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| Number | Title | Issue Date |
| 8183341 | Antibacterial compounds and processes for its production This invention relates to a novel antibiotic compounds, pharmaceutically acceptable salts and derivatives thereof, and to methods for obtaining such compounds. ... | 05/22/2012 |
| 8143253 | Organic compounds Compounds of formula I in free or salt or solvate form, where R1, R2 and R5 have the meanings as indicated in the specification, are useful for treating diseases mediated by the ALK-5 and/or ALK-4 receptor. Pharmaceutical c... | 03/27/2012 |
| 8129541 | 5-phenylthiazole derivatives and use as PI3 kinase inhibitors Compounds of formula I in free or salt form, wherein R1, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating diseases mediate... | 03/06/2012 |
| 8119666 | 1,2,5-thiazolidine derivatives useful for treating conditions mediated by protein tyrosine phosphatases (PTPase) Compounds of the formula are inhibitors of protein tyrosine phosphatases (PTPases) and, thus, may be employed for the treatment of conditions mediated by PTPase activity. The compounds of the present invention may also be e... | 02/21/2012 |
| 8097617 | Organic compounds New compounds of the Formula (I): for the treatment of non-insulin-dependent diabetes mellitus. ... | 01/17/2012 |
| 8084448 | Organic compounds Compounds of the formula are inhibitors of protein tyrosine phosphatases (PTPases) and, thus, may be employed for the treatment of conditions mediated by PTPase activity. The compounds of the present invention may also be e... | 12/27/2011 |
| 8058276 | Heterobicyclic carboxamides as inhibitors for kinases The invention relates to novel organic compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula (I) and to the use of a compound of formula (I) for the preparation of pharmac... | 11/15/2011 |
| 8034810 | Arylsulfonamido-substituted hydroxamic acid derivatives α-Amino hydroxamic acid derivative of the formula I, in which R is C2-C7-alkyl, which is mono-, di- or trisubstituted by halogen, nitro, lower acyloxy, trifluoromethoxy, cyano, C3-C5 | 10/11/2011 |
| 8030497 | Benzimidazole derivatives A compound of formula (I) or a pharmaceutically acceptable salt or prodrug ester thereof: wherein R1-R7 are as disclosed in the specification. ... | 10/04/2011 |
| 8008479 | Organic compounds A process for preparing compounds of formula (I) or a solvate or hydrate thereof, where R, R1, R2, R3 and R5 have the meanings as indicated in the specification. Such compounds are useful in the treatment of a number of co... | 08/30/2011 |
| 6986997 | Method for screening using an OAT1 transporter protein A protein capable of transporting organic anions having amino acid sequences represented by SEQ ID NO: 1 or 2 or amino acid sequences derived therefrom by deletion, substitution or addition of one or more amino acid residues; and a gene coding for the protein. The p... | 01/17/2006 |
| 6737376 | Porous ceramic Porous ceramics are described, which are produced by a) mixing an aqueous solution of a suitable ionotropically orientable polyanion, either with oxides, hydroxides or hydrated oxides, which are present in the form of a sol, of the metals Al, Zr, Ti an... | 05/18/2004 |
| 7482347 | Piperazine derivatives with CCR-3 inhibiting activity Compounds of formula I in free or salt form, wherein Ar, R1, R2, R3, X and T have the meanings as indicated in the specification, are useful for treating a condition mediated by CCR-3, parti... | 01/27/2009 |
| 7482462 | Acylsulfonamides as inhibitors of steroid sulfatase A compound of formula wherein R1 is haloalkyl, alkenyl, phenyl, thienyl, pyridine, benzthiazolyl, chromanyl (1,2-dihydrobenzopyranyl) or (C6-18)aryl, and R1 or R2 independently of... | 01/27/2009 |
| 7452886 | Pyrrolo pyrimidines as agents for the inhibition of cystein proteases The invention provides compounds of Formula I or a pharmaceutically acceptable salt or ester thereof wherein the symbols have meaning as defined, which are inhibitors of cathepsin K and find use pharmaceutically for treatment of diseases and medical conditions in wh... | 11/18/2008 |
| 7439362 | Piperazinyl-or piperidinylamine-sulfamic acid amides as inhibitors of steroid sulfatase Piperazinyl- or piperidinylamine-sulfamic acid amides and their use for the manufacture of a medicament in diseases mediated by the action of steriod sulfatase. ... | 10/21/2008 |
| 7378416 | MIF-inhibitors 3,4-dihydro-benzo[e][1,3]oxazin-2-ones which are substituted at the nitrogen atom by unsubstituted or substituted (C3-8)cycloalkyl, (C1-4)alkyl(C3-8)cycloalkyl, (C6-18)aryl or (C6-18)aryl(C1-4)alkyl a... | 05/27/2008 |
| 7361661 | 8-quinolinxanthine and 8-isoquinolinxanthine derivatives as PDE 5 inhibitors A compound of formula (I) R1 is hydrogen or alkyl optionally substituted by hydroxy, alkoxy, or alkylthio, R2 is hydrogen, alkyl, hydroxyalkyl, alkylcarbonyloxyalkyl, alkoxyalkyl, alkylthioalkyl, alken... | 04/22/2008 |
| 7291634 | α-amino-N-hydroxy-acetamide derivatives The invention relates to α-amino-N-hydroxy-acetamide derivatives of formula I, wherein R is di-lower alkyl amino, 1,2,3-triazol-1-yl, 1,2,3-triazol-2-yl or 1,2,4-triazol-4-yl, m represents an integer from 1 up to ... | 11/06/2007 |
| 7288537 | Azetidine derivatives as CCR-3 receptor antagonists Compounds of formula I in free or salt form, wherein Ar, X, Y, R1, R2, R3, R5, m, n, p and q have the meanings as indicated in the specification, are useful for treatin... | 10/30/2007 |
| 7268137 | Ocular therapy A method for treating a subject suffering from epiretinal membrane formation or retinal detachment due to epiretinal membrane formation is disclosed. The method comprises administering a compound of the formula: ... | 09/11/2007 |
