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Attorney: ELMORE PATENT LAW GROUP, PC


Number of applications: 168
Last date: June 04, 2009

1          
Application No.Application TitleIssue Date
20090143487Enhanced stability of proteins immobilized on nanoparticles
This invention is directed to the application of a previously unknown property of nanomaterials—its ability to enhance protein activity and stability at high temperatures, in organic solvents, and in polymer composites. Nanomaterials such as single-walled carbon nanot...
06/04/2009
20090143403Methods for Administering Aripiprazole
The present invention relates, in part, to the discovery that a pharmaceutical composition comprising aripiprazole and a carrier administered in a bolus injection resulted in an extended release profile similar to that obtained by the injection of a poly lactide-co-glyc...
06/04/2009
20090142299MACROCYCLIC TETRAZOLYL HEPATITIS C SERINE PROTEASE INHIBITORS
The present invention relates to compounds of Formula I, II, III or IV, or pharmaceutically acceptable salts, esters, or prodrugs thereof:

which inhibit serine protease activity, particularly the activity of ...

06/04/2009
20090136538Stable vaccine formulation
An aqueous vaccine composition comprises a protein adsorbed on a solid and one or more stabilising agents, further characterized in that
    • 05/28/2009
20080300348Polymer
The application provides a method of producing a comb polymer comprising the steps of:

(a) Providing:

    • 12/04/2008
20080292587OXIMYL DIPEPTIDE HEPATITIS C PROTEASE INHIBITORS
The present invention discloses compounds of formulae I, or pharmaceutically acceptable salts, esters, or prodrugs thereof:

which inhibit serine protease activity, particularly the activity of hepatitis C vir...

11/27/2008
20080286233PIPERIZINYL MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS
The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof:

which inhibit serine protease activity, particularly the activity of hepatitis C vir...

11/20/2008
20080287449AZA-TRIPEPTIDE HEPATITIS C SERINE PROTEASE INHIBITORS
The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof:

which inhibit serine protease activity, particularly the activity of hepatitis C vir...

11/20/2008
20080281075ASYMMETRIC SYNTHESIS OF PEPTIDES
The present invention provides a process comprising substitution of an acceptor molecule comprising a group —XC(O)— wherein X is O, S or NR8, where R8 is C1-6 alkyl, C6-12 aryl or hydrogen, with a nucleophile, wherein the ...
11/13/2008
20080279821ARYLPIPERIDINYL AND ARYLPYRROLIDINYL MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS
The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof:

which inhibit serine protease activity, particularly the activity of hepatitis C vir...

11/13/2008
20080274080AZA-PEPTIDE MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS
The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof:

which inhibit serine protease activity, particularly the activity of hepatitis C vir...

11/06/2008
20080274082OXIMYL HYDROXYAMIC ANALOGS AS HEPATITIS C VIRUS PROTEASE INHIBITOR
The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof:

which inhibit serine protease activity, particularly the activity of hepatitis C vir...

11/06/2008
20080267917N-FUNCTIONALIZED AMIDES AS HEPATITIS C SERINE PROTEASE INHIBITORS
The present invention relates to functionalized amides of Formula I or Formula II, including pharmaceutically acceptable salts, esters, or prodrugs thereof which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Co...
10/30/2008
20080267918QUINOXALINYL DIPEPTIDE HEPATITIS C VIRUS INHIBITORS
The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof:

which inhibit serine protease activity, particularly the activity of hepatitis C vir...

10/30/2008
20080269228HYDRAZIDE-CONTAINING HEPATITIS C SERINE PROTEASE INHIBITORS
The present invention relates to novel hydrazide-containing compounds of Formula I or Formula II, including pharmaceutically acceptable salts, esters, or prodrugs thereof which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS...
10/30/2008
20080267916CYCLIC P3 TRIPEPTIDE HEPATITIS C SERINE PROTEASE INHIBITORS
The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof:

which inhibit serine protease activity, particularly the activity of hepatitis C vir...

10/30/2008
200802622086-11 Bridged Oxime Erythromycin Derivatives
The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof:

which exhibit antibacterial properties. The present invention further relates to phar...

