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| Application No. | Application Title | Issue Date |
| 20110036411 | PINCHING CHANNELS FOR FRACTIONATION OF FRAGMENTED SAMPLES The invention provides a device, system, and method for isolating one or more sample components of a sample material following separation of the sample material into a plurality of sample components. The device includes first and second pinching channels, a separation c... | 02/17/2011 |
| 20110024296 | Analyte Injection System This invention provides methods and systems for injection of analytes into a separation channel for resolution and detection. Samples can be preconditioned and concentrated by isotachophoresis (ITP) before the injection is triggered by a detected voltage event. Separati... | 02/03/2011 |
| 20100233030 | Western Blot by Incorporating an Affinity Purification Zone An upstream affinity purification region is used to bind one or more component of interest in a mixture of components prior to separating the mixture of components. Detection of the separated components and a released component of interest provide identification of the ... | 09/16/2010 |
| 20100129896 | SYSTEM FOR DIFFERENTIATING THE LENGTHS OF NUCLEIC ACIDS OF INTEREST IN A SAMPLE Systems for differentiating the lengths of nucleic acids of interest in a sample are provided. The system includes a microfluidic device, a detector, and a software system. The microfluidic device includes an amplification microchannel or microchamber containing a react... | 05/27/2010 |
| 20080131904 | Sequencing by Incorporation Nucleotides and nucleotide analogs are used in various sequencing by incorporation/sequencing by synthesis methods. Nucleotide analogs comprising 3′-blocking groups are used to provide reversible chain-termination for sequencing by synthesis. Typical blocking groups i... | 06/05/2008 |
| 20080090244 | METHODS OF DETECTING LOW COPY NUCLEIC ACIDS Methods are provided for detecting low copy nucleic acids of interest in a sample. In one method, a sample comprising a nucleic acid of interest is aliquotted into a plurality of reaction mixtures, at least two of which are single-copy reaction mixtures. The reaction mi... | 04/17/2008 |
| 20080085521 | SINGLE MOLECULE AMPLIFICATON AND DETECTION OF DNA LENGTH Methods and systems for performing single molecule amplification for detection, quantification and statistical analysis of nucleic acids are provided. Methods and systems are provided for determining and quantifying lengths of nucleic acids of interest. ... | 04/10/2008 |
| 20080009075 | Open-Field Serial to Parallel Converter Microfluidic devices and systems for affecting the serial to parallel conversion of materials introduced into the device or system. Material or materials to be converted from a serial orientation, e.g., a single channel, into a parallel orientation, e.g., multiple chann... | 01/10/2008 |
| 20080006533 | Prevention of Precipitate Blockage in Microfluidic Channels The present invention provides novel microfluidic devices and methods for preventing/ameliorating formation of precipitate blockages in microfluidic devices. In particular, the devices and methods of the invention utilize microchannels of specific cross-sectional config... | 01/10/2008 |
| 20080004816 | Software for the display of chromatographic separation data Techniques for displaying chromatographic data using a graphical user interface are provided. Chromatographic separation data that represent a series of measurements for multiple samples at a detection location over time can be displayed on a display device as a series ... | 01/03/2008 |
| 20080003690 | Prevention of Precipitate Blockage in Microfluidic Channels The present invention provides novel microfluidic devices and methods for preventing/ameliorating formation of precipitate blockages in microfluidic devices. In particular, the devices and methods of the invention utilize microchannels of specific cross-sectional config... | 01/03/2008 |
| 20080000774 | Method for modifying the concentration of reactants in a microfluidic device A method of carrying out a chemical reaction on a microfluidic device in which a first reactant at a first concentration is delivered into a reaction channel; within the reaction channel the concentration of the first reactant is changed from the first concentration to ... | 01/03/2008 |
| 20070261479 | Methods and Systems for Monitoring Molecular Interactions The present invention relates to novel methods and systems for determining the interaction of molecules using the phenomenon of Taylor-Aris dispersion present in fluid flow in conduits. The method involves relating a change in dispersion of molecules to their level of i... | 11/15/2007 |