| 7186734 | Aryl imidazoles and related compounds as C5a receptor modulators The invention provides Aryl substituted imidazoles, pyrazoles, pyridizines and related compounds of the Formula where the variables are defined herein. Such compounds are ligands of C5a receptors. Preferr... | 03/06/2007 |
| 7169775 | Amino methyl imidazoles as C5a receptor modulators Amino methyl imidazoles of Formula I are provided: wherein R, R1, R2, R3, R4, R5, and R6 are defined herein. Such compounds are ligands of... | 01/30/2007 |
| 7122250 | Composite resin particle with specific shape factor The invention is a composite resin particle useful as an additive for paints or coatings, powder coatings, cosmetic additives, slush molding resins, spacer for electronic part assembly, standard particles for electric measurement devices, toner, hot melt adhesive as... | 10/17/2006 |
| 7112660 | Modified cytokine The invention relates to methods for the stabilisation of cytokines and to cytokines generated by such methods. The methods of the invention involve mutating the amino acid sequence of a cytokine so as to remove solvent-exposed hydrophobic residues, and/or mutating ... | 09/26/2006 |
| 7074819 | Benzopyran or thiobenzopyran derivatives The present invention relates to a novel benzopyran or thiobenzopyran derivative represented by formula (1): pharmaceutically acceptable salt or stereoisomer thereof, in which X, R1, R2, R3, R4 and A are defined as describ... | 07/11/2006 |
| 7074799 | Substituted quinazolin-4-ylamine analogues Substituted quinazolin-4-ylamine analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activati... | 07/11/2006 |
| 7074880 | Polyimide aerogels, carbon aerogels, and metal carbide aerogels and methods of making same A preparation process of polyimide aerogels that composed of aromatic dianhydrides and aromatic diamines or a combined aromatic and aliphatic diamines is described. Also descried is a process to produce carbon aerogels derived from polyimide aerogel composed of a ri... | 07/11/2006 |
| 7071287 | Aerogel metallic compositions A preparation process of polyimide aerogels that composed of aromatic dianhydrides and aromatic diamines or a combined aromatic and aliphatic diamines is described. Also descried is a process to produce carbon aerogels derived from polyimide aerogel composed of a ri... | 07/04/2006 |
| 7067545 | Remedies for spinocerebellar ataxia and compositions for treating spinocerebellar ataxia Remedies for spinocerebellar degeneration or compositions for treating the same which contain as the active ingredient one or more members selected from among D-cycloserine, D-serine esters, D-serine and salts thereof. A method for treating spincerebellar degenerati... | 06/27/2006 |
| 7064157 | Flame retardant resin and flame retardant composition containing the same The present invention relates to a phosphorus-containing epoxy resin, which is an epoxy resin modified with a side chain having a reactive phosphorus-containing compound. Also, the present invention relates to a flame-retardant resin composition, which comprises: | 06/20/2006 |
| 7056911 | Dibenz[B,F]azepine compounds, pharmaceutical compositions comprising same and methods of use thereof The invention relates to pharmaceutically active compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention and particularly useful for the treatment or prophylaxis of diseases ... | 06/06/2006 |
| 7053053 | Humanin-like peptide and use thereof A novel polypeptide having a cell death inhibitory activity and use thereof is provided. The polypeptide and the polynucleotide encoding it can be used as a diagnostic, therapeutic or prophylactic agent for various diseases and disorders. Certain suitable diseases a... | 05/30/2006 |
| 7052793 | Composite solid polymer electrolyte membranes The present invention relates to composite solid polymer electrolyte membranes (SPEMs) which include a porous polymer substrate interpenetrated with an ion-conducting material. SPEMs of the present invention are useful in electrochemical applications, including fuel... | 05/30/2006 |
| 7045497 | Use of peptide The present invention relates to use of peptide to which G-protein coupled receptor protein recognizes as a ligand. Since the ligand polypeptide of the present invention has a stimulating action on oxytocin secretion, it is useful as a drug for ameliorating, preserv... | 05/16/2006 |
| 7008996 | Water-dispersed powder slurry coating A water-dispersed powder slurry coating comprises: (A) a particulate comprising (a1) a resin having an active hydrogen; (B) a reactive surfactant having an optionally blocked isocyanate group and/or an epoxy group; and an aqueous medium in which the particulate and ... | 03/07/2006 |
| 6995161 | Substituted arylpyrazines Arylpyrazine compounds are provided, including arylpyrazines that can bind with high affinity and high selectivity to CRF1 receptors, including human CRF1 receptors. The invention thus includes methods for treatment of disorders and diseases as... | 02/07/2006 |
| 6991908 | Antiobestic agents methods for screening antiobestic agents and kits comprising same The present invention provides a method for screening a compound or its salt that alters the binding property between MCH or its salt and SLC-1 or its salt, characterized by using MCH or its derivative or a salt thereof and SLC-1 or its salt is useful for screening ... | 01/31/2006 |
| 6974668 | Development of method for screening physiologically active pyrrole imidazole derivative A method for screening the effect of a segment A (chemical species A) on a substance (for example, a cell) containing DNA or RNA by using artificial chemical species. Namely, a method of detecting or identifying the function of a chemical species A on a substance co... | 12/13/2005 |
