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"Rail travel at high speeds is not possible because passengers, unable to breathe, would die of asphyxia."
Dionysius Lardner, Professor of Natural Philosophy and Astronomy at University College, London ; 1830
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| Application No. | Application Title | Issue Date |
| 20110046114 | ARYL- AND HETEROARYL-SUBSTITUTED TETRAHYDROBENZAZEPINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II): where... | 02/24/2011 |
| 20110045008 | THERAPEUTIC AGENTS FOR INDUCING PLATELET FRAGMENTATION AND TREATING THROMBOEMBOLIC DISORDERS The present invention is directed to a therapeutic agent comprising a GPIIIa(49-66) specific targeting agent and a thrombi-specific homing agent. Also disclosed is the use of the therapeutic agent in carrying out a method of treating thromboembolic disorders and a metho... | 02/24/2011 |
| 20110039729 | GLYCOSYLATED PROTEIN EXPRESSION IN PROKARYOTES The present invention relates to a prokaryotic host cell comprising eukaryotic glycosyltransferase activity, where the eukaryotic glycosyltransferase activity is eukaryotic dolichyl-linked UDP-GlcNAc transferase activity and eukaryotic mannosyl-transferase activity. Als... | 02/17/2011 |
| 20110036691 | LIQUID SWITCHES AND SWITCHING DEVICES AND SYSTEMS AND METHODS THEREOF A dispensing apparatus includes a housing defining a channel, a plunger slidably engaged with an inner surface of the channel, a substrate with one or more passages each having two or more openings, a liquid in each of the one or more passages, at least one fluid, and a... | 02/17/2011 |
| 20110030078 | TRYPANOSOME RESISTANT NON-HUMAN TRANSGENIC ANIMAL The present invention is directed to a Trypanosome-resistant, non-human transgenic animal whose somatic and germ cells comprise a nucleic acid which encodes an apolipoprotein L-I polypeptide (apoL-I). The apoL-I protein has the amino acid sequence selected from the grou... | 02/03/2011 |
| 20110030077 | METHODS OF MODULATING THE ORGANIC SOLUTE AND STEROID TRANSPORTER (OSTalpha-OSTbeta) ACTIVITY AND TREATING ASSOCIATED CONDITIONS The present invention is directed to methods of modulating bile acid and lipid transport via the organic solute and steroid transporter Ostα-Ostβ. The present invention is further directed to methods of treating a patient having dyslipidemia or a condition associated ... | 02/03/2011 |
| 20110028427 | DIETARY FIBER AND METHOD FOR PREPARING DIETARY FIBER The invention relates to a soluble antioxidant dietary fiber obtained from pineapple and a method of processing pineapple pulp to provide a soluble antioxidant fiber.... | 02/03/2011 |
| 20110027793 | KIT FOR MEASURING IN VIVO MUTATION FREQUENCY AT AN ENDOGENOUS GENE LOCUS The present invention relates a method for the enumeration of in vivo gene mutation. The method utilizes differential staining of GPI-anchor deficient erythrocyte populations to distinguish between wild-type and pig-a gene mutants. Quantitative analyses can be conducted... | 02/03/2011 |
| 20110027335 | COATED MEDICAL DEVICES An implantable medical device carries on at least part of its external surface a coating. The coating consists essentially of a terpolymer of vinyl pyrrolidone, acrylic acid and activated acrylic acid, and optionally a colouring agent.... | 02/03/2011 |
| 20110027223 | USE OF ELECTROPHILIC COMPOUNDS FOR INDUCING PLATELET PRODUCTION OR MAINTAINING PLATELET FUNCTION The present invention is directed to a method of inducing platelet production that includes contacting a megakaryocyte with an electrophilic compound under conditions effective to induce platelet production by the contacting megakaryocyte. Methods of treating a patient ... | 02/03/2011 |
| 20110021757 | TRANSGENIC SILKWORM CAPABLE OF PRODUCING ANTIBODY AND METHOD FOR PRODUCTION THEREOF The present inventors produced transgenic silkworms which comprise a promoter of a DNA encoding a protein specifically expressed in the silk gland and a DNA encoding a recombinant antibody whose expression is regulated directly or indirectly by the promoter, and which s... | 01/27/2011 |
| 20110018390 | Methods for controlling velocity of at least partially resonant actuators systems and systems thereof A method, computer readable medium, and system for controlling velocity of at least partially resonant actuator system includes obtaining at an actuator controller computing system a selected operating velocity within an operational velocity range for at least one of on... | 01/27/2011 |
| 20110015572 | PREFILLED RETRACTABLE SYRINGE, PLUNGER AND NEEDLE ASSEMBLY A retractable syringe, plunger and releasable needle retaining assembly are provided. The retractable syringe typically has a glass barrel and is prefilled with fluid contents before use. The releasable needle retaining system comprises a retractable needle, a needle se... | 01/20/2011 |
