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| Number | Title | Issue Date |
| 7094874 | Soluble CTLA4 mutant molecules The present invention provides soluble CTLA4 mutant molecules which bind with greater avidity to the CD80 and/or CD86 antigen than wild type CTLA4 or non-mutated CTLA4Ig. The soluble CTLA4 molecules have a first amino acid sequence comprising the extracellular domai... | 08/22/2006 |
| 7070776 | Methods for blocking binding of CD28 receptor to B7 The invention identifies the B7 antigen as a ligand that is reactive with the CD28 receptor on T cells. The invention further provides methods for using antibodies to B7, or fragments thereof, to regulate CD28 positive T cell response and immune responses mediated b... | 07/04/2006 |
| 6887471 | Method to inhibit T cell interactions with soluble B7 This invention provides methods for regulating T cell interactions with B7 positive cells. Methods are provided for using B7 antigen, its fragments and derivatives reactive with CTLA4 receptor, to regulate CTLA4 positive T cell responses, and immune responses mediat... | 05/03/2005 |
