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| Number | Title | Issue Date |
| 6350859 | Class BI and CI scavenger receptors Two distinct scavenger receptor type proteins having high affinity for modified lipoproteins and other ligands have been isolated, characterized and cloned. HaSR-BI, an AcLDL and LDL binding scavenger receptor, which is distinct from the type I and type I... | 02/26/2002 |
| 6280944 | Assay for pathogenicity of anti-DNA antibodies Assays that are prognostic for patients that will develop nephritis have been developed where patient serum is screened for the presence of anti-dsDNA antibodies that are cross reactive with A and D SnRNP proteins. The assays are based on the use of eithe... | 08/28/2001 |
| 6261544 | Poly(hydroxy acid)/polymer conjugates for skin applications A method for alleviating the symptoms of a cosmetic or dermatologic skin condition is described. An effective amount of a poly(hydroxy acid)/polymer conjugate in a pharmaceutically or cosmetically acceptable vehicle is provided. Topical compositions of th... | 07/17/2001 |
| 6245537 | Removing endotoxin with an oxdizing agent from polyhydroxyalkanoates produced by fermentation Polyhydroxyalkanoate (PHA) that contains a pyrogen such as endotoxin due to a process of producing the PHA is treated to remove the pyrogen by a process that does not affect the inherent chemical and physical properties of the PHA to obtain a biocompatibl... | 06/12/2001 |
| 6238925 | Method for determining likelihood of developing clinical tolerance It has been discovered that one can predict the likelihood a child will outgrow an allergy, especially a food allergy, by screening for IgE antibodies immunoreactivities with linear versus conformational epitopes. The child is first screened using standar... | 05/29/2001 |
| 6239101 | Thrombin binding polypeptides Small, buffer soluble polypeptides having amino acid structures corresponding to residues 234-486, 310-486, and 407-486, of thrombomodulin and functionally equivalent analogs thereof inhibiting the clotting activity of thrombin and increasing protein C ac... | 05/29/2001 |
| 6235313 | Bioadhesive microspheres and their use as drug delivery and imaging systems Bioadhesive polymers in the form of, or as a coating on, microcapsules containing drugs or bioactive substances which may serve for therapeutic, or diagnostic purposes in diseases of the gastrointestinal tract, are described. The polymeric microspheres al... | 05/22/2001 |
| 6235061 | Poly(organophosphazene) matrices for bone replacement A highly porous three-dimensional biodegradable poly(organophosphazene) matrix with hydrolytically unstable side chains is prepared and used as a scaffold for the growth of osteoblast cells. In a preferred embodiment, the poly(organophosphazene) includes ... | 05/22/2001 |
| 6234990 | Ultrasound enhancement of transdermal transport Methods and devices for application of ultrasound to a small area of skin for enhancing transdermal transport. An ultrasound beam having a first focal diameter is channelled into a beam having a second, smaller diameter without substantial loss of energy.... | 05/22/2001 |
| 6231892 | Compositions for coating microcapsules and other surfaces Biocompatible microcapsules useful for transplanting foreign material into an animal body, and the method of their production, are described, wherein the microcapsules contain an outermost layer of water soluble non-ionic polymers such as PEO to create re... | 05/15/2001 |
| 6231847 | Method of treating vascular proliferative responses This invention relates to a method of treating vascular proliferative responses in a patient that comprises intravenously administering to the patient a proliferative response inhibiting amount of poly(arginine).... | 05/15/2001 |
| 6231536 | Method and compositions for treatments of cancers A method to treat cancer uses ultrapheresis, refined to remove compounds of less than 120,000 daltons molecular weight, followed by administration of replacement fluid, to stimulate the patient's immune system to attack solid tumors. In the preferred embo... | 05/15/2001 |
| 6232522 | Non-human animal model for systemic lupus erythematosis A specific method has been developed to produce an autoimmune response and resulting clinical symptoms for a particular disease process. Peptides or other structures derived from an autoantigen and which are bound by auto antibody or T cell receptors are ... | 05/15/2001 |
