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"I hate what they've done to my child...I would never let my own children watch it. "
Vladimir Zworykin, television pioneer ; Talking about an invention in which he played a critical role.
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| Application No. | Application Title | Issue Date |
| 20110045457 | ASSAYS FOR ADSORBED INFLUENZA VACCINES Influenza hemagglutinin (HA) binds to aluminium salt adjuvants and cannot easily be directly assayed directly a single radial immunodiffusion (SRID) test. The invention modifies the SRID protocol for an adsorbed antigen by including a step in which antigen is desorbed p... | 02/24/2011 |
| 20110045022 | VACCINES INCLUDING ANTIGEN FROM FOUR STRAINS OF INFLUENZA VIRUS Vaccines of the invention include at least four influenza virus strains. In some embodiments, the vaccines are produced in cell culture rather than in eggs. In some embodiments, the vaccines include an adjuvant. In some embodiments, the vaccines are not split or whole v... | 02/24/2011 |
| 20110045017 | HIV VACCINE FOR MUCOSAL DELIVERY This invention is directed to pharmaceutical compositions comprising an HIV antigen and a mucosal adjuvant and methods for raising an immune response in a subject by administering these compositions. Preferably, the pharmaceutical compositions of the invention can be us... | 02/24/2011 |
| 20110045015 | CONJUGATED BETA-1,3-LINKED GLUCANS Glucans having exclusively or mainly β-1,3 linkages are used as immunogens. These comprise β-1,3-linked glucose residues. Optionally, they may include β-1,6-linked glucose residues, provided that the ratio of β-1,3-linked residues to β-1,6-linked residues is at lea... | 02/24/2011 |
| 20110038900 | NANOPARTICLES FOR USE IN PHARMACEUTICAL COMPOSITIONS In various aspects of the present invention, nanoparticle compositions are provided which comprise (a) nanoparticles comprising at least one biodegradable polymer and (b) at least one pharmaceutical associated with the nanoparticles. In other aspects of the present inve... | 02/17/2011 |
| 20110038879 | IMMUNOGENIC AND THERAPEUTIC COMPOSITIONS FOR STREPTOCOCCUS PYOGENES Compositions for preventing and/or treating S. pyogenes infection which comprise one or more active agents. The active agents are SLO antigens, nucleic acid molecules encoding the SLO antigens, and/or antibodies which selectively bind to the SLO antigens.... | 02/17/2011 |
| 20110034462 | ORGANIC COMPOUNDS The present invention relates to compounds of the formula; and their use in therapy. ... | 02/10/2011 |
| 20110033485 | ANALOGUES OF GLYCOLIPIDS USEFUL AS IMMUNOADJUVANTS The invention provides analogs of alpha-galactosyl ceramide that increase the immune response elicited by various antigens. It also provides methods of using such compounds to increase the effectiveness of vaccines.... | 02/10/2011 |
| 20110027314 | Influenza Vaccines Containing Hemagglutinin and Matrix Proteins An immunogenic composition comprising influenza virus haemagglutinin and matrix proteins. These may be from influenza viruses grown in cell culture rather than eggs. The matrix protein may be a fragment of a full-length viral matrix protein e.g. a matrix M1 fragment wit... | 02/03/2011 |
| 20110022023 | UNITARY WITHDRAWAL SPIKE UNIT SUITABLE FOR FACTORY FITTING A withdrawal spike unit (200) comprises a withdrawal spike component (30′) and an integrally formed adapter component (60′) that is adapted to couple with a vial (10) in a safe and secure manner. The integral formation of the component pa... | 01/27/2011 |
| 20110020396 | HIV Envelope-CD4 Complexes and Hybrids Env-CD4 polypeptide complexes and hybrids that expose cryptic epitopes important in virus neutralization are disclosed. Method of diagnosis, treatment and prevention using the polypeptides are also provided.... | 01/27/2011 |
| 20110020390 | MENINGOCOCCAL FHBP POLYPEPTIDES fHBP is a protein in Neisseria meningitidis. Three families of fHBP are known. To increase the ability of a fHBP protein to elicit antibodies that are cross-reactive between the families, fHBP is selected or engineered to have a sequence which can elicit broad-sp... | 01/27/2011 |
