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Felix Hoffmann, a German chemist, was searching for something to relieve his father's arthritis. In doing so, he "rediscovered" acetylsalicylic acid and in 1900, patented a stable process for developing it. Hence, we have aspirin.
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| Application No. | Application Title | Issue Date |
| 20090291434 | Gene expression markers for colorectal cancer prognosis A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprising determining evidence of the expression of one or more predictive RNA transcripts or their expression products in a biological sample of cancer cells obtained from the subjec... | 11/26/2009 |
| 20090123482 | ASSAYS FOR DETERMINING COMPOUNDS WHICH MODULATE TRAM PHOSPHORYLATION Disclosed are assays for the determination and quantification of the phosphorylation of TRAM (Trif-related adaptor molecule). TRAM is rapidly phosphorylated upon LPS stimulation by protein kinase C epsilon (PKCε) and that this phosphorylation is vital for TRAM to funct... | 05/14/2009 |
| 20090102414 | Solar-Powered Charger A solar-powered charger includes a solar collector configured to generate electrical energy when exposed to light, a battery coupled to the solar collector configured to receive and store the electrical energy, a connector coupled to the solar collector and the battery ... | 04/23/2009 |
| 20090076777 | System and Method for Change Detection of Information or Type of Data A method is provided of determining the how information from any information system changes over time. WebPages A through WebPages Z with nodes A through Z, are located, where A through Z are integers. Timestamp values for each of a node from A through Z are retrieved. ... | 03/19/2009 |
| 20090055353 | Multi-Mode Location Based E-Directory Service Enabling Method, System, and Apparatus A method prepares a response when providing e-Directory services to a user making a user request for location-based supplier information. The method includes identifying from said user request a desired location for which the user is requesting supplier information, ide... | 02/26/2009 |
| 20090055099 | Proteomic analysis of biological fluids The invention concerns the identification of proteomes of biological fluids and their use in determining the state of maternal/fetal conditions, including maternal conditions of fetal origin, chromosomal aneuploidies, and fetal diseases associated with fetal growth and ... | 02/26/2009 |
| 20090054811 | Method and apparatus for analyte measurement test time A method is provided for the analyte measurement by a user using an analyte measurement device. A penetrating member and unused analyte detecting member of the analyte measurement device are presented into an active position. The penetrating member is fired to prick the... | 02/26/2009 |
| 20090041791 | Heterocyclic self-immolative Linkers and Conjugates The present invention provides heterocyclic linker compounds useful for linking drug moieties to ligands. The compounds also include drug-ligand conjugates comprising a ligand capable of targeting a selected cell population, and a drug connected to the ligand by a heter... | 02/12/2009 |
| 20080305873 | Universal Toy Controller System And Methods An apparatus, system, and methods, for an game controller system are provided. In one embodiment, an apparatus is provided that allows for universal control of games. In some embodiments, the games are hosted at an online portal, which contains a software module allowin... | 12/11/2008 |
| 20080303787 | Touch Screen Apparatus And Methods A touch screen computing apparatus, methods, and software product are provided. In one embodiment, an the computing apparatus provides a plurality of regions on a touch screen that are mapped to functions. In some embodiments, the regions include a keyboard region, a ga... | 12/11/2008 |
| 20080299849 | Methods And Apparatus For Flushing Marine Propulsion Units An apparatus and method for flushing marine propulsion units are provided. In one embodiment, the apparatus comprises a basin with anterior, posterior, side walls and a base. The basin is made from a watertight material and has sufficient depth to partially submerge a m... | 12/04/2008 |
| 20080300061 | Online Interactive Game System And Methods An apparatus, system, and methods, for an online entertainment system are provided. In one embodiment, an apparatus is provided that allows for universal control of games. In some embodiments, the games are hosted at an online portal, which contains a software module al... | 12/04/2008 |
| 20080293777 | Weight Loss Treatment The present invention relates to the use of 2-phenyl-1,2-benzisoselenazol-3(2H)-one and other selenium-containing compounds for weight loss.... | 11/27/2008 |