| 6228934 | Methods and apparatus for the production of amorphous polymer suspensions Methods and apparati have been developed for producing a suspension of predominately amorphous polymer particles, wherein the method includes thermally treating a suspension that includes crystalline or semi-crystalline polymer particles. The thermal trea... | 05/08/2001 |
| 6228396 | Colonic drug delivery composition A colonic drug delivery composition is provided and comprises a starch capsule containing a drug, the starch capsule being provided with a coating such that the drug will only be released from the capsule in the colon. The coating may be a pH sensitive ma... | 05/08/2001 |
| 6228578 | Non-radioactive hybridization assay and kit A non-radioactive hybridization assay and kit for the detection of genetic defects, microbial infections or viral infections, such as human papillomavirus. A test sample is treated with a base and incubated with nucleic acid probes, diluted in a neutraliz... | 05/08/2001 |
| 6225103 | Cloning and characterization of napsin A previously unknown aspartic protease capable of cleavage of proteins by hydrolysis, referred to herein as "napsin", has been cloned from a human liver library. Two cDNA clones have been cloned, sequenced and expressed. These encode isozymes of the prote... | 05/01/2001 |
| 6223455 | Spray drying apparatus and methods of use Improved spray drying apparati, and methods of use thereof, have been developed. The spray drying equipment includes a primary drying chamber and a secondary drying apparatus which includes tubing having a length sufficient to increase the contact time be... | 05/01/2001 |
| 6225053 | Detection of hepatitis B virus An improved assay disclosed for detecting viral nucleic acid sequences. The improvement involves concentration viral particles from a biological sample by centrifugation. Once concentrated, the nucleic acid molecules in the viral particles can be manipula... | 05/01/2001 |
| 6218520 | DNA sequences encoding human membrane cofactor protein (MCP) Human membrane cofactor protein, a protein involved in regulation of complement activity, has been purified to homogeneity. The gene encoding this protein has been retrieved and permits deduction of the entire amino acid sequence and the recombinant produ... | 04/17/2001 |
| 6217894 | Compliant tissue sealants An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, the system is compliant, in that it is capable of conforming t... | 04/17/2001 |
| 6217908 | Bioadhesive microspheres and their use as drug delivery and imaging systems Bioadhesive polymers in the form of, or as a coating on, microcapsules containing drugs or bioactive substances which may serve for therapeutic, or diagnostic purposes in diseases of the gastrointestinal tract, are described. The polymeric microspheres al... | 04/17/2001 |
| 6214920 | Polyhydroxyalkanoate molding compositions Molding compositions including polyhydroxyalkanoates are provided. The use of polyhydroxyalkanoates as a binder in molding compositions provides improved binder removal in the finished molded product, and offers a wide range of physical properties suitabl... | 04/10/2001 |
| 6214387 | Biodegradable polymer matrices for sustained delivery of local anesthetic agents Biodegradable controlled release microspheres for the prolonged administration of a local anesthetic agent, and a method for the manufacture thereof are disclosed. The microspheres are formed of a biodegradable polymer degrading significantly within a mon... | 04/10/2001 |
| 6214606 | Yeast heat shock protein 60 and analogs A purified, biologically active yeast mitochondrial heat shock protein exhibiting an Mr of about 60K (hsp60) and its biologically active analogs exhibiting an Mr of 55K-65K are disclosed. Polynucleotide segments that encode hsp60 and... | 04/10/2001 |
| 6210884 | Rolling circle replication reporter systems Disclosed are compositions and a method for of amplifying nucleic acid sequences useful for detecting the presence of molecules of interest. The method is useful for detecting specific nucleic acids in a sample with high specificity and sensitivity. The m... | 04/03/2001 |
| 6207749 | Comb copolymers for regulating cell-surface interactions Synthetic comb copolymers which elicit controlled cellular response, methods of applying these polymers to various surfaces, and methods of using the polymers for modifying biomaterial surfaces, in tissue engineering applications and as drug delivery devi... | 03/27/2001 |
