Did You Know...
...that in 1800 ether was first used by partyers as a fun diversion? Sniffing the gas led to hilarious and raucous laughter as people watched each other become more and more intoxicated and silly. Several doctors independently realized the value ether would have to anesthetize surgery patients. Of those who claimed rights to the "discovery," none had a happy ending. One had a seizure and died defending his rights. Another spent his life in an asylum because he had been denied acclaim. A third became addicted to chloroform and, in a New York City jail, he soaked a cloth in the drug, severed an artery and bled to death.
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| Number | Title | Issue Date |
| 7998409 | Specimen-transport module for multi-instrument clinical workcell A specimen-transport module adapted for use with each of a plurality of specimen-processing instruments of a multi-instrument clinical workcell. Such module is adapted to transport individual racks of specimen-containers relative to a specimen-aspiration probe of an... | 08/16/2011 |
| 7854892 | Specimen-transport module A specimen-transport module adapted for use with each of a plurality of specimen-processing instruments of a multi-instrument clinical workcell. Such module is adapted to transport individual racks of specimen-containers relative to a specimen-aspiration probe of an... | 12/21/2010 |
| 7850914 | Specimen-transport module for a multi-instrument clinical workcell A specimen-transport module adapted for use with each of a plurality of specimen-processing instruments of a multi-instrument clinical workcell. Such module is adapted to transport individual racks of specimen-containers relative to a specimen-aspiration probe of an... | 12/14/2010 |
| 7838481 | Formaldehyde-free cleaner composition for cleaning blood analyzers and method of use A formaldehyde-free cleaner composition and method of use for maintaining a blood analyzer are disclosed. The cleaner composition includes surfactants, a proteolytic enzyme, non-formaldehyde releasing antimicrobials, alkaline metal salts, and a buffer. The cleaner c... | 11/23/2010 |
| 7803523 | Whole blood preparation for cytometric analysis of cell signaling pathways This invention is directed to a method for preparation of a biological sample for measurement of protein epitopes that allows for the preservation of intracellular protein epitopes and detection of signal transduction pathways based on the ability to capture transie... | 09/28/2010 |
| 7794666 | Method and apparatus for controlling reaction temperature in bio-chemical instruments Method and apparatus for controlling the temperature of one or more reaction vessels in a bio-chemical analyzer comprises a heat-exchange block, preferably made of cast aluminum or the like, and a thermoelectric device for heating or cooling the block to within a de... | 09/14/2010 |
| 7754487 | Hematology linearity control composition, system and method of use A linearity control system includes a series of linearity control compositions, each thereof includes white blood cell analogs and stabilized red blood cells in a suspension medium. The concentration of the white blood cell analogs in the series of control compositi... | 07/13/2010 |
| 7691636 | Method and apparatus for compensating for variations in particle trajectories in electrostatic sorter for flowcell cytometer A flow cytometer subsystems monitors a particle sensing zone within a fluid transport chamber for the presence of a particle (e.g., blood cell) traveling therethrough, and produces an output pulse, whose width is representative of the trajectory and thereby the leng... | 04/06/2010 |
| 7678583 | Method of lysis of erythrocytes A multifunctional reagent for erythrocytes containing an amount sufficient to produce the lysis of erythrocytes or the sphering of erythrocytes in such a way that they can be detected by a cytometer or an automatic counting device, of a carbamate or of an agent indu... | 03/16/2010 |
| 7678578 | Cell permeabilization and stabilization reagent and method of use A cell permeabilization and stabilization reagent and method of use are disclosed. The reagent contains a N-acyl sarcosine or a salt thereof, a pH adjusting agent to adjust pH of the reagent in a range from about 4 to about 6; and an aqueous medium; the reagent havi... | 03/16/2010 |
| 7661326 | Apparatus for aspirating and dispensing liquids in an automated analyzer Apparatus for aspirating and dispensing liquid samples in an analytical instrument, e.g., a hematology instrument, includes a liquid-sampling valve that, while operating to segment and position for dispensing one or more precise volumes of a liquid sample that has b... | 02/16/2010 |
| 7609369 | Methods of detection of iron deficiency and hemochromatosis New diagnostic parameters or indexes for detection of absolute iron deficiency, latent iron deficiency, functional iron deficiency, or latent functional iron deficiency have been disclosed. The parameters include a RBC size factor, RSf1 defined by the for... | 10/27/2009 |
