William F. Semple, a dentist, was awarded the first US Patent on chewing gum in 1869. His recipe contained powdered chalk.
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| Number | Title | Issue Date |
| 7964029 | Process flowstream collection system A device and process for separating liquid and gas phases in a flowstream containing a liquefied gas or supercritical fluid under pressure mixed with a liquid. A splitter vessel separates the liquid from gas phases and transfers liquid to a collection container whil... | 06/21/2011 |
| 7905133 | Variable ratio flow splitter for a flowstream A splitter for a pressurized primary flowstream of a mobile phase is provided. The splitter comprises a first splitting stage that divides the primary flowstream between a major split flowstream and a minor split flowstream by means of a first and a second restricti... | 03/15/2011 |
| 7592327 | Asthma/allergy therapy that targets T-lymphocytes and/or eosinophils A pharmaceutical composition for the treatment and/or prophylaxis of diseases caused by type I hypersensitivity reactions consisting essentially of Glicophosphopeptical, or pure Nigella Sativa seeds, in a concentration which stimulate Th1 lymphocytes and sele... | 09/22/2009 |
| 7569663 | Chimeric proteins and methods for using the same Novel chimeric proteins are disclosed. The proteins comprise at least two portions. The first portion binds to a first cell and decreases the cell's ability to send a trans signal to a second cell; the second portion sends its own trans signal to the second cell. Me... | 08/04/2009 |
| 7435585 | Auto-stimulating cells and methods for making and using the same Methods for transferring one or more proteins to a cell are disclosed. The protein or proteins to be transferred are in the form of a fusion protein, and contain at least one domain encoding for a protein or peptide having trans signaling and/or adhesion function. T... | 10/14/2008 |
| 7292141 | Audible alarm enhancement for monitoring systems An alarm system for a computer-based monitoring system such as a patient medical monitoring system is provided. The system comprises a main processor connected to a first speaker, a second processor communicatively connected to the main processor for exchange of mes... | 11/06/2007 |
| 7238286 | Combination trickling filter and overflow tank for secondary treatment of wastewater, and associated method of managing wastewater overflow A method and apparatus for controlling water flow in a wastewater treatment plant is provided. The method comprises the steps of providing a trickling filter effluent water basin having filter media provided over a storage space for water. Water outlet flow from the... | 07/03/2007 |
| 6835861 | Low energy method of pyrolysis of hydrocarbon materials such as rubber A low energy method of pyrolysis of rubber or other hydrocarbon material is provided. The hydrocarbon material is heated while maintaining a vacuum, using a clay catalyst. In an additional embodiment, the temperature of the reaction chamber and corresponding fuel in... | 12/28/2004 |
| 6797489 | PP14 fusion proteins and methods for making and using the same Novel fusion proteins comprising PP14 are disclosed. The fusion proteins retain the immunoregulatory function of native PP14, but offer significant advantages. Methods for using the fusion proteins, and sequence encoding the same in the treatment of immune system di... | 09/28/2004 |
| D494789 | Seat | 08/24/2004 |
| 6770652 | Multiple acting anti-angiogenic and cytotoxic compounds and methods for using the same This invention discloses pyrrolo pyrimidine compounds, and pharmaceutically acceptable salts, solvates and prodrugs thereof, of the following formula (3): These compounds are useful in therapeutically and/or prophylactic... | 08/03/2004 |
| 6755925 | Method of resisting corrosion in metal reinforcing elements contained in concrete and related compounds and structures In some embodiments, alternate sources of aluminum or calcium are provided in various ways including the desired compounds. The further object of the present invention contemplate in situ creation of the compound in interest in fresh concrete and as a slurry which c... | 06/29/2004 |
| 6732482 | Method of resisting corrosion in metal reinforcing elements contained in concrete and related compounds and structures A method of resisting corrosion in concrete containing metal elements is provided. It includes introducing into fresh concrete, containing metal elements, at least one compound capable of sequestering chloride ions. The method may also involve employing a compound w... | 05/11/2004 |
