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| Number | Title | Issue Date |
| 8163751 | Acylated indanyl amines and their use as pharmaceuticals The present invention relates to acylated indanyl amines according to the general formula (I) wherein R1-R4 have the meanings given in the description, A is CH2, CHO... | 04/24/2012 |
| 8163741 | Use of aryl-substituted polycyclic amines as medicaments The invention relates to therapeutic use of aryl-substituted polycyclic amines of the formula I, especially bicyclic amines, and to the physiologically tolerated salts and physiologically functional derivatives thereof; whe... | 04/24/2012 |
| 8119375 | Method for the production of ramipril An improved method for preparing ramipril is disclosed, and also an intermediate for use in the method. ... | 02/21/2012 |
| 8106213 | Sulfur substituted sulfonylaminocarboxylic acid N-arylamides, their preparation, their use and pharmaceutical preparations comprising them The present invention relates to compounds of the formula I wherein A1, A2, R1, R2, R3, X and n are as defined in the claims, which are valuable pharmaceutically active... | 01/31/2012 |
| 8106099 | Combination of phenylcarboxamides with blockers of the IKr channel and their use for the treatment of atrial arrhythmias The invention relates to the combination of one or more IKr channel blockers and of one or more Kv1.5 blockers, in particular phenyl-carboxamides of the formula Ia or Ib or pharmaceutically tolerable salts thereo... | 01/31/2012 |
| 8106023 | 1,4-benzothiepin-1, 1-dioxide derivatives with improved properties method for producing the same, drugs containing said compounds and the use thereof This invention relates to Novel 1,4-benzothiepin-1,1-dioxide derivatives with improved properties, method for producing the same, drugs containing said compounds and use thereof. ... | 01/31/2012 |
| 8088799 | Pharmaceutical composition comprising a sodium hydrogen exchange inhibitor and an angiotensin converting enzyme inhibitor This invention is directed to a pharmaceutical composition comprising the sodium-hydrogen exchanger (NHE) inhibitor cariporide and an angiotensin converting enzyme (ACE) inhibitor which exhibits unexpectedly efficacious properties for preventing heart failure and ot... | 01/03/2012 |
| 8067614 | N-substituted (benzoimidazol-2-yl)phenylamines, processes for their preparation, their use as a medicament or diagnostic aid, and a medicament comprising them This invention is directed to the compound of formula (I), compositions containing said compounds to inhibit the sodium-proton exchanger of subtype 3 (NHE3) which are useful in the prevention or treatment of various disorders in a patient suffering from a disease st... | 11/29/2011 |
| 8057441 | Cap for drug delivery devices This invention relates to a cap for drug delivery devices, in particular of the injector-type comprising a needle and a needle cover, wherein said cap is suitable as a needle safety tool, by comprising a needle cover retaining portion. In particular, the present inv... | 11/15/2011 |
| 8053590 | Method for producing enantiomeric form of 2,3-diaminopropionic acid derivatives The invention relates to a method for producing enantiomers form of 2,3-diaminopropionic acid derivatives of formula (I) by asymmetric hydrogenation from compounds of formula (II). ... | 11/08/2011 |
| 8048854 | Amidated insulin glargine The invention relates to insulin glargine which is modified by amidation, especially Gly(A21), Arg(B31), Arg amide (B32) human insulin (insulin glargine amide). ... | 11/01/2011 |
| 8026069 | Process for identification of compounds for modulating the activity of sodium/calcium exchange transporter The invention refers to a cell free assay for determining the activity of a Na+/Ca2+ exchanger (NCX) protein by means of a cell free electrophysiological sensor chip, a kit of parts comprising the sensor chip with a NCX protein as well as the m... | 09/27/2011 |
| 8017350 | Glimepiride- and insulin-induced glycosylphosphatidylinositol-specific phospholipase C regulation The present invention relates to a method for identification of a chemical compound which modulates the activity of mammalian GPI-PLC wherein a] a mammalian cell is incubated with glimepiride; b] hcDIGs of the cells of a] are prepared; c] the hc... | 09/13/2011 |
| 8008352 | Pentafluorosulfanylbenzoylguanidines, processes for their preparation, their use as medicaments or diagnostic aids, and medicaments comprising them Pentafluorosulfanylbenzoylguanidines, of the formula I and II in which R1 to R4 have the meanings stated in the claims, are suitable as antiarrhythmic medicaments with a cardioprotective component for the prophylaxis of inf... | 08/30/2011 |
