 |
| 7908089 | Patient classification Clinical patient tissue samples are classified according to the physiological status of cells present in the sample. In some embodiments of the invention, such cells are classified according to their ability to respond to therapeutic agents and treatments. In other ... | 03/15/2011 |
| 7906345 | Magnetic nanoparticles, magnetic detector arrays, and methods for their use in detecting biological molecules Magnetic nanoparticles and methods for their use in detecting biological molecules are disclosed. The magnetic nanoparticles can be attached to nucleic acid molecules, which are then captured by a complementary sequence attached to a detector, such as a spin valve d... | 03/15/2011 |
| 7906129 | Methods for treating a plant exposed to a phytotoxicant Methods of treating a plant exposed to a phytotoxicant are provided. Embodiments of the subject methods include identifying a plant exposed to a phytotoxicant and applying an assimilable carbon-skeleton energy component-comprising composition to the identified plant... | 03/15/2011 |
| 7906009 | Small volume in vitro analyte sensor A sensor designed to determine the amount and concentration of analyte in a sample having a volume of less than about 1 μL. The sensor has a working electrode coated with a non-leachable redox mediator. The redox mediator acts as an electron transfer agent between ... | 03/15/2011 |
| 7905999 | Biosensor strips and methods of preparing same A biosensor strip having a low profile for reducing the volume of liquid sample needed to perform an assay. In one embodiment, the biosensor strip comprises an electrode support; an electrode arrangement on said electrode support; a cover; a sample flow channel; and... | 03/15/2011 |
| 7905998 | Biosensor A biosensor comprises a space part for sucking and housing a sample formed of two upper and lower plates, the two plates being stuck together by an adhesive layer, the space part for sucking and housing the sample being constituted so as to be partially opened in th... | 03/15/2011 |
| 7902351 | Inhibition of viral gene expression using small interfering RNA The invention provides methods, compositions, and kits comprising small interfering RNA (shRNA or siRNA) that are useful for inhibition of viral-mediated gene expression. Small interfering RNAs as described herein can be used in methods of treatment of HCV infection... | 03/08/2011 |
| 7902121 | MHC-antigen arrays for detection and characterization of immune responses T cells are profiled with respect to their expression of antigen receptor. The cells are arrayed on a planar or three-dimensional substrate through binding to immobilized or partially diffused MHC-antigen complexes. The cells may further be characterized with respec... | 03/08/2011 |
