Did You Know...
...that it was melting ice cream that inspired the invention of the outboard motor? It was a lovely August day and Ole Evinrude was rowing his boat to his favorite island picnic spot. As he rowed, he watched his ice cream melt and wished he had a faster way to get to the island. At that moment the idea for the outboard motor was born!
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| Application No. | Application Title | Issue Date |
| 20090048296 | HIGH CONCENTRATION LOCAL ANESTHETIC FORMULATIONS A transdermal topical anesthetic formulation, which can be used to ameliorate or inhibit neuropathic pain, has been developed. In the preferred embodiment, the topical anesthetic is a local anesthetic such as lidocaine, most preferably lidocaine free-base in a gel, and ... | 02/19/2009 |
| 20090042292 | B7-DC Variants Compositions and methods for costimulating T cells (i.e., increasing antigen-specific proliferation of T cells, enhancing cytokine production by T cells, stimulating differentiation ad effector functions of T cells and/or promoting T cell survival) are provided. Suitabl... | 02/12/2009 |
| 20090023639 | Methods of Treatment A method of treating weight loss due to underlying disease in a patient, the method comprising administering to the patient an effective amount of an agent which reduces sympathetic nervous system activity. A method of treating weight loss due to underlying disease in a... | 01/22/2009 |
| 20090018209 | CURCUMIN AND CURCUMINOID INHIBITION OF ANGIOGENESIS Methods for treating diseases or disorders of the skin which are characterized by angiogenesis have been developed using curcumin and curcumin analogs. Based on the results obtained with curcumin, it has been determined that other angiogenesis inhibitors can also be use... | 01/15/2009 |
| 20090012604 | POLYMERIC, DEGRADABLE DRUG-ELUTING STENTS AND COATINGS Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally poly-L-lactic acid and other absorbable polymers and additives. ... | 01/08/2009 |
| 20090012029 | Cyst Nematode Resistant Transgenic Plants Compositions and methods for providing cyst nematode resistance are provided. One aspect provides transgenic plants or cells comprising an inhibitory nucleic acid specific for one or more cyst nematode esophageal gland cell polypeptides. Other aspects provide transgenic... | 01/08/2009 |
| 20090011991 | Novel Curcuminoid-Factor VIIA Constructs as Suppressors of Tumor Growth and Angiogenesis The fluorinated curcuminoid (3,5-bis-(2-fluorobenzylidene)-piperidin-4-one-acetate is about ten times more effective at arresting the growth of tumor cells than cisplatin. Conjugates for delivering a cytotoxic compound, such as a curcuminoid, specifically to cancer cell... | 01/08/2009 |
| 20090010948 | ANTI-TUMOR VACCINES DELIVERED BY DENDRITIC CELLS DEVOID OF INTERLEUKIN-10 It has been discovered that reducing, inhibiting or preventing the expression of immunosuppressive cytokines or tolergenic agents in antigen presenting cells improves the ability of the antigen presenting cell to promote an immune response. One embodiment provides a gen... | 01/08/2009 |
| 20090011444 | DETECTION AND DIAGNOSIS OF INFLAMMATORY DISORDERS Soluble H4 (sH4) levels have been discovered to correlate with the stage or severity of inflammatory disorders including autoimmune disorders. In particular, circulating levels of sH4 can be used as a diagnostic for determining the severity of an inflammatory disorder o... | 01/08/2009 |
| 20080318895 | INTRANASAL DELIVERY OF NUCLEIC ACID MOLECULES Aerosol delivery of nucleic acids to the lungs using viral vectors, polymers, surfactants, or excipients has been described. Compositions for intranasal administration are described that contain nucleic acids without viral or plasmid vectors and with little to no polyme... | 12/25/2008 |
| 20080317866 | COLLAGEN-BASED MICROSPHERES AND METHODS OF PREPARATION AND USES THEREOF A method of manufacture of ECM microparticles incorporating bioactive molecules for drug delivery has been developed, using a modified emulsification method or a water-in-oil-phase-separation method. The microspheres are photochemically crosslinked to control the releas... | 12/25/2008 |
| 20080317807 | STRONTIUM FORTIFIED CALCIUM NANO-AND MICROPARTICLE COMPOSITIONS AND METHODS OF MAKING AND USING THEREOF Compositions containing strontium fortified calcium nanoparticles and/or microparticles, and methods of making and using thereof are described herein. The strontium fortified calcium compounds contain calcium ions, calcium atoms, strontium ions, strontium atoms, and com... | 12/25/2008 |
| 20080317830 | Compositions and Methods for the Treatment of Wounds and Scar Tissue Compositions for the treatment of wounds and/or scars are described herein. The compositions contain between 1 and up to 30% by weight, more preferably between 1 and 20%, most preferably between about 5 and 10% by weight particles, such as titanium dioxide or a similar ... | 12/25/2008 |
