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| Number | Title | Issue Date |
| 4916163 | Spray-dried lactose formulation of micronized glyburide An improved, more bioavailable formulation of glyburide is provided which consists preponderantly by weight of spray-dried lactose is described. This formulation utililzes micronized glyburide, but is more economically manufacatured than heretofore known ... | 04/10/1990 |
| 4645766 | 1,2-dihydro-2-oxo-3-hydroxymethyl pyridines, compositions and use The present invention relates to certain 1,2-dihydro-2-oxo-6-alkyl-3-pyridine carboxylic acids, carboxylate esters, and methanols, their preparation and their use as antihyperglycemic agents.... | 02/24/1987 |
| 4638100 | Aromatic or inter-oxa 2-decarboxy-2-hydroxymethyl-PGF compounds The present invention comprises certain aromatic and inter-oxa analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. These prostaglandin F analogs exhibit prostaglandin F activity and are accordingly usefu... | 01/20/1987 |
| 4576758 | Anti-inflammatory lipoxin B analogs The present invention relates to analogs of lipoxin B (LX-B) and discloses the anti-inflammatory uses for these analogs. Particularly, the present invention relates to analogs of 5D,14,15-trihydroxy-6,8,10,12-eicosatetraenoic acid, including certain ... | 03/18/1986 |
| 4560514 | Inflammatory lipoxin A and anti-anflammatory lipoxin B compounds The present invention provides novel lipoxins A and B and a method of stimulating with lipoxin A compounds and attenuating with lipoxin B compounds the activation of neutrophils by exposure to an effective concentration of lipoxins or a derivative thereof... | 12/24/1985 |
| 4480070 | Compositions and process Isocyanate compositions are disclosed which yield aqueous emulsions on admixture with water. The emulsions are sufficiently stable to permit employment as particle board binders and like uses. The compositions of the invention are derived by reaction of a... | 10/30/1984 |
| 4477684 | 11-Deoxy-11-alkyl-PGE compounds from PGA compounds by lithium alkylation The present invention provides a process for the preparation of 11-alkylprostaglandin E compounds from corresponding prostaglandin A compounds via reaction with alkyllithium complexes, and novel 11-deoxy-11-alkylprostaglandin E compounds use... | 10/16/1984 |
| 4467083 | Copolyamide-imides Copolyamide-imides characterized by thermoplasticity, high heat resistance and high impact resistance are derived by the reaction of 4,4'-methylenebis(phenyl isocyanate), optionally in admixture with a minor amount (up to 10 mole percent) of toluene diiso... | 08/21/1984 |
| 4465639 | Process for polyisocyanates Addition of controlled amounts of water to the reaction mixture produced by phosgenation of a mixture of polymethylene polyphenyl polyamines (and like polyamines produced by condensation of formaldehyde and aromatic amines) prior to complete removal of ex... | 08/14/1984 |
| 4463185 | 1-(6-Hydroxy-4- or -7-methoxy-5-benzofuranyl)-4-substituted-1,3-butanediones The present invention provides novel 1-(6-hydroxy-4- or 7-methoxy or 4,7-dimethoxy-5-benzofuranyl)-4-substituted-1,3-butanediones which are useful as intermediates in the synthesis of khellin and related anti-atherosclerotic furochromones.... | 07/31/1984 |
| 4461917 | 9-Deoxy-9-methylene-PGE compounds This invention comprises certain analogs PGE or 11-deoxy-PGE compounds in which the carbonyl at C-9 is replaced by methylene. Also provided in this invention, are novel chemical processes and novel chemical intermediates useful in the preparation of the a... | 07/24/1984 |
| 4459420 | Pyrogallol synthesis of anti-atherogenic furochromones The present invention provides a total synthesis of known intermediates useful in the synthesis of khellin and antiatherosclerotic analogs thereof from pyrogallol. Pyrogallol is converted to 3,6,7-benzofurantriol triacetate using zinc chloride and chlorac... | 07/10/1984 |