| 7994168 | Hexahydro-pyrazino[1,2-A]pyrimidine-4,7-dione derivatives substituted with amino acids The invention relates to substituted hexahydropyrazino[1,2-a]pyrimidine-4,7-dione derivatives substituted with amino acids, and to the physiologically tolerated salts thereof, processes for their preparation and their use as medicaments. ... | 08/09/2011 |
| 7993301 | Drive mechanisms suitable for use in drug delivery devices The present invention relates to drive mechanisms suitable for use in drug delivery devices, in particular pen-type injectors, wherein a number of pre-set doses of medicinal product can be administered. In particular, the present invention relates to such drug deliv... | 08/09/2011 |
| 7982045 | 2′-substituted 1,1′-biphenyl-2-carboxamides, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them Compounds of the formula I, in which R(1), R(2), R(3), R(4), R(5), R(6), R(7), R(8), R(30) and R(31) have the meanings indicated in the claims, are very particularly suitable as novel and antiarrythmic active compounds, in ... | 07/19/2011 |
| 7968550 | Substituted N-aryl heterocycles, process for their preparation and their use as medicaments The invention relates to substituted N-aryl heterocycles and to the physiologically tolerated salts and physiologically functional derivatives thereof. Compounds of the formula I in which the radicals have the stated... | 06/28/2011 |
| 7956085 | 1,4-benzothiepine 1,1-dioxide derivatives substituted by benzyl radicals, method for their preparation, pharmaceuticals comprising these compounds, and the use thereof This invention relates to Novel 1,4-benzothiepine 1,1-dioxide derivatives substituted by benzyl radicals, method for their preparation, pharmaceuticals comprising these compounds, and the use thereof. ... | 06/07/2011 |
| 7947706 | Substituted pyrrolopyridines, compositions containing them, manufacturing process therefor and use thereof The invention relates to compounds of formula (I): wherein Ra, R1, Ar, L, A, W, Y, and Z are as defined in the disclosure; to compositions containing them; and to the preparation and use thereof, in particular as anticancer... | 05/24/2011 |
| 7939293 | Method for producing carboxy-terminal-amidified peptides The invention relates to the production of carboxy-terminal (C-terminal) amidified peptides with C-terminal amidified lysin, in particular with the biological activity of GLP-1, the chemical and/or biotechnological precursors and intermediate products thereof. The i... | 05/10/2011 |
| 7932416 | Ortho-substituted pentafluorosulfanylbenzenes, process for their preparation and their use as valuable synthetic intermediates Pentafluorosulfanyl-benzenes according to Formula (I): a process for their preparation and their use as valuable synthetic intermediates for preparing, for example, medicaments, diagnostic aids, liquid crystals, polymers, p... | 04/26/2011 |
| 7923468 | 1,4-benzothiepin-1,1-dioxide derivatives which are substituted with cyclohexyl groups, method for producing the same, drugs containing said compounds and use thereof This invention relates to Novel 1,4-benzothiepin-1,1-dioxide derivatives which are substituted with cyclohexyl groups, method for producing the same, drugs containing said compounds and use thereof. ... | 04/12/2011 |
| 7919628 | CXCR2 inhibitors The invention relates to compounds of the formula I: in which R1, R2, X, A, B, D and Y1 to Y4 have the meanings indicated in the claims, and/or a pharmaceutically acceptable salt and/or a prodrug thereof. Because of their p... | 04/05/2011 |
| 7910606 | Pyrazole-derivatives as factor Xa inhibitors The present invention is directed to a compound of formula I, in which R0; R1; R2; R3; R4; Q; V, G and M have the meanings indicated below. The compound of formula I is... | 03/22/2011 |
| 7897346 | Polyamide nucleic acid derivatives and agents, and processes for preparing them The present invention relates to PNA derivatives which carry, at the C terminus, or at both the C and N termini of the PNA backbone, one or more phosphoryl radicals. The phosphoryl radicals carry, where appropriate, one or more labeling groups, groups for crosslinki... | 03/01/2011 |
| 7892778 | Method of screening for gamma-secretase activity The present invention relates to an improved process for determining γ-secretase activity and for detecting γ-secretase, a subunit protein of γ-secretase, or a γ-secretase-like proteinase. In particular, the present invention relates to processes for the identif... | 02/22/2011 |
