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| Application No. | Application Title | Issue Date |
| 20110038858 | METHODS OF TREATING HEMATOLOGIC CANCERS USING PNP INHIBITORS SUCH AS FORODESINE IN COMBINATION WITH ALKYLATING AGENTS OR ANTI-CD20 AGENTS The present application relates to treatment of hematologic cancers, which treatments can include, e.g., administration of a purine nucleoside phosphorylase (PNP) inhibitor, an alkylating agent and/or an anti-CD20 agent, and related compositions and kits.... | 02/17/2011 |
| 20110028415 | USE OF 3-(INDOLYL)- OR 3-(AZAINDOLYL)-4-ARYLMALEIMIDE DERIVATIVES IN LEUKENIA MANAGEMENT The present invention relates to the use of a compound of formula (I) wherein R1 is H, C1-C6-alkyl, phenyl-C1-C4-alkyl or phenyl, R2 is a phenyl group which is substituted with 2 or 3 C1-C... | 02/03/2011 |
| 20110022161 | IODINATED POLYMERS The invention provides medical devices that comprise an iodinated polymer and that can be viewed using X-Ray imaging techniques. The invention also provides novel iodinated polymers that can be incorporated into or coated on medical devices.... | 01/27/2011 |
| 20110016934 | LOCK A lock (10) which includes a body and an actuator (36) which is pivotally displaceable between a rest position and a displaced position. The lock further includes a first member (64) which is longitudinally displaceable by the actuator (36) a... | 01/27/2011 |
| 20110015264 | INTRAMUSCULAR ANTIVIRAL TREATMENTS The invention provides unit dosage forms, kits, and methods useful for treating viral infections.... | 01/20/2011 |
| 20110015204 | PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS The present invention provides compounds of Formula (I), including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT pr... | 01/20/2011 |
| 20110009621 | SUPPORTED TRANSITION METAL COMPLEX AND USE THEREOF IN CATALYSIS The invention relates, in particular, to supported transition metal complexes based on a polystyrene matrix comprising structural units of the formula (Ia): or supported transition metal complexes based on a ... | 01/13/2011 |
| 20110009411 | THERAPEUTIC COMPOSITIONS AND THE USE THEREOF The invention includes methods, compositions, and kits useful for treating a viral infection by coadministering 6-(3-chloro-2-fluorobenzyl)-1-[(2S)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid or a pharmaceutically acceptable salt... | 01/13/2011 |
| 20110008396 | COMPOSITIONS AND METHODS FOR TREATING CARDIOVASCULAR CONDITIONS The invention provides amphiphilic macromolecule encapsulates that are useful for treating cardiovascular diseases including conditions related to or emanating from atherosclerosis.... | 01/13/2011 |
| 20110003859 | N- (6-AMINOPYRIDIN-3-YL) -3- (SULFONAMIDO) BENZAMIDE DERIVATIVES AS B-RAF INHIBITORS FOR THE TREATMENT OF CANCER Compounds of Formula (I) are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammali... | 01/06/2011 |
| 20110003809 | IMIDAZO [4,5-B] PYRIDINE DERIVATIVES USED AS RAF INHIBITORS Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian... | 01/06/2011 |
| 20110002886 | TETRAHYDROFURO [3,4-D] DIOXOLANE COMPOUNDS FOR USE IN THE TREATMENT OF VIRAL INFECTIONS AND CANCER The invention provides compounds of formula (I), as described herein, or pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates that are useful for preparing the compounds. The ... | 01/06/2011 |
| 20100331566 | SYNTHETIC METHODS AND COMPOSITIONS The invention provides synthetic methods that utilize bromo or chloro substituents as blocking groups during the functionalization of aromatic rings, as well as compounds that are prepared from such methods.... | 12/30/2010 |
| 20100331385 | PYRAZOLE UREA DERIVATIVES USED AS KINASE INHIBITORS Compounds of Formula (I) where R1 and R2 are as defined herein, and pharmaceutically acceptable salts thereof, are useful in the treatment and prevention of various disorders mediated by kinases... | 12/30/2010 |
| 20100331331 | THERAPEUTIC COMPOSITIONS AND THE USE THEREOF The invention includes methods, compositions, and kits useful for treating a viral infection by administering 6-(3-chloro-2-fluorobenzyl)-1-[(2S)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid or a pharmaceutically acceptable salt t... | 12/30/2010 |
| 20100331283 | Mitotic kinesin inhibitors and methods of use thereof This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmac... | 12/30/2010 |
| 20100324041 | PYRROLOPYRIDINES AS KINASE INHIBITORS Compounds of Formula (I) are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula (I) and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in ... | 12/23/2010 |
| 20100310512 | ANTIVIRAL COMPOUNDS The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.... | 12/09/2010 |
| 20100310498 | ACTIVE AGENTS AND THEIR OLIGOMERS AND POLYMERS Conjugates comprising at least two active agents linked by a diglycolic acid or polyglycol diacid linker are disclosed. The invention also concerns oligomers and polymers of these conjugates and their use in therapeutic and industrial applications for localized, immedia... | 12/09/2010 |
| 20100292480 | PROCESS AND INTERMEDIATES FOR PREPARING INTEGRASE INHIBITORS The invention provides synthetic processes and synthetic intermediates that can be used to prepare 4-oxoquinolone compounds having useful integrase inhibiting properties.... | 11/18/2010 |
