Did You Know...
...Chester Carlson was a patent agent who tired of having to make multiple copies of patent applications using the only duplication method available at the time: carbon paper. In 1959 he came up with a new copying system and took it to IBM for evaluation. The "experts" at IBM determined potential sales to be only 5,000 units because people wouldn't want to use a bulky machine when they had carbon paper. Carlson's invention was the xerography process, the company founded on the system is Xerox.
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| Number | Title | Issue Date |
| 7906629 | Protease inhibitor conjugates and antibodies useful in immunoassay Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for the HIV protease inhibitor saquinavir. The novel ha... | 03/15/2011 |
| 7781165 | Benzimidazolium compounds and salts of benzimidazolium compounds for nucleic acid amplification The present invention is directed to the use of a benzimidazolium compound comprising a side chain at at least one of its N-residues, said chain being either a Cn-alkyl or a substituted Cn-alkyl, characterized in that preferably n is ≧3, as an additive for a nucle... | 08/24/2010 |
| 7741472 | Polynucleotide containing a phosphate mimetic The present invention concerns modified oligonucleotides and processes for their production wherein these oligonucleotides contain at least once the structure P═N-Acc where Acc is an electron acceptor or an electron acceptor substituted with a residue R and R is a... | 06/22/2010 |
| 7741068 | Methods for differentiation between cardiac and pulmonary causes of chronic dyspnea The present invention relates to a method for differentiating in a subject suffering from chronic shortness of breath (dyspnea) between (i) a pulmonary disease, (ii) a cardiovascular complication, (iii) a cardiovascular complication accompanied by a pulmonary diseas... | 06/22/2010 |
| 7741054 | High throughput prion assays The invention is directed to a method for performing a high throughput test to determine the presence of PrPsc in a tissue sample taken post mortem from brain, the test comprising the workflow of (A) sample preparation, (B) sample treatment, (C) sample analysis, (D)... | 06/22/2010 |
| 7732214 | Differentiation of acute and chronic myocardial necrosis in symptomatic patients The present invention provides methods for diagnosing an acute cardiovascular event and for differentiating between an acute cardiovascular event and chronic heart failure based on measuring a cardiac troponin and a natriuretic peptide in a sample from a patient and... | 06/08/2010 |
| 7732160 | Methamphetamine derivatives and conjugates for immunoassay Compounds of methamphetamine derivatives having a meta-substituted alkyl linker on the benzene ring and a protective group on the nitrogen of the methamphetamine hapten. Such compounds have the structure. wherein R1 | 06/08/2010 |
| 7731938 | CYFRA 21-1 as a marker for colorectal cancer The present invention relates to the assessment of colorectal cancer. It discloses the use of the CYFRA 21-1 assay in the assessment of colorectal cancer. It also relates to a method for assessing colorectal cancer in vitro using a liquid sample, derived from an ind... | 06/08/2010 |
| 7695980 | Chemiluminescent compounds and their use The present invention relates to novel chemiluminescent compounds, to a method for synthesizing these compounds, to derivatives and conjugates comprising these compounds, to the use of these compounds or conjugates thereof in chemiluminescence based assays, especial... | 04/13/2010 |
| 7685829 | Process and device for producing a current of humid air Process and device for generating a current of humid air having a defined relative humidity comprising the steps of generating a current of air in a tubing arrangement, generating hot water vapor, introducing the water vapor into the air current to generate flowing ... | 03/30/2010 |
| 7662920 | Fluorescent polypeptide complex The present invention relates to a method of producing a fluorescent polypeptide complex characterized in that an isolated fluorescent polypeptide is inter-molecularly cross-linked with itself or one or more other polypeptides and wherein said complex is of 40 nm to... | 02/16/2010 |
| 7655416 | Diagnosing risk of cardiovascular complications using natiuretic peptides The present invention relates to the use of cardiac hormones, particularly natriuretic peptides, for diagnosing the risk of suffering from a cardiovascular complication, particularly heart disease or acute coronary syndrome, as a consequence of cardiotoxic medicatio... | 02/02/2010 |
| 7651679 | Biochemical markers for acute pulmonary embolism The present invention relates to a method of differentiating between a singular and a multiple lung embolism in a subject suspected to suffer from acute lung embolism comprising determining the amount of NT-proBNP in a sample of a subject suspected to suffer from ac... | 01/26/2010 |
| 7649085 | Saquinavir conjugates and antibodies useful in immunoassay Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for the HIV protease inhibitor saquinavir. The novel ha... | 01/19/2010 |
| 7645369 | Separation method and device for protein mixtures A separation device and a separation method for biomolecular sample material and in particular protein mixtures. For this purpose a separation element 10 for the two-dimensional and preferable electrophoretic separation of components of the sample material is... | 01/12/2010 |
| 7642059 | Single receptor assays for immunosuppressive drugs A highly specific homogeneous assay method for an immunosuppressive drug using an immunophilin in a single receptor format is provided. In the simplest format, a single receptor is utilized analogous to a competitive immunoassay whereby an immunophilin is substitute... | 01/05/2010 |
| 7608466 | Process and device for producing reagent carriers The invention concerns a process for producing reagent carriers having a binding capability that are suitable for determining analytes in liquids, wherein the process comprises at least one step of treating a respective reagent carrier body in particular by transfer... | 10/27/2009 |
| 7608418 | NT-proANP and NT-proBNP for diagnosing cardiac diseases Described are methods for diagnosing a cardiac disease, particularly an acute cardiac event, in a patient presenting with symptoms of acute cardiac decompensation, comprising the steps of (a) measuring, typically in vitro, the level of NT-proBNP (N-terminal brain na... | 10/27/2009 |
