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| Number | Title | Issue Date |
| 8183360 | Population scale HLA-typing and uses thereof The present invention provides a portable system for real-time population-scale HLA genotyping and/or allelotyping in a field environment and methods of such population-scale HLA genotyping. The individual components of the system are portable to and operable within... | 05/22/2012 |
| D659518 | Carabiner with threaded lock and swiveling strap attachment | 05/15/2012 |
| 8147803 | Ultrasmall superparamagnetic iron oxide nanoparticles and uses thereof The present invention provides a biomimetic contrast agent comprising an amine-functionalized iron (II) oxide/iron(III) oxide nanoparticle core a targeting ligand attached to the nanoparticle core via a linker and an inert outer layer of a hydrophilic polymer conjug... | 04/03/2012 |
| 8147429 | Pelvic floor function diagnostic and therapeutic station and uses thereof The instant invention provides a pelvic floor function diagnostic and therapeutic station, which includes a vaginal/ano-rectal plug and station. The important components of the station are a catheter holder with a pressure measuring (sleeve sensor or other alterativ... | 04/03/2012 |
| 8123068 | Trophy cooler A trophy cooler is provided, that is easy to transport and provides adequate separation of meat, skin and trophy-head while providing sufficient cooling. The trophy-cooler comprises a chamber comprising an inner wall of insulatory material. The trophy cooler further... | 02/28/2012 |
| 8088390 | Methods for the early diagnosis of ovarian cancer The present invention discloses the protease stratum corneum chymotryptic enzyme (SCCE) is specifically over-expressed in ovarian and other malignancies. A number of SCCE peptides can induce immune responses to SCCE, thereby demonstrating the potential of these pept... | 01/03/2012 |
| 8057999 | Extracellular serine protease The present invention provides a DNA encoding a TADG-14 protein selected from the group consisting of: (a) isolated DNA which encodes a TADG-14 protein; (b) isolated DNA which hybridizes to isolated DNA of (a) above and which encodes a TADG-14 protein; and (c) isola... | 11/15/2011 |
| 8053199 | Molecular phenotyping of severe asthma The present invention discloses a method for classifying individuals into those who have airway hyperreactvitiy and those with asthma based on cytokine expression patterns. It is contemplated that such a method will enable rapid identification of individuals requiri... | 11/08/2011 |
| 8053052 | Adhesive laminates for rapid wound occlusion Provided herein are protective laminate devices comprising a biocompatible non-adherent substance and a fast-setting adhesive and methods of use. Also provided is a dispenser for an adhesive tape. The protective laminate devices and methods may be used for wound clo... | 11/08/2011 |
| 8052962 | Oral soap composition for cleaning teeth Provided herein is an oral soap composition comprising an orally-acceptable soap base effective to clean teeth that includes one or more natural oils, a saponifying agent and distilled water. The oral soap composition may be liquid or solid. Also provided are oral s... | 11/08/2011 |
| 8030447 | Substrate peptide sequences for plague plasminogen activator and uses thereof The present invention is directed to peptide sequences that were identified from combinatorial libraries and could serve as substrates of plague plasminogen activator (Pla). Another aspect of the present invention is drawn to peptides derived from the substrates for... | 10/04/2011 |
| RE42782 | Method and device for synchronous mapping of the total refraction non-homogeneity of the eye and its refractive components An instrument for measuring aberration refraction of an eye is provided, having: a lens system defining an instrument optical axis and an alignment device for aligning the visual axis of the eye with the instrument optical axis. A light source produces a probing bea... | 10/04/2011 |
| 8027039 | Subwavelength resolution optical microscopy Provided herein are methods for imaging subwavelength structures in three dimensions and with high resolution. The methods comprise illuminating subwavelength structures with an illuminating wavelength of light and detecting the self-image generated thereby at a dis... | 09/27/2011 |
| 8014855 | Feedback control device for transcutaneous drug delivery and uses therefor Provided herein is a device for altering a biological membrane in an individual comprising a means for delivering energy to the surface of the biological membrane, a means for monitoring a physiological state of the biological membrane during delivery of said energy... | 09/06/2011 |