| 6716880 | Compounds for the treatment of estrogen-dependent illnesses and methods for making and using the same Novel sulfatase inhibitor/estrogen receptor blocker compounds useful in the treatment of estrogen dependent illnesses are disclosed. The compounds generally comprise a sulfamate moiety and an aromatic, estrogen receptor blocker moiety. Methods for synthesizing these... | 04/06/2004 |
| D487857 | Seat | 03/30/2004 |
| 6712990 | Magnetorheological fluids and related method of preparation Magnetorheological (MR) fluids, dispersions of magnetically soft particles in fluids (gases, liquids, or semi-solids such as greases), are disclosed. The present invention uses the initial steps of a sol-gel process to assist in preparation of MR fluids that have si... | 03/30/2004 |
| 6696455 | Pyrimidine derivatives and methods of making and using these derivatives This invention discloses compounds, and pharmaceutically acceptable salts thereof, useful in therapeutically and/or prophylactically treating patients with an illness. Such illnesses include cancer, and secondary infections caused by Pneumocystis carinii ... | 02/24/2004 |
| 6610138 | Method of resisting corrosion in metal reinforcing elements contained in concrete and related compounds and structures A method of resisting corrosion in concrete containing metal elements is provided. It includes introducing into fresh concrete, containing metal elements, at least one compound capable of sequestering chloride ions. The method may also involve employing a... | 08/26/2003 |
| 6606155 | Method analysis for the presence of wood treatment substances on wood A method of determining the presence and quantity of wood treatment substance (pesticides, water repellants, dimension stabilizers and the like) on wood is provided. The wood treatment substance is combined with a fluorescent material and applied to wood.... | 08/12/2003 |
| 6605670 | Resorcinolic derivatives and methods of making and using the same Methods of making low molecular weight methylene acceptors are provided. The methylene acceptors are prepared by reacting a polyhydric phenol with an aromatic olefinic compound in the presence of an acid catalyst, and then further reacting the products of... | 08/12/2003 |
| 6586607 | Process for making diglycidylether of alkoxylated resorcinol A process for the preparation of diglycidylether of alkoxylated resorcinol using novel catalysts is disclosed. In particular, it has been found that antimony, indium and tellurium halides are effective catalysts for preparation of the diglycidylether of a... | 07/01/2003 |
| 6582732 | Synergistic combination of insecticides to protect wood and wood-based products from insect damage A wood treatment material having a synergistic combination of insecticides including boron-containing compounds and synthetic pyrethroids, is provided. This combination is shown to be especially effective in providing resistance to insect attack when wood... | 06/24/2003 |
| 6541551 | Resorcinolic derivative for rubber compounds A vulcanizable rubber composition and method for making the same are disclosed. The rubber composition comprises a rubber component mixed with a methylene donor and methylene acceptor; the methylene acceptor is 3-hydroxydiphenylamine.... | 04/01/2003 |
| 6537999 | Pyrimidine derivatives and methods of making and using these derivatives This invention discloses pyrimidine derivatives, and pharmaceutically acceptable salts and prodrugs thereof, of the following formula: ##STR1## wherein L and M are selected from the group consisting of carbon and CH, the chemical bond between L and M is s... | 03/25/2003 |
| 6531637 | Resorcinol production from the hydrolysis of meta-phenylenediamine A process for the preparation of resorcinol using the meta-phenylenediamine hydrolysis reaction is provided. A reactor vessel made of a suitable material such as zirconium or a zirconium alloy is used, thus resisting corrosion and formation of resinous ma... | 03/11/2003 |
| 6518426 | Pyrimidine derivatives and methods of making and using these derivatives Novel pyrrolo[3,2-d]pyrimidine derivatives of the following general formula ##STR1## are disclosed. These compounds are useful in the treatment of bacterial infections such as Toxoplasmosis gondii and Pneumocystis carinii, and various types of cancer, thr... | 02/11/2003 |
| 6514493 | cDNA clone for tumor rejection antigen gp110 and tumor peptide vaccine An isolated cDNA molecule comprising an amino acid sequence encoding an amino-terminal protein fragment of murine glycoprotein 110 is disclosed. Therapeutic methods for treating tumor-bearing patients are also disclosed, as are prophylactic methods for va... | 02/04/2003 |