| 7586589 | Methods of determination of responsiveness to erythropoietin treatment Methods for determining the responsiveness of a patient to recombinant human erythropoietin therapy are disclosed. In one approach, the method includes obtaining a volume-Hgb factor (VHf) defined as a product function of MCV and Hgb from a patient's blood sample; co... | 09/08/2009 |
| 7541190 | Method of measurement of cellular hemoglobin A method of measuring cellular hemoglobin of a blood sample includes mixing a blood sample with a permeation reagent, and incubating the sample mixture to permeate cellular membrane of red blood cells and to cause hemoglobin aggregation within the cells; adding a ne... | 06/02/2009 |
| 7482165 | Method of preventing white blood cell interferences to red blood cell measurements of a blood sample Methods of prevention and correction of white blood cell interferences to the measurements of mean cell volume (MCV), red blood cell concentration (RBC) and hematocrit (Hct) of a blood sample are disclosed. The interference to MCV can be prevented by identifying a v... | 01/27/2009 |
| 7481978 | Apparatus for aspirating liquids from sealed containers Apparatus for aspirating liquid from a container, e.g., a test tube, having a puncturable stopper includes a pair of stepper motors that share a common linear actuator or drive member. One motor operates to axially advance the linear drive member (preferably a lead ... | 01/27/2009 |
| 7393688 | Method of using a hematology reference control for measurement of immature granulocytes A method of using a reference control for measurement of immature granulocytes on a blood analyzer is disclosed. The method includes analyzing a reference control that contains an immature granulocyte component made of processed red blood cells for simulating immatu... | 07/01/2008 |
| 7392908 | Methods and apparatus for sorting particles hydraulically A method and apparatus for selectively sorting individual particles, such as blood cells of a particular type of interest, from a plurality of particles of different types. Particles of interest are individually differentiated from other particles in a known manner,... | 07/01/2008 |
| 7390662 | Method and apparatus for performing platelet measurement The present invention relates to a hematology instrument system that discriminates platelets from red blood cells, debris and other particles within a blood sample. The instrument system uses an optical trigger and collects data at optical sensor locations relative ... | 06/24/2008 |
| 7361512 | Low hemoglobin concentration cell percentage and method of use in detection of iron deficiency A method of producing low hemoglobin concentration cell percentage (LHCC %) and the method of use for detection of iron deficiency have been disclosed. LHCC % is a sigmoid function of mean cell hemoglobin concentration (MCHC), which correlates linearly with hypochro... | 04/22/2008 |
| 7361510 | Methods of detection of iron deficiency New diagnostic indexes and the method of use for detection of iron deficiency have been disclosed. These include a logistic function of mean cell hemoglobin (MCH) and mean cell volume (MCV), and a logistic function of mean cell hemoglobin concentration (MCHC) and MC... | 04/22/2008 |
| 7354773 | Method and apparatus for preparing cell samples for intracellular antigen detection using flow cytometry A method and apparatus for preparing biological cell samples for intracellular analysis. The invention is based upon the recognition that many of the steps of the conventional methods for such sample preparation can be eliminated, leading to a process that readily l... | 04/08/2008 |
| 7354767 | Reference control composition containing a nucleated red blood cell component made of non-nucleated blood cells A reference control composition containing a nucleated red blood cell component and the method of making are disclosed. The reference control composition includes a nucleated red blood cell component made of fixed non-nucleated blood cells and a suspension medium. T... | 04/08/2008 |
| 7344890 | Method for discriminating platelets from red blood cells A method for discriminating and quantifying platelets within an analyzed blood sample involves initially diluting the blood sample with a ghosting reagent that causes a change in the index of refraction of the red blood cells. Owing to the change in the index of ref... | 03/18/2008 |
| 7331474 | Specimen-container rack for automated clinical instrument A magnetically-attractive specimen-container rack for use with a magnetic transport system for transporting racks of specimen-containers to or within an automated clinical instrument for analysis and/or processing. The specimen-container rack comprises a pair of U-s... | 02/19/2008 |
| 7300797 | Lysis reagent for blood cell analysis A multifunctional reagent for erythrocytes containing an amount sufficient to produce the lysis of erythrocytes or the sphering of erythrocytes in such a way that they can be detected by a cytometer or an automatic counting device, of a carbamate or of an agent indu... | 11/27/2007 |