10/23/2008
20080261986PHARMACEUTICAL FORMULATIONS FOR IONTOPHORETIC DELIVERY OF AN ANTI-FUNGAL DRUG
Pharmaceutical formulations suitable for iontophoresis thereof that provide enhanced iontophoretic delivery of an anti-fungal drug to at least one body surface are described. Also described are pharmaceutical formulations suitable for iontophoresis comprising terbinafin...
10/23/2008
20080257713CATALYTIC REACTORS WITH ACTIVE BOUNDARY LAYER CONTROL
The present invention provides efficient catalytic reactors with active boundary layers in a presence of at least one mechanical disturbance and methods of improving the efficiency of the catalytic reaction with the use of at least one mechanical disturbance. The presen...
10/23/2008
20080253971Particles for inhalation having sustained release properties
The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates...
10/16/2008
20080249339Charged Polymers for Ethanol Dehydration
The systems and methods described herein provide for modified lignins and other compositions that may be useful as entrainers. In embodiments, they may be useful for dehydrating ethanol so that it can be used as an energy source....
10/09/2008
20080248105POLYMORPHIC FORMS OF 6-11 BICYCLIC KETOLIDE DERIVATIVES
The present invention includes EP-13420 polymorphic crystalline forms: Form I, Form II, Form Ia, and monohydrate and amorphous EP-13420 which posses distinct physical properties. In another embodiment of the present invention, there are provided methods of producing the...
10/09/2008
20080242865PROCESSES FOR THE PREPARATION OF HYDROXYLAMINES
The present invention relates generally to novel methods for the synthesis of O-(6-pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine which is an essential reagent in the synthesis of one of the bridged erythromycin derivatives and their respective pharmaceutically acceptab...
10/02/2008
20080241253Formulations for Spray-Drying Large Porous Particles
Particles having a tap density less than about 0.4 g/cm3 are formed by spray drying from a colloidal solution including a carboxylic acid or salt thereof, a phospholipid, a divalent salt and a solvent such as an aqueous-organic solvent. The colloidal solution can also i...
10/02/2008
20080234314FUSED AMINO PYRIDINE AS HSP90 INHIBITORS
The present invention relates to HSP90 inhibitors containing fused amino pyridine core that are useful as inhibitors of HSP90 and their use in the treatment of HSP90 related diseases and disorders such as cancer, an autoimmune disease, or a neurodegenerative disease....
09/25/2008
20080234355DNA METHYL TRANSFERASE INHIBITORS CONTAINING A ZINC BINDING MOIETY
The present invention relates to inhibitors of DNMT containing zinc moiety derivatives that have enhanced or unique properties as inhibitors of DNA methyl transferases (DNMT) and their use in the treatment of DNMT related diseases and disorders such as cancer. The said ...
09/25/2008
20080234297HSP90 Inhibitors Containing a Zinc Binding Moiety
The present invention relates to HSP90 inhibitors and their use in the treatment of cell proliferative diseases such as cancer. The said derivatives may further act as HDAC inhibitors....
09/25/2008
20080234629WATER ELECTROLYSIS TO FACILITATE DRUG DELIVERY BY IONTOPHORESIS
The present invention is an iontophoretic system that electrolyzes water to enhance the iontophoretic delivery of an active agent. The invention provides a cartridge adapted for use in iontophoretic system comprising electronics associated with a working electrode capab...
09/25/2008
20080233614PRODUCTION OF RECOMBINANT COLLAGENASES COLG AND COLH IN ESCHERICHIA COLI
The present invention provides codon-optimized genes designed to help maximize heterologous protein expression level. The present invention provides codon-optimized recombinant colG and colH collagenase sequences....
09/25/2008
20080234332RAF KINASE INHIBITORS CONTAINING A ZINC BINDING MOIETY
The present invention relates to Raf kinase inhibitors containing zinc-binding and their use in the treatment of Raf related diseases and disorders such as cancer. The said derivatives may further act as HDAC inhibitors....
09/25/2008
20080233199Coacervation Process
Methods of forming compositions for the sustained release of water soluble active agents, including biologically active polypeptides and products produced by the process are described. Improved product characteristics and ease of scale-up can be achieved using a novel c...
09/25/2008
20080226730PARTICLES FOR INHALATION HAVING RAPID RELEASE PROPERTIES
The invention generally relates to formulations having particles comprising phospholipids, bioactive agent and excipients and the pulmonary delivery thereof. Dry powder inhaled insulin formulations are disclosed. Improved formulations comprising DPPC, insulin and sodium...
09/18/2008
20080227690PARTICLES FOR INHALATION HAVING RAPID RELEASE PROPERTIES
The invention generally relates to formulations having particles comprising phospholipids, bioactive agent and excipients and the pulmonary delivery thereof. Dry powder inhaled insulin formulations are disclosed. Formulations comprising DPPC, insulin and sodium citrate ...
09/18/2008
20080227804Polymorphic Forms of Naltrexone
This invention relates to the discovery of novel polymorphic forms of naltrexone, including solvates, hydrates, anhydrous and other crystalline forms and combinations thereof. These novel forms of naltrexone impart advantages in pharmaceutical formulations incorporating...
09/18/2008
20080217013TUNABLE SURFACTANTS FOR OIL RECOVERY APPLICATIONS
The systems and methods described herein provide for modified lignins and other compositions that may be useful as surfactants. These compositions have particular utility for energy-related applications. In embodiments, they may be useful for enhanced oil recovery. In e...
09/11/2008
20080221132Multi-Functional Small Molecules as Anti-Proliferative Agents
The present invention relates to the compositions, methods, and applications of a novel approach to selective inhibition of several cellular or molecular targets with a single small molecule. More specifically, the present invention relates to multi-functional small mol...
09/11/2008
20080213319CHEMOREPULSION OF CELLS
The present invention provides compositions and methods of controlling the direction and/or movement of migratory cells. Specifically, the invention is directed to the identification of novel chemorepellents and unimodal fugetaxins, their agonists and antagonists which ...
09/04/2008
20080200543Immunomodulating Agent, Anti-Cancer Agent and Health Food Containing Monoacetyldiacylglycerol Derivatives
The uses of mono acetyl diacyl glycerol derivatives extracted from deer antler for immunomodulating agent disclosed. Medical supplies and health foods containing the same as an effective ingredient also disclosed. Mono acetyl diacyl glycerol derivatives shows significan...
08/21/2008
20080194578QUINAZOLINE BASED EGFR INHIBITORS CONTAINING A ZINC BINDING MOIETY
The present invention relates to quinazoline containing zinc-binding moiety based derivatives that have enhanced and unexpected properties as inhibitors of epidermal growth factor receptor tyrosine kinase (EGFR-TK) and their use in the treatment of EGFR-TK related disea...
08/14/2008
20080187516ACYCLIC OXIMYL HEPATITIS C PROTEASE INHIBITORS
The present invention discloses compounds of formula I or pharmaceutically acceptable salts, esters, or prodrugs thereof:

which inhibit serine protease activity, particularly the activity of hepatitis C virus...

08/07/2008
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