| 4455307 | Antihypertensive use of triazolobenzodiazepines This specification concerns the use to treat hypertension in mammals of novel and known 4H-s-triazolo[4,3-a][1,4]benzodiazepines, known 4H-s-triazolo[4,3-a][1,3,4]benzotriazepines and 2,4-dihydro-2-alkyl-1H-s-triazolo[4,3-a][1,4]benzodiazepin-1-ones, and ... | 06/19/1984 |
| 4448816 | Compounds, compositions and process Described are compounds characterized by the following formula: ##STR1## wherein Cn H2n is alkylene from 2 to 12 carbon atoms and Cm H2m is alkylene from 2 to 20 carbon atoms. Each of the alkylene groups ca... | 05/15/1984 |
| 4438274 | Antiatherosclerotic furochromones The present specification provides novel analogs of khellin, a natural product, which are useful in the treatment and prevention of atherosclerosis. Particularly, the present disclosure provides novel 5H-furo[3,2-g]-benzopyran-5-one substituted at the fou... | 03/20/1984 |
| 4434296 | Process for preparing intermediates for antiatherosclerotic compounds The present specification provides a total synthesis of known intermediates useful in the synthesis of khellin and antiatherosclerotic analogs thereof. 3-Furoic acid is treated with succinic anhydride and diesterified to 3-carboxy-δ-oxo-2-furanbutanoic a... | 02/28/1984 |
| 4424350 | 2-Decarboxy-2-tetrazolyl-PGI2 compounds The present invention relates to 2-decarboxy-2-tetrazolyl-PGI2 amides, having pharmacological activity. Particularly, the compounds described herein are useful as platelet aggregation inhibitors.... | 01/03/1984 |
| 4420632 | Composition and process The present specification provides novel analogs of carbacyclin (CBA2), 6a-carba-prostacyclin (6a-carba-PGI2), which have pronounced prostacyclin-like pharmacological activity, e.g., as platelet antiaggregatory agents. Specifically t... | 12/13/1983 |
| 4412071 | Antiatherosclerotic compositions The present invention provides novel antiatherosclerotic furobenzoxazinones, e.g., 4,9-dimethoxy-4H-furo[3,2-g][1,3]benzoxazin-4-ones. These compounds are structurally and pharmacologically related to khellin and are useful antiatherosclerotic agents... | 10/25/1983 |
| 4401824 | Benzopyran compounds, derivatives of prostaglandins Novel compounds of the following general formula: ##STR1##... | 08/30/1983 |
| 4399146 | Treatment of atherosclerosis with khellin-related furochromones The present specification relates to the antiatherosclerotic use of khellin and related furochromones, and further provides novel antiatherogenic furochromones.... | 08/16/1983 |
| 4398025 | 2-Decarboxy-2-tetrazolyl-19-hydroxy-PG compounds The present invention provides novel 2-decarboxy-2-hydroxymethyl-19,20-didehydro-13,14-dihydro-PG1 compounds methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.... | 08/09/1983 |
| 4367341 | Antiatherosclerotic 7-substituted methoxyfurochromones The present invention provides novel 7-substituted methoxyfurochromones, which are useful as antiatherosclerotic agents.... | 01/04/1983 |
| 4366313 | 2-Decarboxy-2-tetrazolyl-6-keto-PGE1 compounds Prostaglandin E (PGE)-type derivatives and analogs having a 6-keto feature are disclosed, including processes for preparing them and the appropriate intermediates, said derivatives having pharmacological activity.... | 12/28/1982 |
| 4366320 | 4-Substituted phenyl-1,2,4-triazoline-3,5-diones and their dihydro analogs as analytical reagents A novel reagent useful for preparing adducts of diene so that the diene may be assayed by gas liquid chromatography utilizing an electron capture detection system.... | 12/28/1982 |
| 4365075 | ω-Aryl-PGD compounds Prostaglandin analogs with the following cyclopentane ring structure: ##STR1## are disclosed along with intermediates useful in their preparation and processes for their preparation. These analogs are useful for the same pharmacological purposes as t... | 12/21/1982 |
