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Attorney: SMITH HOPEN, PA


Number of applications: 288
Last date: February 24, 2011

1                
Application No.Application TitleIssue Date
20110046002Seven Gene Breast Cancer Predictor
The invention provides a molecular marker set that can be used for prognosis of breast cancer in a patient using histologically normal tissue. The invention also provides methods for evaluating prognosis of breast cancer in a patient based on a molecular molecular signa...
02/24/2011
20110036258MECHANICAL COMMAND TO ARM FUZE
A mechanical safe and arm device for rotating munitions reduces arming scatter so that the “no arm” and “all arm” distance are substantially the same. A first spring holds a flywheel, a pinion gear, and a drive gear against rotation until centrifugal forces caus...
02/17/2011
20110027884COMBINATION OF INSULIN AND ASCORBATE TO ENHANCE WOUND HEALING
Provided is a method of stimulating collagen synthesis and proteoglycan (lumican and keratocan) accumulation. Collagenase isolated keratocytes were cultured with or without insulin with or without ascorbate. Insulin stimulates the synthesis of collagen but does not affe...
02/03/2011
20110023225Portable spa with variable speed throttling water massage system
The present invention is directed to a portable spa with a throttling system having a throttling parameter, a sequencing parameter, and a time parameter, wherein water is discharged at varying rates and pressures through different sequences of jet groups for an interval...
02/03/2011
20110004887VECTOR-BASED MAGNIFIED POINTER
A method of rendering magnified pointing indicia including the steps of monitoring application program interface messaging and intercepting a call for a unique system pointer identifier. A stored collection of predefined vector shapes is accessed and from that a predefi...
01/06/2011
20110000388Mechanical self destruct for runaway escapements
An escapement fuze self-destruct mechanism for a projectile includes a drive weight that maintains a biasing member in a compressed state by centrifugal force when a projectile's RPM speed is above a preselected threshold. When the RPM speed falls below the preselected ...
01/06/2011
20100331625ENDOSCOPIC OVERTUBE
An over-tube was developed for receiving and guiding endoscopic instruments into a patient's anus, through the colon, and into the peritoneum. The over-tube has a flexible sheath adapted for insertion into the anus through the colon and out the peritoneum of a patient. ...
12/30/2010
20100330956Real-Time Replenishment with Electronic Confirmation for Sale of Prepaid Long Distance
A method and system of providing an electronic receipt, such as a SMS text message, to a consumer responsive to a purchase of long distance calling minutes, real-time replenishment of the customer's account, and seamless, pin-less use of the purchased long-distance from...
12/30/2010
20100323939ALCOHOL-BASED SKIN CLEANSER
The invention provides a composition for cleansing skin comprising an emulsifiable organic solvent, such as ethanol or isopropyl alcohol, water, sodium benzoate, and a natural essential oil comprising a complex solution of compounds derived from a plant having topical a...
12/23/2010
20100313338Compact Protective Hood with Fold Lines
A compact protective hood comprising a pre-molded, substantially non-elastic crown having at least one preformed fold line whereby the package size of the hood is reduced by folding the hood along the at least one preformed fold line...
12/16/2010
20100307096Wheelchair Ramp for Shower Access
A frame for building a ramp provides wheelchair users ingress and egress to a shower area. A first embodiment includes a first flat inclined surface and an arcuate surface. In a second embodiment, the frame has first and second flat inclined surfaces having first and se...
12/09/2010
20100300455RESPIRATION PILLOW
A device for face-down, prone respiration comprising a head support made of resilient material having a facial cavity conformable to the contours of a person's face, a plenum cavity in fluid communication with the person's face, a substantially L-shaped support base rem...
12/02/2010
20100292087METHOD OF PREDICTING CHEMOTHERAPEUTIC RESPONSIVENESS OF CANCER
Disclosed is a method of predicting clinical tumor outcome by providing gene expression from a tumor sample. The method utilizes a novel genetic screen to identify genes that contribute to chemotherapeutic responsiveness, using formalin fixed paraffin embedded clinical ...
11/18/2010
20100281818METHOD FOR BUILDING WIND TURBINE TOWER
A method for erecting a tower includes the steps of providing a first pre-cast section of concrete and positioning it atop a foundation. A radially-inwardly extending ledge is attached to an interior wall of the first pre-cast section and a plurality of jacks is positio...
