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| Number | Title | Issue Date |
| 5759830 | Three-dimensional fibrous scaffold containing attached cells for producing vascularized tissue in vivo A cell-scaffold composition is prepared in vitro for implanting to produce functional organ tissue in vivo. The scaffold is three-dimensional and is composed of fibers of a biocompatible, biodegradable, synthetic polymer. Cells derived from vascularized o... | 06/02/1998 |
| 5726723 | Sub-twisted nematic liquid crystal display A sub-twisted nematic liquid crystal display (SBTN-LCD) device (30) having a liquid crystal layer (34) characterized as a polarization rotator below an optical threshold voltage, a half-wavelength plate at approximately a saturation voltage, and a transpa... | 03/10/1998 |
| 5712269 | M2 receptor ligand for the treatment of neurological disorders Muscarinic M2 receptor ligands are described which are suitable for the treatment of neurological disorders, and which may be administered with minimal side-effects. A method of synthesis of these compounds is also described.... | 01/27/1998 |
| 5712091 | Method of selecting genetically superior shrimp A method for the selection of shrimp having a genetically-transmitted favorable growth characteristic for improved aquacultured shrimp production. A genetic marker for the favorable characteristic is prepared by isolating Penaeus shrimp nuclear DNA by ext... | 01/27/1998 |
| 5705732 | Universal donor cells Genetically engineered cells are provided which can serve as universal donor cells in such applications as reconstruction of vascular linings or the administration of therapeutic agents. The cells include a coding region which provides protection against ... | 01/06/1998 |
| 5695993 | Cloning and regulation of an endothelial cell protein C/activated protein C receptor Human protein C and activated protein C were shown to bind to endothelium specifically, selectively and saturably (Kd=30 nM, 7000 sites per cell) in a Ca2+ dependent fashion. Expression cloning revealed a 1.3 kb CDNA that coded for a novel type... | 12/09/1997 |
| 5690930 | DNA encoding the heme-regulated eukaryotic initiation factor 2 kinase The cDNA which encodes heme-regulated eIF-2 kinase (HRI) has been cloned from a lambda Zap II cDNA library of rabbit reticulocytes. The rabbit HRI cDNA is highly homologous to human HRI and hybridizes to the human HRI DNA under moderately stringent... | 11/25/1997 |
| 5681845 | DMPO spin trapping compositions and methods of use thereof Spin trapping compositions in general have now been discovered to be effective in treating a variety of disorders, including disorders such as those arising from ischemia, infection, inflammation, exposure to radiation or cytotoxic compounds, not just of ... | 10/28/1997 |
| 5679362 | Packaged fungal culture stable to long term storage A method for packaging an insect infection chamber that attracts insects, then infects them with a lethal dosage of fungus, where the packaging maintains high humidity within the chamber, allows fee exchange of gases, and is impermeable to microbes, inclu... | 10/21/1997 |
| 5667778 | Injectable bladder muscle cells-polymer suspension for treatment of vesicoureteral reflux and incontinence A method of treatment of vesicoureteral reflux, incontinence and other defects is described wherein bladder muscle cells are mixed with a liquid polymeric material to form a suspension. This is injected into the area of the defect, in an amount effective ... | 09/16/1997 |
| 5665359 | Method and compositions for lowering blood lipids It has been discovered that the Chinese fruit known as shanzha, and extracts and purified component derived therefrom, can be administered orally to animals to reduce levels of cholesterol in the blood. The mechanism of action is believed to include the "... | 09/09/1997 |
| 5663063 | Method for producing polyester biopolymers A method for controlling and modifying biopolymer synthesis by manipulation of the genetics and enzymology of synthesis of polyhydroxybutyrate (PHB) and polyhydroxyalkanoate (PHA) polyesters at the molecular level in procaryotic and eukaryotic cells, espe... | 09/02/1997 |
| 5661026 | Gene encoding bacterial beta-ketothiolase The present invention is a method for controlling biopolymer synthesis by determining the genetics and enzymology of polyhydroxybutyrate (PHB) biosynthesis at the molecular level. The purified enzymes and genes provide the means for developing new PHB-lik... | 08/26/1997 |