| 20080282978 | Process For Manufacturing A Gallium Rich Gallium Nitride Film A process for the manufacture of a gallium rich gallium nitride film is described. The process comprises (a) preparing a reaction mixture containing a gallium species and a nitrogen species, the gallium species and the nitrogen species being selected such that, when the... | 11/20/2008 |
| 20080288870 | SYSTEM, METHODS, AND APPARATUS FOR MULTI-USER VIDEO COMMUNICATIONS A computer software product, methods and apparatus for improved video communications are provided. In one embodiment, an apparatus is provided that is configured to allow multi-user video communication. The video communications are streamed to and stored on a server dev... | 11/20/2008 |
| 20080288989 | System, Methods and Apparatus for Video Communications A computer software product, methods and apparatus for improved video communications are provided. In one embodiment, an apparatus is provided that is configured to send v-mail messages. The v-mail messages contain a video stream that is stored on a second device on a n... | 11/20/2008 |
| 20080282818 | Sensors with nanoparticles A sensor is provided with a base with at least one resistive track which includes a nano particle based conductive ink. A contact device makes contact along at least a portion of the resistive track and provides an indication of position or movement.... | 11/20/2008 |
| 20080287831 | Methods and apparatus for lancet actuation A lancet driver is provided wherein the driver exerts a driving force on a lancet during a lancing cycle and is used on a tissue site. The driver comprises of a drive force generator for advancing the lancet and a processor coupled to the drive force generator capable o... | 11/20/2008 |
| 20080279963 | PHYSIOLOGICALLY BALANCED, IONIZED, ACIDIC SOLUTION AND METHODOLOGY FOR USE IN WOUND HEALING Described herein is a physiologically-balanced, acidic solution. Typically the solution is prepared by a chemical reactions or by the electrolysis of a solution comprising a mixture of an inorganic salt to form a physiologically balanced solution. This invention also re... | 11/13/2008 |
| 20080279687 | Waterwheel Apparatus and Methods An improved waterwheel and methods for its use are provided. In an exemplary embodiment, the waterwheel is an undershot waterwheel utilized for electrical power generation. In another embodiment, the waterwheel may be partially or fully submerged. The waterwheel of the ... | 11/13/2008 |
| 20080272463 | Method and Apparatus for Growing a Group (III) Metal Nitride Film and a Group (III) Metal Nitride Film A process and apparatus for growing a group (III) metal nitride film by remote plasma enhanced chemical vapour deposition are described. The process comprises heating an object selected from the group consisting of a substrate and a substrate comprising a buffer layer i... | 11/06/2008 |
| 20080269947 | Automated Vending of Products Containing Controlled Substances The present invention provides for devices and methods for vending regulated products, particularly controlled substances, including those containing pseudoephedrine. The present invention allows for the identification of consumers through reliable log-in-procedures, al... | 10/30/2008 |
| 20080270908 | Systems And Methods For Contacting An Acquaintance Systems and methods are disclosed enabling users to post searchable data, such as information about themselves and others as well as details of a personal encounter such as the date, time and place where it occurred, to a user interface in a computer network. Search and... | 10/30/2008 |
| 20080265177 | Fluorescence Detection A fluorescence detection system comprises a light source (22), dichroic mirror (32), excitation port (16), emission port (14), and a detector. The light source (22) is, for example, a pulsed ultraviolet LED, with a light emission that ... | 10/30/2008 |
| 20080261694 | Hand-held interactive game A game apparatus has a plurality of actuation devices in which at least two of the actuation devices require different mechanical actions for actuation. The apparatus further includes a speaker, a display screen, and a processor coupled to each of the actuation devices ... | 10/23/2008 |
| 20080259969 | Slectable Multiwavelength Laser for Outputting Visible Light The invention provides a laser system (100) wherein the output may be selected from two or more different wavelengths of output laser light. The system (100) comprises a laser capable of having at least two different wavelengths of laser light resonating i... | 10/23/2008 |
