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| Number | Title | Issue Date |
| 7905880 | Method and apparatus for tubal occlusion A device for sterilizing females by occluding the uterotubal junction. The device includes a catheter with a releasable heat generating plug which is used to thermally damage the uterotubal junction and cause it to constrict around the plug, after which the plug is ... | 03/15/2011 |
| 7846661 | Methods of detecting an amplified nucleic acid The present invention is directed to methods of generating a signal indicative of the presence of said target nucleic acid sequence in a sample, comprising, incubating a sample comprising a an amplified target nucleic acid and a nucleic acid polymerase which substan... | 12/07/2010 |
| 7838225 | Methods for detection of a target nucleic acid by forming a cleavage structure using a reverse transcriptase The invention relates to and methods for generating a signal indicative of the presence of a target nucleic acid in a sample. The compositions and methods include a reverse transcriptase, a nuclease, an upstream primer and downstream probe. ... | 11/23/2010 |
| 7824859 | Methods for detection of a target nucleic acid by forming a cleavage structure using an RNA polymerase The invention relates to compositions and methods for generating a signal indicative of the presence of a target nucleic acid in a sample, where the compositions and methods include an RNA polymerase, a FEN nuclease, and a probe. ... | 11/02/2010 |
| 7807365 | Cleavage of nucleic acids The invention relates to compositions and methods of generating a signal indicative of the presence of a target nucleic acid in a sample, where the method includes forming a cleavage structure by incubating a sample comprising a target nucleic acid with a probe. The... | 10/05/2010 |
| 7803530 | Detection and typing of human papillomavirus using PNA probes The invention provides methods for detection and typing of HPV infection using PNA probes. More specifically, methods are provided for detecting high-risk types of HPV infection with minimal numbers of PNA probes or using PNA probes to selectively amplify only high-... | 09/28/2010 |
| 7794935 | Reverse transcriptase compositions for flap-mediated detection of a target nucleic acid sequence The invention relates to compositions for generating a signal indicative of the presence of a target nucleic acid in a sample. The compositions include a reverse transcriptase, a nuclease, an upstream primer and downstream probe. ... | 09/14/2010 |
| 7767396 | Compositions for detection of a target nucleic acid sequence The invention relates to compositions for generating a signal indicative of the presence of a target nucleic acid in a sample, where the compositions include a probe having a 5′ region and a 3′ flap and a P. furiosus polymerase having 3′ exonuclease act... | 08/03/2010 |
| 7736854 | Methods of detection of a target nucleic acid sequence The present invention is directed to methods of generating a signal indicative of the presence of a target nucleic acid in a sample by forming a cleavage structure comprising duplex and single-stranded nucleic acid by incubating a sample comprising a target nucleic ... | 06/15/2010 |
| 7678541 | Methods and compositions for the detection of a nucleic acid using a non-invasive cleavage reaction The invention provides methods, compositions and kits for generating a signal indicative of the presence of a target nucleic acid sequence in a sample comprising forming a cleavage structure by incubating a sample comprising a target nucleic acid sequence with upstr... | 03/16/2010 |
| 7655405 | Compositions and kits for detection of a target nucleic acid The present invention is directed to kits and compositions for generating a signal indicative of the presence of a target nucleic acid sequence in a sample, comprising a nucleic acid polymerase lacking 5′ to 3′ exonuclease activity and a thermostable FEN nucleas... | 02/02/2010 |
| 7628765 | Increasing retrievable cells from a breast duct The invention provides methods that increase retrievable cells from ductal fluid of a patient. Ductal fluid typically contains ductal epithelial cells and other markers that can aid in identifying a breast condition, including breast cancer and precancer. ... | 12/08/2009 |
| 7625705 | Methods and compositions for detection of a target nucleic acid sequence utilizing a probe with a 3′ flap The invention provides compositions, kits and methods of generating a signal indicative of the presence of a target nucleic acid sequence in a sample by forming a cleavage structure. The cleavage structure is formed by incubating a sample containing a target nucleic... | 12/01/2009 |
| 7585632 | Compositions and methods for the detection of a nucleic acid using a cleavage reaction The invention relates to compositions and methods for generating a signal indicative of the presence of a target nucleic acid in a sample utilizing a primer-probe duplex. ... | 09/08/2009 |
| 7534568 | Methods for detection of a target nucleic acid by forming a cleavage structure with a cleavage resistant probe The invention relates to compositions and methods for generating a signal indicative of the presence of a target nucleic acid in a sample utilizing a cleavage resistant probe. ... | 05/19/2009 |