| 6476840 | Radiation-curable thermal printing ink and ink ribbons and methods of making, using and printing using the same A radiation-curable ink, a method of making the ink, a thermal transfer printer ribbon having a radiation-curable ink layer, and a thermal transfer printer with an actinic energy source are provided. A method of thermal transfer printing using an ink ribb... | 11/05/2002 |
| 6472457 | Nonformaldehyde, nonfuming resorcinolic resins and methods of making and using the same Methods for preparing formaldehyde-free resorcinol resins are disclosed. The methods generally comprise reacting resorcinol first with dicyclopentadiene and then reacting that mixture with an olefinic compound. The resins produced by this method are also ... | 10/29/2002 |
| 6451286 | Pharmaceutical compositions for buccal and pulmonary administration comprising an alkali metal alkyl sulfate and at least three micelle-forming compounds Pharmaceutical compositions comprising a macromolecular pharmaceutical agent in mixed micellar form are disclosed. The mixed micelles are formed from an alkali metal alkyl sulfate, and at least three different micelle-forming compounds as described in the... | 09/17/2002 |
| 6436918 | Steroid sulfatase inhibitors and methods for making and using the same Novel sulfatase inhibitor compounds useful in the treatment of estrogen dependent illnesses are disclosed. These compounds generally comprise a steroid nucleus substituted at the C17 position. Methods for synthesizing these compounds and using them in the... | 08/20/2002 |
| 6436367 | Aerosol formulations for buccal and pulmonary application A mixed micellar aerosol pharmaceutical formulation includes a micellar proteinic pharmaceutical agent, an alkali metal lauryl sulphate, at least three micelle forming compounds, a phenol and a propellant. The micelle forming compounds are selected from t... | 08/20/2002 |
| 6433000 | Compounds for the treatment of estrogen-dependent illnesses and methods of making and using the same Novel sulfatase inhibitor/estrogen receptor blocker compounds useful in the treatment of estrogen dependent illnesses are disclosed. The compounds generally comprise a sulfamate moiety and an aromatic, estrogen receptor blocker moiety. Methods for synthes... | 08/13/2002 |
| 6432383 | Method for administering insulin A mixed micellar pharmaceutical formulation includes a micellar proteinic pharmaceutical agent, an alkali metal lauryl sulphate, alkali metal salicylate, a pharmaceutically acceptable edetate and at least one absorption enhancing compounds. The absorption... | 08/13/2002 |
| 6423720 | Pyrimidine compounds and methods for making and using the same This invention discloses compounds, and pharmaceutically acceptable salts, solvates and prodrugs thereof, useful in therapeutically and/or prophylactically treating patients with an illness. Such illnesses include cancer, and secondary infections caused b... | 07/23/2002 |
| 6420370 | Pyrimidine derivatives and method of making and using derivatives This invention discloses compounds, and pharmaceutically acceptable salts thereof, useful in therapeutically and/or prophylactically treating patients with an illness. Such illnesses include cancer, and secondary infections caused by Pneumocystis carinii ... | 07/16/2002 |
| 6416789 | Synergistic combination of fungicides to protect wood and wood-based products from fungal decay, mold and mildew damage A wood treatment material having a synergistic combination of fungicides including boron-containing compounds, organo-iodine compounds and amine-oxides is provided. This combination is shown to be especially effective in providing resistance to decay, mol... | 07/09/2002 |
| 6399595 | Steroid sulfatase inhibitors and methods for making and using the same Novel sulfatase inhibitor compounds useful in the treatment of estrogen dependent illnesses are disclosed. These compounds generally comprise a steroid nucleus substituted at the C17 position. Methods for synthesizing these compounds and using them in the... | 06/04/2002 |
| 6375975 | Pharmaceutical compositions for buccal and pulmonary application Pharmaceutical compositions comprising a macromolecular pharmaceutical agent in mixed micellar form are disclosed. The mixed micelles are formed from an alkali metal alkyl sulfate, and at least three different micelle-forming compounds as described in the... | 04/23/2002 |
| 6350458 | Mixed micellar drug deliver system and method of preparation Pharmaceutical compositions comprising a macromolecular pharmaceutical agent in micellar form are disclosed. The micelles are formed from an alkali metal alkyl sulfate, and at least one additional micelle-forming compound as described in the specification... | 02/26/2002 |