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| Application No. | Application Title | Issue Date |
| 20110046891 | CO-CRYSTALLIZATION OF ERR-alpha WITH A LIGAND THAT FORMS A REVERSIBLE COVALENT BOND The crystal structure of the ligand binding domain of ERR-α in complex with a ligand that forms a reversible thioether bond to Cys325 of ERR-α, methods to measure dissociation rates for ligands that form reversible covalent bonds, and methods to design ligands that fo... | 02/24/2011 |
| 20110046745 | INSTRUMENT AND ASSOCIATED METHOD OF TRIALING FOR MODULAR HIP STEMS A trial (100) for use in performing joint arthroplasty is provided. The trial (100) fits to a cavity (103) in the canal (105) of a long bone (107) and assists in the performing of a trial reduction in performing joint arthroplasty. The... | 02/24/2011 |
| 20110046348 | METHODS OF PREPARING PEPTIDE DERIVATIVES The invention relates to methods of preparing peptide hydrazides useful in as intermediates in preparing derivatized peptides and amenable to conversion to reactive azide comprising species. The invention relates to chemical methods of preparing such species from protec... | 02/24/2011 |
| 20110046151 | PIPERAZINYL DERIVATIVES USEFUL AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR The present invention is directed to piperazinyl derivatives useful as inhibitors of the NPY Y2 receptor, pharmaceutical compositions comprising said compounds, processes for the preparation of said compounds and the use of said compounds for the treatment and/or preven... | 02/24/2011 |
| 20110046139 | BENZOCYCLOHEPTANE AND BENZOXEPINE DERIVATIVES The present invention relates to a compound of formula (I) including any stereochemically isomeric form thereof, wherein the substituents are as defined in the specification and the claims; a N-oxide thereof,... | 02/24/2011 |
| 20110046132 | BENZOIMIDAZOLES AS PROLYL HYDROXYLASE INHIBITORS The present invention is directed to benzoimidazole compounds of the formula (1) and enantiomers, diastereomers, racemates, and pharmaceutically acceptable salts thereof. Compounds of the present invention are useful in pharmaceutical compositions and methods for the tr... | 02/24/2011 |
| 20110046099 | STEROID HORMONE PRODUCTS AND METHODS FOR PREPARING THEM The present invention relates to steroid hormone products, such as oral contraceptive products, including at least one steroid active ingredient mixed with an excipient and having improved dissolution and release rate properties. The invention further relates to methods... | 02/24/2011 |
| 20110046095 | STEROID HORMONE PRODUCTS AND METHODS FOR PREPARING THEM The present invention relates to steroid hormone products, such as oral contraceptive products, including at least one steroid active ingredient mixed with an excipient and having improved dissolution and release rate properties. The invention further relates to methods... | 02/24/2011 |
| 20110045477 | HUMAN SKIN EXPLANT CULTURE SYSTEM AND USE THEREFOR The present invention features a human skin explant culture system and uses thereof.... | 02/24/2011 |
| 20110045112 | VARIABLE FOCUS OPHTHALMIC DEVICE This invention discloses methods and apparatus for providing a variable optic insert into an ophthalmic lens. An energy source is capable of powering the variable optic insert included within the ophthalmic lens. In some embodiments, an ophthalmic lens is cast molded fr... | 02/24/2011 |
| 20110045034 | Gelatin Sponge Comprising an Active Ingredient, Its Preparation and Use The invention relates to an improved dry cross-linked gelatin sponge comprising a layer of an active ingredient, to methods of its preparation and uses thereof.... | 02/24/2011 |
| 20110044527 | Methods and Algorithms for Cell Enumeration in a Low-Cost Cytometer The enumeration of cells in fluids by flow cytometry is widely used across many disciplines such as assessment of leukocyte subsets in different bodily fluids or of bacterial contamination in environmental samples, food products and bodily fluids. For many applications ... | 02/24/2011 |
| 20110040333 | Instruments and Methods for Minimally Invasive Spine Surgery A minimally invasive surgical method includes inserting a first port that defines a first pathway to a first vertebra, advancing a first anchor through the first port to the first vertebra, inserting a second port that defines a second pathway to a second vertebra, adva... | 02/17/2011 |