| 7422858 | Apparatus and method for separating viral particles from cells A method for analyzing a sample to detect cells infected by Human Papilloma Virus (HPV) is provided. The method includes passing a medium containing the sample across a filter. The filter has a pore size that is greater than a dimension of a HPV particle, but smalle... | 09/09/2008 |
| 7405045 | Identification of viral agents in breast ducts and antiviral therapy therefore Methods and systems for identifying a virus in breast ducts are provided. In addition, antiviral therapy for treating a virally infected breast duct is also provided. Patients with a viral infection identified in the breast ducts may be at risk for developing breast... | 07/29/2008 |
| 7384418 | Methods and devices for delivery of agents to breast milk ducts The invention provides devices, kits and methods for delivering an agent to a breast milk duct. Intraductal agent delivery provides an opportunity to treat a breast condition locally and avoid the pitfalls of systemic drug delivery for a local condition. Time-releas... | 06/10/2008 |
| 7344834 | Method for DNA amplification using DNA blocking probes A process is disclosed for the amplification of a DNA template by subjecting a sample of biological material containing a target nucleotide sequence to amplification using a non-extendable oligonucleotide blocker. The method comprises using oligonucleotide primers a... | 03/18/2008 |
| 7344506 | Cell collection device This invention relates generally to medical devices, and more particularly, an apparatus and method for collecting cells or tissue samples from the cervix of a patient for medical testing. ... | 03/18/2008 |
| 7294126 | Apparatus and method for treating venous reflux Disclosed is an ablation method and apparatus used to close veins for treatment of venous insufficiency disease. The apparatus includes a catheter proportioned for insertion into a vein, a pair of inflatable balloons spaced apart on the catheter body, and an ablatio... | 11/13/2007 |
| 7276047 | Ductal lavage microcatheter with user activated valve and Nitinol introducer A medical instrument including a ductal access device comprising a low profile, ergonomic manifold hub usable to introduce fluids into a breast duct and collect ductal fluid samples including ductal epithelial cells and clumps of ductal epithelial cells from within ... | 10/02/2007 |
| 7229420 | Medical instrument for accessing a breast duct for performing a medical procedure A medical instrument including a ductal access device comprising a low profile, ergonomic manifold hub usable to introduce fluids into a breast duct and collect ductal fluid samples including ductal epithelial cells and clumps of ductal epithelial cells from within ... | 06/12/2007 |
| 7204829 | Apparatus, methods and kits for simultaneous delivery of a substance to multiple breast milk ducts Apparatus, methods and kits for simultaneous delivery of a fluid or other substance to two or more breast milk ducts are provided. The fluid can be delivered for a variety of purposes including lavage of the ducts and administering an agent for therapeutic, prophyla... | 04/17/2007 |
| 7198902 | Apparatus and method for separating viral particles from cells A method for analyzing a sample to detect cells infected by Human Papilloma Virus (HPV) is provided. The method includes passing a medium containing the sample across a filter. The filter has a pore size that is greater than a dimension of a HPV particle, but smalle... | 04/03/2007 |
| 7195601 | Method of opening a ductal sphincter using controlled fluid pressure The invention provides methods, devices, and systems for collecting breast ductal fluids. The devices include a ductal access device comprising a low profile, ergonomic manifold hub usable to introduce fluids into a breast duct and collect ductal fluid samples inclu... | 03/27/2007 |
| 7132232 | Identification of viral agents in breast ducts and antiviral therapy therefore Methods and systems for identifying a virus in breast ducts are provided. In addition, antiviral therapy for treating a virally infected breast duct is also provided. Patients with a viral infection identified in the breast ducts may be at risk for developing breast... | 11/07/2006 |
| 7029462 | Apparatus, methods and kits for simultaneous delivery of a substance to multiple breast milk ducts Apparatus, methods and kits for simultaneous delivery of a fluid or other substance to two or more breast milk ducts are provided. The fluid can be delivered for a variety of purposes including lavage of the ducts and administering an agent for therapeutic, prophyla... | 04/18/2006 |
| 6939672 | Nucleic acid extraction solution and use thereof Disclosed are methods and compositions for extracting nucleic acids from a biological sample. In particular, disclosed is a nucleic acid extraction solution together with methods using such a solution for extracting nucleic acid sequences from biological samples con... | 09/06/2005 |
| 6936443 | Detection and typing of human papillomavirus using PNA probes The invention provides materials and methods for detection and typing of HPV infection using PNA probes. More specifically, methods are provided for detecting high-risk types of HPV infection with minimal numbers of PNA probes or using PNA probes to selectively ampl... | 08/30/2005 |
