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| Number | Title | Issue Date |
| 7947650 | Article of manufacture The present invention relates to a method for the treatment of a cartilage disorder, including cartilage damaged by injury or degenerative cartilagenous disorders. The method involves contacting the cartilage with an IGF-1 analog with altered affinity for IGF-bindin... | 05/24/2011 |
| 7939268 | Compositions and methods for the diagnosis and treatment of tumor The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. ... | 05/10/2011 |
| 7935671 | Pantropic neurotrophic factors Pantropic neurotrophic factors which have multiple neurotrophic specificities are provided. The pantropic neurotrophic factors of the present invention are useful in the treatment of neuronal disorders. Nucleic acids and expression vectors encoding the pantropic neu... | 05/03/2011 |
| 7932059 | dUTP-based compositions for reducing primer-aggregate formations during nucleic acid amplification Methods and compositions are provided for enhanced specificity and sensitivity of amplification reaction mixtures. Compositions in accordance with the present invention provide for reduced formation of primer-aggregates during amplification reactions. Reaction mixes... | 04/26/2011 |
| 7930109 | Crystal structure of CRIg and C3b:CRIg complex The present invention concerns determination of the crystal structure of the macrophage specific receptor, CRIg (earlier referred to as STIgMA), and its complex with the C3b and C3c subunits of complement C3 (C3b:CRIg and C3c:CRIg complexes). The invention further c... | 04/19/2011 |
| 7926029 | System and method of progressive domain specialization product solutions The present invention relates to a software development infrastructure and/or methodology in, for example, multi-platform computing environments. More specifically, this invention relates to a software development system and an approach for providing, for example in... | 04/12/2011 |
| 7919672 | Suppression of B-cell apoptosis in transgenic animals expressing humanized immunoglobulin The invention provides a novel approach to increase immunoglobulin expression in non-human transgenic animals. For instance, the invention provides a method to increase humanized immunoglobulin production in animals genetically engineered to express one or several h... | 04/05/2011 |
| 7919608 | Nucleic acid molecules and other molecules associated with plants Expressed Sequence Tags (ESTs) isolated from maize are disclosed. The ESTs provide a unique molecular tool for the targeting and isolation of novel genes for plant protection and improvement. The disclosed ESTs have utility in the development of new strategies for u... | 04/05/2011 |
| 7919254 | Tissue analysis and kits therefor This invention relates to methods of analyzing a tissue sample from a subject. In particular, the invention combines morphological staining and/or immunohistochemistry (IHC) with fluorescence in situ hybridization (FISH) within the same section of a tissue sample. T... | 04/05/2011 |
| D635142 | USB device for facilitating VoIP calls | 03/29/2011 |
| 7908991 | Air powered signaling system A portable air horn apparatus includes a housing, an air horn assembly for generating a warning sound, a switch for activating the air horn assembly and a power source. A microprocessor is provided in communication with the switch, the air horn assembly and the powe... | 03/22/2011 |
| 7906708 | Slow-maturing, determinate peas A determinate pea plant, where peas of the pea plant have a wrinkled-seed phenotype, and where the pea plant is slow-maturing. ... | 03/15/2011 |
| 7893323 | Transformation of . with agrobacterium using embryogenic callus cultures The present invention relates to a method for transforming Allium species with a heterologous gene using Agrobacterium. ... | 02/22/2011 |
| 7892549 | Treatment with anti-ErbB2 antibodies The present invention concerns the treatment of disorders characterized by the overexpression of ErbB2. More specifically, the invention concerns the treatment of human patients susceptible to or diagnosed with cancer overexpressing ErbB2 with a combination of an an... | 02/22/2011 |
| 7888478 | Compositions and methods for the treatment of tumor of hematopoietic origin The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same. ... | 02/15/2011 |
| 7846690 | Cloning of honey bee allergen The present invention relates to a nucleic acid encoding a polypeptide capable of binding to IgE from subjects allergic to venom of an insect from the order Hymenoptera having a homology of more than 70% to the amino acid sequence of SEQ ID NO: 2, which is the honey... | 12/07/2010 |
| 7846453 | Methods of stimulating ErbB4 receptor phosphorylation The invention concerns a novel neuregulin related ligand (NRG3) including fragments and variants thereof, as new members of the neuregulin family of compounds. The invention also concerns methods and means for producing NRG3. The native polypeptides of the invention... | 12/07/2010 |
| 7879334 | Fusion molecules and treatment of IgE-mediated allergic diseases The invention concerns bifunctional fusion molecules for the treatment of IgE-mediated allergic conditions and FcεRI-mediated autoimmune conditions. The invention provides a new therapeutic approach for the treatment of both acute and late-phase allergic responses ... | 02/01/2011 |
| 7879324 | Fusion molecules and methods for treatment of immune diseases The invention concerns bifunctional fusion molecules, and novel, safer and more efficacious methods for the treatment of immune disorders resulting from excessive or unwanted immune responses. The invention provides methods for the suppression of type I hypersensiti... | 02/01/2011 |
| 7875431 | Methods for detecting inflammatory bowel disease The present invention provides for a method of detecting the presence of inflammatory bowel disease in gastrointestinal tissues or cells of a mammal by detecting increased expression of LY6 genes in the tissues or cells of the mammal relative to a control. ... | 01/25/2011 |
