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| Application No. | Application Title | Issue Date |
| 20090143487 | Enhanced stability of proteins immobilized on nanoparticles This invention is directed to the application of a previously unknown property of nanomaterials—its ability to enhance protein activity and stability at high temperatures, in organic solvents, and in polymer composites. Nanomaterials such as single-walled carbon nanot... | 06/04/2009 |
| 20090143403 | Methods for Administering Aripiprazole The present invention relates, in part, to the discovery that a pharmaceutical composition comprising aripiprazole and a carrier administered in a bolus injection resulted in an extended release profile similar to that obtained by the injection of a poly lactide-co-glyc... | 06/04/2009 |
| 20090142299 | MACROCYCLIC TETRAZOLYL HEPATITIS C SERINE PROTEASE INHIBITORS The present invention relates to compounds of Formula I, II, III or IV, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of ... | 06/04/2009 |
| 20090136538 | Stable vaccine formulation An aqueous vaccine composition comprises a protein adsorbed on a solid and one or more stabilising agents, further characterized in that
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| 20080300348 | Polymer The application provides a method of producing a comb polymer comprising the steps of: (a) Providing:
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| 20080292587 | OXIMYL DIPEPTIDE HEPATITIS C PROTEASE INHIBITORS The present invention discloses compounds of formulae I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C vir... | 11/27/2008 |
| 20080286233 | PIPERIZINYL MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis C vir... | 11/20/2008 |
| 20080287449 | AZA-TRIPEPTIDE HEPATITIS C SERINE PROTEASE INHIBITORS The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis C vir... | 11/20/2008 |
| 20080281075 | ASYMMETRIC SYNTHESIS OF PEPTIDES The present invention provides a process comprising substitution of an acceptor molecule comprising a group —XC(O)— wherein X is O, S or NR8, where R8 is C1-6 alkyl, C6-12 aryl or hydrogen, with a nucleophile, wherein the ... | 11/13/2008 |
| 20080279821 | ARYLPIPERIDINYL AND ARYLPYRROLIDINYL MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis C vir... | 11/13/2008 |
| 20080274080 | AZA-PEPTIDE MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis C vir... | 11/06/2008 |
| 20080274082 | OXIMYL HYDROXYAMIC ANALOGS AS HEPATITIS C VIRUS PROTEASE INHIBITOR The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis C vir... | 11/06/2008 |
| 20080267917 | N-FUNCTIONALIZED AMIDES AS HEPATITIS C SERINE PROTEASE INHIBITORS The present invention relates to functionalized amides of Formula I or Formula II, including pharmaceutically acceptable salts, esters, or prodrugs thereof which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Co... | 10/30/2008 |
| 20080267918 | QUINOXALINYL DIPEPTIDE HEPATITIS C VIRUS INHIBITORS The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis C vir... | 10/30/2008 |
| 20080269228 | HYDRAZIDE-CONTAINING HEPATITIS C SERINE PROTEASE INHIBITORS The present invention relates to novel hydrazide-containing compounds of Formula I or Formula II, including pharmaceutically acceptable salts, esters, or prodrugs thereof which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS... | 10/30/2008 |
| 20080267916 | CYCLIC P3 TRIPEPTIDE HEPATITIS C SERINE PROTEASE INHIBITORS The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis C vir... | 10/30/2008 |
| 20080262208 | 6-11 Bridged Oxime Erythromycin Derivatives The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to phar... | 10/23/2008 |
| 20080261986 | PHARMACEUTICAL FORMULATIONS FOR IONTOPHORETIC DELIVERY OF AN ANTI-FUNGAL DRUG Pharmaceutical formulations suitable for iontophoresis thereof that provide enhanced iontophoretic delivery of an anti-fungal drug to at least one body surface are described. Also described are pharmaceutical formulations suitable for iontophoresis comprising terbinafin... | 10/23/2008 |
| 20080257713 | CATALYTIC REACTORS WITH ACTIVE BOUNDARY LAYER CONTROL The present invention provides efficient catalytic reactors with active boundary layers in a presence of at least one mechanical disturbance and methods of improving the efficiency of the catalytic reaction with the use of at least one mechanical disturbance. The presen... | 10/23/2008 |
| 20080253971 | Particles for inhalation having sustained release properties The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates... | 10/16/2008 |
| 20080249339 | Charged Polymers for Ethanol Dehydration The systems and methods described herein provide for modified lignins and other compositions that may be useful as entrainers. In embodiments, they may be useful for dehydrating ethanol so that it can be used as an energy source.... | 10/09/2008 |
| 20080248105 | POLYMORPHIC FORMS OF 6-11 BICYCLIC KETOLIDE DERIVATIVES The present invention includes EP-13420 polymorphic crystalline forms: Form I, Form II, Form Ia, and monohydrate and amorphous EP-13420 which posses distinct physical properties. In another embodiment of the present invention, there are provided methods of producing the... | 10/09/2008 |
| 20080242865 | PROCESSES FOR THE PREPARATION OF HYDROXYLAMINES The present invention relates generally to novel methods for the synthesis of O-(6-pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine which is an essential reagent in the synthesis of one of the bridged erythromycin derivatives and their respective pharmaceutically acceptab... | 10/02/2008 |