| 20070246076 | Methods for Prevention of Surface Adsorption of Biological Materials to Capillary Walls in Microchannels Methods for reducing surface adsorption of biological materials to the walls of microfluidic conduits in microscale devices are provided. In an example of the methods, one or more colloidal-size particles, such as colloidal silica particles, are flowed in a fluid within... | 10/25/2007 |
| 20070202015 | Microfluidic device with controlled substrate conductivity A method to achieve controlled conductivity in microfluidic devices, and a device formed thereby. The method comprises forming a microchannel or a well in an insulating material, and ion implanting at least one region of the insulating material at or adjacent the microc... | 08/30/2007 |
| 20070199821 | AUTOMATED TWO-DIMENSIONAL GEL ELECTROPHORESIS An automated, two-dimensional gel electrophoresis technique includes methods and apparatuses for performing a functionally equivalent, automated two-dimensional gel electrophoresis process in an integrated, robotic apparatus. ... | 08/30/2007 |
| 20070196238 | Integrated dissolution processing and sample transfer system The invention provides a system and method for dissolution testing. The system includes multiple dissolution vessels and a dose carrier positioned above the dissolution vessels. The dose carrier holds multiple removable carousels that receive individual doses for dissol... | 08/23/2007 |
| 20070184463 | Microfluidic device for purifying a biological component using magnetic beads A method of purifying a biological component found in a biological sample by extracting the biological component from the biological sample. The method is performed using a microfluidic device having at least one well for receiving the biological sample and at least one... | 08/09/2007 |
| 20070177147 | Microfluidic devices for electrophoretic analysis of materials The present invention provides a microfluidic system for electrophoretic analysis of materials in the fields of chemistry, biochemistry, biotechnology, molecular biology and numerous other fields. Light absorbance signals are received by a photodetector from periodicall... | 08/02/2007 |
| 20070161071 | Assay methods and systems Methods, systems, kits for carrying out a wide variety of different assays that comprise providing a first reagent mixture which comprises a first reagent having a fluorescent label. A second reagent is introduced into the first reagent mixture to produce a second reage... | 07/12/2007 |
| 20070157973 | Multi-reservoir pressure control system Improved microfluidic devices, systems, and methods allow selective transportation of fluids within microfluidic channels of a microfluidic network by applying, controlling, and varying pressures at a plurality of reservoirs. Modeling the microfluidic network as a serie... | 07/12/2007 |
| 20070154895 | Multi-assay microfluidic chips This invention provides systems and methods of running multiple different analyses on a microfluidic device. Results from such analyses can be useful in high throughput screening of samples or correlation of multiple as ... | 07/05/2007 |
| 20070154358 | Methods and apparatus for minimizing evaporation of sample materials from multiwell plates Methods and devices for reducing evaporation of sample materials from the wells of multiwell plates are disclosed which find particular utility when the plates are placed in a stacked configuration. An example of the methods includes providing at least a first multiwell... | 07/05/2007 |
| 20070151852 | Mixed mode microfluidic systems Methods and systems that employ hybrid fluid flow profiles for optimized movement of materials through channel networks. These systems employ hybrid pressure-based and electrokinetic based flow systems for moving materials through interconnected channel networks while m... | 07/05/2007 |
| 20070119711 | High throughput separations based analysis systems and methods Methods and systems for use in separating sample materials into different fractions employing pressure-based fluid flow for simultaneous loading of a sample and a reagent into a sample loading channel of a microfluidic device. The sample is loaded from an external sourc... | 05/31/2007 |
| 20070099200 | High throughput mobility shift The present invention provides novel microfluidic devices and methods for performing pulsed field mobility shift assays in microfluidic devices. In particular the devices and methods of the invention utilize differences between electrophoretic mobilities (e.g., as betwe... | 05/03/2007 |
| 20070080063 | Microfluidic sample delivery devices, systems, and methods An electrode alignment apparatus may be used with a microfluidic device for accurate and repeatable alignment of electrode pins with reservoirs on the microfluidic device. The apparatus includes a base unit and an electrode block assembly that are moveable with respect ... | 04/12/2007 |