| 8014494 | Single-arc dose painting for precision radiation therapy Provided herein are methods and systems for designing a radiation treatment for a subject using single arc dose painting. The methods and systems comprise an algorithm or a computer-readable product having the same, to plan the radiation treatment. The algorithm con... | 09/06/2011 |
| 7999161 | Laser-activated nanothermolysis of cells Provided herein are methods and system to increase selective thermomechanical damage to a biological body, such as a cancer cell or cell associated with a pathophysiological condition. The biological body or cancer cell is specifically targeted with nanoparticulates... | 08/16/2011 |
| 7983850 | Diagnosis, prognosis, identification, and classification of multiple myeloma based on gene expression profiling Provided herein is a method for gene expression profiling multiple myeloma patients into distinct subgroups via DNA hybridization and hierarchical clustering analysis of the hybridization data where the results may further be used to identify therapeutic gene target... | 07/19/2011 |
| 7968698 | Optimized core promoters and uses thereof The present invention provides core promoter motif ten elements (MTE) and core promoter constructs comprising the MTEs and an initiator element (Inr) in combination with one or both of a TATA box and a downstream promoter element (DPE) which increases gene expressio... | 06/28/2011 |
| 7967839 | Electromagnetic treatment of tissues and cells Provided herein are methods, devices and compositions to conductively or to inductively fix substrates, including tissues, using electromagnetic energy. Also provided is a method of controlling the fixing process via feedback monitoring of a property of the composit... | 06/28/2011 |
| 7967750 | Lie detection via electrogastrography The present invention provides a device and methods of lie detection utilizing electrogastrography to monitor changes in the gastric electric rhythm of a subject. Also provided are methods of discriminating between the stress of deception induced in a subject during... | 06/28/2011 |
| 7935679 | Gene expression profiling based identification of CKS1B as a potential therapeutic target in multiple myeloma Gene expression profiling is a powerful tool that has varied utility. It enables classification of multiple myeloma into subtypes and identifing genes directly involved in disease pathogensis and clinical manifestation. The present invention used gene expression pro... | 05/03/2011 |
| 7935531 | Methods for the early diagnosis of ovarian cancer The disclosed nucleic acid primer sets, used in combination with quantitative amplification (PCR) of tissue cDNA, can indicate the presence of specific proteases in a tissue sample. Specifically, the present invention relates to expression of hepsin protease. The de... | 05/03/2011 |
| 7927795 | Gene expression profiling in primary ovarian serous papillary tumors and normal ovarian epithelium Gene expression profiling and hierarchal clustering analysis readily distinguish normal ovarian epithelial cells from primary ovarian serous papillary carcinomas. Laminin, tumor-associated calcium signal transducer 1 and 2 (TROP-1/Ep-CAM; TROP-2), claudin 3, claudin... | 04/19/2011 |
| 7923010 | Methods and materials for treating autoimmune diseases and conditions Disclosed are methods for treating an autoimmune disease or condition in a subject. The methods include administering to the subject a compound which inhibits the subject's classical complement pathway. Also disclosed are methods for suppressing hyperacute graft rej... | 04/12/2011 |
| 7912538 | Controlled release transdermal drug delivery Provided herein is a device for controlling the release of a substance at a site of interest in a biological membrane comprising a means of monitoring a physiological state at the site of interest; and a means of releasing a variable amount of the substance to the s... | 03/22/2011 |
| 7902145 | Terminal sterilization of injectable collagen products Methods of sterilizing dermal fillers and injectable collagen material have been developed which reduce the level of active biological contaminants or pathogens without adversely affecting the material, i.e., wherein the dermal fillers and injectable collagen materi... | 03/08/2011 |
| 7897340 | Use of tumor susceptibilty gene 101 (TSG 101) as a prognostic and diagnostic marker The present invention discloses the link between oncogenic Ras and TSG101 and the negative effect of TSG101 on the expression of p21 in ovarian cancer. The present also discloses the use of TSG101 as a prognostic, diagnostic marker and a potential therapeutic target... | 03/01/2011 |