| 7892744 | Analysis and use of PAR1 polymorphisms for evaluating the risk of cardiovascular disorders The invention relates to polynucleotide sequences comprising genetic variations of the PAR1 gene at positions 3090 and/or 3329. The occurrence of these variants in humans correlates with increased occurrence of particular cardiovascular disorders. The invention furt... | 02/22/2011 |
| 7888020 | Association of EDG5 polymorphism V286A with type II diabetes mellitus and venous thrombosis/pulmonary embolism and the use thereof The present invention relates to a method of identifying an increase in risk for type II Diabetes mellitus, venous thrombosis, or pulmonary embolism in a subject, wherein the presence of an amino acid exchange at position 286 from valine (Val) to alanine (Ala) in th... | 02/15/2011 |
| 7879864 | Substituted 8-aminoalkoxy-xanthine compounds and compositions useful in the treatment of hyperlipidemia and diabetes Compounds for the treatment of elevated blood glucose levels and the physiological and metabolic disorders arising therefrom are disclosed which are inhibitors of the enzyme dipeptidyl peptidase IV (DDP-IV) and comprise novel substituted bicyclic 8-pyrrolidinoxanthi... | 02/01/2011 |
| 7879563 | Method of screening for a carnitine transporter agonist or antagonist and its uses The present invention is directed to a method of screening for a carnitine transporter agonist or for a carnitine transporter antagonist, to a kit for carrying out the method of screening for a carnitine transporter agonist or for a carnitine transporter antagonist,... | 02/01/2011 |
| 7872034 | Arylcycloalkyl-substituted alkanoic acid derivatives, processes for their preparation and their use as pharmaceuticals The invention relates to arylcycloalkyl-substituted alkanoic acid derivatives and to their physiologically acceptable salts and physiologically functional derivatives. What is described are compounds of the formula I, | 01/18/2011 |
| 7872032 | 1, 3, 4-oxadiazol-2-ones as PPAR delta modulators and their use thereof The present invention is directed to 1,3,4-oxadiazalones, compounds of formula I and their pharmaceutically acceptable salts stereoisomers, tautomers, or solvates thereof. Novel compounds include those of formula I, in which radicals are as defined herein. | 01/18/2011 |
| 7863280 | Substituted 2-pyridone derivatives, method for their preparation and their use as medicament This invention relates to compounds of formula (I), wherein R1 and R3 independently represent fluorine, methoxy, —OCF3, C2-C3-alkenyl or C1-C4-alkyl which is optional... | 01/04/2011 |
| 7858328 | High-throughput Enzyme-linked immuno absorbent assay (ELISA) for determination of Rho-kinase (ROK) activity The invention is referring to an assay for measuring the activity of a ROK (Rho kinase) protein by means of a biotinylated peptide. ... | 12/28/2010 |
| 7850662 | Drive mechanisms suitable for use in drug delivery devices A drive mechanism suitable for use in drug delivery devices is disclosed. The drive mechanism may be used with injector-type drug delivery devices, such as those permitting a user to set the delivery dose. The drive mechanism may include a housing, a dose dial sleev... | 12/14/2010 |
| 7838547 | Aryl-substituted polycyclic amines, method for the production thereof, and use thereof as a medicament The invention relates to aryl-substituted polycyclic amines of formula I, especially bicyclic amines, and to the physiologically tolerated salts and physiologically functional derivatives thereof; where the symbols and radi... | 11/23/2010 |
| 7838528 | Substituted bicyclic 8-pyrrolidinoxanthines, methods for their production, pharmaceutical formulations and their use Compounds for the treatment of elevated blood glucose levels and the physiological and metabolic disorders arising therefrom are disclosed and comprise novel substituted bicyclic 8-pyrrolidinoxanthines and their derivatives of formula I: | 11/23/2010 |
| 7825144 | Method for the production of oxazoles by condensing aromatic aldehydes with α-ketoximes to N-oxides and then reacting the same with activated acid derivatives The invention is related to a process for preparing compounds of the formula IV by means of conversion of aromatic aldehydes of the formula I using α-ketoximes of the formula II via N-oxides of the formula III to halomethyloxazoles of the formula IV, | 11/02/2010 |
| 7803950 | Method for the production of diarylcycloalkyl derivatives The invention relates generally to a process for preparing diarylcycloalkyl derivatives of the formula (I). wherein the respective R-group substituents are defined herein. These compounds of formula (I) are activators for p... | 09/28/2010 |