11/11/2010
20100280437MULTICHANNEL TROCAR
A multi-channel trocar developed for use in ‘minimal-access surgery/single incision laparoscopic surgery. The trocar permits surgical access of two or more articulating laparoscopic instruments or scopes through one skin incision using a dividing membrane to separate ...
11/04/2010
20100278920Polyacrylate Nanoparticle Drug Delivery
Drug delivery of resistance reversal agents by polyacrylate nanoparticles for treatment of drug (e.g. chloroquine) resistant malaria. Also provided are drug delivery by polyacrylate nanoparticles of ciprofloxacin for treatment of anthrax....
11/04/2010
20100274084TRANS-ENDOSCOPIC HYDRAULIC BALLOON APPARATUS
A trans-endoscopic hydraulic balloon dilation apparatus includes a fluid reservoir containing a hydraulic fluid. A shaft has a lumen in fluid communication with a leading end of the fluid reservoir. A balloon is mounted on the shaft and an opening in the shaft enables h...
10/28/2010
20100267841Composition for Topical Use Containing an Extract of Stryphnodendron; Its Preparation As Well As Its Application
The present invention relates to topical compositions containing extracts of the plant genus Stryphnodendron as well as their preparation and application. The compositions contain between 1% and 6% of total phenols and are useful for the treatment of cutaneous wo...
10/21/2010
20100267736METHODS AND COMPOSITIONS TO ENHANCE THE EFFICACY OF PHOSPHODIESTERASE INHIBITORS
Methods for treatment of sexual dysfunction in men and women using combination of phosphodiesterase (PDE) type 5 inhibitors and 1-deprenyl or propargylamine compounds are described. Methods of reducing the dosage and preventing the side effects of PDE type5 inhibitors a...
10/21/2010
20100267735METHODS AND COMPOSITIONS TO ENHANCE THE EFFICACY OF PHOSPHODIESTERASE INHIBITORS
Methods for treatment of sexual dysfunction in men and women using combination of phosphodiesterase (PDE) type 5 inhibitors and 1-deprenyl or propargylamine compounds are described. Methods of reducing the dosage and preventing the side effects of PDE type5 inhibitors a...
10/21/2010
20100267733Synergistic Modulation of Microglial Activation by Nicotine and THC
Treatment of microglial cells with nicotine and THC synergistically attenuate the microglial activation. Using microglial activation, the combination of THC and nicotine interact synergistically reduced LPS induced TNF-α release, showing that the combination of THC and...
10/21/2010
20100262908Document Navigation Method
A document navigation tool that automatically navigates a document based on previous input from the user. The document navigation tool is utilized each time a page loads. The method recognizes user behavior on pages using patterns, which are based on four criterion: loc...
10/14/2010
20100251918COMMAND AND ARM FUZE ASSEMBLY HAVING SMALL PISTON ACTUATOR
A command to arm apparatus includes a housing having a hollow interior. A pivotally-mounted rotor is disposed in the hollow interior. The rotor has a first, safe position of rotational adjustment that prevents detonation of an explosive and a second, armed position of r...
10/07/2010
20100248328HYPERACTIVE VARIANTS OF 5-AMINOLEVULINATE SYNTHASE AND METHODS OF USE
The rate of porphyrin biosynthesis in mammals is controlled by the activity of the pyridoxal 5′-phosphate-dependent enzyme 5-aminolevulinate synthase. Assuming the turnover in this enzyme is controlled by conformational dynamics at a highly conserved active site loop,...
09/30/2010
20100243091Scrim-Enforced Pipe Liner
Stretch-resistant liners for lining pipes, pipes lined with stretch-resistant liners, and methods for lining pipes with stretch-resistant liners. The liners are made from a lamination that includes a sealing layer, a strength layer of stretch-resistant woven material th...
09/30/2010
20100241472ILLNESS SPECIFIC DIAGNOSTIC SYSTEM
A method for diagnosing diseases in human subjects and a computer system implementing the method. The novel method uses historical patient medical records to create tables, which are used by a medical center to determine what diagnostic test is associated with confirmat...
09/23/2010
20100240540GENOTYPIC TUMOR PROGRESSION CLASSIFIER AND PREDICTOR
Actively dividing tumors appear to progress to a life threatening condition more rapidly than slowly dividing tumors. Assessing actively dividing tumors currently involves a manual assessment of the number of mitotic cells in a histological slide prepared from the tumor...