| 20110040302 | ADJUSTABLE SURGICAL INSTRUMENT A surgical instrument is described which comprises an alignment guide having a first part including a distal end and a second part having a proximal end. The first part is attached to the second part by a pivot mechanism so that the first part can be tilted relative to ... | 02/17/2011 |
| 20110040249 | Human Anti-IL-23 Antibodies, Compositions, Methods and Uses A human anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.... | 02/17/2011 |
| 20110040206 | IN SITU OFFSET COMPENSATION FOR PRESSURE SENSORS A pressure sensor having a substrate and a first, deformable membrane, partially supported by the substrate, which generates a first sensor reading when deformed by pressure. A second membrane is contiguous to the first membrane. When the second membrane is energized, i... | 02/17/2011 |
| 20110040158 | PATIENT MONITORING AND DRUG DELIVERY SYSTEM AND METHOD OF USE Disclosed is a patient monitoring and drug delivery system and associated methods for use during diagnostic, surgical or other medical procedures. The functionality of the invention enables many time consuming and laborious activities to be minimized or moved to a part ... | 02/17/2011 |
| 20110040150 | ROBOTIC DRIVE FOR CATHETER Apparatus for controlling a steerable invasive probe having a handle. The apparatus includes a platform and a jig, which is mounted on the platform and is configured to receive the handle. The jig includes at least a first gear that is positioned and shaped to rotate th... | 02/17/2011 |
| 20110040088 | FUSED HETEROCYCLIC COMPOUNDS Certain fused pyrrole- and pyrazole-containing heterocyclic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.... | 02/17/2011 |
| 20110039876 | SOLUTION FORMULATIONS OF SIROLIMUS AND ITS ANALOGS FOR CAD TREATMENT Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompa... | 02/17/2011 |
| 20110039352 | METHODS TO MEASURE DISSOCIATION RATES FOR LIGANDS THAT FORM REVERSIBLE COVALENT BONDS The crystal structure of the ligand binding domain of ERR-α in complex with a ligand that forms a reversible thioether bond to Cys325 of ERR-α, methods to measure dissociation rates for ligands that form reversible covalent bonds, and methods to design ligands that fo... | 02/17/2011 |
| 20110039050 | ULTRA-THIN MULTI-LAYER PROTECTION An implantable medical device including a plurality of components on a substrate, and a biocompatible multi-layer coating applied by vapour deposition to conform to and sealingly cover at least a portion of the components and/or the substrate. The coating is applied in ... | 02/17/2011 |
| 20110038131 | PACKAGING WITH ACTIVE PROTECTION LAYER An implantable medical device including a plurality of components on a substrate, and a biocompatible multi-layer coating applied at least in part by vapour deposition to conform to and sealingly cover at least a portion of the components and/or the substrate. The coati... | 02/17/2011 |
| 20110038130 | PLASMA ENHANCED POLYMER ULTRA-THIN MULTI-LAYER PACKAGING An implantable medical device including a plurality of components on a substrate, and a biocompatible multi-layer polymeric coating applied by vapour deposition to conform to and sealingly cover at least a portion of the components and/or the substrate. The coating is a... | 02/17/2011 |
| 20110035018 | PROSTHESIS WITH COMPOSITE COMPONENT A joint prosthesis with three components is disclosed. The prosthesis includes a first component, a composite component and a bearing component. The bearing can be mounted on and fixed to the composite component and has an articulation surface to articulate with an arti... | 02/10/2011 |
| 20110035017 | PROSTHESIS WITH CUT-OFF PEGS AND SURGICAL METHOD A joint prosthesis system has two metal implant components and a bearing. One of the metal implant components has an articulation surface for articulation with the bearing. The other metal implant component has a mounting surface for supporting the bearing. An extension... | 02/10/2011 |
| 20110034989 | RAPID-EXCHANGE BALLOON CATHETER SHAFT AND METHOD A balloon catheter or stent delivery system for medical treatment of a patient has a proximal hub, a balloon, and an improved shaft design. The catheter shaft has a rapid-exchange configuration, and a tubular outer body that includes a hypotube extending from the cathet... | 02/10/2011 |
