Did You Know...
...that Charles Goodyear performed some of his experiments on rubber while in debtor's prison? He was there so often he referred to it as his "hotel". Chronically in debt because of poor business sense and ill health, Goodyear depended on the generosity of friends and family. Even after he unlocked the secret to vulcanizing rubber, he was unable to improve his financial situation. When he died, his estate was $200,000 in debt.
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| Application No. | Application Title | Issue Date |
| 20100130468 | INDOLE CARBOXAMIDES AS IKK2 INHIBITORS The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula (I): wherein R1, R2, R3, R4 | |
| 20100120669 | THIADIAZOLE DERIVATIVES, INHIBITORS OF STEAROYL-COA DESATURASE The present invention relates to substituted thiadiazole compounds of the formula (I): and pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing them and their use in medicine. ... | 05/13/2010 |
| 20100113545 | GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS Compounds of formula (I) or a salt thereof are provided: wherein R1, R2, R3, R4, R5, R6, R15, R7, R8 and m ar... | 05/06/2010 |
| 20100113475 | PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R11, R12, R13, ... | 05/06/2010 |
| 20100113444 | PROLYL HYDROXYLASE INHIBITORS The invention described herein relates to certain pyrimidinetrione N-substituted glycine derivatives of formula (I), (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one... | 05/06/2010 |
| 20100111945 | NOVEL USES The present invention relates generally to the use of human IL-18 combinations in the treatment of cancers. In particular, the present invention relates to combination of human IL-18 and an anti-CD20 antibody.... | 05/06/2010 |
| 20100105713 | GLYT1 Transporter Inhibitors and Uses Thereof in Treatment of Neurological and Neuropsychiatric Disorders Compounds of formula (I) or a salt thereof are provided: wherein R6, R7, R9, R10, R11, X, n, p, Ar and m are as defined in the description. Uses of the c... | 04/29/2010 |
| 20100105652 | PURINES AS CYSTEINE PROTEASE INHIBITORS Substituted heteroaryl nitrile salt of Formula I, processes for their preparation, pharmaceutical compositions comprising such compounds and use of the compounds as cysteine protease inhibitors are provided.... | 04/29/2010 |
| 20100105042 | NOVEL METHODS The present invention provides methods for site-specifically integrating at least one first nucleic acid into a genome of at least one cell, comprising:
| 04/29/2010 |
| 20100099690 | XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS The present invention relates to compounds which are xanthine derivatives, processes for the manufacture of said derivatives, pharmaceutical formulations containing the active compounds and the use of the compounds in therapy, for example, in the treatment of diseases w... | 04/22/2010 |
| 20100099631 | Novel Use The present invention relates to the use of the combined oral administration of caffeine with carbohydrate for increasing the rate of muscle glycogen resynthesis after strenuous exercise.... | 04/22/2010 |
| 20100087424 | TRICYCLIC NITROGEN CONTAINING HETEROCYCLES AS ANTIBACTERIAL AGENTS Tricyclic nitrogen containing compounds and their use as antibacterials.... | 04/08/2010 |
| 20100086554 | METHODS FOR ADMINISTERING ANTI-IL-5 ANTIBODIES The present invention relates to methods of treating nasal polyposis, in a human, comprising the step of administering to said human in need thereof an effective amount of a composition comprising at least one anti-11-5 antibody wherein said antibody comprises a heavy c... | 04/08/2010 |
| 20100086547 | METHODS FOR ADMINISTERING ANTI-IL-5 ANTIBODIES The present invention relates generally to the methods for the treatment and diagnosis of conditions mediated by IL-5 and excess eosinophil production, and more specifically to mAbs, Fabs, chimeric and humanized antibodies. More particularly, methods are provided for re... | 04/08/2010 |
| 20100086499 | TOOTH WHITENING COMPOSITION The present invention provides an effective tooth whitening composition comprising a chlorine dioxide precursor, an organic acid anhydride and an orally acceptable carrier.... | 04/08/2010 |
| 20100081805 | Preparation of a Quinolinyloxydiphenylcyclopropanedicarboxamide The present invention relates to a process of preparing a compound of the following formula III: wherein R1-R4 are as defined herein. The present invention also relates to the preparatio... | 04/01/2010 |
| 20100081792 | Ligand The invention provides a dual-specific ligand comprising a first and second single variable domain, each having binding specificity for a antigenic target. The invention also provides for a single variable domain monomer ligand that specifically binds to an antigenic ta... | 04/01/2010 |
| 20100080897 | Continuous Coating of Pellets A continuous dosage form coating apparatus uses vibrational impulses to maintain a dosage forms in a fluid state to expose them to a coating material atomized by spraying.... | 04/01/2010 |
| 20100076017 | SITAMAQUINE TOSYLATE FOR THE TREATMENT OF LEISHMANIASIS Disclosed in a novel compound of formula (IA) and its use in the treatment of leishmaniasis infections. ... | 03/25/2010 |