| 20110020385 | COMBINATIONS OF PNEUMOCOCCAL RrgB CLADES Pneumococcal pilus subunit RrgB has at least three clades. Serum raised against a given clade is active against pneumococci which express that RrgB clade, but is not active against strains which express one of the other two clades i.e. there is intra-clade cross-protect... | 01/27/2011 |
| 20110020352 | ENDOGENOUS RETROVIRUSES UP-REGULATED IN PROSTATE CANCER Human endogenous retroviruses of the HML-2 family show up-regulated expression in prostate tumors. This finding can be used in prostate cancer screening, diagnosis and therapy.... | 01/27/2011 |
| 20110014652 | Norovirus and sapovirus antigens Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of... | 01/20/2011 |
| 20110014230 | PREPARATION OF INFLUENZA VIRUS VACCINE ANTIGENS A number of improvements for preparing vaccine antigens from disintegrated influenza viruses are disclosed. A splitting step can be followed by detergent exchange. Splitting can take place in the presence of a buffer with a higher ionic strength and/or in the presence o... | 01/20/2011 |
| 20110014219 | Norovirus and Sapovirus antigens Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of... | 01/20/2011 |
| 20110008279 | Methods and Compositions Relating to Adhesins as Adjuvants This invention is in the field of immunology and relates to the discovery that adhesins are potent activators of dendritic cells.... | 01/13/2011 |
| 20110003300 | RAPID STERILITY MICROASSAY The present invention relates to a method for detecting a viable microorganism in a pharmaceutical composition comprising the steps of providing a filterable pharmaceutical composition; filtering the pharmaceutical composition to provide at least three membranes upon wh... | 01/06/2011 |
| 20110002958 | Alphavirus Vectors for Respiratory Pathogen Vaccines Described herein are compositions and methods for stimulating an immune response to one or more proteins derived from one or more respiratory pathogens. In particular, the invention relates to alphavirus replicons, alphavirus vector constructs, and alphavirus replicon p... | 01/06/2011 |
| 20100330121 | RECOMBINANT ALPHAVIRUS-BASED VECTORS WITH REDUCED INHIBITION OF CELLULAR MACRO-MOLECULAR SYNTHESIS Isolated nucleic acid molecules are disclosed, comprising an alphavirus nonstructural protein gene which, when operably incorporated into a recombinant alphavirus particle, eukaryotic layered vector initiation system, or RNA vector replicon, has a reduced level of vecto... | 12/30/2010 |
| 20100324272 | PANCREATIC CANCER GENES The present invention provides the art with the DNA coding sequences of polynucleotides that are up-or-down-regulated in cancer and dysplasia. These polynucleotides and encoded proteins or polypeptides can be used in the diagnosis or identification of cancer and dysplas... | 12/23/2010 |
| 20100322958 | MODIFIED SACCHARIDES Modified capsular saccharides comprising a blocking group at a hydroxyl group position on at least one of the monosaccharide units of the corresponding native capsular saccharide, wherein the blocking group is of the formula (Ia) or (Ib): —OX—Y (Ia) or —O—R... | 12/23/2010 |
| 20100316698 | POLYNUCLEOTIDES ENCODING ANTIGENIC HIV TYPE C POLYPEPTIDES, POLYPEPTIDES AND USES THEREOF The present invention relates to polynucleotides encoding immunogenic HIV type C polypeptides. Uses of the polynucleotides in applications including DNA immunization, generation of packaging cell lines, and production of HIV Type C proteins are also described.... | 12/16/2010 |
| 20100303864 | CONSERVED AND SPECIFIC STREPTOCOCCAL GENOMES The invention relates to polynucleotides which are conserved or specific to one or more species of Streptococcus, Streptococcus species serotypes, and/or serotype isolates. In particular, the invention relates to polynucleotides from Streptococcus which ar... | 12/02/2010 |
| 20100303822 | Polypeptides from non-typeable haemophilus influenzae Polypeptides comprising non-typeable Haemophilus influenzae (NTHi) amino acid sequences. Over 2500 specific NTHi proteins are disclosed. The invention also provides related polypeptides, nucleic acids, antibodies and methods. These can all be used in medicine for... | 12/02/2010 |
| 20100297164 | Chlamydial Antigens The invention is in the field of immunology and vaccinology. In particular, it relates to antigens derived from Chlamydia trachomatis that are expressed on the cell surface and so are ideal for use in immunisation as well as combinations of these antigens.... | 11/25/2010 |
