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| Application No. | Application Title | Issue Date |
| 20110045525 | Method for Flagging a Sample A hematology analyzer is provided. In certain embodiments, the hematology analyzer comprises: a) a flow cell; b) a light source for directing light to the flow cell; c) a plurality of detectors for detecting a plurality of optical characteristics of a blood cell passing... | 02/24/2011 |
| 20110040102 | PROCESS FOR THE PREPARATION OF INDAZOLYL UREAS THAT INHIBIT VANILLOID SUBTYPE 1 (VR1) RECEPTORS The present invention relates to a process of preparing indazolyl ureas that are useful as antagonists of the vanilloid receptor subtype 1 (VR1).... | 02/17/2011 |
| 20110015216 | Solid Pharmaceutical Dosage Form A solid pharmaceutical dosage form providing improved oral bioavailability is disclosed for inhibitors of HIV protease. In particular, the dosage form comprises a solid dispersion of at least one HIV protease inhibitor and at least one pharmaceutically acceptable water-... | 01/20/2011 |
| 20110015173 | PYRROLOPYRIDINE INHIBITORS OF KINASES The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1a, R1b, R1c, X, and Y are defined in the description. The present inven... | 01/20/2011 |
| 20110015172 | PYRROLOPYRAZINE INHIBITORS OF KINASES The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1a, R1b, X, and Y are defined in the description. The present invention relates als... | 01/20/2011 |
| 20110008430 | Solid Pharmaceutical Dosage Form A solid pharmaceutical dosage form providing improved oral bioavailability is disclosed for inhibitors of HIV protease. In particular, the dosage form comprises a solid dispersion of at least one HIV protease inhibitor and at least one pharmaceutically acceptable water-... | 01/13/2011 |
| 20110003827 | HIV protease inhibiting compounds A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.... | 01/06/2011 |
| 20100331353 | 3,9-DIAZASPIRO[5,5]UNDECANE AMIDES AND UREAS AND METHODS OF USE THEREOF Compounds of formula (I) are useful in treating conditions or disorders ameliorated by α4β2 postive allosteric modulators. Also disclosed are pharmaceutical compositions of compounds of formula (I), methods... | 12/30/2010 |
| 20100331294 | 4-SUBSTITUTED-2-AMINO-PYRIMIDINE DERIVATIVES Compounds of the formula wherein R1 and R2 are as disclosed herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor full or partial ago... | 12/30/2010 |
| 20100328662 | METHOD AND APPARATUS FOR RAPIDLY COUNTING AND IDENTIFYING BIOLOGICAL PARTICLES IN A FLOW STREAM A method for increasing the throughput, or the precision, or both the precision and the throughput, of a flow cytometer, or of a hematology analyzer employing a flow cytometer, by utilizing the technique of laser rastering. Laser rastering involves sweeping a laser beam... | 12/30/2010 |
| 20100324722 | SYSTEM FOR MANAGING INVENTORIES OF REAGENTS A system for managing the inventory of reagents for a laboratory automation system. The system for managing the inventory of reagents comprises a controller, software for the controller, and a refrigerator capable of refrigerating reagents, detecting the presence or abs... | 12/23/2010 |
| 20100324027 | DIAZAHOMOADAMANTANE DERIVATIVES AND METHODS OF USE THEREOF The invention relates to compounds that are diazahomoadamantane derivatives, compositions comprising such compounds, and methods of using such compounds and compositions.... | 12/23/2010 |
| 20100323020 | STABLE NANOPARTICULATE DRUG SUSPENSION A liquid pharmaceutical composition comprises an aqueous medium having suspended therein a solid particulate Bc1-2 family protein inhibitory compound such as ABT-263, having a D90 particle size not greater than about 3 μm; wherein the aqueous medium further ... | 12/23/2010 |
