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| Number | Title | Issue Date |
| 6245801 | Branched alkyl pyrrolidine-3-carboxylic acids ##STR1## Branched alkyl pyrrolidines of formula (I) are disclosed and are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, and neuropatnologica... | 06/12/2001 |
| 6225352 | Low molecular weight dendritic compounds as pharmaceutical agents This invention is for low molecular weight dendritic polymers (dendroids) of Formula I ##STR1## are useful as agents in the treatment of cancer, Alzheimers disease, thrombosis, inflammatory diseases, and bacterial resistance.... | 05/01/2001 |
| 6194437 | Non-peptide bombesin receptor antagonists The compounds of the instant invention are novel compounds of Formula I ##STR1## or a pharmaceutically acceptable salt thereof wherein Ar is phenyl or pyridyl unsubstituted or substituted. Ar1 can be independently selected from Ar and can also ... | 02/27/2001 |
| 6191134 | Amide derivatives of substituted quinoxaline 2, 3-diones as glutamate receptor antagonists A novel series of substituted quinoxaline 2,3-diones useful as neuroprotective agents are taught. Novel intermediates, processes of preparation, and pharmaceutical compositions containing the compounds are also taught. The compounds are glutamate receptor... | 02/20/2001 |
| 6184235 | 2-phenyl benzimidazole derivatives as MCP-1 antagonists The present invention relates to novel compounds and medical methods of treatment of inflammation, atherosclerosis, restenosis, and immune disorders especially those associated with lymphocyte or monocyte accumulation such as arthritis and transplant reje... | 02/06/2001 |
| 6177423 | Isoquinolones Benzo[de]isoquinoline-1,3-dione of Formula ##STR1## or a pharmaceutically acceptable salt thereof wherein R is hydrogen or a protecting group typically used in the art for protecting alcohols and R1 -R5 are each independently chosen ... | 01/23/2001 |
| 6153650 | Substituted gamma aminobutyric acids as pharmaceutical agents Novel gamma aminobutyric acids of formula (I) are disclosed and are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorder... | 11/28/2000 |
| 6143755 | Pharmaceutical methods of treatment with ACAT inhibitors and HMG-CoA reductase inhibitors The present invention is a combination of an ACAT inhibitor, for example, sulfamic acid, [[2,4,6-tris(1-methylethyl)phenyl]acetyl]-, 2,6-bis(1-methylethyl) phenyl ester, and an HMG-CoA-reductase inhibitor, for example, atorvastatin, effective for lipid re... | 11/07/2000 |
| 6133307 | Certain benzofuranyl-N-[pyrrolidin-1-YL]-N-methyl-acetamide derivatives useful as opioid agonists The novel compounds of formula (I) of the instant invention are selective kappa opioid agonists useful in the treatment of arthritis, hypertension, pain, inflammation, migraine, inflammatory disorders of the gastrointestinal tract, IBS, and psoriasis. The... | 10/17/2000 |
| 6133263 | Endothelin antagonists with ether-linked groups Novel nonpeptide endothelin antagonists with ether-linked groups are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating atherosclerosis, restenosis, Raynaud's phenomenon, mild or sev... | 10/17/2000 |
| 6124280 | Substituted phenols as novel calcium channel blockers The present invention relates to novel substituted phenols and derivatives thereof useful in the treatment of neurological disorders. Methods of preparing the compounds, intermediates useful in the preparation and pharmaceutical compositions containing th... | 09/26/2000 |
| 6124309 | Method and pharmaceutical composition for regulating lipid concentration The present invention is a combination of an ACAT inhibitor, for example, sulfamic acid, [[2,4,6-tris(1-methylethyl)phenyl]acetyl]-, 2,6-bis(1-methylethyl) phenyl ester, and an HMG-CoA-reductase inhibitor, for example, atorvastatin, effective for lipid re... | 09/26/2000 |
| 6117909 | Methods of using sulfamic acid derivatives for lowering serum or plasma level of Lp(a) The present invention is directed to new therapeutic uses of compounds of formula: ##STR1## wherein X and Y are oxygen, sulfur, or (CR'R")n wherein n is 1 to 4; R is hydrogen, alkyl, or benzyl; R1 and R2 are phenyl, ... | 09/12/2000 |
