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| Number | Title | Issue Date |
| 8071782 | Synthesis of 1,3,4-trisubstituted and 1,3,4,5-tetrasubstituted pyrazoles This invention concerns the synthesis of highly substituted pyrazoles, which are structural components of pharmacological compounds, through reaction of hydrazones with nitroolefins. ... | 12/06/2011 |
| 8063206 | Processes for the preparation of cyclopropyl-amide derivatives The present invention is directed to novel processes for the preparation of cyclopropyl-amide derivatives, useful for the treatment of disorders and conditions mediated by the histamine receptor. ... | 11/22/2011 |
| 8026242 | Cyclopropyl amines as modulators of the histamine Hreceptor Certain cyclopropyl amines are histamine H3 modulators useful in the treatment of histamine H3 receptor mediated diseases. ... | 09/27/2011 |
| 8013157 | Synthesis of unsaturated piperidines from piperidones with a silyl reagent Syntheses of unsaturated piperidines from piperidones through a silyl piperidine reagent via the Shapiro reaction and palladium-catalyzed cross-coupling reactions with organo halides. ... | 09/06/2011 |
| 7947718 | Isoxazole compounds as histamine Hmodulators Certain isoxazole compounds are histamine H3 modulators useful in the treatment of histamine H3 receptor mediated diseases. ... | 05/24/2011 |
| 7915404 | Methods for the preparation of pyrazole-containing compounds The present invention is directed to novel processes for the preparation of fused pyrazole compounds, useful for the treatment of disorders and conditions mediated by serotonin receptor activity. ... | 03/29/2011 |
| 7910582 | Cyclopropyl amines as modulators of the histamine Hreceptor Certain cyclopropyl amines are histamine H3 modulators useful in the treatment of histamine H3 receptor mediated diseases. ... | 03/22/2011 |
| 7897771 | Fused heterocyclic compounds Certain fused pyrrole- and pyrazole-containing heterocyclic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases. ... | 03/01/2011 |
| 7893257 | Process for the preparation of piperazinyl and diazepanyl benzamide derivatives The present invention is directed to a novel process for the preparation of piperazinyl and diazepanyl benzamide derivatives, useful for the treatment of disorders and conditions mediated by a histamine receptor, preferably the H3 receptor. ... | 02/22/2011 |
| 7846930 | Diaryl-substituted tetrahydroisoquinolines as histamine Hreceptor and serotonin transporter modulators Certain diaryl-substituted tetrahydroisoquinoline compounds are histamine H3 receptor and/or serotonin transporter modulators useful in the treatment of histamine H3 receptor- and/or serotonin-mediated diseases. ... | 12/07/2010 |
| 7844326 | Electrotransport device having an integrally molded reservoir housing This invention relates to an electrotransport device, which incorporates a conductive element within the reservoir housing of the device, which permits electrical communication from within the housing to outside of the housing without the use of opening, which requi... | 11/30/2010 |
| 7807837 | Scalable synthesis of imidazole derivatives Imidazole derivatives, compositions containing them, methods of preparing them, including regioselective scale-up synthetic methods, and methods of using them. ... | 10/05/2010 |
| 7801599 | Transdermal electrotransport delivery device including an antimicrobial compatible reservoir composition A transdermal electrotransport drug delivery device having an anode, a cathode and a source of electrical power electrically connected to the anode and the cathode. At least one of the anode and the cathode includes an electrode and a reservoir comprised of a housin... | 09/21/2010 |
| 7795426 | Processes for the preparation of cyclopropyl-amide derivatives The present invention relates to processes for the preparation of cyclopropyl-amine derivatives of formula (II), as defined in the specification, useful for the treatment of disorders and conditions mediated by the histamine receptor. | 09/14/2010 |
| 7777031 | Substituted pyridyl amide compounds as modulators of the histamine H3 receptor Processes are disclosed for making certain compounds of Formula (II): or their pharmaceutically active salts, that are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-... | 08/17/2010 |
| 7767666 | Butyl and butynyl benzyl amine compounds Certain substituted butyl and butynyl benzyl amine compounds are histamine H3 receptor and/or serotonin transporter modulators useful in the treatment of histamine H3 receptor- and/or serotonin-mediated diseases. ... | 08/03/2010 |
| 7754882 | Hexahydro-pyrrolo-isoquinoline compounds Certain hexahydro-pyrrolo-isoquinoline compounds are histamine H3 receptor and serotonin transporter modulators useful in the treatment of histamine H3 receptor- and serotonin-mediated diseases. ... | 07/13/2010 |
| 7728129 | Processes for the preparation of piperazinyl and diazapanyl benzamide derivatives The present invention is directed to novel processes for the preparation of substituted piperazinyl and diazepanyl benzamides of formula (I), as defined in the specification, useful for the treatment of disorders and conditions mediated by the histamine receptor. | 06/01/2010 |
| 7708731 | Electrotransport delivery device with voltage boosting circuit An electrotransport device (10) for delivering therapeutic agents includes an adjustable voltage boos multiple controller (100, 200) for boosting the voltage from a power source (102, 202) to a working voltage Vw having a value just s... | 05/04/2010 |
| 7687499 | Cyclopropyl amines as modulators of the histamine Hreceptor Certain cyclopropyl amines are histamine H3 modulators useful in the treatment of histamine H3 receptor mediated diseases. ... | 03/30/2010 |
| 7598255 | Pyrimidine compounds as serotonin receptor modulators Certain pyrimidine-containing compounds are serotonin receptor modulators useful in the treatment of serotonin-mediated diseases. ... | 10/06/2009 |
| 7598249 | Piperazinyl and piperidinyl ureas as modulators of fatty acid amide hydrolase Certain piperazinyl and piperidinyl urea compounds are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activ... | 10/06/2009 |