| 5660825 | Method of inhibition of complement mediated inflammatory response A composition and methods for use thereof relating to polypeptides having the ability to act as an inhibitor of complement C5b-9 complex activity. The compositions contain an 18 kDa protein found on the surface of human erythrocytes, a 37 kDa protein foun... | 08/26/1997 |
| 5654381 | Functionalized polyester graft copolymers Synthetic, functionalized, graft copolymers of polyesters and amino acids are provided. The copolymers are formed in one embodiment by providing a linear polyester-poly(amino acid) copolymer, and reacting the amino acid groups in the linear polymer with a... | 08/05/1997 |
| 5654273 | Synducin mediated modulation of tissue repair The membrane permeating antibacterial peptide, PR-39, previously found only in the intestine, was purified from wound fluid and shown to possess syndecan-1 and syndecan-4 inductive activity specifically in mesenchymal cells. This is a newly recognized fun... | 08/05/1997 |
| 5651986 | Controlled local delivery of chemotherapeutic agents for treating solid tumors A method and devices for localized delivery of a chemotherapeutic agent to solid tumors, wherein the agent does not cross the blood-brain barrier and is characterized by poor bioavailability and/or short half-lives in vivo, are described. The devices cons... | 07/29/1997 |
| 5648095 | Preparation of microparticles Hollow microcapsules or solid microspheres for use in diagnostic procedures, as well as methods for making the microcapsules, are provided, which are formed by combining a volatile oil with an aqueous phase including a water soluble material such as a sta... | 07/15/1997 |
| 5641660 | Glutamicum threonine biosynthetic pathway The present invention is a method for the isolation and characterization of C. glutamicum genes involved in amino acid biosynthesis, specifically, encoding hom, thrB, and thrC, and sequences regulating their expression. Techniques for modifying or replaci... | 06/24/1997 |
| 5637454 | Assays and treatments of autoimmune diseases A specific method has been developed to identify the etiologic or immunogenic agent responsible for the production of autoantibodies characteristic of a particular disorder or immune response. The antigen is first isolated, then divided into overlapping s... | 06/10/1997 |
| 5631162 | Retroviral vectors for transducing ଲ-globin gene and ଲ-locus control region derivatives A process and means for the design and the optimization of retroviral vectors transducing human ଲ-globin gene and ଲ-Locus Control Region (ଲ-LCR) derivatives, hereafter referred to as [ଲ-globin/LCR] retroviruses, which successfully ... | 05/20/1997 |
| 5629011 | Composition for nasal administration A composition for nasal administration of polar metabolites of opioid analgesics comprises a polar metabolite of an opioid analgesic and an absorption promoting agent. Preferred metabolites morphine-6-glucuronide and morphine-6-sulphate. A preferred absor... | 05/13/1997 |
| 5629009 | Delivery system for controlled release of bioactive factors A composition and method for controlled release of water-soluble proteins comprising a surface-eroding polymer matrix and water-soluble bioactive factors is described. The composition bioerodes in the biological environment of the subject at a controlled ... | 05/13/1997 |
| 5627233 | Multifunctional organic polymers Described herein is a multi-functional polymeric material for use in inhibiting adhesion and immune recognition between cells and cells, cells and tissues, and tissues and tissues. One component of the polymeric material adsorbs well to cells or tissue, a... | 05/06/1997 |
| 5626862 | Controlled local delivery of chemotherapeutic agents for treating solid tumors A method and devices for localized delivery of a chemotherapeutic agent to solid tumors, wherein the agent does not cross the blood-brain barrier and is characterized by poor bioavailability and/or short half-lives in vivo, are described. The devices cons... | 05/06/1997 |
| 5626861 | Polymeric-hydroxyapatite bone composite A method for the fabrication of three-dimensional macroporous polymer matrices for use as bone graft or implant material was developed. The composites are formed from a mixture of biodegradable, biocompatible polymer and hydroxyapatite (HA), a particulate... | 05/06/1997 |