| 20080311167 | Topical Composition for Treating Pain Topical compositions having as the active ingredient a lipid, fatty acid ester, natural wax, sterol, or combinations thereof referred to herein as “lipophilic vehicle” or “LV” and methods of use, have been developed for the amelioration or prevention of pain or ... | 12/18/2008 |
| 20080311044 | Methods of determining hair follicle inductive properties The present invention provides a method for determining hair inductive properties of a composition comprising injecting a composition comprising dissociated dermal cells and epidermal cells into skin of a mammal and determining whether at least one hair follicle forms.... | 12/18/2008 |
| 20080299110 | Methods and kits for diagnosing and treating acute joint injury The present invention provides methods, reagents and kits for diagnosing and/or for the prognosis of non-autoimmune acute joint inflammation by detecting cytokine biomarkers in a sample obtained from an individual thought to be suffering from joint injury. The cytokine ... | 12/04/2008 |
| 20080281178 | TRANSDERMAL ANALYTE MONITORING SYSTEMS AND METHODS FOR ANALYTE DETECTION Transdermal analyte monitoring systems (TAMS) having increased longevity and improved analyte detection are described herein. Kits for use with the TAMS and methods of using the TAMS and kits are also described. In a preferred embodiment, the TAMS includes a protective,... | 11/13/2008 |
| 20080281091 | Process for the Preparation of Porphyrin Derivatives as Antimicrobial Agents by Photodynamic Therapy (Pdt) There is provided a process for the preparation of 5,15-bis-[4-(3-trimethylammonio-propyloxy)-phenyl]-porphyrin dihalide, wherein the process comprises step (a) of providing 4-(3-bromopropyloxy)benzaldehyde, step (b) of providing dipyrrolmethane, step (c) of reacting th... | 11/13/2008 |
| 20080280699 | Water Repellant Golf Balls Containing a Hydrophobic or Superhydrophobic Outer Layer or Coating Water-repellant, self-cleaning coatings and methods of making and using thereof are described herein. In one embodiment, a hydrophobic or super hydrophobic coating is applied to the surface of a golf ball to make the golf-ball water-repellant and self-cleaning. Suitable... | 11/13/2008 |
| 20080280781 | Methods and Compositions for Increasing Membrane Permeability Methods and compositions for increasing membrane permeability are provided. One aspect provides protein resulting from a fusion between a membrane-active peptide and second peptide. Nucleic acids, and vectors encoding the, pore forming fusion proteins are also provided.... | 11/13/2008 |
| 20080272002 | System and Method for Proteomics Significantly higher yield and better resolution in pI gels are obtained by creating traps having two or more layers of gel containing closely stepped immobilized pH buffers. Proteins move from a pH at which they are negatively charged towards an anode at which they are... | 11/06/2008 |
| 20080275468 | SKIN PERMEATION DEVICE FOR ANALYTE SENSING OR TRANSDERMAL DRUG DELIVERY Devices, systems, kits and methods for increasing the skin's permeability controlled by measured skin electrical parameter are described herein. They may be used for transdermal drug delivery and/or analyte extraction or measurement. The controlled abrasion device conta... | 11/06/2008 |
| 20080275208 | POLYHYDROXYALKANOATE BIOPOLYMER COMPOSITIONS Several novel PHA polymer compositions produced using biological systems include monomers such as 3-hydroxybutyrate, 3-hydroxypropionate, 2-hydroxybutyrate, 3-hydroxyvalerate, 4-hydroxybutyrate, 4-hydroxyvalerate and 5-hydroxyvalerate. These PHA compositions can readily... | 11/06/2008 |
| 20080274979 | TREATMENT OF LEAKY OR DAMAGED TIGHT JUNCTIONS AND ENHANCING EXTRACELLULAR MATRIX Self assembling peptides and peptidomimetics can be utilized for the treatment and support of disorders associated with leaky or damaged tight junction and weak, diseased, or injured extracellular matrix. The self-assembling materials generally have alternating hydrophi... | 11/06/2008 |
| 20080260834 | VITAMIN D3 ANALOG LOADED POLYMER FORMULATIONS FOR CANCER AND NEURODEGENERATIVE DISORDERS Localized delivery of 1,25 D3 directly to a target area using biodegradable polymeric matrices maximizes the efficacy of this drug while minimizing systemic exposure and toxicity. Anticalcemic analogs of 1,25 D3 have also been incorporated into con... | 10/23/2008 |
| 20080260706 | Transient Transfection with RNA A method of mRNA production for use in transfection is provided, that involves in vitro transcription of PCR generated templates with specially designed primers, followed by polyA addition, to produce a construct containing 3′ and 5′ untranslated sequence (“UTR”... | 10/23/2008 |
