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Attorney: FISH & RICHARDSON PC


Number of applications: 5578
Last date: January 20, 2011

1                      
Application No.Application TitleIssue Date
20110015212PYRIMIDINONES AS PI3K INHIBITORS
The present invention provides pyrimidinones that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and...
01/20/2011
20100306854Generating Obfuscated Data
A method for obfuscating data includes: reading values occurring in one or more fields of multiple records from a data source; storing a key value; for each of multiple of the records, generating an obfuscated value to replace an original value in a given field of the r...
12/02/2010
20100305983Providing Travel Information Using Cached Query Answers
Systems and techniques for presenting travel information to a user are described. A code that includes predetermined travel parameters specified by the user is included in a web page. Access to the web page by a user is detected. A travel query is populated with the pre...
12/02/2010
20100305578Uterine Manipulators and Related Components and Methods
A uterine manipulator tip includes a finger and an expandable member. The finger is configured to be confined within a cervix. The expandable member is carried by the finger and is configured to engage a cervical canal between an internal cervical os and an external cer...
12/02/2010
20100305496FLOW LIMITER FOR A FLUID FLOWING IN AN ASPIRATION BRANCH OF A SURGICAL SYSTEM, AND SURGICAL SYSTEM
The invention relates to a flow limiter (8) for a fluid flowing in an aspiration branch of a surgical system. which fluid is a surgical fluid and has emulsified particles in a surgical intervention, with a limiter element (81) that comprises at least one f...
12/02/2010
20100305433NON-CONTACT CARDIAC MAPPING, INCLUDING RESOLUTION MAP
A non-contact cardiac mapping method is disclosed that includes: (i) inserting a catheter into a heart cavity having an endocardium surface, the catheter including multiple, spatially distributed electrodes; (ii) measuring signals at the catheter electrodes in response ...
12/02/2010
20100305308Lactoferrin
A pure lactoferrin polypeptide containing no more than two metal ions per molecule, or a mixture of the polypeptide and a fragment thereof. The polypeptide or the mixture stimulates skeletal growth and inhibits bone resorption. Also disclosed is a method of treating a b...
12/02/2010
20100304401YS68 GENE INVOLVED IN PRIMITIVE HEMATOPOIESIS
A novel gene, dubbed “YS68”, involved in primitive hematopoiesis was successfully isolated from cDNA derived from mouse yolk sacs. In addition, a human gene corresponding to this gene was successfully isolated. Expression characteristics of these genes suggested the...
12/02/2010
20100304371COMPOSITIONS AND METHODS FOR DETECTING MYCOBACTERIA
The present invention features compositions and methods that can be used to analyze samples for the presence of mycobacterium from MTC, M. bovis and M. tuberculosis. Moreover, the methods can be used, for example, to differentiate M. bovis fr...
12/02/2010
20100303105GENERATING PULSE TRAINS IN Q-SWITCHED LASERS
The invention relates to methods and systems for generating a pulse train having several individual pulses, wherein the individual pulses have a desired pulse characteristic, by means of a Q-switched solid state laser system, which includes, e.g., a modulator for influe...
12/02/2010
20100302976Front-End Circuit
A front-end circuit for a mobile radio includes a first Frequency Division Duplexing (FDD) transmission path for a first FDD mobile radio system, where the first FDD transmission path includes a transmission amplifier and a duplexer that includes a transmission filter e...
12/02/2010
20100302546OPTICAL MEASUREMENT OF SAMPLES
A portable device includes a base unit, an extension, and a mirror. The base unit includes a light source, a light detector, and at least one window through which light exits from, and is received by, the base unit. The extension is configured, during use, to be attache...
12/02/2010
20100300766Convex Crested Insert With Deflected Wedge Surfaces
This invention relates to carbide inserts used on roller cone bits for oil and gas drilling applications as well as for other geological drilling applications, and more specifically, relates to the convex crested insert with deflected wedge surfaces. The insert comprise...
12/02/2010
20100299149Character Models for Document Narration
Disclosed are techniques and systems to provide a narration of a text in multiple different voices where the portions of the text narrated using the different voices are selected by a user. Also disclosed are techniques and systems for associating characters with portio...
11/25/2010
20100298582Intermediate Compounds and Processes for the Preparation of 7-benzyloxy-3-(4-methoxyphenyl)-2H-1-benzopyran
Disclosed herein is a compound of formula (I):

wherein:

    • B...
11/25/2010
20100298581Processes for Preparing Isoflavonoids using 7-benzyloxy-3-(4-methoxyphenyl)-2H-1-benzopyran as a Starting Material
Disclosed herein are processes for the preparation of isoflavonoids, in particular haginin E, equol, daidzein, formononetin and the like, in which 7-benzyloxy-3-(4-methoxyphenyl)-2H-1-benzopyran is used as a common starting material....
11/25/2010
20100298542Modified Antibody Constant Region
The present inventors succeeded in improving the antibody constant region to have increased stability under acid conditions, reduced heterogeneity originated from disulfide bonds in the hinge region, reduced heterogeneity originated from the H chain C terminus, and incr...
11/25/2010
201002983553-[4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL]OCTANE- OR HEPTANE-NITRILE AS JAK INHIBITORS
The present invention relates to the Janus kinase (JAK) inhibitors 3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]octanenitrile or 3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]heptanenitrile, as well as its compositions and methods of use, which is use...
11/25/2010
20100298334N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS
The present invention relates to N-(hetero)aryl-pyrrolidine derivatives of Formula I:

which are JAK inhibitors, such as selective JAK1 inhibitors, useful in the treatment of JAK-associated diseases including,...

11/25/2010
20100297684ACTIVATIBLE DYES
Novel, activatable dyes, such as photoactivatable dyes, e.g., oxazine dyes, are described. Some of the dyes are targeting dyes that can, e.g., target biomolecules, such as polypeptides, proteins, or nucleic acids. Upon activation, such as by irradiation, the novel dyes ...
11/25/2010
20100297651Methods of Modulating Vesicular Trafficking
Described are methods of identifying compounds useful for modulating vesicular trafficking, particularly those that disrupt the interactions between ARNO and the V-ATPase a2-subunit. Also described are peptides that modulate vesicular trafficking....
11/25/2010
20100297362METHOD FOR PROCESSING AN OBJECT WITH MINIATURIZED STRUCTURES
A method for processing an object with miniaturized structures is provided. The method includes feeding a reaction gas onto a surface of the object. The method also includes processing the object by directing an energetic beam onto a processing site in a region, which i...
11/25/2010
20100297298MEAL REPLACEMENT BEVERAGE
Meal replacement compositions are described herein. The meal replacement compositions are made using all natural ingredients and includes relatively high amounts of fiber and protein and relatively low amounts of fat. In some instances, a single serving of a meal replac...
11/25/2010
20100296546OPTICAL GUIDE WITH TEMPERATURE SENSING MATRIX
The invention relates to an optical element for guiding and forming a laser beam, and to a method for recording beam parameters, particularly in a laser system, comprising a carrier substrate (40) and a coating (39), which is applied to at least one side o...
11/25/2010
20100296085RAMAN SPECTROMETRY ASSEMBLY
A Raman spectrometry assembly includes a Raman spectrometer having a laser light source and a Raman signal analyzer, an interface module comprising a housing which is connectable to and disconnectable from the spectrometer, and a fiber optic assembly which is connectabl...
11/25/2010
20100294930SCANNING CHARGED PARTICLE BEAMS
Methods are disclosed that include exposing, in direct succession, portions of a surface of a sample to a charged particle beam, the portions of the surface of the sample forming a row in a first direction, the charged particle beam having an average spot size fat the s...
11/25/2010
20100293802Multiple Display Electronic Caliper
In addition to other aspects disclosed, a caliper is configured to measure at least one physical dimension. The caliper has a display configured to present a first representation and a second representation of a measurement provided by the caliper. The format of the fir...
11/25/2010
20100293487Provider-to-provider Consultations
Amongst other things, a computer-implemented method comprises receiving, by one or more computers, data indicating that a first service provider is authorized to engage in a consultation with a second service provider; and receiving, by one or more computers, a request ...