| 20100291598 | PRION ELISA Assays for detecting PrPSc in a sample are described. In particular, pathogenic prion ELISAs are described. The assays utilize pathogenic prion-specific reagents to capture the PrPSc and digestion with a site-specific protease, for example trypsin ... | 11/18/2010 |
| 20100291134 | TRUNCATED HEPATITIS C VIRUS NS5 DOMAIN AND FUSION PROTEINS COMPRISING SAME The invention provides truncated HCV NS5 polypeptides and fusion proteins comprising the truncated NS5 polypeptides, fused to at least one other HCV epitope derived from another region of the HCV polyprotein. The fusions can be used in methods of stimulating an immune r... | 11/18/2010 |
| 20100291129 | Norovirus and sapovirus antigens Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of... | 11/18/2010 |
| 20100285135 | Nanoparticles For Use In Immunogenic Compositions Disclosed herein are sterile-filtered lyophilized nanoparticle compositions which contain at least one biodegradable polymer, at least one surfactant, at least one cryoprotective agent and at least one antigen. Also disclosed are methods of making and using such composi... | 11/11/2010 |
| 20100285069 | MENINGOCOCCAL VACCINE FORMULATIONS A dual formulation for vaccines against Neisseria meningitidis serogroup B (‘Men-B’) comprises (i) an oil-in-water emulsion adjuvant and (ii) a Men-B immunogenic component in lyophilised form. The lyophilised Men-B antigens can be reconstituted into liquid ad... | 11/11/2010 |
| 20100285062 | COMBINED MUCOSAL AND PARENTERAL IMMUNIZATION AGAINST HIV HIV antigens are mucosally administered in one or more priming immunization(s), and then HIV antigens are parenterally administered in one or more boosting immunization(s). Thus the invention provides a method for raising an immune response in a patient, comprising: (i)... | 11/11/2010 |
| 20100282684 | LIPOPOLYSACCHARIDE DECONTAMINATION Materials and methods for the selective removal of lipopolysaccharide during the purification of molecules of bio-pharmaceutical interest are based on a polymeric substrate that binds lipopolysaccharide. Preferably, the polymeric substrate is selective for at least one ... | 11/11/2010 |
| 20100272755 | FERMENTATION PROCESSES FOR CULTIVATING STREPTOCOCCI AND PURIFICATION PROCESSES FOR OBTAINING CPS THEREFROM This invention is in the field of bacterial cultures and specifically relates to the optimization of culture conditions to improve the production of bacterial capsular polysaccharides from Streptococcus strains in fed batch culture and to novel purification metho... | 10/28/2010 |
| 20100272725 | Neisserial antigens The invention provides proteins from Neisseria meningitidis (strains A & B) and from Neisseria gonorrhoeae, including amino acid sequences, the corresponding nucleotide sequences, expression data, and serological data. The proteins are useful antigens ... | 10/28/2010 |
| 20100267931 | HETEROLOGOUS EXPRESSION OF NEISSERIAL PROTEINS Alternative and improved approaches to the heterologous expression of the proteins of Neisseria meningitidis and Neisseria gonorrhoeae. These approaches typically affect the level of expression, the ease of purification, the cellular localisation, and/or t... | 10/21/2010 |
| 20100266631 | Compositions and Methods for Generating an Immune Response Utilizing Alphavirus-Based Vector Systems Compositions and methods are provided for Eukaryotic Layered Vector Initiation Systems and Alphavirus replicon particles for introducing heterologous sequences into cells for generating immune responses.... | 10/21/2010 |
| 20100266626 | ADJUVANTED GLUCANS The use of beta-glucans as antigens for immunising against fungi is known. According to the invention, the beta-glucans are administered together with an adjuvant. The adjuvant improves the immune response. The glucan will usually be conjugated to a carrier. Suitable gl... | 10/21/2010 |
| 20100256375 | SUBSTITUTED BENZIMIDAZOLES AND METHODS OF PREPARATION Methods for preparing new substituted benzimidazole compounds having formula (I) useful for treating kinase mediated disorders are provided wherein R1, R2, R3, R4, a, b, and c are defined herein ... | 10/07/2010 |