| 7541359 | N-heteroarylpiperazinyl ureas as modulators of fatty acid amide hydrolase Certain N-heteroarylpiperazinyl urea compounds of Formula (I), as defined in the specification, are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, ... | 06/02/2009 |
| 7390780 | Gene delivery mediated by liposome-DNA complex with cleavable peg surface modification A liposome composition and method for delivery of a nucleic acid in vivo or ex vivo is described. The liposomes in the composition are comprised of (i) a cationic lipid and (ii) a lipid joined to a hydrophilic polymer by a releasable linkage. The liposomes are assoc... | 06/24/2008 |
| 7131960 | Apparatus and method for piercing skin with microprotrusions A method and device are described for applying a microprotrusion member (44) including a plurality of microprotrusions (90) to the stratum corneum with impact. The method and device are used to improve transport of an agent across the skin for agent de... | 11/07/2006 |
| 7097631 | Self-actuating applicator for microprojection array An applicator for applying a microprojection member to the stratum corneum of a patient having a housing, a piston moveable within the housing and a cap adapted to activate the applicator. The applicator is self-setting and auto-triggering, which allows the applicat... | 08/29/2006 |
| 7005140 | Lipid particles having asymmetric lipid coating and method of preparing same A method of preparing lipid particles having an asymmetric lipid coating is described. The lipid composition of the outer lipid coating of the particles varies from the inner to outer surfaces. The asymmetric lipid particles are formed by preparing a lipid compositi... | 02/28/2006 |
| 6218388 | Benzimidazoles for inhibiting protein tyrosine kinase mediated cellular proliferation Benzimidazoles of Formula I below are inhibitors of protein tyrosine kinases, and are useful in treating cellular proliferation. ##STR1## The compounds are especially useful in treating cancer, atherosclerosis, restenosis, and psoriasis.... | 04/17/2001 |
| 6194459 | Methods for treating physiological conditions associated with the use, or sequelae of use, of cocaine or other psychomotors stimulants Known cyclic amino acids, such as gabapentin and pregabalin, are used for treating physiological conditions associated with the use, or sequelae of use, of cocaine or other psychomotor stimulants and other addictive drugs/substances. Physiological conditi... | 02/27/2001 |
| 6133299 | Methods for treating neurodegenerative diseases and disorders using N-(2,6-disubstituted aromatic)-N'-pyridinyl ureas and other anticonvulsant compounds The instant invention is novel uses of known N-(2,6-disubstituted phenyl)-N'-3- and 4-pyridinyl ureas and pharmaceutically acceptable acid addition salts thereof. Such compounds as N-(2-chloro-6-methylphenyl)-N'-4-pyridinyl urea monohydrochloride or ... | 10/17/2000 |
| 6043407 | Debridement pad A debridement pad is provided having fibrinolysin enzyme, desoxyribonuclease enzyme and cellulosic material in the form of a lyophilized sponge-like pad. Placement of the pad over an open wound produces a gel which has a protective effect and which releas... | 03/28/2000 |
| 6028095 | Treatment of inflammatory bowel disease using histamine H3 -receptor agonists The present invention comprises a method for treating inflammatory bowel disease (IBD) by administering to a mammal in need thereof a therapeutically effective amount of at least one histamine H3 -receptor agonist. It has been unexpectedly foun... | 02/22/2000 |
| 5981595 | Sulfonyl urea and carbamate ACAT inhibitors A pharmaceutically useful compound which lowers blood cholesterol levels having the formula ##STR1## wherein X is oxygen or --NH--; Ar is phenyl, substituted phenyl, naphthyl or substituted naphthyl; R1 is hydrogen, lower alkyl or benzyl; ... | 11/09/1999 |
| 5792474 | Process for the production of retarded pharmaceutical compositions According to the present invention, there is provided a continuous method for the production of retarded pharmaceutical compositions by an extrusion process. A mixture of an active material, a low and high melting lipid or lipoid components is introduced ... | 08/11/1998 |
| 5686104 | Stable oral CI-981 formulation and process of preparing same An oral pharmaceutical composition is provided for treating hypercholestereolemia or hyperlipidemia containing an advantageous formulation for stabilizing the HMG-CoA coenzyme A inhibitor, CI-981 Hemi-Calcium, of formula (IA) ##STR1## with effec... | 11/11/1997 |
| 5666962 | Thermography as a method of measuring viral activity in a herpes labialis infection Disclosed is a non-invasive method of measuring the progress of viral activity in a mammalian herpes labialis episode, the method comprising the step of measuring the temperature of the symptomatic area of the herpes labialis episode during the episode. A... | 09/16/1997 |
| 5656296 | Dual control sustained release drug delivery systems and methods for preparing same The present invention pertains to a dual control sustained release drug delivery system which comprises a core and a porous coating layer over the core, wherein the coated core comprises (A) a core comprising in percentages by weight of the core compositi... | 08/12/1997 |
| 5650174 | Composition for peroral therapy of cognition impairment and a process thereof A solid composition for peroral therapy of cognition impairment is formulated to stabilize the acid labile drug, CI-979 HCl, by layering a mixture of thereof with a binder on mini-sugar spheres, and finally covering the structure with a protective coating... | 07/22/1997 |
| 5641536 | Tablet coating method A method for coating pharmaceutical tablets is disclosed in which polymeric coating ingredients are combined with saccharides in a melt spinning operation to form composite particulates. The particulates are then dispersed in water to form an aqueous poly... | 06/24/1997 |
| 5641513 | Tablet coating method A method for coating pharmaceutical tablets is disclosed in which polymeric coating ingredients are combined with saccharides in a melt spinning operation to form composite particulates. The particulates are then dispersed in water to form an aqueous poly... | 06/24/1997 |
