Famous Patents
The first commercial microwave oven was nearly 6 feet tall and weighed in at 750 pounds.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Application No. | Application Title | Issue Date |
| 20110045023 | Recombinant RSV Virus Expression Systems And Vaccines The present invention relates to genetically engineered recombinant respiratory syncytial viruses and viral vectors which contain deletions of various viral accessory gene(s) either singly or in combination. In accordance with the present invention, the recombinant resp... | 02/24/2011 |
| 20110033378 | Cysteine Engineered Antibodies For Site-Specific Conjugation Cysteine engineered antibodies useful for the site-specific conjugation to a variety of agents are provided. Methods for the design, preparation, screening, selection and use of such antibodies are also provided.... | 02/10/2011 |
| 20110008365 | METHODS OF TREATING SCLERODERMA The present invention relates to methods for treating/ameliorating seleroderma and associated symptoms.... | 01/13/2011 |
| 20110008329 | Methods of Treating RSV Infections And Related Conditions The present invention provides methods for managing, treating and/or ameliorating a respiratory syncytial virus (RSV) infection (e.g., acute RSV disease, or a RSV upper respiratory tract infection (URI) and/or lower respiratory tract infection (LRI)), and/or a symptom o... | 01/13/2011 |
| 20100331208 | Cell Display Of Antibody Libraries The present invention relates to a viral vector encoding for a library of antibodies or antibody fragments that are displayed on the cell membrane when expressed in a cell. The present invention provides cells comprising the viral vector nucleic acids and methods of scr... | 12/30/2010 |
| 20100330118 | INFLUENZA HEMAGGLUTININ AND NEURAMINIDASE VARIANTS Polypeptides, polynucleotides, reassortant viruses, immunogenic compositions and vaccines comprising influenza hemagglutinin and neuraminidase variants and method using thereof are provided.... | 12/30/2010 |
| 20100330103 | Antibodies Directed to Alpha V Beta 6 And Uses Thereof Targeted binding agents, such antibodies directed to the antigen αVβ6 and uses of such agents are described. In particular, fully human monoclonal antibodies directed to the antigen αVβ6 are disclosed. Nucleotide sequences encoding, and amino acid sequences comprisi... | 12/30/2010 |
| 20100303827 | Protein Formulation The present invention provides stable lyophilized formulations of bispecific antibodies or fragments thereof.... | 12/02/2010 |
| 20100303736 | ANTI-IL-9 ANTIBODY FORMULATIONS AND USES THEREOF The present invention provides liquid formulations of antibodies or antibody fragments that immunospecifically bind to an IL-9 polypeptide, which formulations exhibit stability, low to undetectable levels of aggregation, and very little to no loss of the biological acti... | 12/02/2010 |
| 20100298545 | EphA2 AGONISTIC MONOCLONAL ANTIBODIES AND METHODS OF USE THEREOF The present invention relates to methods and compositions designed for the treatment, management, or prevention of cancer, particularly, metastatic cancer. The methods of the invention comprise the administration of an effective amount of one or more antibodies that bin... | 11/25/2010 |
| 20100298541 | Protein Scaffolds The invention provides protein scaffolds and methods of preparing, screening, engineering and using such protein scaffolds.... | 11/25/2010 |
| 20100291073 | METHODS OF REDUCING EOSINOPHIL LEVELS The present invention relates to a method of reducing the numbers of eosinophils in a human subject comprising administration to a subject an IL-5R binding molecule that comprises (a) a region that specifically binds to the IL-5R and (b) an immunoglobulin Fc region. In ... | 11/18/2010 |
| 20100278929 | ANTIBODY FORMULATIONS HAVING OPTIMIZED AGGREGATION AND FRAGMENTATION PROFILES The present invention provides methods of optimizing the production and purification of antibody formulations that immunospecifically bind to antigens of interest and are suitable for parenteral administration to a subject, which formulations exhibit increased stability... | 11/04/2010 |
| 20100278852 | ANTIBODIES AGAINST AND METHODS FOR PRODUCING VACCINES FOR RESPIRATORY SYNCYTIAL VIRUS The present invention relates to novel respiratory syncytial virus (RSV) F peptides and compositions comprising them. The present invention also relates to methods of evaluating anti-RSV antibody binding to F peptides. The present invention also relates to antibodies th... | 11/04/2010 |