| 7300804 | Method and apparatus for controlling the uniform smearing of a biological liquid over a substrate A method and apparatus for controlling the processing of a liquid sample, e.g., a blood sample, based on a measurement related to the sample's ability to coat a surface against which the sample is brought into contact while being routinely transported. Preferably, t... | 11/27/2007 |
| 7285417 | Reference control containing a nucleated red blood cell component A method of making a reference control containing a nucleated red blood cell component includes providing a blood cell containing a nucleus; treating the blood cell with a treatment solution to alter a nucleus property from a natural value to a target value suitable... | 10/23/2007 |
| 7284453 | Method and apparatus for maximizing liquid aspiration from small vessels Apparatus and method for aspirating liquid from a container, e.g., a test tube or other vessel, includes apparatus for sensing that an aspiration probe tip is contacting the inside bottom wall of the container, whereby a maximum volume of liquid can be aspirated fro... | 10/23/2007 |
| 7275430 | Method and apparatus for detecting liquid levels in liquid-storage containers A method and apparatus for sensing different levels of liquids in their respective containers in a liquid-consuming and/or producing instrument system. According to a preferred embodiment, an elongated liquid-sensing probe having axially spaced electrodes adapted to... | 10/02/2007 |
| 7264111 | Magnetic specimen-transport system for automated clinical instrument A magnetic specimen-transport system for transporting racks of specimen-containers to or within an automated clinical instrument for analysis and/or processing. The magnetic specimen-transport system that is adapted to transport magnetically-attractable racks of spe... | 09/04/2007 |
| 7256891 | Sensor alignment apparatus for an analysis system An apparatus for analyzing a population of particles is set forth. The apparatus includes an emitter adapted to generate a beam of electromagnetic radiation, such as from a laser, and a particle chamber disposed in a path of the electromagnetic radiation beam. The a... | 08/14/2007 |
| 7256048 | Method for detection of malaria and other parasite infections A method of detecting parasite infection, particularly malaria, includes mixing a blood sample with a lytic reagent system to lyse red blood cells, and to form a sample mixture; performing a differential analysis of white blood cells of the sample mixture on a blood... | 08/14/2007 |
| 7235404 | Cyanide-free lytic reagent composition and method of use for hemoglobin and white blood cell measurement A cyanide-free lytic reagent composition and method of use for measuring the total hemoglobin concentration and white blood cells in a blood sample are disclosed. The lytic reagent composition includes a quaternary ammonium surfactant to lyse red blood cells and rel... | 06/26/2007 |
| 7232687 | Multiple sorter monitor and control subsystem for flow cytometer An optical illumination and monitoring subsystem controls the operation of a flow cytometer having a carrier fluid that flows along a channel coupled to a droplet generator, which controls a point at which droplets break off from the carrier fluid, and a droplet sor... | 06/19/2007 |
| 7208319 | Method of measurement of nucleated red blood cells Methods are provided for measurement of nucleated red blood cells in a blood sample. The methods include exposing a blood cell sample to a reagent system to lyse mature red blood cells, subsequently analyzing nucleated red blood cells in a flow cell by axial light l... | 04/24/2007 |
| 7207939 | Apparatus and method for analyzing a liquid in a capillary tube of a hematology instrument An apparatus and method for determining the density and fluid-type of a fluid flowing in a capillary tube, the velocity and viscosity of a blood sample flowing in a capillary tube, the erythrocyte sedimentation rate (ESR) of a blood sample after flow has been brough... | 04/24/2007 |
| 7198953 | Method of using a reference control composition for measurement of nucleated red blood cells Methods of using a reference control composition containing a nucleated red blood cell component for measurement of nucleated red blood cells are disclosed. The nucleated red blood cell component is made of stabilized or processed nucleated blood cells which have im... | 04/03/2007 |
| 7195919 | Hematology controls for reticulocytes and nucleated red blood cells The present invention is drawn to a hematology control made from particles a particle having a biopolymer attached to a surface of the particle. The particle simulates a component of a blood sample, such as a reticulocyte or nucleated red blood cell component of a b... | 03/27/2007 |
| 7176031 | Reference control for optical measurement of nucleated red blood cells of a blood sample Reference control compositions and the method of use are disclosed for measurement of nucleated red blood cells, which includes one set of synthetic spherical particles having a mean particle diameter ranging from 6.2 μm to 6.8 μm and a refractive index from 1.58 ... | 02/13/2007 |