11/18/2010
20100293007Provider Decision Support
A computer-implemented method is described for retrieving, from a data repository that stores decision support information, decision support information pertinent to a consumer of services with whom a service provider is engaged in a real-time consultation; and generati...
11/18/2010
20100292776Bioerodible Endoprosthesis
A stent includes a first tubular element formed of a first bioerodible metal composition and second tubular element formed of a second biodegradable metal composition. The first and second tubular elements are concentrically arranged; and the first and second bioerodibl...
11/18/2010
20100292606Signal Processing in Physiological Noise
The invention relates to systems and methods for estimating a response of at least a part of a physiological system to a first deterministic stimulus signal. The methods include separating a measured first signal into a plurality of segments, each segment representing a...
11/18/2010
20100292374CROSSLINKED POLYMERS AND METHODS OF MAKING THE SAME
Methods are described that include elongating, e.g., by stretching and/or compressing, a polymeric material, such as an ultra-high molecular weight polyolefin (e.g., an ultra-high molecular weight polyethylene (UHMWPE)), below, or above a melt temperature of the polymer...
11/18/2010
20100292238Phenoxymethyl Heterocyclic Compounds
Phenoxymethyl compounds that inhibit at least one phosphodiesterase 10 are described as are pharmaceutical compositions containing such compounds an methods for treating various CNS disorders by administering such compounds to a patient in need thereof....
11/18/2010
20100292052Exercising Apparatus
An apparatus is disclosed for enabling an operator to exercise comprising a frame having a body, a base and a top. A load is positioned on the frame for providing a resistive force. A press is positioned on the frame for displacement by the operator. A linkage joins the...
11/18/2010
20100291577Toll-Like Receptor 9 Modulators
TLR9 is localized to endoplasmic reticulum and upon stimulation with a TLR9 ligand, is transported to a tubular lysosomal compartment as is CpG-DNA. Furthermore, it is shown that TLR9 and CpG-DNA directly bind. It was also found that the MyD88 translocates in response t...
11/18/2010
20100291568METHODS FOR GENETIC ANALYSIS OF DNA TO DETECT SEQUENCE VARIANCES
Methods for determining genotypes and haplotypes of genes are described. Also described are single nucleotide polymorphisms and haplotypes in the ApoE gene and methods of using that information....
11/18/2010
20100291506DEVICE FOR DEBRIDEMENT OF IMPLANTS, AND A METHOD FOR DEBRIDEMENT OF IMPLANTS USING THE DEVICE
A device (10) for debridement of dental implants, which are arranged into bone tissue and are surrounded by gingiva of a jaw of a human being, has a debriding element (11) and an axle (12) with a fastener (13) for attachment to a rotational a...
11/18/2010
20100290520SELECTING TRANSFORMS FOR COMPRESSING VISUAL DATA
Encoding data includes: computing a first set of coefficients based on a plurality of transforms each computed over a different portion of an array of data, and a second set of coefficients based on a transform computed over the array of data; choosing a set of coeffici...
11/18/2010
20100290389Multi-carrier System Selection
In general, a method performed on a personal base station includes transmitting a first pilot signal to a portable access terminal operating in an idle mode in a macrocell that uses a first carrier frequency. The first pilot signal is transmitted in the first carrier fr...
11/18/2010
20100290042Use of Free-space Coupling Between Laser Assembly, Optical Probe Head Assembly, Spectrometer Assembly and/or Other Optical Elements for Portable Optical Applications Such as Raman Instruments
An apparatus includes: a handheld Raman analyzer that can include: a common platform; a laser assembly mounted on a laser platform, the laser platform supported on the common platform by a first material and a second thermally conductive material wherein the first mater...
11/18/2010
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