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| Application No. | Application Title | Issue Date |
| 20090130126 | DNA EXPRESSION VECTORS The invention relates to DNA vectors containing a transcription regulatory sequence derived from Human Cytomegalovirus major immediate early gene that includes exon 1, but not intron A. Vectors, host cells, pharmaceutical and vaccine compositions comprising such host ce... | 05/21/2009 |
| 20090123496 | PURIFICATION OF HBV ANTIGENS FOR USE IN VACCINES The present invention relates to a method for the production of a hepatitis B antigen suitable for use in a vaccine, the method comprising purification of the antigen in the presence of cysteine, to vaccines comprising such antigens.... | 05/14/2009 |
| 20090118280 | Compounds Which Potentiate AMPA Receptor and Uses Thereof in Medicine Compounds of formula (I) and salts are provided: along with pharmaceutical compositions, uses in medicine, e.g., treating disease or condition mediated by a reduction or imbalance in glutamate receptor functi... | 05/07/2009 |
| 20090105478 | NOVEL COMPOUNDS Novel substituted 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.... | 04/23/2009 |
| 20090104229 | NOVEL USE The invention provides the use of a) an HIV Tat protein or polynucleotide; or b) an HIV Nef protein or polynucleotide; or c) an HIV Tat protein or polynucleotide linked to an HIV Nef protein or polynucleotide (Nef-Tat); and an HIV gp120 protein or polynucleotide in the ... | 04/23/2009 |
| 20090093478 | N-AROYL CYCLIC AMINES Disclosed are N-aroyl cyclic amine derivatives having the formula: wherein the substituent variables are as defined herein, and their use as pharmaceuticals.... | 04/09/2009 |
| 20090082390 | PIPERIDINE COMPOUNDS FOR USE AS OREXIN RECEPTOR ANTAGONIST This invention relates to N-aroyl cyclic amine derivatives and their use as pharmaceuticals, specifically as orexin receptor antagonists.... | 03/26/2009 |
| 20090082377 | Matrix Metalloproteinase Inhibitors The present invention relates to compounds of Formula (I): or pharmaceutically acceptable salts thereof, corresponding preparation processes, pharmaceutical formulations and methods for use as inhibitors of m... | 03/26/2009 |
| 20090076274 | BENZOXAZINONE DERIVATIVES, PREPARATION THEREOF AND USES IN THE TREATMENT OF CNS AND OTHER DISORDERS Intermediates useful in the preparation of compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed: wherein A, R1, R2, R3, | 03/19/2009 |
| 20090053291 | FUSION PROTEINS COMPRISING HIV-1 TAT AND/OR NEF PROTEINS The invention provides (a) an HIV Tat protein or derivative thereof linked to either (i) a fusion partner or (ii) an HIV Nef protein or derivative thereof; or (b) an HIV Nef protein or derivative thereof linked to either (i) a fusion partner or (ii) an HIV Tat protein o... | 02/26/2009 |
| 20090053214 | Humanised Anti-MAG Antibody or Functional Fragment Thereof The present invention relates to altered antibodies to myelin associated glycoprotein (MAG), pharmaceutical formulations containing them and to the use of such antibodies in the treatment and/or prophylaxis of neurological diseases/disorders.... | 02/26/2009 |
| 20090048444 | Process for Preparing Pyrido[2,3-d]pyrimidin-7-one and 3,4-Dihydropyrimido[4,5-d]pyrimidin-2(1H)-one Derivatives The present invention is directed to a novel method of preparing of 2,4,8-trisubstituted pyrido[2,3-d]pyrimidin-7-one pharmacophores of Formula (II) or (IIa) wherein 02/19/2009 | |
| 20090048442 | Novel compounds Novel substituted pyrimido[4,5-d]pyrimidin-2-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.... | 02/19/2009 |
| 20090048318 | METHODS FOR TREATING DEGENERATIVE DISEASES/INJURIES Invented is a method of treating cardiovascular disease/injury, in a mammal, including a human, in need thereof which comprises the administration of a therapeutically effective amount of a non-peptide TPO receptor agonist to such mammal.... | 02/19/2009 |
| 20090029986 | N-AROYL CYCLIC AMINES Disclosed are N-aroyl cyclic amine derivatives having the formula: wherein the substituent variables are as defined herein, and their use as pharmaceuticals.... | 01/29/2009 |
| 20090022670 | NOVEL COMPOUNDS Disclosed are imidazo[1,2-a]pyridin-2-ylmethyl substituted piperidine derivatives of formula (I) and their use as pharmaceuticals.... | 01/22/2009 |
| 20090017020 | RECOMBINANT IL-5 ANTAGONISTS USEFUL IN TREATMENT OF IL-5 MEDIATED DISORDERS Chimeric, humanized and other IL-5 mAbs, derived from high affinity neutralizing mAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided.... | 01/15/2009 |
| 20090018131 | QUINAZOLINE DERIVATIVES AS P13 KINASE INHIBITORS Invented is a method of inhibiting the activity/function of PI3 kinases using quinazoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative... | 01/15/2009 |
| 20090012099 | Novel Compounds Disclosed is a method for use of phenyl sulfone compounds of formula (I) in the treatment of Alzheimer's disease and age related cognitive decline. ... | 01/08/2009 |