| 5625124 | Animal model for helicobacter pylori infection Transgenic non-human animals are described which serve as a model for H. pylori infection of epithelial cells of the stomach and small intestine. The gut epithelial cells of the transgenic animals express one or more surface carbohydrate antigens which ac... | 04/29/1997 |
| 5625030 | Methods for synthesizing oligomers containing hydroxy acid units Methods for synthesizing oligomers containing hydroxy acids, and optionally containing other types of monomers or oligomers such as amino acids, carbohydrates, nucleotides and peptides, are provided which are rapid, simple, and readily automated. The olig... | 04/29/1997 |
| 5624904 | Method for treating gram positive septicemia Macrophage scavenger receptor protein or active fragments thereof bind specifically to the lipoteichoic acid residues on the Gram-positive bacterial cell wall. This protein or active fragments thereof can be used in a variety of methods including methods ... | 04/29/1997 |
| 5618850 | Hydroxy-acid cosmetics A method for alleviating the symptoms of a cosmetic or dermatologic skin condition is described. An effective amount of a poly(hydroxy acid)/polymer conjugate in a pharmaceutically or cosmetically acceptable vehicle is provided. Topical compositions of th... | 04/08/1997 |
| 5618563 | Biodegradable polymer matrices for sustained delivery of local anesthetic agents An improved biodegradable controlled release system consisting of a polymeric matrix incorporating a local anesthetic for the prolonged administration of the local anesthetic agent, and a method for the manufacture thereof, are disclosed. The polymers and... | 04/08/1997 |
| 5614501 | Compositions and methods for animal husbandry and for treating gastrointestinal disorders Compositions containing hemicelluloses in combination with polyphenols, methods of preparing the compositions, and methods of treating humans or animals with the composition are provided. Also provided is a method for increasing growth rate, improving fee... | 03/25/1997 |
| 5611344 | Microencapsulated fluorinated gases for use as imaging agents It has been discovered that the incorporation of fluorinated gases, especially a perfluorocarbon such as octafluoropropane, into synthetic polymeric microparticles, significantly enhances echogenicity as compared with microparticles having air incorporate... | 03/18/1997 |
| 5605821 | Expression control sequences of the P-selectin gene DNA molecules and methods for the regulated expression of a gene in endothelial cells or megakaryocytes, are described, wherein the 5' flanking region of the P-selectin gene, or portions thereof, is ligated to the 5' end of a gene. The DNA molecules are a... | 02/25/1997 |
| 5604131 | cDNA-genomic DNA hybrid sequence encoding APP770 containing a genomic DNA insert of the KI and OX-2 regions A nucleic acid construct is described which when expressed in cells, results in the production of APP695, APP751 and APP770. The construct is the cDNA for APP770 with the genomic sequences encoding the KI and OX-2 regions substituting for those regions pr... | 02/18/1997 |
| 5601835 | Polymeric device for controlled drug delivery to the CNS Disclosed is a polymeric drug delivery system for delivery of any substance to the central nervous system. The delivery system is preferably implanted in the central nervous system for delivery of the drug directly to the central nervous system. These imp... | 02/11/1997 |
| 5585478 | D4 gene and methods of use thereof The sequence, molecular structure and expression of a cDNA clone, denoted D4, of human and murine origin, preferentially expressed in hematopoietic cells is described herein. The human cDNA clone has been expressed in bacteria and the predicted 24 Kd prot... | 12/17/1996 |
| 5580961 | Heterodimeric T lymphocyte receptor subunit Disclosed is a heterodimeric T lymphocyte receptor subunit. The subunit consists of variable, joining, constant, transmembrane, and cytoplasmic regions. The structure, amino acid, and nucleotide sequence of the lymphocyte receptor submit were determined u... | 12/03/1996 |
| 5578325 | Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers Injectable particles are provided that are not rapidly cleared from the blood stream by the macrophages of the reticuloendothelial system, and that can be modified as necessary to achieve variable release rates or to target specific cells or organs as des... | 11/26/1996 |
| 5576436 | Fluorescent ligands Conjugates of fluorescent labels with specific, selective, and high affinity ligands for receptors have been synthesized and used to directly measure binding to receptors.... | 11/19/1996 |