| 20110014228 | IL23 MODIFIED VIRAL VECTOR FOR RECOMBINANT VACCINES AND TUMOR TREATMENT The present invention relates to recombinant replicable viral vectors and viruses which are modified with IL23. This IL23 modified virus is highly immunogenic and attenuated for neurotropic pathology found in the wild type viruses. These viruses and vectors can be used ... | 01/20/2011 |
| 20110011916 | ANASTOMOSIS DEVICE The present invention is directed to a circular anastomosis surgical stapler and methods of use. The circular anastomosis surgical stapler includes an operator control assembly, a tubular shaft having a distal end that is associated with a head portion, and an actuating... | 01/20/2011 |
| 20110008774 | PROTEIN DISCOVERY USING INTRACELLULAR RIBOSOME DISPLAY The present invention relates to a method of identifying a protein that binds to a target molecule and has intracellular functionality. This method includes providing a construct comprising a deoxyribonucleic acid molecule encoding the protein which binds to the target ... | 01/13/2011 |
| 20110007873 | IMAGING ARRAY DATA ACQUISITION SYSTEM AND USE THEREOF The present invention relates to an imaging system, computer readable medium, and method for dynamic imaging of an object to be examined. The imaging system includes detection array comprising an array of modular devices positioned such that one or more modular devices ... | 01/13/2011 |
| 20110003793 | AZINONE-SUBSTITUTED AZEPINO[b]INDOLE AND PYRIDO-PYRROLO-AZEPINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF Novel MCH-1 receptor antagonists are disclosed. These compounds are used in the treatment of various disorders, including obesity, anxiety, depression, non-alcoholic fatty liver disease, and psychiatric disorders. Methods of making these compounds are also described in ... | 01/06/2011 |
| 20110003739 | AZINONE-SUBSTITUTED AZABICYCLOALKANE-INDOLE AND AZABICYCLOALKANE-PYRROLO-PYRIDINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF Novel MCH-1 receptor antagonists are disclosed. These compounds are used in the treatment of various disorders, including obesity, anxiety, depression, non-alcoholic fatty liver disease, and psychiatric disorders. Methods of making these compounds are also described in ... | 01/06/2011 |
| 20110003738 | AZINONE-SUBSTITUTED AZAPOLYCYCLE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF Novel MCH-1 receptor antagonists are disclosed. These compounds are used in the treatment of various disorders, including obesity, anxiety, depression, non-alcoholic fatty liver disease, and psychiatric disorders. Methods of making these compounds are also described in ... | 01/06/2011 |
| 20110003737 | AZABICYCLOALKANE-INDOLE AND AZABICYCLOALKANE-PYRROLO-PYRIDINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF Novel MCH-1 receptor antagonists are disclosed. These compounds are used in the treatment of various disorders, including obesity, anxiety, depression, non-alcoholic fatty liver disease, and psychiatric disorders. Methods of making these compounds are also described in ... | 01/06/2011 |
| 20110002846 | CD24 AS A BRAIN TUMOR STEM CELL MARKER AND A DIAGNOSTIC AND THERAPEUTIC TARGET IN PRIMARY NEURAL AND GLIAL TUMORS OF THE BRAIN The present invention is directed to methods of treating a primary brain tumor and preventing the migratory spread of a primary brain tumor in a subject. These methods involve utilizing the CD24 surface protein selectively expressed on tumor progenitor cells as a therap... | 01/06/2011 |
| 20110001353 | AUXILIARY POWER SYSTEMS AND METHODS THEREOF An auxiliary power supply system includes a passive ultra-capacitor buffer module and an auxiliary power unit coupled to the passive ultra-capacitor. The auxiliary power unit is configured to receive a current supply from the passive ultra-capacitor buffer module. The a... | 01/06/2011 |
| 20100333223 | CARBOHYDRATE BINDING PLANT HYDROLASES WHICH ALTER PLANT CELL WALLS The present invention discloses a transgenic plant cell which includes a nucleic acid construct. The nucleic acid construct contains a nucleic acid molecule encoding a plant endo-1,4-β-xylanase and/or a plant endo-1,4-β-glucanase, where the plant endo-1,4-β-xylanase ... | 12/30/2010 |
| 20100332155 | MICROELECTROMECHANICAL VISCOSITY MEASUREMENT DEVICES AND METHODS THEREOF A viscosity measurement device includes a flexible membrane, an actuation heating element, and a displacement sensor apparatus. The actuation heating element is on and spaced in from an outer periphery of the flexible membrane. The displacement sensor apparatus is coupl... | 12/30/2010 |
| 20100331339 | (1-AZINONE)-SUBSTITUTED PYRIDOINDOLES Substituted pyridoindoles for incorporation in pharmaceutical compositions employed in the treatment of various diseases correspond to formula (I) wherein R1 is H or optionally substituted alkyl; R... | 12/30/2010 |