| 20100322948 | Bone morphogenetic protein (BMP)-binding domains of proteins of the repulsive guidance molecule (RGM) protein family and functional fragments thereof, and use of same The present invention relates to the identification and use of bone morphogenetic protein (BMP)-binding domains of members of the repulsive guidance molecule (RGM) protein family, and polypeptide fragments and fusion proteins derived therefrom. The domains, i.e., peptid... | 12/23/2010 |
| 20100322822 | SYSTEM FOR MANAGING INVENTORY OF BULK LIQUIDS A system for managing bulk liquids for an automated clinical analyzer. The system comprises (a) at least one local reservoir for storing a bulk liquid for impending use, (b) at least one container for holding a bulk liquid before the liquid is transferred to a local res... | 12/23/2010 |
| 20100317680 | PYRIMIDINE INHIBITORS OF KINASES The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein A1, A2, A3, A4, X and Y are defined in the description. The pr... | 12/16/2010 |
| 20100317568 | Anti-Viral Compounds Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.... | 12/16/2010 |
| 20100311767 | Method for the treatment of amyloidoses The present invention relates to a method for the treatment of an amyloidosis such as Alzheimer's disease in a subject in need thereof, characterized in that it comprises administering an agonist of the P/Q type voltage-gated presynaptic calcium channel to said subject.... | 12/09/2010 |
| 20100311751 | SOLID DISPERSIONS CONTAINING AN APOPTOSIS-PROMOTING AGENT A pro-apoptotic solid dispersion comprises, in essentially non-crystalline form, a Bcl-2 family protein inhibitory compound, e.g., ABT-263, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier and (b) a pharmaceuti... | 12/09/2010 |
| 20100311079 | ASSAY FOR CARDIAC TROPONIN AUTOANTIBODIES The invention provides among other things methods and kits based on assaying for cardiac troponin autoantibodies, either in conjunction with an assay for cardiac troponin and/or as an independent indicator of cardiac pathology, such as myocarditis, cardiomyopathy, and/o... | 12/09/2010 |
| 20100310648 | PHARMACEUTICAL DOSAGE FORM FOR ORAL ADMINISTRATION OF A BCL 2 FAMILY INHIBITOR The invention relates to a pharmaceutical dosage form which comprises a solid dispersion product comprising N-(4-(4-((2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohex-1-en-1-yl)methyl)piperazin-1-yl)benzoyl)-4-(((1R)-3-(morpholin-4-yl)-1-((phenylsulfanyl)methyl)propyl)amino)-... | 12/09/2010 |
| 20100310607 | PHARMACEUTICAL FORMULATIONS The present invention relates to oral formulations comprising an active agent comprising at least one of 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoic acid, salts of 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoic acid or buffered 2-[4-(4-chlorobenzoyl)phenoxy]-2-... | 12/09/2010 |
| 20100308066 | CONTAINER A container (210) for holding granular or powdered material and formed by a top wall (212), a bottom wall (214), a front wall (216), a rear wall (218), a first side wall (220), and a second side wall (222). A rotatably re... | 12/09/2010 |
| 20100308044 | STRENGTH CONTAINER A sealable container (210) for flowable material formed with top (212) and flexible and stiffened bottom (214) walls joined by front (216), rear (218), and opposite side walls (220, 222). The top wall including an openable lid (... | 12/09/2010 |
| 20100305126 | Pyrimidine Inhibitors of Kinase Activity The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts or solvates thereof, wherein G1, R2, R3, R4, R5, n, p, q, Ar... | 12/02/2010 |
| 20100305118 | PYRIMIDINE INHIBITORS OF KINASE ACTIVITY Described herein are compounds of formula (I) or pharmaceutical acceptable salts or solvates thereof, wherein G1, L1, R2, R3, n, p, Ar1, and Ar2 | |
| 20100305112 | PYRIMIDINE INHIBITORS OF KINASE ACTIVITY Described herein are compounds of formula (I) or pharmaceutical acceptable salts or solvates thereof, wherein L1, R1, R2, R3, R4, R5, and m ar... | 12/02/2010 |