| 20110034962 | Spinal Rod Approximator Spinal rod approximator for seating a stabilizing rod in a rod-receiving portion of a spinal implant and inserting closure mechanism is provided. In one embodiment, a spinal rod approximator is provided including a body with gripping branches, inserter shaft, threaded c... | 02/10/2011 |
| 20110034567 | SEMI-CRYSTALLINE, FAST ABSORBING POLYMER FORMULATION The present invention relates to a composition comprising a semi-crystalline, absorbable copolymer formulation wherein the first component is hydroxy-capped polycondensation product of diglycolic acid and a mixture of two idols, diethylene glycol (DEG) and ethylene glyc... | 02/10/2011 |
| 20110034502 | NALMEFENE PRODRUGS The present invention relates to ester prodrugs of nalmefene of formula (I), pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment of substance abuse disorders such as alcohol abuse and al... | 02/10/2011 |
| 20110030160 | BRISTLE CONFIGURATION A bristle configuration providing enhanced cleaning of teeth. The bristle pattern includes large tufts having a greater cross-sectional area than standard toothbrush bristle tufts. The large tufts are contoured so that the top ends of the bristles comprising the large t... | 02/10/2011 |
| 20110029092 | PROSTHESIS WITH SURFACES HAVING DIFFERENT TEXTURES AND METHOD OF MAKING THE PROSTHESIS A joint prosthesis system is suitable for cemented fixation. The system has two metal implant components and a bearing. One of the metal implant components has an articulation surface for articulation with the bearing. The other metal implant component has a mounting su... | 02/03/2011 |
| 20110029090 | PROSTHESIS WITH MODULAR EXTENSIONS A joint prosthesis system has two implant components and a bearing. One of the implant components has an articulation surface for articulation with the bearing. The other implant component has a mounting surface for supporting the bearing. At least one of the first and ... | 02/03/2011 |
| 20110029070 | ADHESION PROMOTING PRIMER FOR COATED SURFACES An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a first diameter to a second diameter. A plurality of different beneficial agents may be loaded into different openings within the ... | 02/03/2011 |
| 20110028993 | MATERIAL FOR MECHANICAL SKIN RESURFACING TECHNIQUES An article useful for mechanical skin resurfacing techniques is suitable for transferring mechanical energy from a handheld device to skin placed in contact with the article. The article may be characterized by its Durable Abrasiveness, Compressibility, Displacement, an... | 02/03/2011 |
| 20110028935 | METHOD OF PACKAGING AN ABSORBENT ARTICLE AND ATTACHING THE ABSORBENT ARTICLE TO AN UNDERGARMENT A method of individually packaging an absorbent article and attaching the absorbent article to an undergarment including the steps of providing a tri-folded absorbent article having two end portions and an intermediate portion, providing a pouch containing the tri-folde... | 02/03/2011 |
| 20110028933 | METHOD OF PACKAGING AN ABSORBENT ARTICLE AND ATTACHING THE ABSORBENT ARTICLE TO AN UNDERGARMENT A method of individually packaging an absorbent article and attaching the absorbent article to an undergarment including the steps of providing a tri-folded absorbent article having two end portions and an intermediate portion, providing a pouch containing the tri-folde... | 02/03/2011 |
| 20110028932 | INDIVIDUALLY PACKAGED ABSORBENT ARTICLE ASSEMBLY An individually packaged absorbent article assembly including a tri-folded absorbent article having two end portions and an intermediate portion, and a pouch containing the tri-folded absorbent article, the pouch being structured and arranged to enable a user to selecti... | 02/03/2011 |
| 20110028931 | INDIVIDUALLY PACKAGED ABSORBENT ARTICLE ASSEMBLY An individually packaged absorbent article assembly including a tri-folded absorbent article having two end portions and an intermediate portion, and a pouch containing the tri-folded absorbent article, the pouch be structured and arranged to enable a user to selectivel... | 02/03/2011 |
| 20110028433 | QUINAZOLINONE DERIVATIVES AS TUBULIN POLYMERIZATION INHIBITORS The present invention provides compounds of formula (I), their use as inhibitors of tubulin polymerization as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R1... | 02/03/2011 |