| 20100292244 | HYDROXYLATED PYRIMIDYL CYCLOPENTANE AS AKT PROTEIN KINASE INHIBITOR The present invention provides a compound and pharmaceutically acceptable salts thereof, comprising the Formula I. Also provided are methods of using the compound of this invention as an AKT protein kinase inhibitor and for the treatment of hyperproliferative diseases s... | 11/18/2010 |
| 20100291699 | COMPOSITIONS AND METHODS FOR SIMULTANEOUS DETECTION OF VOLATILE SULFUR COMPOUNDS AND POLYAMINES Disclosed are compositions and methods useful for the rapid and facile simultaneous detection of malodorous bacterial metabolites in samples of expired breath and other fluids. The invention enables estimation, by simple visual inspection and comparison against standard... | 11/18/2010 |
| 20100291673 | ALTERNATIVE EXPORT PATHWAYS FOR VECTOR EXPRESSED RNA INTERFERENCE The present invention is directed to nucleic acid molecules containing a loop sequence designed to circumvent exportin-5 mediated export, and methods using these novel molecules.... | 11/18/2010 |
| 20100291181 | THERAPEUTIC DEVICES FOR PATTERNED CELL GROWTH The invention provides therapeutic devices comprising a polymeric anti-inflammatory agent that biodegrades to release anti-inflammatory agents. The therapeutic devices are useful for repair and regeneration of a variety of injured tissues.... | 11/18/2010 |
| 20100291180 | NERVE GUIDANCE TUBES Provided herein are cell guidance tubes and methods for their use.... | 11/18/2010 |
| 20100285122 | TABLETS FOR COMBINATION THERAPY The invention provides solid dose forms (e.g. tablets) comprising a compound of Formula I, a compound of Formula II, a compound of Formula III and a salt of Formula IV. ... | 11/11/2010 |
| 20100280043 | PYRAZOLOPYRIDINES AS KINASE INHIBITORS Compounds of Formula I are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mamm... | 11/04/2010 |
| 20100280027 | PHARMACEUTICAL COMPOUNDS Provided herein are methods of treating diseases or disorders arising from abnormal cell growth, function or behavior associated with PI3 kinase, which method includes administering to a patient in need thereof a compound that is a fused pyrimidine of formula (I):<... | 11/04/2010 |
| 20100279286 | METHOD OF DETECTING EQUINE POLYSACCHARIDE STORAGE MYOPATHY The present invention relates to diagnosing Polysaccharide Storage Myopathy (PSSM) disease in equines.... | 11/04/2010 |
| 20100273850 | 4-HETEROARYL-SUBSTITUTED PHENOXYPHENYLACETIC ACID DERIVATIVES Compounds of Formula I: I in which D1, D2, R1, R2, R7, R8 and A have the meanings given in the specification, are DP2 receptor modulators useful in the treatment of immunologic diseases. 10/28/2010 | |
| 20100273833 | 2-SULFINYL- AND 2-SULFONYL-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE AS CYTOKINE INHIBITORS The invention relates to 2-sulfinyl- or 2-sulfonyl-substituted imidazole derivatives of the formula (I) in which the radicals R1, R2, R3 and R4 have the meaning indicated in the description. The compounds of the invention have... | 10/28/2010 |
| 20100272670 | BIODEGRADABLE POLYANHYDRIDES WITH NATURAL BIOACTIVE MOLECULES The invention provides polymers that include a biologically active molecule and methods for their use.... | 10/28/2010 |
| 20100267075 | MICROFLUIDIC LYSIS The invention provides methods for isolating and identifying nucleated cells from biological samples using a microfluidic device.... | 10/21/2010 |
| 20100265163 | SYSTEM AND APPARATUS FOR DISPLAY PANELS Various embodiments of the present invention provide for systems and apparatuses directed toward using a display panel to processes display information and non-display information. Further embodiments, utilize a display panel in conjunction with a contact lens assembly ... | 10/21/2010 |
| 20100260868 | METHOD OF TREATMENT USING CHECKPOINT KINASE 1 INHIBITORS Methods of treating cancer by administering a DNA damaging agent and a CHK1 Inhibitor on a dosing regimen are provided.... | 10/14/2010 |
| 20100256366 | METHODS AND INTERMEDIATES FOR PREPARING PHARMACEUTICAL AGENTS The invention provides methods and intermediates that are useful for preparing a compound of formula I: and salts thereof.... | 10/07/2010 |
| 20100256356 | HETEROBICYCLIC PYRAZOLE COMPOUNDS AND METHODS OF USE Compounds of Formulas Ia and Ib, and stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting receptor tyrosine kinases and for treating disorders mediated thereby. Methods of using compo... | 10/07/2010 |
| 20100256143 | PHARMACEUTICAL COMPOUNDS The invention provides a pyrimidine compound of formula (I): wherein R1 and R2 have any of the values defined herein; or a pharmaceutically acceptable salt thereof. The compounds are inh... | 10/07/2010 |
| 20100247542 | TRUNCATED VARIANT OF THE MAMMALIAN TARGET FOR RAPAMYCIN (MTOR) PROTEIN The invention relates to mTORbeta, a splice form of mTOR, nucleic acids encoding mTOR beta, and antibodies against mTOR beta. The invention also relates to methods of producing mTOR beta and methods of screening for an agent that modulates mTOR beta expression and/or ac... | 09/30/2010 |
| 20100240664 | SOLUBILIZED TOPOISOMERASE POISON AGENTS The invention provides compounds of formula I: wherein A, B, W, Y, Z, and R1 have any of the meanings defined in the specification and their pharmaceutically acceptabl... | 09/23/2010 |