| 4354021 | 2-Decarboxy-2-tetrazolyl-6-alkoxy-PGI1 compounds Prostacyclin I1, (PGI1) derivatives and analogs having a 6-alkoxy feature and having pharmacological activity and processes for preparing them are disclosed.... | 10/12/1982 |
| 4349689 | Methano carbacyclin analogs The present specification provides novel analogs of carbacyclin (CBA2), 6a-carba-prostacyclin (6a-carba-PGI2), which have pronounced prostacyclin-like pharmacological activity, e.g., as platelet anti-aggregatory agents. Specifically ... | 09/14/1982 |
| 4346041 | Composition and process The present specification provides novel analogs of carbacyclin (CBA2), 6a-carba-prostacyclin (6a-carba-PGI2), which have pronounced prostacyclin-like pharmacological activity, e.g., as platelet antiaggregatory agents. Specifically t... | 08/24/1982 |
| 4338457 | Composition and process The present invention relates to novel compositions of matter and novel processes for preparing these compositions of matter. Moreover, there are provided novel methods by which certain of these novel compositions of matter are employed for pharmacologica... | 07/06/1982 |
| 4338325 | PGI2 Pharmacologically acceptable salts The present invention relates to PGI2 pharmacologically acceptable salts, having pharmacological activity. Particularly, the compounds described herein are useful as platelet aggregation inhibitors.... | 07/06/1982 |
| 4337338 | 2,5-Inter-o-phenylene-3,4-dinor-5,9-epoxy-6-iodo-PGF1 amides The present invention provides 2,5-inter-o-phenylene-3,4-dinor-5,9-epoxy-6-iodo-PGF1 amides. These compounds are intermediates for preparing 2,5-inter-o-phenylene-3,4-dinor-prostacyclin analogs, which are useful for pharmacological ... | 06/29/1982 |
| 4337337 | 2,5-Inter-o-phenylene-3,4-dinor-5,9-epoxy-6-iodo-PGF1 compounds The present invention provides 2,5-inter-o-phenylene-3,4-dinor-6,9-epoxy-6ଲ-6-iodo-PGF1 compounds. These compounds are intermediates for preparing 2,5-inter-o-phenylene-3,4-dinor-prostacyclin analogs, which are useful for phar... | 06/29/1982 |
| 4337204 | PGI2 Lower alkyl esters The present invention relates to PGI2 lower alkyl esters, having pharmacological activity. Particularly, the compounds described herein are useful as platelet aggregation inhibitors.... | 06/29/1982 |
| 4337203 | 2,5-Inter-o-phenylene-3,4-dinor-5,9-epoxy PGF1 amides The present invention provides 2,5-inter-o-phenylene-3,4-dinor-5,9-epoxy-PGF1 amides. These compounds are useful for a wide variety of pharmacological and therapeutical purposes, e.g., as antithrombotic agents.... | 06/29/1982 |
| 4336371 | 2-Decarboxy-2-tetrazolyl-13,14-dihydro-PG2 compounds The present invention provides novel 2-decarboxy-2-tetrazolyl-13,14-dihydro-PG2 compounds methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.... | 06/22/1982 |
| 4336392 | 2-Decarboxy-2-tetrazolyl-PG1 compounds The present invention provides novel 2-decarboxy-2-tetrazolyl-PG1 compounds, methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.... | 06/22/1982 |
| 4336393 | 2-Decarboxy-2-tetrazolyl-13,14-dihydro-PG1 compounds The present invention provides novel 2-decarboxy-2-tetrazolyl-13,14-dihydro-PG1 compounds, methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.... | 06/22/1982 |
| 4336372 | 2-Decarboxy-2-tetrazolyl-PG2 compounds The present invention provides novel 2-decarboxy-2-tetrazolyl-PG2 compounds, methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.... | 06/22/1982 |
| 4328338 | 2,5-Inter-o-phenylene-3,4-dinor-6,9-epoxy-6ଲ-PGF1 amides The present invention provides 2,5-inter-o-phenylene-3,4-dinor-6,9-epoxy-6ଲ-PGF1 amides. These compounds are useful for a wide variety of pharmacological and therapeutical purposes, e.g., as antithrombotic agents.... | 05/04/1982 |