| 6110911 | Cyclic amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists A novel series of substituted quinoxaline 2,3-diones useful as neuroprotective agents are taught. Novel intermediates, processes of preparation, and pharmaceutical compositions containing the compounds are also taught. The compounds are glutamate antagoni... | 08/29/2000 |
| 6103761 | Agents acting at cholecystokinin receptors The invention concerns a series of novel bis-urea derivatives, nonpeptides, which show good binding affinity for the CCK-B receptor. The compounds, compositions containing them, methods of preparation, and utilities including anxiety, gastric acid secreti... | 08/15/2000 |
| 6103932 | Substituted cyclic amino acids as pharmaceutical agents Substituted cyclic amino acids of formula ##STR1## are disclosed and are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, and neuropatholo... | 08/15/2000 |
| 6096744 | Sulfonamide derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists A novel series of substituted quinoxaline 2,3-diones useful as neuroprotective agents are taught. Novel intermediates, processes of preparation, and pharmaceutical compositions containing the compounds are also taught. The compounds are glutamate antagoni... | 08/01/2000 |
| 6093744 | N-acyl sulfamic acid esters useful as hypocholesterolemic agents The instant invention is new compounds of Formula I ##STR1## their use as cerebrovascular agents in diseases such as stroke, peripheral vascular disease, restenosis, and as agents for regulating plasma cholesterol concentrations, for treating hyperch... | 07/25/2000 |
| 6093719 | Method and pharmaceutical composition for regulating lipid concentration The present invention is a combination of an ACAT inhibitor, for example, sulfamic acid, [[2,4,6-tris(1-methylethyl)phenyl]acetyl]-, 2,6-bis(1-methylethyl) phenyl ester, and an HMG-CoA-reductase inhibitor, for example, atorvastatin, effective for lipid re... | 07/25/2000 |
| 6063774 | Tricyclic quinoxaline derivatives as neuroprotective agents Neuroprotective agents have forumula I ##STR1## wherein a is a ring of 6 to 8 members; n and n' are 1 or 2, R2 is hydrogen or oxygen of carbonyl, R1, R2, R3, R4, R5 and R6 independent... | 05/16/2000 |
| 6057313 | Glutamate (ampa/kainate) receptor antagonists: N-substituted fused azacycloalkylquinoxalinediones Novel N-substituted azacycloalkyl ring fused 2,3-quinoxalinediones are disclosed represented by the formula: ##STR1## or a pharmaceutically acceptable salt thereof, wherein R1 is hydrogen, alkyl or W-alkyl; X and Y are independently hydrog... | 05/02/2000 |
| 6057315 | Antibacterial agents Described are antibacterial agents of formula (I): X is O, S or N--R.sub.8 ; R.sub.1, R.sub.2, R.sub.3 and R.sub.8 are independently H, straight or branched alkyl of 1-6 carbons, cycloalkyl of 3-6 carbons, alkenyl or alkynyl of from 2 to 6 atoms, R hetero... | 05/02/2000 |
| 6046355 | Dihydropyrones with improved antiviral activity This invention pertains to improved antiviral activity of 6,6-disubstituted-5,6-dihydropyran-2-ones caused by judicious placement of certain polar substituents at the 3 and/or 6 positions. The same substituents which enhance the cellular activity also diminish... | 04/04/2000 |
| 6043241 | Ketoacid endothelin antagonists Compounds of the Formula I ##STR1## are nonpeptide antagonists of endothelin which are useful in treating a variety of diseasses such as elevated levels of endothelin, acute respiratory distress syndrome (ARDS), atherosclerosis, restenosis, Rayn... | 03/28/2000 |
| 6040479 | Racemic separation of ketamine The present invention is concerned with an improved process for the resolution of racemic 2-(o-chlorophenyl)-2-methylaminocyclohexanone (ketamine).... | 03/21/2000 |
| 6040316 | 3-alkyl-3-phenyl-piperidines The small nonpeptides of the instant invention are tachykinin antagonists of formula ##STR1## or a pharmaceutically acceptable salt thereof wherein: R1 is straight or branched alkyl of from 5 to 15 carbon atoms, aryl, or heteroaryl; R... | 03/21/2000 |