| 20070053799 | Microfluidic device with controlled substrate conductivity A method to achieve controlled conductivity in microfluidic devices, and a device formed thereby. The method comprises forming a microchannel or a well in an insulating material, and ion implanting at least one region of the insulating material at or adjacent the microc... | 03/08/2007 |
| 20070026421 | Method and apparatus for generating thermal melting curves in a microfluidic device The present invention provides novel methods and devices that employ microfluidic technology to generate molecular melt curves. In particular, the devices and methods in accordance with the invention are useful in providing for the analysis of PCR amplification products... | 02/01/2007 |
| 20060275817 | Sequencing by Incorporation Nucleotides and nucleotide analogs are used in various sequencing by incorporation/sequencing by synthesis methods. Nucleotide analogs comprising 3′-blocking groups are used to provide reversible chain-termination for sequencing by synthesis. Typical blocking groups i... | 12/07/2006 |
| 20060263903 | Method for determining diffusivity and molecular weight in a microfluidic device The present invention is directed to a method for determining the molecular weight and diffusivity of a sample solute by providing a plus shaped microchannel network on a microfluidic chip, having at least four microchannels intersecting at a cross point; flowing a samp... | 11/23/2006 |
| 20060261033 | Alignment of multicomponent microfabricated structures Multilayered microfluidic devices include structures that are used to align elements that make up the devices. Such elements include additional substrate layers, external sampling elements, and the like. In one embodiment, a multilayered microfluidic device includes fir... | 11/23/2006 |
| 20060258019 | Methods and Devices for High Throughput Fluid Delivery Methods and devices for delivering fluids into microfluidic device body structures are described. The methods and devices include the use of fluid manifolds that are integrated or interchangeable with device body structures. Methods of fabricating manifolds are also pro... | 11/16/2006 |
| 20060246493 | Method and apparatus for use in temperature controlled processing of microfluidic samples Embodiments of the invention comprise microfluidic devices, instrumentation interfacing with those devices, processes for fabricating that device, and methods of employing that device to perform PCR amplification. Embodiments of the invention are also compatible with qu... | 11/02/2006 |
| 20060246533 | Method and apparatus for performing peptide digestion on a microfluidic device The invention provides methods and apparatuses that allow a protein sample to undergo reduction, alkylation, and digestion in a continuous flow process carried out within a microfluidic device. Methods and apparatuses in accordance with the invention can be employed as ... | 11/02/2006 |
| 20060227325 | Compact optical detection system for a microfluidic device An optical detection system for a microfluidic device and a dry-focus microfluidic device compatible with the compact optical detection system are described. The system includes an LED; means for collimating light emitted by the LED; an aspherical, fused-silica objectiv... | 10/12/2006 |
| 20060219557 | Methods and systems for reducing background signal in assays Methods and systems of monitoring reactions, e.g., assays, that filter out background signal from substrate, in detecting the product. The methods and systems controllably move detectable reaction product from a first location to a second location at which the product i... | 10/05/2006 |
| 20060211055 | Capture and release assay system and method A method for detecting one or more components of interest in a fluid-borne sample in a microchannel of a microfluidic device includes flowing the fluid-borne sample, in which the one or more components of interest are bound to a first labeled component binding moiety to... | 09/21/2006 |
| 20060211134 | Priming module for microfluidic chips Methods and apparatuses for priming sample substrates such as DNA sipper chips are disclosed. According to one aspect of the present invention, a priming system that is suitable for priming a substrate which has a plurality of wells and at least one channel includes a b... | 09/21/2006 |
| 20060188979 | Method and apparatus for improved temperature control in microfluidic devices A microfluidic system and method for employing it to control fluid temperatures of fluids residing within microchannels of a microfluidic device. The microfluidic device is provided with a top layer and a bottom layer and microchannels configured therebetween. Temperatu... | 08/24/2006 |