| 20080259971 | Method for improving high frequency operation of a vertical cavity surface emitting laser (VCSEL) with monolithically integrated bridge arm A vertical cavity laser apparatus is provided. In one embodiment, the apparatus includes an electrically responsive substrate; a support block positioned on the electrically responsive substrate; a bridge arm structure coupled to the support block, the structure having ... | 10/23/2008 |
| 20080249024 | Peptides facilitating or inhibiting a nterograde transport The present invention concerns amyloid precursor protein (APP)-based peptide sequences and their uses to facilitate or inhibit anterograde (synapse-directed) transport. The peptide sequences are of the formula GYENPTYX1X2X3X4X5X6X7X8 (SEQ ID NO: 13), 10/09/2008 | |
| 20080241825 | Materials and Methods for Treatment of Cancer Glypican 5 is shown for the first time to have a role in proliferation of cancer cells, including tumours which do not show chromosomal amplification at 13q31. The use of glypican 5 (GPC5) antagonists and binding agents for the treatment of cancer, particularly rhabdomy... | 10/02/2008 |
| 20080231942 | MOBILE CHARGE INDUCED PERIODIC POLING AND DEVICE Devices and methods are disclosed for realizing a high quality bulk domain grating structure utilizing mobile charges that are generated by means of photo-excitation in a substrate. An effect of light exposure (UV, visible, or a combination of wavelengths) is to generat... | 09/25/2008 |
| 20080227471 | METHOD FOR TRACKING CREDIT CARD FRAUD A system and method for automatically comparing obtained wireless device location information from a wireless network and comparing that location with another independent source geographic location is provided. Location information is derived from two or more sources in... | 09/18/2008 |
| 20080226659 | METHODS OF TREATMENT USING ANTI-ERBB ANTIBODY-MAYTANSINOID CONJUGATES The application concerns methods of treatment using anti-ErbB receptor antibody-maytansinoid conjugates, and articles of manufacture suitable for use in such methods. In particular, the invention concerns ErbB receptor-directed cancer therapies, using anri-ErbB receptor... | 09/18/2008 |
| 20080220536 | Methods for Identifying Compounds that Modulate Enzymatic Activities by Employing Covalently Bonded Target-Extender Complexes with Ligand Candidates The present invention relates to the use of “tethering” to identify compounds that modulate enzymatic activity.... | 09/11/2008 |
| 20080214956 | METHODS AND APPARATUS FOR LANCET ACTUATION A lancet driver is provided wherein the driver exerts a driving force on a lancet during a lancing cycle and is used on a tissue site. The driver comprises of a drive force generator for advancing the lancet and a processor coupled to the drive force generator capable o... | 09/04/2008 |
| 20080214789 | ANTIANGIOGENESIS THERAPY OF AUTOIMMUNE DISEASE IN PATIENTS WHO HAVE FAILED PRIOR THERAPY The present application describes therapy with angiogenesis antagonists such as anti-VEGF antibodies. In particular, the application describes the use of such antagonists to treat autoimmune disease in a patient who has failed prior treatment such as treatment with DMAR... | 09/04/2008 |
| 20080208704 | Methods to conduct sales of products or services over a communication network Methods are provided for conducting sales of a product or service over a communication network. A gateway system is provided that has a database with one or more catalogs of content for products or services. Buyers select products or services through the gateway system.... | 08/28/2008 |
| 20080208712 | Computer based systems to conduct sales of products or services over a communication network A computer based system is provided for sales of a product or service. A gateway system is provided that has a database with one or more catalogs of content for products or services: A merchant interface, for a merchant, is coupled to the gateway system. A buyer interfa... | 08/28/2008 |
| 20080206202 | METHODS FOR APPLICATION OF ENDOGENOUS OR EXOGENOUS STEM/PROGENITOR OR THEIR PROGENY FOR TREATMENT OF DISEASE We propose here that endogenous stem/progenitor cells of the developing or adult nervous system be genetically modified in situ, to express therapeutically advantageous gene products. Furthermore, we propose here that endogenous or other exogenous stem cells or their pr... | 08/28/2008 |
| 20080199886 | IGF BINDING PROTEINS IGFBP-3 fusion proteins are provided that are useful, for example, in cell-based assays, as IGF antagonists, and in mapping IGF-I and IGF-II binding sites on other molecules such as wild-type IGFBP-3 and IGF agonist peptides identified by phage display. Methods for maki... | 08/21/2008 |
| 20080200653 | COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF TUMOR The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.... | 08/21/2008 |