09/23/2010
20100234891TRANSLATIONAL MANIPULATION POLYAXIAL SCREW HEAD
A novel surgical screw is presented as a polyaxial, multiaxial, or monoaxial screw. The polyaxial screw allows versatile angulation between a bone anchor section and a screw body and allows the surgeon to attach a rod to the invention in a top-loading manner and manipul...
09/16/2010
20100233969RECONFIGURABLE CHAMBER FOR EMULATING MULTIPATH FADING
Disclosed is a compact reconfigurable channel emulator, which may be used to emulate severe fading environments and test wireless systems and subsystems for operation in severe channel environments. Examples include radios, coding schemes, diversity methods and antennas...
09/16/2010
20100233712Method for Early Detection of Cancers
The invention includes methods for detecting the presence of a neoplastic condition by comparing a sample level of a BIF-1 to a reference, wherein a low level of BIF-1 in the sample correlates with the presence of a neoplastic condition. Another method involves determin...
09/16/2010
20100224095Reduced Friction Projectile
A projectile includes a leading part formed by a tip, a tip base, and a leading rod. A trailing part includes a main base, a truncate base, and a trailing rod. A leading end of a cylindrical interface abuts an annular shoulder where the tip meets the tip base and a trai...
09/09/2010
20100222764Intracranial Catheter and Methods of Use
A catheter assembly for intracranial treatment of a subject that includes an outer tube that may be connected to an infusion or osmotic pump and delivered through a bendable catheter to the target brain site of the subject. The assembly facilitates regular accurate plac...
09/02/2010
20100221233COMPOSITIONS AND METHODS FOR ENHANCING NEUROPROTECTION VIA ADMINISTRATION OF STEM CELLS AND BLOOD BRAIN BARRIER PERMEABILIZERS
The present invention provides compositions and methods for enhancing the neuroprotective effect of umbilical cord blood cells. More particularly, the present invention provides methods of treating neurodegenerative disorders by administering umbilical cord blood cells ...
09/02/2010
20100218696Firearms Projectile
A projectile structured to be discharged from a firearm includes a body having a nose portion and a tail portion separable from one another when the projectile strikes a target. The body further includes an interface disposed intermediate opposite ends of the body of th...
09/02/2010
20100204337ANTIBACTERIAL S-HETEROSUBSTITUTED DISULFIDES
Synthetically-derived S,S-heterodisubstituted disulfides that exhibit potent in vitro antibacterial activity against a variety of bacteria, including Staphylococcus aureus, methicillin-resistant Staphylococcus aureus and Francisella tularensis. The ...
08/12/2010
20100199908SHOCK ABSORBING COCKPITS
A watercraft cockpit includes a floor, sidewalls and forward and rearward bulkheads. A frame assembly having four corners supports the cockpit and includes an upper frame and a lower frame that are rotatably connected to one another. A pair of shock-absorbing members is...
08/12/2010
20100196915Method of Detecting Oncogenesis of Hematopoietic Cells
Disclosed in a method of detecting cancer using IL-27 receptors. IL27R is a cytokine receptor identified as a novel oncogene from an acute myeloid leukemia patient. It induces cancer-like properties when expressed in cells and can activate a protein that causes various ...
08/05/2010
20100196569QUINOA GRAIN PROCESSING AND PRODUCTS
Quinoa grain products having a reduced bitter flavor with a sweet taste or crunchy texture. Despite numerous beneficial properties, quinoa grain has not been utilized in a wide variety of products. Provided are efficient processes for quinoa to obta...
08/05/2010
20100184963QUINOA PROTEIN CONCENTRATE, PRODUCTION AND FUNCTIONALITY
The present invention relates to a new source of high quality plant protein, termed, “quinoa protein concentrate” or “QPC”, which contains at least about 50 wt % protein which is food-grade and/or pharmaceutical-grade and methods of preparing such protein...
07/22/2010
20100184065Method of Predicting Non-Response to First Line Chemotherapy
The invention provides a method for determining a prognosis of colorectal cancer in a colorectal cancer patient, comprising classifying said patient as having a good prognosis or a poor prognosis using measurements of a plurality of gene products in a cell sample taken ...
07/22/2010
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