| 7894992 | Diagnosis and classification of multiple myeloma Gene expression profiling between normal B cells/plasma cells and multiple myeloma cells revealed four distinct subgroups of multiple myeloma plasma cells that have significant correlation with clinical characteristics known to be associated with poor prognosis. Dia... | 02/22/2011 |
| 7863275 | Uses of tetrahydrobiopterin and derivatives thereof The present invention discloses methods of treating diabetic gastroparesis by administering tetrahydrobiopterin or a derivative thereof. ... | 01/04/2011 |
| 7854932 | Immunogenic compositions comprising progastrin and uses thereof The present invention is drawn to immunotherapeutic methods to treat tumors/cancers that produce progastrin ectopically or are dependent on progastrin for their growth. Disclosed herein are immunogenic compositions comprising agents that target progastrin, agents th... | 12/21/2010 |
| 7824868 | Formation of superfibronectin by BBK32 and uses therefor Provided herein is a method for inducing formation of a conformationally distinct superfibronectin by contacting plasma fibronectin with BBK32 protein or a BBK32 peptide and the BBK32-induced superfibronectin so formed. Also provided are methods of inhibiting endoth... | 11/02/2010 |
| 7812003 | Antisense microRNA and uses therefor Provided herein are methods to suppress specificity protein (Sp) activity in a cell associated with a cell proliferative disease. The methods are effective to inhibit a microRNA in the cell using an antisense microRNA oligonucleotide which results in an increase in ... | 10/12/2010 |
| 7811750 | Molecular determinants of myeloma bone disease and use thereof To identify molecular determinants of lytic bone disease in multiple myeloma, the expression profiles of ˜12,000 genes in CD138-enriched plasma cells from newly diagnosed multiple myeloma patients exhibiting no radiological evidence of lytic lesions (n=28) were com... | 10/12/2010 |
| 7807651 | Methods and materials for pain management Disclosed are methods for treating pain in a subject. The method includes upregulating expression of opioid receptors in the subject's dorsal root ganglion neurons. Also disclosed are methods of treating neuropathic and/or chronic pain in a subject. The method inclu... | 10/05/2010 |
| 7807618 | Methods and compositions for delivering enzymes and nucleic acid molecules to brain, bone and other tissues Disclosed are methods for delivering an enzyme to a subject's brain or bone. The methods include administering a hyaluronidase to the subject and administering the enzyme to the subject. The hyaluronidase and the enzyme are administered to the subject under conditio... | 10/05/2010 |
| 7807346 | High-throughput assay for virus entry and drug screening The present invention provides a rapid virus entry/binding detection assay. An enzyme such as luciferase was incorporated at the C-terminal end of viral envelope proteins of the HIV Nef protein that would specifically associate with cell membranes to deliver the enz... | 10/05/2010 |
| 7806528 | System and method for detecting central retinal distortions associated with macular diseases Provided herein are methods and systems to screen for subjects at risk for retinal-associated eye diseases or to monitor the progression/regression thereof. Generally, the method comprises simultaneously or sequentially displaying to a potentially at-risk individual... | 10/05/2010 |
| 7795211 | Methods for the early diagnosis of ovarian cancer The present invention discloses the protease hepsin is specifically over-expressed in ovarian and other malignancies. A number of hepsin peptides can induce immune responses to hepsin, thereby demonstrating the potential of these peptides in monitoring and the devel... | 09/14/2010 |
| 7785841 | Methods for the early diagnosis of ovarian cancer The disclosed nucleic acid primer sets, used in combination with quantitative amplification (PCR) of tissue cDNA, can indicate the presence of specific proteases in a tissue sample. Specifically, the present invention relates to expression of PUMP-1 protease (matrix... | 08/31/2010 |
| 7769432 | Minimally invasive diagnosis and treatment for breast cancer The present invention provides a treatment method to excise a cancerous lesion, such as in the breast, with subsequent ablation of the margin. The method provides for location and excision with ablation under open guidance or guided imaging and for diagnosis by cyto... | 08/03/2010 |