| 20100075982 | Pyridinone Derivative For The Treatment of Premature Ejaculation The invention provides 3-(methyloxy)-1-{4-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]butyl}-2(1H)-pyridinone of formula (I), or a pharmaceutically acceptable salt thereof.... | 03/25/2010 |
| 20100075968 | Imidazolidine Carboxamide Derivatives as P2X7 Modulators The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof: The compounds or salts modulate P2X7 receptor function and are capable of antagonizing the effects of ... | 03/25/2010 |
| 20100075928 | CANCER TREATMENT METHOD Invented is a method of treating cancer and pre-cancerous syndromes in a mammal, including a human, in need thereof which comprises the administration of a therapeutically effective amount of a non-peptide TPO receptor agonist to such mammal.... | 03/25/2010 |
| 20100074947 | Pharmaceutical Formulations The present invention is directed to novel pharmaceutically acceptable polymeric compositions suitable for melt extrusion and injection moulding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being... | 03/25/2010 |
| 20100069416 | Azabicyclo [3.1.0] Hexyl Derivatives as Modulators of Dopamine D3 Receptors The present invention relates to certain azabicyclo compounds of formula (I)′: wherein the various groups are defined herein and that are modulators of dopamine D3 receptors, e.g. to treat drug d... | 03/18/2010 |
| 20100069409 | "NOVEL COMPOUNDS" Novel substituted 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds, and 1,5,7-trisubstituted-3,4-dihydro-pyrimido[4,5-d]pyrimidin-2-(M)-one compounds and compositions, and their use in therapy as CSBP/RK/p38 kinase inhibitors.... | 03/18/2010 |
| 20100069391 | Novel sEH Inhibitors and Their Use The invention is directed to novel sEH inhibitors and their use in the treatment of diseases mediated by the sEH enzyme.... | 03/18/2010 |
| 20100068246 | Process for Providing a Quantity of a Particulate Material, Product and Apparatus A process for providing a predetermined quantity of a particulate material in which the particulate material is deposited on a defined area of a sticky surface of a substrate. The process is suitable for deposition of particulate drug material on a substrate such as a s... | 03/18/2010 |
| 20100068166 | ORAL COMPOSITION COMPRISING DIMETHICONE COPOLYOL Oral compositions comprising silicone polyols are described for lubricating and hydrating the buccal cavity and are of benefit in alleviating the symptoms of xerostomia (dry mouth).... | 03/18/2010 |
| 20100063097 | Azabicyclo [3.1.0] Hexane Derivatives as Modulators of Dopamine D3 Receptors The present invention relates to certain azabicyclic compounds of formula (I)′: wherein the several groups are defined herein and are modulators of dopamine D3 receptors, e.g. to treat drug depen... | 03/11/2010 |
| 20100063078 | SPIROCOMPOUNDS USEFUL AS MODULATORS FOR DOPAMINE D3 RECEPTORS The present invention relates to novel compounds of formula (I) or salts thereof: wherein
| 03/11/2010 |
| 20100063004 | TOPICAL PHARMACEUTICAL COMPOSITION This invention relates to a novel topical pharmaceutical composition. In particular, this invention is an overnight topical composition for treating cold sores.... | 03/11/2010 |
| 20100056760 | SIALOADHESIN FACTOR-2 ANTIBODIES Monoclonal antibodies have been generated that bind to human sialoadhesion factor-2. These antibodies are useful as diagnostic and therapeutic reagents.... | 03/04/2010 |
| 20100056595 | Pyrazole Derivatives as P2X7 Modulators The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof:
| |
| 20100056523 | INHIBITORS OF AKT ACTIVITY Invented are novel 1H-imidazo[4,5-c]pyridin-2-yl compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.... | 03/04/2010 |
| 20100056502 | COMPOUNDS Tricyclic nitrogen containing compounds and their use as antibacterials.... | 03/04/2010 |
| 20100055166 | NOVEL METHOD AND COMPOSITIONS The present invention relates to, inter alia, a method of raising an immune response against a pathogen which comprises administering (i) one or more first immunogenic polypeptides derived from said pathogen; (ii) one or more adenoviral vectors comprising one or more he... | 03/04/2010 |
| 20100048895 | Process for Preparing Heterocyclic Derivatives The present invention relates to a novel process, useful for preparing key intermediates of formula (I) in the synthesis of various compounds, among them compounds which are potent and specific antagonists of D3 receptors, 02/25/2010 | |
| 20100048656 | GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS Compounds of formula (I) or a salt thereof are provided: wherein R6, R7, R8, R9, X, Ar, n, and m are as defined in the description. Uses of the compounds as medicam... | 02/25/2010 |
| 20100048617 | COMPOUNDS The present invention relates to substituted 3-Aminopyrazole compounds of formula (I) and pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing them and their use in medicine. I... | 02/25/2010 |
| 20100048544 | PYRROLO (3, 2, 1-IJ) QUINOLINE-4-ONE-DERIVATIVES FOR TREATING TUBERCULOSIS Tricyclic nitrogen-containing compounds of Formula (I) or pharmaceutically acceptable salts and/or N-oxides thereof: compositions containing them, their use in the treatment of tuberculosis, and methods for t... | 02/25/2010 |
