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| Application No. | Application Title | Issue Date |
| 20110038805 | COMPOUNDS COMPRISING PARAMAGNETIC CHELATES ARRANGED AROUND A CENTRAL CORE AND THEIR USE IN MAGNETO RESONANCE IMAGING AND SPECTROSCOPY The present invention relates to novel compounds of formula (I) and (II), compositions comprising compounds of formula (II) and their use as contrast agents in magnetic resonance (MR) imaging (MRI) and MR spectroscopy (MRS).... | 02/17/2011 |
| 20110038804 | MR IMAGING AGENT, IMAGING MEDIUM AND METHODS OF IMAGING WHEREIN SUCH AN IMAGING MEDIUM IS USED The invention relates to hyperpolarised 13C-α-ketoisocaproate, its use as imaging agent, an imaging medium comprising hyperpolarised 13C-α-ketoisocaproate and methods of 13C-MR detection wherein such an imaging medium is used. Further,... | 02/17/2011 |
| 20110038802 | METHOD OF DETERMINING ALANINE TRANSAMINASE (ALT) ACTIVITY BY 13C-MR DETECTION USING HYPERPOLARISED 13C-PYRUVATE The invention relates to a method of determination of alanine transaminase (ALT) activity by 13C-MR detection using an imaging medium which comprises hyperpolarised 13C-pyruvate.... | 02/17/2011 |
| 20110036453 | NOZZLE FOR DNP POLARIZER DNP polarizer comprising a housing receiving a free end of a tubular fluid conduit positioned in fluid communication with a nozzle supported by said housing, said nozzle including an input port, a dispense port and a tapering inner surface or a stepped inner surface def... | 02/17/2011 |
| 20110033390 | MR IMAGING AGENT OR MEDIUM COMPRESSING HYPERPOLARISED 13C ALANINE AND METHODS OF IMAGING WHEREIN SUCH AN IMAGING MEDIUM IS USED The invention relates to hyperpolarised 13C-alanine, its use as imaging agent, an imaging medium comprising hyperpolarised 13C-alanine and methods of 13C-MR detection wherein such an imaging medium is used. Further, the invention relates... | 02/10/2011 |
| 20110033387 | METHOD OF DETERMINATION OF PDH ACTIVITY AND IMAGING MEDIA FOR USE IN SAID METHOD The invention relates to a method of determination of PDH activity by 13C-MR detection using an imaging medium which comprises hyperpolarised 13C-pyruvate and to imaging media for use in said method.... | 02/10/2011 |
| 20110028751 | PERFLUORO SULFONYL HALIDES AND RELATED SPECIES AS POLYMER SUPPORT MODIFIERS Activated Supports, support-bound activators, strongly acidic supports, and silylating supports are provided; the activated support having the formula: wherein L is a linking group component; X is F, Cl, OH, ... | 02/03/2011 |
| 20110027178 | IMAGING THE CENTRAL NERVOUS SYSTEM The present invention provides novel compounds which may be used as in vivo imaging agents. The compounds of the invention are useful in a method to image the expression of P2X7 receptors in a subject, as a means to facilitate the diagnosis of a range of dise... | 02/03/2011 |
| 20110021834 | CONTINUOUS PROCESS OF PREPARING INTERMEDIATE FOR NON-IONIC X-RAY CONTRAST AGENTS This invention relates to an improved method for the synthesis of 5-amino-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (Compound B), an intermediate in the industrial preparation of non-ionic X-ray contrast agents. In particular, it relates to a continuou... | 01/27/2011 |
| 20110021833 | CRYSTALLIZATION OF AN INTERMEDIATE FOR SYNTHESIZING NON-IONIC X-RAY CONTRAST AGENTS This invention relates generally to the crystallization process of 5-amino-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide (“Compound B”), an iodinated intermediate in the preparation of non-ionic X-ray contrast agents. The instant process uti... | 01/27/2011 |
| 20110021832 | SYNTHESIS OF IODIXANOL IN WATER This invention relates to the synthesis of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the dimerisation of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isoph... | 01/27/2011 |
| 20110021831 | SYTNHESIS OF IODIXANOL IN 1-METHOXY-2-PROPANOL AND WATER OR METHANOL This invention relates to the synthesis of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the dimerisation of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isoph... | 01/27/2011 |