| 20100305109 | POTASSIUM CHANNEL MODULATORS Disclosed herein are KCNQ potassium channels modulators of formula (I) wherein ring G1, X, R1, and R2 are as defined in the specification. Compositions comprising such compoun... | 12/02/2010 |
| 20100305089 | Fused Bicycloheterocycle Substituted Azabicyclic Alkane Derivatives The invention relates to fused bicycloheterocycle substituted azabicyclic alkane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.... | 12/02/2010 |
| 20100305086 | Pharmaceutical Compositions for the Treatment of Pain This invention discloses a method of treatment of osteoarthritis pain by administration of a composition containing a nicotinic acetylcholine receptor ligand and a nicotinic acetylcholine receptor subtype α4β2 allosteric modulator. The present application also relates... | 12/02/2010 |
| 20100301245 | Assembly For Mounting Of Tube Pinch Type Solenoid Valve An assembly for mounting tube pinch type solenoid valves. The assembly comprises a mounting panel, a rear panel, and at least one rod for connecting the mounting panel to the rear panel. The mounting panel has at least one aperture for receiving a tube pinch type soleno... | 12/02/2010 |
| 20100298292 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF The present application relates to aryl- and heteroaryl-fused decahydropyrroloazepine, octahydrooxepinopyrrole, octahydropyrrolothiazepine dioxide, decahydrocyclohepta[c]pyrrole, and octahydrocyclohepta[c]pyrrole derivatives of formula (I) ... | 11/25/2010 |
| 20100298291 | FUSED BICYCLIC-SUBSTITUTED AMINES AS HISTAMINE-3 RECEPTOR LIGANDS Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 r... | 11/25/2010 |
| 20100297778 | Conjugate Having Cleavable Linking Agent A method and reagent that can be used to eliminate the signal caused by non-specific binding of a labeled conjugate, e.g., a specific binding member attached to a label, to a solid phase, e.g., a magnetic microparticle. The method and the reagent involve the use of a cl... | 11/25/2010 |
| 20100291709 | HUMAN NT-PRO B-TYPE NATRIURETIC PEPTIDE ASSAY HAVING REDUCED CROSS-REACTIVITY WITH OTHER PEPTIDE FORMS The present disclosure relates to assays for detecting and/or quantifying the amount of human NT-pro B-type natriuretic peptide or human NT-pro B-type natriuretic peptide fragment in a test sample.... | 11/18/2010 |
| 20100286109 | AMIDE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS AND METHODS OF USE THEREOF The invention relates to novel amide derivatives that are positive allosteric modulators of neuronal nicotinic receptors, compositions comprising the same, processes for preparing such compounds, and methods for using such compounds and compositions.... | 11/11/2010 |
| 20100286032 | PRODRUGS OF HIV PROTEASE INHIBITORS A compound of the formula is disclosed as a prodrug of an HIV protease inhibitor. Methods and compositions for inhibiting HIV protease activity and treating HIV infection are also disclosed.... | 11/11/2010 |
| 20100280248 | NOVEL COMPOUNDS THAT ARE USEFUL FOR IMPROVING PHARMACOKINETICS Novel compounds of formula 1 or a pharmaceutically acceptable salt thereof inhibit cytochrome P450 monooxygenase.... | 11/04/2010 |
| 20100280055 | Flavoring Systems for Pharmaceutical Compositions and Methods of Making Such Compositions A flavoring system for a liquid pharmaceutical composition and pharmaceutical compositions containing such flavoring systems are disclosed. Flavoring systems of the invention include at least one sweetening agent, at least two flavored ingredients, and at least one flav... | 11/04/2010 |
| 20100279432 | INDIRECTLY LABELLED ASSAY CONJUGATES AND METHODS OF PREPARING AND USING SAME Indirectly labelled assay conjugates prepared by a method that includes the step of submitting the binding member comprised by the conjugate to denaturing conditions prior to labelling the binding member. The indirectly labelled assay conjugates demonstrate an increased... | 11/04/2010 |