| 7569676 | Ecstasy-class derivatives, immunogens, and antibodies and their use in detecting ecstasy-class drugs The present invention comprises novel analogs of ecstasy-class compounds and novel ecstasy-class immunogens leashed out of, i.e., derived from, the methylenedioxy position. The invention also comprises unique monoclonal antibodies generated using MDO-leashed MDMA im... | 08/04/2009 |
| 7569367 | Nucleic acid preparation from whole blood for use in diagnosis of transmissible spongiform encephalopathy The present invention deals with a method of preparing nucleic acids, particularly RNA, from a whole blood sample. The nucleic acids purified by the method of the invention are particularly suited for detection of nucleic acid marker molecules. Preferred are markers... | 08/04/2009 |
| 7563902 | Chemiluminescent compounds and their use The present invention relates to novel chemiluminescent compounds, to a method for synthesizing these compounds, to derivatives and conjugates comprising these compounds, to the use of these compounds or conjugates thereof in chemiluminescence based assays, especial... | 07/21/2009 |
| 7517700 | Core-shell particles Colloidal metal particles having a coating comprising non cross-linked, SH-activated dextran or aminodextran. Biomolecules may be linked directly or indirectly to the particles, which are useful as detection reagents in immunological assays. ... | 04/14/2009 |
| 7491495 | Adsorption of nucleic acids to a solid phase The present invention is directed to a method for adsorbing, i.e. non-covalently binding, nucleic acids to a solid phase using a two-step procedure. Furthermore, the present invention pertains to a method for isolating nucleic acids from a biological sample. In the ... | 02/17/2009 |
| 7482437 | Protease inhibitor conjugates and antibodies useful in immunoassay Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for the HIV protease inhibitor saquinavir. The novel ha... | 01/27/2009 |
| 7482145 | Deglycosylated enzymes for conjugates By deglycosylating an enzyme derived from a eukaryotic organism prior to forming a conjugate, i.e. prior to attaching the enzyme to a molecule capable of binding to a target molecule, the sensitivity of an assay for detecting the presence or determining the quantity... | 01/27/2009 |
| 7476727 | Conjugates of mycophenolic acid The present invention provides a method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The analyte can be a drug or drug derivative, hormone, polypeptide, or olig... | 01/13/2009 |
| 7465797 | 6-monoacetylmorphine derivatives useful in immunoassay Analogs of 6-monoacetyl morphine (6-MAM) are described. These include analogs derivatized at either the C-3 position, the C-6 position, or the nor position of the molecule. These analogs allow for elaboration with linkers terminated by a functional group such as an ... | 12/16/2008 |
| 6992177 | Saquinavir derivatives useful in immunoassay Analogs of saquinavir functionalized at the quinoline portion of the molecule are described. These include pyridyl analogs (replacing the quinoline ring) with a functional handle out of the ring allowing for elaboration with linkers terminated by a functional group ... | 01/31/2006 |
| 6929929 | Method for the expression of proteins in in vitro translation systems with coexpression of folding helper proteins The present invention concerns a method for the expression of target proteins in in vitro translation systems, characterized in that folding helper proteins are co-expressed in this system. The co-expressed folding helper proteins are selected from one or several of... | 08/16/2005 |
| 6902920 | Method for producing an active heterodimeric AMV-RT in prokaryotic cells The heterologous expression of the reverse transcriptase from the Avian Myeloblastosis Virus (AMV-RT) in prokaryotic cells and in particular Escherichia coli (E. coli) is described in the present invention. The invention also includes certain measures ... | 06/07/2005 |
| 6884602 | Expression of alkaline phosphatase in yeast This invention involves a process for selecting and producing eukaryotic alkaline phosphatase in yeast. Yeast cells are subjected to multiple transformations using a vector comprising a first resistance marker gene and the alkaline phosphatase gene. Those strains th... | 04/26/2005 |
| 6875850 | Reagent for labelling nucleic acids The present invention concerns a labelling reagent in which the label is bound via an amide bond and a linker to a residue of the molecule which is essentially characterized in that the N atom of the amide bond and the label are linked together directly by a covalen... | 04/05/2005 |
| 6783957 | Method for synthesis of polypeptides in cell-free systems The method of polypeptide synthesis in eukaryotic or porkaryotic cell-free systems based on a modified verion of synthesis in the continuous flow or continuous exchange modes when, in addition to input into the reaction mixture of components maintaining the synthesi... | 08/31/2004 |
| 6720417 | Method and device for refining nucleic acids A device for isolating nucleic acids which reduces the transfer of contaminants during nucleic acid isolation methods which is composed of two vessels which are linked by a closing element in which a material that binds nucleic acids is placed. The nucleic acid can ... | 04/13/2004 |
| 6432722 | Stabilization and amplification of electrochemiluminescence signals The invention concerns the stabilization and amplification of electrochemiluminescence signals in detection methods.... | 08/13/2002 |
| 6368814 | Tricyclic antidepressant derivatives and immunoassay The present invention is directed to novel tricyclic antidepressant drug derivatives synthesized for covalent attachment to proteins or polypeptide antigens for use in the preparation of antibodies or receptors to tricyclic antidepressant drugs and tricyc... | 04/09/2002 |
| 6331402 | Reduction of interference of immunoassays by substances derived from the framework regions of antibodies The invention concerns an immunological process for the detection of an analyte in a sample, in particular of tumor markers wherein for the reduction of interference substances containing a peptide sequence derived from the framework regions of the variab... | 12/18/2001 |
| 4503012 | Reagent dispensing system Liquid-transfer equipment as for dispensing liquid reagents for chemical assays, which provides time-controlled metering of the quantity of liquid dispensed even though the liquid supply reservoir is not pressurized.... | 03/05/1985 |