| 20110021830 | SYTNHESIS OF IODIXANOL IN PROPYLENEGLYCOL This invention relates to the synthesis of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the dimerisation of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isoph... | 01/27/2011 |
| 20110021829 | SYTNHESIS OF IODIXANOL IN METHANOL This invention relates to the synthesis of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the dimerisation of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isoph... | 01/27/2011 |
| 20110021828 | RECOVERING UNREACTED INTERMEDIATE FROM DESALINATED AND DESOLVENTIZED DIMERISATION REACTION MIXTURE BY ULTRAFILTRATION This invention relates generally to industrial preparation of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), a non-ionic X-ray contrasting agent. It further relates to a method of recovering int... | 01/27/2011 |
| 20110021827 | CRYSTALLIZATION OF IODIXANOL USING ULTRASOUND This invention relates to the manufacture of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis (2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the purification of iodixanol by crystallization by using ultrasound.... | 01/27/2011 |
| 20110021826 | CRYSTALLIZATION OF IODIXANOL USING MILLING This invention relates to the manufacture of iodixanol(1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the purification of iodixanol by crystallization by using wet milling.... | 01/27/2011 |
| 20110021825 | PROCESS FOR ISOLATING IODIXANOL FROM AN AQUEOUS SOLUTION This invention relates to the isolation of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the isolation of iodixanol from an aqueous solution.... | 01/27/2011 |
| 20110021824 | ADSORPTIVE PURIFICATION METHOD FOR IODIXANOL This invention relates generally to non-ionic X-ray contrast agents. It further relates to a method of using solid adsorbents to reduce backpeaks content in the purification of iodixanol. In particular, it relates to the use of non-polar organic adsorbents with the aver... | 01/27/2011 |
| 20110021823 | PROCESSING CRUDE IODIXANOL MIXTURE BY NANOFILTRATION This invention relates generally to industrial preparation of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), a non-ionic X-ray contrasting agent. It further relates to a method for preparing a c... | 01/27/2011 |
| 20110021822 | CONTINUOUS DEACETYLATION AND PURIFICATION PROCESS IN SYNTHESIS OF NON-IONIC X-RAY CONTRAST AGENTS This invention relates to an improved method for the synthesis of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (“Compound A”), an intermediate in the industrial preparation of non-ionic X-ray contrast agents. In particular, it relates to a... | 01/27/2011 |
| 20110021821 | CONTINUOUS ACETYLATION PROCESS IN SYNTHESIS OF NON-IONIC X-RAY CONTRAST AGENTS This invention relates to an improved method for the synthesis of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (“Compound A”), an intermediate in the industrial preparation of non-ionic X-ray contrast agents. In particular, it relates to a... | 01/27/2011 |
| 20110021814 | METHOD FOR REDUCING AMINOISOPHTHALIC ACID BISAMIDE RELATED IMPURITIES IN PREPARATION OF NON-IONIC X-RAY CONTRAST AGENTS This invention relates generally to the preparation of non-ionic X-ray contrast agents, iohexol, ioversol, and iodixanol. It further relates to a method for improving the purity of 5-amino-N,N′-bis(2,3-dihydroxypropyl)-isophthalamide (or ABA), an intermediate in the i... | 01/27/2011 |
| 20110020238 | STABILIZING AQUEOUS SOLUTION OF IODINE CHLORIDE BY ADDING SODIUM CHLORIDE This invention relates generally to non-ionic X-ray contrast agents. It further relates to the preparation of iodine chloride, a key reagent in the synthesis of non-ionic X-ray contrast agents such as iodixanol and iohexol. In particular, the iodine chloride is produced... | 01/27/2011 |
| 20110020235 | MR METHODS OF GRADING A TUMOR USING AN IMAGING MEDIUM THAT COMPRISES HYPERPOLARISED 13C-PYRUVATE The invention relates to MR methods of grading a tumor using an imaging medium which comprises hyperpolarized 13C-pyruvate.... | 01/27/2011 |
| 20110017673 | ENDOTOXIN REMOVAL IN CONTRAST MEDIA This invention relates to the manufacture of contrast media, and more specifically to the removal of endotoxins in such contrast media.... | 01/27/2011 |