| 7868149 | Plant genome sequence and uses thereof The present invention is in the field of plant biochemistry and genetics. More specifically the invention relates to nucleic acid molecules from plant cells, in particular, genomic DNA sequences from rice plants and nucleic acid molecules that contain markers, in pa... | 01/11/2011 |
| 7863262 | Nitroxyl progenitors in the treatment of heart failure Administration of an HNO/NO− donating compound, such as Angeli's salt, increases myocardial contractility while concomitantly lowering left ventricular preload in subjects experiencing heart failure. Moreover, administration of the HNO/NO− ... | 01/04/2011 |
| 7863050 | Methods and compositions for purification of nucleic acid from a host cell Methods and compositions are provided for gently lysing and solubilizing cells. Methods and compositions are further provided for quickly purifying high quality low molecular weight nucleic acid from host cells. Target cells are treated with a pre-chilled lysis solu... | 01/04/2011 |
| 7858339 | Process for bacterial production of polypeptides Refractile particles containing a heterologous polypeptide as an insoluble aggregate are recovered from bacterial periplasm. The process involves culturing bacterial cells so as to express nucleic acid encoding phage lysozyme and nucleic acid encoding the heterologo... | 12/28/2010 |
| 7858330 | Compositions and methods for the treatment of tumor of hematopoietic origin The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same. ... | 12/28/2010 |
| 7855182 | Materials and methods for treatment of cancer Glypican 5 is shown for the first time to have a role in proliferation of cancer cells, including tumors which do not show chromosomal amplification at 13q31. The use of glypican 5 (GPC5) antagonists and binding agents for the treatment of cancer, particularly rhabd... | 12/21/2010 |
| 7850966 | Method of treating breast cancer using anti-HER2 antibody variants The present invention concerns novel antibody variants, particularly anti-HER2 antibody variants having substitutions at positions within the variable domains of the heavy and light chains. ... | 12/14/2010 |
| 7834146 | Recombinant polypeptides associated with plants Recombinant polynucleotides and recombinant polypeptides useful for improvement of plants are provided. The disclosed recombinant polynucleotides and recombinant polypeptides find use in production of transgenic plants to produce plants having improved properties. | 11/16/2010 |
| 7829552 | Phosphorus-containing thyromimetics The present invention relates to compounds of phosphonic acid containing T3 mimetics, stereoisomers, pharmaceutically acceptable salts, co-crystals, and prodrugs thereof and pharmaceutically acceptable salts and co-crystals of the prodrugs, as well as their preparat... | 11/09/2010 |
| 7812220 | Engineering β-ketoacyl ACP synthase for novel substrate specificity Methods of altering substrate specificity of beta-ketoacyl-ACP synthase, and engineered beta-ketoacyl-ACP synthases so produced are provided. DNA sequences and constructs for expression of engineered beta-ketoacyl-ACP synthases, as well as the novel beta-ketoacyl-AC... | 10/12/2010 |
| 7811773 | Analytical method The instant invention describes an analytical assay to accurately measure an analyte in the presence of an interfering substance. ... | 10/12/2010 |
| 7811556 | Polymeric modifiers and pharmaceutical compositions A copolymer or a pharmacologically acceptable salt thereof is provided, which contains, as constitutional units, (a) one or more structural units of formula (I): wherein m is an integer of from 3 to 100, Alk represents alkyline, and R1 and R2 a... | 10/12/2010 |
| 7811437 | Conductive media for electrophoresis A series of low molarity conductive media based on non-buffering univalent cations, such as sodium chloride-sodium acetate (SCA), sodium boric acid (SB), lithium boric acid, and lithium acetate mitigate the “runaway” positive feedback heating loop produced by co... | 10/12/2010 |
| 7807799 | Reducing protein A leaching during protein A affinity chromatography A method for reducing leaching of protein A during protein A affinity chromatography is described which involves reducing temperature or pH of, or by adding one or more protease inhibitors to, a composition that is subjected to protein A affinity chromatography.... | 10/05/2010 |
| 7799976 | Tomato plants that exhibit resistance to The present invention relates to tomato plants that exhibit resistance to Botrytis cinerea and methods for developing new inbreds, hybrid, apomictic and genetically engineered tomato plants that possess resistance to Botrytis cinerea and having commerc... | 09/21/2010 |
| 7795504 | Coordinated decrease and increase of gene expression of more than one gene using transgenic constructs The present invention is directed to nucleic acid molecules and nucleic acid constructs, and other agents associated with simultaneous up- and down-regulation of expression of RNAs. Specifically it includes methods of simultaneously enhancing the expression of a fir... | 09/14/2010 |
| 7790870 | Membrane-anchored GP41 peptides that inhibit subsequent HIV viral entry The invention relates to the genetically engineered treatment of an HIV infection by the expression of membrane-anchored gp41 peptides. With this treatment vectors are made available for the first time which code for a fusion protein that contains a peptide derived ... | 09/07/2010 |
| 7771719 | Pharmaceutical compositions, kits, and therapeutic uses of antagonist antibodies to IL-17E The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric ... | 08/10/2010 |
| 7754858 | Antibodies to tumor necrosis factor receptor associated factor polypeptides The invention concerns antibodies to new tumor necrosis factor receptor associated factors, designated TRAF. The new factors are capable of specific association with the intracellular domain of the type 2 TNF receptor (TNF-R2), and are involved in the mediation of t... | 07/13/2010 |
| 7754441 | Compositions and methods for the treatment of tumor of hematopoietic origin The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same. ... | 07/13/2010 |
