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...Chester Carlson was a patent agent who tired of having to make multiple copies of patent applications using the only duplication method available at the time: carbon paper. In 1959 he came up with a new copying system and took it to IBM for evaluation. The "experts" at IBM determined potential sales to be only 5,000 units because people wouldn't want to use a bulky machine when they had carbon paper. Carlson's invention was the xerography process, the company founded on the system is Xerox.

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Attorney: BARNES & THORNBURG LLP (Roche)


Number of applications: 20
Last date: November 11, 2010

Application No.Application TitleIssue Date
20100283995SYSTEM AND METHOD FOR THE AUTOMATED ANALYSIS OF SAMPLES
The present invention pertains to a system for the automated analysis of samples, comprising: a first optical device including at least one receptacle for receiving at least one of said samples and a receptacle-associated optical unit including at least one receptacle-a...
11/11/2010
20100268118SYSTEM FOR REMOVAL AND INFUSION OF BODY FLUID, AND METHOD FOR ITS OPERATION
The invention relates to a system for the extraction and infusion of a body fluid, in particular a system for the extraction and infusion of blood, having a fluid distribution device with an outer structural element at which several connection ports are formed and an in...
10/21/2010
20090305316Thermostable mutants of pyrroloquinoline quinone dependent glucose dehydrogenase
The present invention relates to a mutant protein of PQQ-dependent s-GDH characterized in that in at least one of the positions 122 and 124 the amino acid lysine is present, wherein these positions correspond to the amino acid positions known from the A. calcoaceticu...
12/10/2009
20090304547PORTABLE ANALYTICAL DEVICE
A portable analytical device is provided for analysis of a component of a body fluid. A measuring facility within the device may carry out the analysis on a test element inserted therein. The test element may contain a reagent that reacts with a liquid sample of the bod...
12/10/2009
20090222247SYSTEM FOR DETERMINING BASAL RATE PROFILES
A system and method are provided for generating a plurality of basal rate models that together model delivery of a corresponding plurality of basal rates of a diabetes treatment drug to a patient over a period of time. Information may be collected from a plurality of pa...
09/03/2009
20090220987Use of Intramolecularly, Covalently Cross-Linked Proteins As Binding Partners In Immunoassays
The invention concerns the use of intramolecularly, covalently cross-linked proteins and covalently cross-linked reverse transcriptase from HIV as immunological binding partners in immunoassays. It also concerns immunological test procedures for detecting an analyte in ...
09/03/2009
20090148874MUTANTS OF PYRROLOQUINOLINE QUINONE DEPENDENT SOLUBLE GLUCOSE DEHYDROGENASE
A mutant of PQQ-dependent soluble glucose dehydrogenase (s-GDH; EC 1.1.5.2) is provided with improved specificity for glucose as compared to maltose, having a substitution of threonine at position 348 by either glycine, alamine or serine, wherein said mutant additionall...
06/11/2009
20090110603Method For Detecting And Compensating An Underdosage Of Test Strips
The invention concerns a method for detecting an underdosage of an analytical test element and optionally for compensating the underdosage. The invention also concerns an analytical system and a test element which are suitable for detecting an underdosage.

04/30/2009

20090044604Portable Measuring Facility for Determining A Medically Significant Analyte Concentration
A portable measuring facility for determining the concentration of an analyte in a living body may comprise a sensor configured to determine the concentration of an analyte in a liquid, and a liquid conveying facility. The liquid conveying facility may have a liquid lin...
02/19/2009
20090041624FLUIDIC STRUCTURE AND METHOD FOR PRODUCTION OF A FLUID STRUCTURE
A fluidic structure and a method for production of a fluidic structure are provided. The method may comprise, in order, introducing at least one externally accessible opening into at least one base substrate of the fluidic structure, partially introducing at least one s...
02/12/2009
20080293082INSTRUMENT
A method and apparatus for performing a first measurement on a biological fluid or control, which first measurement varies with both the concentration of a first component and at least one of the presence and concentration of a second component. The method and apparatus...
11/27/2008
20080275326SENSOR FOR MONITORING A CONDITION OF A PATIENT
A sensor may include a substrate having a sensing portion defining a sensor thereon and a circuit mounting portion defining at least one electrically conductive pad that is electrically connected to the sensor. The sensor may be configured to produce a signal indicative...
11/06/2008
20080214910SYSTEM AND METHOD FOR OPERATING AN ELECTROCHEMICAL ANALYTE SENSOR
A method of operating an electrochemical analyte sensor having one or more electrodes may comprise applying a time-varying input signal to at least one of the one or more electrodes, monitoring a time-varying output signal produced by the sensor in response to applicati...
09/04/2008
20080138795Use of Intramolecularly, Covalently Cross-Linked Proteins As Binding Partners In Immunoassays
The invention concerns the use of intramolecularly, covalently cross-linked proteins and covalently cross-linked reverse transcriptase from HIV as immunological binding partners in immunoassays. It also concerns immunological test procedures for detecting an analyte in ...
06/12/2008
20080113450METHOD AND DEVICE FOR MIXING SAMPLES ON A SUPPORT
A method for detecting analytes in a liquid is provided in which the liquid is subjected to a mixing treatment on an area of a support which has in particular immobilized reactants, wherein in the mixing treatment the liquid is impinged upon by a stream of gas that swee...
05/15/2008
20080108094DETERMINATION OF APOPTOTIC PRODUCTS IN TUMOR PATIENTS UNDERGOING THERAPY
The present invention concerns a method for the determination of apoptotic products in samples taken from patients in which apoptosis is induced as a result of disease or therapy, which is characterized in that the concentration of the apoptotic products in samples take...
05/08/2008
20080064084Method For Producing Recombinant Trypsin
The present invention concerns a method for producing recombinant trypsin from porcine pancreas in Pichia pastoris which is soluble and secreted into the culture medium, whereby expression at pH 3.0-4.0 substantially prevents activation of trypsinogen to β-tryps...
03/13/2008
20080058628INSULIN BOLUS RECOMMENDATION SYSTEM
A system for recommending insulin bolus quantities to an insulin user includes a display unit and memory unit coupled to a control circuit with a user blood glucose target stored in the memory unit. The control circuit is programmed to receive the user's current blood g...
03/06/2008
20070281293Use of intramolecularly, covalently cross-linked proteins as binding partners in immunoassays
The invention concerns the use of intramolecularly, covalently cross-linked proteins and covalently cross-linked reverse transcriptase from HIV as immunological binding partners in immunoassays. It also concerns immunological test procedures for detecting an analyte in ...
12/06/2007
20070243566Genetically Engineered Pyrroloquinoline Quinone Dependent Glucose Dehydrogenase Comprising an Amino Acid Insertion
The present invention relates to improved variants of soluble pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenases (s-GDH) comprising an amino acid insertion between positions 428 and 429 as corresponding to the amino acid sequence known from Acinetobacter...
10/18/2007
 
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