| 20080241253 | Formulations for Spray-Drying Large Porous Particles Particles having a tap density less than about 0.4 g/cm3 are formed by spray drying from a colloidal solution including a carboxylic acid or salt thereof, a phospholipid, a divalent salt and a solvent such as an aqueous-organic solvent. The colloidal solution can also i... | 10/02/2008 |
| 20080234314 | FUSED AMINO PYRIDINE AS HSP90 INHIBITORS The present invention relates to HSP90 inhibitors containing fused amino pyridine core that are useful as inhibitors of HSP90 and their use in the treatment of HSP90 related diseases and disorders such as cancer, an autoimmune disease, or a neurodegenerative disease.... | 09/25/2008 |
| 20080234355 | DNA METHYL TRANSFERASE INHIBITORS CONTAINING A ZINC BINDING MOIETY The present invention relates to inhibitors of DNMT containing zinc moiety derivatives that have enhanced or unique properties as inhibitors of DNA methyl transferases (DNMT) and their use in the treatment of DNMT related diseases and disorders such as cancer. The said ... | 09/25/2008 |
| 20080234297 | HSP90 Inhibitors Containing a Zinc Binding Moiety The present invention relates to HSP90 inhibitors and their use in the treatment of cell proliferative diseases such as cancer. The said derivatives may further act as HDAC inhibitors.... | 09/25/2008 |
| 20080234629 | WATER ELECTROLYSIS TO FACILITATE DRUG DELIVERY BY IONTOPHORESIS The present invention is an iontophoretic system that electrolyzes water to enhance the iontophoretic delivery of an active agent. The invention provides a cartridge adapted for use in iontophoretic system comprising electronics associated with a working electrode capab... | 09/25/2008 |
| 20080233614 | PRODUCTION OF RECOMBINANT COLLAGENASES COLG AND COLH IN ESCHERICHIA COLI The present invention provides codon-optimized genes designed to help maximize heterologous protein expression level. The present invention provides codon-optimized recombinant colG and colH collagenase sequences.... | 09/25/2008 |
| 20080234332 | RAF KINASE INHIBITORS CONTAINING A ZINC BINDING MOIETY The present invention relates to Raf kinase inhibitors containing zinc-binding and their use in the treatment of Raf related diseases and disorders such as cancer. The said derivatives may further act as HDAC inhibitors.... | 09/25/2008 |
| 20080233199 | Coacervation Process Methods of forming compositions for the sustained release of water soluble active agents, including biologically active polypeptides and products produced by the process are described. Improved product characteristics and ease of scale-up can be achieved using a novel c... | 09/25/2008 |
| 20080226730 | PARTICLES FOR INHALATION HAVING RAPID RELEASE PROPERTIES The invention generally relates to formulations having particles comprising phospholipids, bioactive agent and excipients and the pulmonary delivery thereof. Dry powder inhaled insulin formulations are disclosed. Improved formulations comprising DPPC, insulin and sodium... | 09/18/2008 |
| 20080227690 | PARTICLES FOR INHALATION HAVING RAPID RELEASE PROPERTIES The invention generally relates to formulations having particles comprising phospholipids, bioactive agent and excipients and the pulmonary delivery thereof. Dry powder inhaled insulin formulations are disclosed. Formulations comprising DPPC, insulin and sodium citrate ... | 09/18/2008 |
| 20080227804 | Polymorphic Forms of Naltrexone This invention relates to the discovery of novel polymorphic forms of naltrexone, including solvates, hydrates, anhydrous and other crystalline forms and combinations thereof. These novel forms of naltrexone impart advantages in pharmaceutical formulations incorporating... | 09/18/2008 |
| 20080217013 | TUNABLE SURFACTANTS FOR OIL RECOVERY APPLICATIONS The systems and methods described herein provide for modified lignins and other compositions that may be useful as surfactants. These compositions have particular utility for energy-related applications. In embodiments, they may be useful for enhanced oil recovery. In e... | 09/11/2008 |
| 20080221132 | Multi-Functional Small Molecules as Anti-Proliferative Agents The present invention relates to the compositions, methods, and applications of a novel approach to selective inhibition of several cellular or molecular targets with a single small molecule. More specifically, the present invention relates to multi-functional small mol... | 09/11/2008 |
| 20080213319 | CHEMOREPULSION OF CELLS The present invention provides compositions and methods of controlling the direction and/or movement of migratory cells. Specifically, the invention is directed to the identification of novel chemorepellents and unimodal fugetaxins, their agonists and antagonists which ... | 09/04/2008 |
| 20080200543 | Immunomodulating Agent, Anti-Cancer Agent and Health Food Containing Monoacetyldiacylglycerol Derivatives The uses of mono acetyl diacyl glycerol derivatives extracted from deer antler for immunomodulating agent disclosed. Medical supplies and health foods containing the same as an effective ingredient also disclosed. Mono acetyl diacyl glycerol derivatives shows significan... | 08/21/2008 |
| 20080194578 | QUINAZOLINE BASED EGFR INHIBITORS CONTAINING A ZINC BINDING MOIETY The present invention relates to quinazoline containing zinc-binding moiety based derivatives that have enhanced and unexpected properties as inhibitors of epidermal growth factor receptor tyrosine kinase (EGFR-TK) and their use in the treatment of EGFR-TK related disea... | 08/14/2008 |
| 20080187516 | ACYCLIC OXIMYL HEPATITIS C PROTEASE INHIBITORS The present invention discloses compounds of formula I or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus... | 08/07/2008 |