| 20110008263 | CONTRAST AGENTS The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing two linked iodinated p... | 01/13/2011 |
| 20110008261 | METHOD TO PRODUCE HYPERPOLARISED AMINO ACIDS AND AMINOSULPHONIC ACIDS The invention relates to a dynamic nuclear polarisation (DNP) method for producing hyperpolarised amino acids and amino sulphonic acids and compositions for use in the method. As a sample, an ammonium salt of an amino acid, an ammonium salt of an aminosulphonic acid, a ... | 01/13/2011 |
| 20110008254 | RADIOPHARMACEUTICAL COMPOSITION The present invention relates to radiopharmaceuticals and in particular to a radiopharmaceutical composition comprising a compound of Formula (I): and polysorbate as an excipient. The radiopharmaceutical composition of the invention reduces problems encountered with pri... | 01/13/2011 |
| 20110008252 | STABALISED 99MTC COMPOSITIONS The present invention relates to stabilised 99mTc radiopharmaceutical compositions of the ligand tetrofosmin, which include an ascorbic acid or ascorbate radioprotectant, in the absence of an antimicrobial preservative. The invention also provides lyophilised... | 01/13/2011 |
| 20110004098 | ESTER IMAGING AGENTS The present invention relates to contrast agents for optical imaging of oesophageal cancer and Barrett's oesophagus in patients. The contrast agents are esters of 5-aminolevulinic acid (5-ALA). They are useful in the diagnosis of oesophageal cancer and Barrett's oesopha... | 01/06/2011 |
| 20110002849 | THERAPY SELECTION METHOD The present invention relates to a method to assist in the determination of therapy for a patient suffering from Barrett's oesophagus, especially where first-line therapy has been unsuccessful and when dysplasia has been diagnosed. The method comprises the use of an ima... | 01/06/2011 |
| 20100324353 | ADHESIVE-STIFFENED BRACHYTHERAPY STRAND A stranded brachytherapy product and methods of forming a stranded brachytherapy product. The methods includes the step of applying an adhesive to a carrier containing at least one brachytherapy seed so as to, upon curing of the adhesive, impart substantial rigidity to ... | 12/23/2010 |
| 20100324264 | SYNTHESIS OF A PEG-6 MOIETY FROM COMMERCIAL LOW-COST CHEMICALS The present invention provides novel synthesis's for obtaining a protecting group aminoxy PEG-6 linker from cost effective, and readily available starting materials and chemicals or modified polyethylene glycols. More specifically, a novel synthesis of obtaining a modif... | 12/23/2010 |
| 20100322868 | CONTRAST AGENTS The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing two linked iodinated p... | 12/23/2010 |
| 20100322857 | RADIOLABELLED PEPTIDE BASED COMPOUNDS AND USES THEREOF The present invention relates to new radiolabelled peptide-based compounds and their use for diagnostic imaging using positron emission tomography (PET). Such compounds may thus be used for diagnosis or therapy of, for example, malignant diseases, heart diseases, endome... | 12/23/2010 |
| 20100316565 | NOVEL IMAGING METHOD The present invention relates to a method useful in facilitating the identification of fibrogenesis in a subject. The method of the invention is particularly useful when applied as part of a method to diagnose fibrogenesis of the liver. The invention also provides a com... | 12/16/2010 |
| 20100310467 | COMPOSITION AND METHOD FOR GENERATING A METABOLIC PROFILE USING 13C-MR DETECTION The invention relates to a method of 13C-MR detection using an imaging medium comprising hyperpolarised 13C-fumarate and imaging media comprising hyperpolarised 13C-fumarate for use in said method.... | 12/09/2010 |
| 20100303734 | CONTRAST AGENTS The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing two linked iodinated p... | 12/02/2010 |
| 20100285570 | FLUORIDE PROCESSING METHOD The invention relates to methods for processing [18F]-fluoride target water using a solid-support bound Cryptand of formula (I) and to apparatus for performing such methods. The resultant [18F]-fluoride is useful for preparation of radiopharmaceuti... | 11/11/2010 |