| 20090012073 | N-AROYL CYCLIC AMINES Disclosed are N-aroyl cyclic amine derivatives having the formula: wherein the substituent variables are as defined herein, and their use as pharmaceuticals.... | 01/08/2009 |
| 20090012122 | N-AROYL CYCLIC AMINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists.... | 01/08/2009 |
| 20090005401 | Novel Compounds This invention relates to a novel group of 8-Alkyl/Aryl-4-aryl-2-N-(alkylamino)-N″-substituted-N′-cyanoguanidino-8H-pyrido[2,3-d]pyrimidin-7-one compounds, processes for the preparation thereof, the use thereof in treating CSBP/p38 kinase mediated diseases and pharm... | 01/01/2009 |
| 20080318944 | N-AROYL CYCLIC AMINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists.... | 12/25/2008 |
| 20080293656 | PROCESSING NUCLEIC ACID The present invention relates to a method of processing nucleic acid. More particularly, it relates to a method of purifying extra-chromosomal DNA by removing cell debris and/or RNA from a process stream comprising extra chromosomal DNA and a precipitate resulting from ... | 11/27/2008 |
| 20080293829 | Novel Compounds This invention relates to newly identified ester-linked gemini surfactant compounds, to the use of such compounds and to their production. The invention also relates to the use of the ester-linked gemini surfactant compounds to facilitate the transfer of polynucleotides... | 11/27/2008 |
| 20080279852 | Methods of treatment with glycosylated antibodies The present invention relates to methods of treating a human patient suffering from rheumatoid arthritis, comprising:
| 11/13/2008 |
| 20080279890 | VIRAL ANTIGENS The present invention relates to a vaccine composition comprising VLPs containing L1 proteins or functional L1 protein derivatives from HPV 16, HPV 18, HPV 31 and HPV 45 genotypes.... | 11/13/2008 |
| 20080262069 | CARVEDILOL PHOSPHATE SALTS AND/OR SOLVATES THEREOF, CORRESPONDING COMPOSITIONS, AND/OR METHODS OF TREATMENT The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen pho... | 10/23/2008 |
| 20080260781 | PROTEOSOME INFLUENZA VACCINE Improved forms of vaccines which comprise proteosomes and protein antigens are described. Vaccines which contain influenza HA as the antigen are used for illustration as to demonstrate efficacy. Improvements in the preparation of the vaccines themselves and the proteoso... | 10/23/2008 |
| 20080255115 | THIAZOLIDINEDIONE DERIVATIVES AS PI3 KINASE INHIBITORS Invented is a method of inhibiting the activity/function of PI3 kinases using thiazolidinedione derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegene... | 10/16/2008 |
| 20080227858 | Inhibitors of matrix metalloproteinase Compounds of formula (I): wherein
| 09/18/2008 |
| 20080221110 | Compounds Tricyclic nitrogen containing compounds and their use as antibacterials... | 09/11/2008 |
| 20080214640 | Thrombopoietin mimetics Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprise... | 09/04/2008 |
| 20080213212 | Sialoadhesin factor-2 antibodies Monoclonal antibodies have been generated that bind to human sialoadhesion factor-2. These antibodies are useful as diagnostic and therapeutic reagents... | 09/04/2008 |
| 20080206189 | METHOD OF TREATING CANCER BY ADMINISTERING CONJUGATES COMPRISING HUMAN IL-18 AND SUBSTITUTION MUTANTS THEREOF Human interleukin-18 (IL-18) polypeptides and substitution mutants thereof were conjugated to water-soluble polymers at specific sites on the human IL-18 protein. These conjugated human IL-18 and substitution mutants thereof retain biological activity. These conjugated ... | 08/28/2008 |
| 20080199494 | VACCINE A vaccine formulation for the prevention or amelioration of HIV infection in humans is provided. The vaccine comprises an HIV antigen, especially a protein which comprises Nef and/or Tat of HIV, and an immunostimulatory CpG oligonucleotide. Methods for making the vaccin... | 08/21/2008 |
| 20080194648 | COMPOUNDS WHICH POTENTIATE GLUTAMATE RECEPTOR AND USES THEREOF IN MEDICINE Compounds of formula (I) or a pharmaceutically acceptable salt, solvate or prodrug thereof, are disclosed: wherein R1 is C1-6alkyl, haloC1-6alkyl, C2-6alkenyl, amin... | 08/14/2008 |
| 20080188469 | VACCINATION The present invention relates to improvements in DNA vaccination and in particular, methods of vaccinating a mammal against disease states, and to the use of imidazo[4,5-c]quinolin-4-amine derivative adjuvants in the manufacture of medicaments for boosting previously va... | 08/07/2008 |
| 20080182852 | ANTHRANILAMIDE INHIBITORS OF AURORA KINASE The present invention relates to a compound represented by the following formula: or a pharmaceutically acceptable salt thereof; | 07/31/2008 |
| 20080181914 | NOVEL VACCINE COMPOSITION An inactivated influenza virus preparation is described which comprises a haemagglutinin antigen stabilised in the absence of thiomersal, or at low levels of thiomersal, wherein the haemagglutinin is detectable by a SRD assay. The influenza virus preparation may compris... | 07/31/2008 |