| 6207217 | Animal nutrition compositions Compositions providing increased energy content of animal feed using plant crop biomass which include a polyhydroxyalkanoate have been developed. In one embodiment, the compositions can be prepared using conventional techniques for harvesting and processi... | 03/27/2001 |
| 6207197 | Gastroretentive controlled release microspheres for improved drug delivery There is provided a drug delivery composition for the controlled release of an active agent in the stomach environment over a prolonged period of time, which comprises a microsphere comprising an active ingredient in the inner core of the microsphere and ... | 03/27/2001 |
| 6206911 | Stent combination Radially expandable intraluminal stents (11) suitable for providing interior support within a human blood vessel are disclosed. A material (33') used to construct the stent (11) is formed into diamond cells (35). The diamond cells (35) each have arms (37)... | 03/27/2001 |
| 6201065 | Multiblock biodegradable hydrogels for drug delivery and tissue treatment Gel-forming macromers including at least four polymeric blocks, at least two of which are hydrophobic and at least one of which is hydrophilic, and including a crosslinkable group are provided. The macromers can be covalently crosslinked to form a gel on ... | 03/13/2001 |
| 6200751 | Endothelial specific expression regulated by EPCR control elements The promoter of the EPCR gene has been isolated from both murine (SEQ. ID No. 1) and human (SEQ. ID No. 2) genomic libraries. The promoter includes a region (nucleotides 3130 to 3350 of SEQ. ID No. 1 which affects selective gene expression in endothelial ... | 03/13/2001 |
| 6200602 | Composition for enhanced uptake of polar drugs from the colon The invention provides a drug delivery composition for colonic delivery comprising a polar drug, an absorption promoter which (a) comprises a mixture of a fatty acid having 6 to 16 carbon atoms or a salt thereof and a dispersing agent, or (b) comprises a ... | 03/13/2001 |
| 6197575 | Vascularized perfused microtissue/micro-organ arrays Systems including (1) a micromatrix and perfusion assembly suitable for seeding and attachment of cells within the matrix and for morphogenesis of seeded cells into complex, hierarchical tissue or organ structures, wherein the matrix includes channels or ... | 03/06/2001 |
| 6197346 | Bioadhesive microspheres and their use as drug delivery and imaging systems Bioadhesive polymers in the form of, or as a coating on, microcapsules containing drugs or bioactive substances which may serve for therapeutic, diagnostic, or diagnostic purposes in diseases of the gastrointestinal tract, are described. The polymeric mic... | 03/06/2001 |
| 6190315 | Sonophoretic enhanced transdermal transport Methods for enhanced transdermal transport wherein the application of ultrasound is required only once for repeated or sustained transdermal extraction or delivery, over a period of time, rather than prior to each extraction or delivery. The method is app... | 02/20/2001 |
| 6183960 | Rolling circle replication reporter systems Disclosed are compositions and a method for of amplifying nucleic acid sequences useful for detecting the presence of molecules of interest. The method is useful for detecting specific nucleic acids in a sample with high specificity and sensitivity. The m... | 02/06/2001 |
| 6176874 | Vascularized tissue regeneration matrices formed by solid free form fabrication techniques Solid free-form fabrication (SFF) methods are used to manufacture devices for allowing tissue regeneration and for seeding and implanting cells to form organ and structural components, which can additionally provide controlled release of bioactive agents,... | 01/23/2001 |
| 6173199 | Method and apparatus for intubation of a patient A catheter having a distal end portion including a sensor responsive to the presence of a magnetic field or flux of a predetermined strength is provided. Also provided is a catheter system which further includes an external magnet. The sensor in the dista... | 01/09/2001 |
| 6165750 | Modified-affinity streptavidin Streptavidin tetramers have at least one monomer containing an amino acid modification that produces a reduced binding affinity for biotin, a modified off-rate, a modified on-rate, or an altered binding enthalpy. Polynucleotides encoding the modified mono... | 12/26/2000 |