| 6020370 | Bridged cyclic amino acids as pharmaceutical agents Bridged cyclic amino acids of formula ##STR1## are disclosed and are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain and neuropathological... | 02/01/2000 |
| 6020519 | Diphenyl-cyclopropenes as selective K-agonists The diphenyl-cyclopropene derivatives of the instant invention are kappa opioids useful in the treatment of pain, inflammation, Parkinsonism, dystonia, cerebral ischemia, diuresis, asthma, psoriasis, irritable bowel syndrome, and stroke. The compounds are... | 02/01/2000 |
| 6017916 | Nonpeptide endothelin antagonists I Novel nonpeptide antagonists of endothelin I are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin, acute and chronic renal failure, hypertension, myoc... | 01/25/2000 |
| 6017905 | Phosphonamide ACAT inhibitors The present invention is directed to compounds useful for the regulation of cholesterol of Formula I, methods for using them and pharmaceutical compositions thereof, ##STR1## wherein Ar and Ar1 are each independently selected from unsubsti... | 01/25/2000 |
| 6017951 | Butenolide endothelin antagonists Novel nonpeptides characterized as having a carbamic group which are antagonists of endothelin I are described, as well as methods for their preparation and pharmaceutical compositions containing the same. The compounds are useful in treating elevated lev... | 01/25/2000 |
| 6015800 | Substituted quinoxaline-2-ones as glutamate receptor antagonists A novel series of substituted quinoxaline 2-ones useful as neuroprotective agents are taught. Novel intermediates, processes of preparation, and pharmaceutical compositions containing the compounds are also taught. The compounds are glutamate receptor ant... | 01/18/2000 |
| 6011052 | Pyrazolone derivatives as MCP-1 antagonists Pyrazolone derivatives of Formula I or a pharmaceutically acceptable salt thereof are MCP-1 antagonists and are thus useful in the treatment of inflammatory diseases or conditions, atherosclerosis, restenosis, and immune disorders such as arthritis and tr... | 01/04/2000 |
| 6005103 | Pyrone derivatives as protease inhibitors and antiviral agents The present invention relates to novel tri- and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The pyrone derivatives are useful in the development of therapies for the treatment ... | 12/21/1999 |
| 6001876 | Isobutylgaba and its derivatives for the treatment of pain The instant invention is a method of using certain analogs of glutamic acid and gamma-aminobutyric acid in pain therapy.... | 12/14/1999 |
| 5998435 | Use of a tachykinin antagonist for the manufacture of a medicament for the treatment of emesis The instant invention is directed to a method for the treatment of emesis comprising administering the compound [R,S]-[2-(1H-Indol-3-yl)-1-methyl-1-(1-phenyl-ethylcarbamoly)-ethyl]-carba mic acid benzofuran-2ylmethyl ester.... | 12/07/1999 |
| 5998468 | Furanone endothelin antagonists Novel nonpeptide antagonists of endothelin (I) are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin, acute and chronic renal failure, hypertension, my... | 12/07/1999 |
| 5981755 | Tachykinin antagonists The invention concerns tachykinin antagonists. The compounds are nonpeptides which have utility in treating disorders mediated by tachykinins. Such disorders are respiratory, inflammatory, gastrointestinal, ophthalmic, allergies, pain, vascular, diseases ... | 11/09/1999 |
| 5968928 | Excitatory amino acid antagonists: fused-azacyclic quinoxalinediones and immunoassays thereof The invention discloses novel fused-azacylic quinoxalinediones. These compounds may be employed as excitatory amino acid antagonists and as analogs for use in immunological assays. The invention is also directed to both a radioimmunoassay and enzyme immun... | 10/19/1999 |
| 5968968 | Diphenyl-cyclopropenes as selective K-agonists Diphenyl-cyclopropene derivatives, their nontoxic, pharmaceutically acceptable acid addition salts and compositions are kapa opiods useful in the treatment of pain, inflammation, Parkinsonism, dystonia, cerebral ischemia, diuresis, asthma, psoriasis, irri... | 10/19/1999 |