| 20100325760 | FAGOPYRITOL SYNTHASE GENES AND USES THEREOF The present invention relates to an isolated DNA molecule encoding a fagopyritol synthase. A method for producing a fagopyritol, an insulin mediator, an insulin mediator analogue, an insulin mediator homologue, or an insulin mediator inhibitor is also described. The met... | 12/23/2010 |
| 20100324025 | Antibacterial Agents Antibacterial compounds of formula I are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of ... | 12/23/2010 |
| 20100323425 | DETECTION OF NUCLEIC ACID DIFFERENCES USING COMBINED ENDONUCLEASE CLEAVAGE AND LIGATION REACTIONS The present invention is a method for detecting DNA sequence differences including single nucleotide mutations or polymorphisms, one or more nucleotide insertions, and one or more nucleotide deletions. Labeled heteroduplex PCR fragments containing base mismatches are pr... | 12/23/2010 |
| 20100317078 | METHODS TO IMPROVE ALCOHOL TOLERANCE OF MICROORGANISMS The present invention is directed to a method of producing organisms tolerant to alcohol, that includes selecting a microorganism needing tolerance to alcohol and modifying the selected microorganism under conditions effective to overproduce inositol by the microorganis... | 12/16/2010 |
| 20100316564 | IMMUNOLOGICAL TARGETING OF PATHOLOGICAL TAU PROTEINS The present invention relates to methods and compositions for treating, preventing, and diagnosing Alzheimer's Disease or other tauopathies in a subject by administering an immunogenic tau peptide or an antibody recognizing the immunogenic tau epitope under conditions e... | 12/16/2010 |
| 20100313025 | METHODS ESTABLISHING A SYMMETRIC ENCRYPTION KEY AND DEVICES THEREOF A method, computer readable medium, and an apparatus for establishing a symmetric encryption key includes determining at one of a plurality of communication devices a first phase difference based on a first transmission from another one of the plurality of communication... | 12/09/2010 |
| 20100303790 | USE OF BILIVERDIN REDUCTASE (BVR) AND BVR PEPTIDE FRAGMENTS TO TREAT CORONARY DISORDERS The present invention relates to methods and compositions for treating coronary disorders and preventing cardiac cell death that involve the use of biliverdin reductase (“BVR”) or BVR peptides to stabilize the expression and activity of intracellular HO-2 in cardiac... | 12/02/2010 |
| 20100301881 | IMPROVEMENTS RELATING TO THE TESTING OF AN EARTH CONNECTION A device (10) is disclosed that is suitable for testing an earth connection (30) that is isolated from a mains electricity supply. The device (10) comprises means (14, 40) for electrically connecting the device (10) to the earth connec... | 12/02/2010 |
| 20100298433 | BRANCHED CHAIN FATTY ACIDS FOR PREVENTION OR TREATMENT OF GASTROINTESTINAL DISORDERS The present invention is directed to a method of preventing or treating a gastrointestinal condition in a subject, that includes administering one or more branched chain fatty acid to the subject under conditions effective to prevent 5 or treat the gastrointestinal cond... | 11/25/2010 |
| 20100297639 | QUANTITATIVE/SEMI-QUANTITATIVE MEASUREMENT OF EPOR ON CANCER CELLS The present invention provides for assays useful in predicting whether a cancer patient risks suffering erythropoietin-induced tumor progression if treated with erythropoietin. More specifically, one embodiment provides for a validated quantitative reverse transcriptase... | 11/25/2010 |
| 20100297603 | ANALYTE-RELEASING BEADS AND USE THEREOF IN QUANTITATIVE ELISPOT OR FLUORISPOT ASSAY The present invention relates to a method of quantifying analyte secreted by a cell or released from a drug delivery vehicle, typically by ELISpot or fluorispot assay. Quantification is possible through the use of an analyte-releasing reagent that includes a bead and th... | 11/25/2010 |
| 20100294271 | SYSTEM FOR THE MANAGEMENT OF MEDICAL TUBING A system for the management of medical tubing, the system includes a tube holder adapted for receiving and retaining medical tubes, and a clip adapted to be engaged with a substrate, in which the tube holder may be releasably engaged with the clip.... | 11/25/2010 |
| 20100292250 | CRYSTALLINE FORMS OF (S)-7-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLOROPHENYL)-1,2,3,4- TETRAHYDROISOQUINOLINE AND USE THEREOF Novel [1,2,4]triazolo[1,5-a]pyridinyl-6-yl-substituted tetrahydroisoquinolines are described in the present invention. These compounds and crystalline forms SA1 and N-2 are used in the treatment of various neurological and physiological disorders. Methods of making thes... | 11/18/2010 |
| 20100292243 | 7-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE AND USE THEREOF Novel [1,2,4]triazolo[1,5-a]pyridinyl-6-yl-substituted tetrahydroisoquinolines are described in the present invention. These compounds and crystalline forms SA1 and N-2 are used in the treatment of various neurological and physiological disorders. Methods of making thes... | 11/18/2010 |