| 20080260819 | SUSTAINED RELEASE COMPOSITIONS OF DRUGS A sustained release pharmaceutical composition has been developed. The composition resists dose dumping when broken, crushed or chewed, which enhances the safety of the dosage form should it be accidentally or intentionally physically compromised. In the preferred embod... | 10/23/2008 |
| 20080254092 | Acellularized Biomaterial from Embryonic Stem Cells Compositions containing acellularized biomaterial derived from differentiating pluripotent cells, for example, embryonic stem cells are provided. The acellularized biomaterial can be used to promote wound healing, promote tissue regeneration, or inhibit scarring. Method... | 10/16/2008 |
| 20080255267 | Disposable Medical Supplies From Hydrolytically Biodegradable Plastics Hydrolytically degradable polymers in the form of biodegradable disposable medical devices for use in medicine and laboratories such as syringes, test tubes, catheters, tubing, trays, medical fabrics, and gloves are described. The devices are formed in whole or in part ... | 10/16/2008 |
| 20080253987 | POLYMERIC TISSUE SEALANT Methods for making biomaterials for use as a tissue sealant, kits containing precursors for forming the biomaterials, and the resulting biomaterials are described herein. The biomaterials are formed from a composition comprising at least a first and a second precursor m... | 10/16/2008 |
| 20080251462 | Decontamination Process and System The present invention provides a decontamination process comprising the step of contacting a aqueous solution containing a pollutant or contaminant with a decontaminating agent, wherein the decontaminating agent is sapropel. The present invention also provides a deconta... | 10/16/2008 |
| 20080248135 | Combination Therapy for Otitis with Antiseptic and pH Adjustment Otitis is treated with a combination of a controlled-release iodine preparation and a pH-lowering preparation. This prevents or delays the onset of antibiotic resistance among causative bacteria and fungi, and, by inhibiting protease activity, improves the rate of heali... | 10/09/2008 |
| 20080248999 | AMYLIN FORMULATIONS A combined insulin and amylin and/or GLP-1 mimetic formulation has been developed wherein the pH of the insulin is decreased so that the amylin and/or GLP-1 remains soluble when mixed together with the insulin. In the preferred embodiment, a bolus insulin is administere... | 10/09/2008 |
| 20080241140 | GENE AMPLIFICATION OF COACTIVATOR COAA AND USES THEREOF It has been discovered that amplifications in the gene coactivator activator (CoAA) blocks stem cell differentiation and induces cancer stem cells. One embodiment provides compositions and methods for treating or alleviating one or more symptoms associated with cancer d... | 10/02/2008 |
| 20080241233 | TARGETED DELIVERY AND EXPRESSION OF PROCOAGULANT HEMOSTATIC ACTIVITY A platelet substitute consisting of large unilamellar lipid vesicles that contain phosphatidylserine or another procoagulant (clot-promoting) phospholipid, a protein that has binding affinity for collagen or other component of the vessel wall that becomes exposed upon v... | 10/02/2008 |
| 20080236769 | Biological De-Inking Method A method of de-inking wastepaper by pulping the paper in the presence of an enzyme is disclosed. The enzyme dislodges the ink particles from the paper fibers. The preferred enzymes are the acid resistant carbohydrases. The de-inking medium is an aqueous solution of the ... | 10/02/2008 |
| 20080241175 | Dendritic Cell Co-Stimulatory Molecules A novel costimulatory protein molecule, B7-DC, which is a member of the B7 family, is described as is DNA coding therefor and expression vectors comprising this DNA. B7-DC protein, fragments, fusion polypeptides/proteins and other functional derivatives, and transformed... | 10/02/2008 |
| 20080236770 | RAPID FATTY ACID ASSAY FOR USE IN PULP PITCH CONTROL Methods are provided for determining the surface fatty acid content in a wood pulp or whitewater sample. The methods comprise reacting free fatty acids which are present on the surface of the wood pulp fibers in the sample or in the whitewater with one or more reagents ... | 10/02/2008 |
| 20080233629 | ENZYMES FOR BIOPOLYMER PRODUCTION In order to optimize the flux or flow of carbon intermediates from normal cellular metabolism into PHAs it is desirable to optimize the expression of the enzymes of the PHA biosynthetic pathway. Gene fusions are genetic constructs where two open reading frames have been... | 09/25/2008 |
| 20080234194 | GROWTH FACTOR MEDIATED COSMECEUTICALS AND USE THEREOF TO ENHANCE SKIN QUALITY It has been discovered that vascular endothelial growth factor (“VEGF”) promotes migration of activated (but not differentiating) keratinocytes to skin. This growth factor specifically increases migration of keratinocytes of the “wounded skin” phenotype but does... | 09/25/2008 |