| 20100278838 | EPHA2 MONOCLONAL ANTIBODIES AND METHODS OF USE THEREOF The present invention relates to methods and compositions designed for the treatment, management, or prevention of cancer, particularly, metastatic cancer. In one embodiment, the methods of the invention comprise the administration of an effective amount of an antibody ... | 11/04/2010 |
| 20100266610 | AUTO-ANTIBODY MARKERS OF AUTOIMMUNE DISEASE The present invention encompasses auto-antibodies associated with autoimmune disorders. The auto-antibodies may be used, for example, in methods of treating patients, methods of diagnosing patients, methods of monitoring disease progression of patients, and methods of p... | 10/21/2010 |
| 20100266594 | IL-9 IN FIBROTIC AND INFLAMMATORY DISEASE The present invention encompasses methods of employing inhibitors of IL-9 in the treatment of fibrotic disorders, e.g., COPD and inflammatory bowel disease.... | 10/21/2010 |
| 20100261172 | INTERFERON ALPHA-INDUCED PHARMACODYNAMIC MARKERS The present invention encompasses type-I IFN and IFNα-induced PD marker expression profiles, kits, and methods for identifying such IFNα-induced PD marker expression profiles. The type-I IFN and IFNα-induced PD marker expression profiles may also be used in, for exam... | 10/14/2010 |
| 20100260770 | IL-33 IN INFLAMMATORY DISEASE The present invention encompasses IL-33 specific binding polypeptides and compositions comprising IL-33 specific binding polypeptides, e.g., antibodies and monomer/multimer domain polypeptides. The invention also encompasses methods employing the IL-33 specific binding ... | 10/14/2010 |
| 20100260765 | TARGETED BINDING AGENTS DIRECTED TO KDR AND USES THEREOF - 035 The invention relates to targeted binding agents against KDR and uses of such agents. More specifically, the invention relates to fully human monoclonal antibodies directed to KDR. The described targeted binding agents are useful in the treatment of diseases associated ... | 10/14/2010 |
| 20100260749 | Modulators of EphA2 and Ephrin-A1 for the treatment of fibrosis-related disease The present invention relates to methods and compositions designed for the treatment, management, prevention and/or amelioration of non-neoplastic hyperproliferative epithelial and/or endothelial cell disorders, including but not limited to disorders associated with inc... | 10/14/2010 |
| 20100254996 | SYNERGISTIC TREATMENT OF CELLS THAT EXPRESS EPHA2 AND ERBB2 The present invention relates to methods of treating hyperproliferative cells that express EphA2 and ErbB2. The present invention further relates to methods of selecting patient populations for treatment methodologies.... | 10/07/2010 |
| 20100254985 | Protein Formulations The present invention provides formulations of proteins comprising a variant Fc region that improve the stability in part by reducing the propensisty of such molecules to rapidly aggregate. The invention provides both liquid and lyophilized formulations either of which ... | 10/07/2010 |
| 20100239593 | RSV-SPECIFIC BINDING MOLECULES AND MEANS FOR PRODUCING THEM The invention provides antibodies and functional equivalents thereof which are capable of specifically binding RSV, and means and methods for producing them.... | 09/23/2010 |
| 20100239585 | Antibodies Against Mammalian Metapneumovirus The present invention provides antibodies that immunospecifically bind to a polypeptide of a mammalian metapneumovirus, compositions comprising said antibodies, and methods for producing such antibodies. In particular, the invention provides monoclonal antibodies that i... | 09/23/2010 |
| 20100233173 | MULTISPECIFIC EPITOPE BINDING PROTEINS AND USES THEREOF The present invention relates to multispecific epitope binding proteins, methods of making, and uses thereof in the prevention, management, treatment or diagnosis of acute or chronic diseases.... | 09/16/2010 |
| 20100216975 | Framework-Shuffling Of Antibodies The present invention relates to methods of reengineering or reshaping antibodies to reduce the immunogenicity of the antibodies, while maintaining the immunospecificity of the antibodies for an antigen. In particular, the present invention provides methods of producing... | 08/26/2010 |
| 20100209434 | ANTIBODY FORMULATION The present invention provides high concentration liquid formulations of antibodies or fragments thereof that specifically bind to a human interferon alpha polypeptide.... | 08/19/2010 |
| 20100203641 | METHODS AND COMPOSITIONS FOR EXPRESSING NEGATIVE-SENSE VIRAL RNA IN CANINE CELLS The present invention provides novel canine pol I regulatory nucleic acid sequences useful for the expression of nucleic acid sequences in canine cells such as MDCK cells. The invention further provides expression vectors and cells comprising such nucleic acids as well ... | 08/12/2010 |
| 20100203045 | EPH RECEPTOR Fc VARIANTS WITH ENHANCED ANTIBODY DEPENDENT CELL-MEDIATED CYTOTOXICITY ACTIVITY The present invention relates to novel Fc variants that immuno-specifically bind to an Eph receptor. The Fc variants comprise a binding region that immunospecifically binds to an Eph receptor and an Fc region that further comprises at least one novel amino acid residue ... | 08/12/2010 |
| 20100196398 | TARGETED BINDING AGENTS DIRECTED TO CD105 AND USES THEREOF The invention relates to targeted binding agents against CD105 and uses of such agents. More specifically, the invention relates to fully human monoclonal antibodies directed to CD105. The described targeted binding agents are useful in the treatment of diseases associa... | 08/05/2010 |
| 20100196388 | TARGETED BINDING AGENTS DIRECTED TO SONIC HEDGEHOG HOMOLOG AND USES THEREOF The invention relates to targeted binding agents against human sonic hedgehog homolog (Shh) and uses of such agents. More specifically, the invention relates to fully human monoclonal antibodies directed to Shh. The described targeted binding agents are useful in the tr... | 08/05/2010 |
| 20100196385 | TARGETED BINDING AGENTS DIRECTED TO DLL4 AND USES THEREOF 524 The invention relates to targeted binding agents against DLL4 and uses of such agents. More specifically, the invention relates to fully human monoclonal antibodies directed to DLL4. The described targeted binding agents are useful in the treatment of diseases associate... | 08/05/2010 |
| 20100190232 | Functional Mutations In Respiratory Syncytial Virus The present invention provides recombinant respiratory syncytial viruses that have an attenuated phenotype and that comprise one or more mutations in the viral P, M2-1 and/or M2-2 proteins, as well as live attenuated vaccines comprising such viruses and nucleic acids en... | 07/29/2010 |
| 20100184959 | Polypeptide Variants The present invention relates to methods for selecting, obtaining or producing Fc variant polypeptides which show altered recognition for an Fc ligand (e.g., FcγR, CIq). Additionally, the Fc variant polypeptides may have altered antibody-dependent cell-mediated cytotox... | 07/22/2010 |
| 20100167270 | METAPNEUMOVIRUS STRAINS AND THEIR USE IN VACCINE FORMULATIONS AND AS VECTORS FOR EXPRESSION OF ANTIGENIC SEQUENCES AND METHODS FOR PROPAGATING VIRUS The invention relates to improved strains of mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae, of the family Paramyxoviridae. The invention further relates to methods for propagating mammalian MPV in the absence of t... | 07/01/2010 |
| 20100166746 | HIGH POTENCY RECOMBINANT ANTIBODIES, METHODS FOR PRODUCING THEM AND USE IN CANCER THERAPY The present invention contemplates improved recombinant anti-tumor antibodies having faster Kon and faster Koff rates, resulting in a uniform tumor penetrance, as compared to the same recombinant anti-tumor antibody without said faster Kon and faster Koff rates, and met... | 07/01/2010 |
| 20100166657 | USE OF EphA4 AND MODULATOR OF EphA4 FOR DIAGNOSIS, TREATMENT AND PREVENTION OF CANCER The present invention relates to methods and compositions designed for the treatment, management, or prevention of cancer, particularly, metastatic cancer. In one embodiment, the methods of the invention comprise the administration of an effective amount of one or more ... | 07/01/2010 |
| 20100158926 | ANTIBODIES TO ERBB2 The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically hind to ErbB2, preferably human ErbB2. In another embodiment, the antibodies or antigen-binding portions thereof inhibit ErbB2. The invention al... | 06/24/2010 |
| 20100150904 | BINDING MEMBERS FOR IGE MOLECULES This invention relates to binding members, especially antibody molecules, for IgE. The binding members are useful for, inter alia, treatment of disorders mediated by IgE including allergies and asthma.... | 06/17/2010 |
