Did You Know...
...that the Slinky toy was the result of a failed attempt by engineer Richard James to produce an antivibration device for ship instruments? His goal was to develop a spring that would instantaneously counterbalance the wave motion that rocks a ship at sea. Instead, he developed the Slinky.
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| Number | Title | Issue Date |
| 8158362 | Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype Polymorphisms in the FLAP and LTA4H gene are shown by genetic association analysis to be susceptibility markers for myocardial infarction (MI) and ACS, as well as stroke and PAOD. Pathway targeting for treatment and diagnostic applications in identifying those who a... | 04/17/2012 |
| 8115005 | Pyrazolylphenyl and pyrrolylphenyl inhibitors of LTA4H for treating inflammation Two chemical genera of pyrazolylphenyl and pyrrolylphenyl derivatives are disclosed. They have the general formula: In these compounds ring (a) is a pyrazole or pyrrole; Q is selected from the group consisting of a direct b... | 02/14/2012 |
| 7851486 | Susceptibility gene for myocardial infarction, stroke, and PAOD; methods of treatment Linkage of myocardial infarction (MI) and a locus on chromosome 13q12 is disclosed. In particular, the FLAP gene within this locus is shown by genetic association analysis to be a susceptibility gene for MI and ACS, as well as stroke and PAOD. Pathway targeting for ... | 12/14/2010 |
| 7585630 | Genetic variants in the TCF7L2 gene as diagnostic markers for risk of type 2 diabetes mellitus Polymorphisms in the gene TCF7L2 are shown by association analysis to be a susceptibility gene for type II diabetes. Methods of diagnosis of susceptibility to diabetes, of decreased susceptibility to diabetes and protection against diabetes, are described, as are me... | 09/08/2009 |
| 7435548 | Methods for producing ex vivo models for inflammatory disease and uses thereof The invention relates to methods for inducing a pro-asthma/pro-inflammatory like state in a resident tissue cell, comprising contacting the cell with one or more cytokines, e.g., IL-β, TNFα or both. Methods are also disclosed for identifying genes that regulate re... | 10/14/2008 |
| 7402684 | Biaryl substituted heterocycle inhibitors of LTA4H for treating inflammation The present invention relates to a chemical genus of biaryl substituted heterocycle inhibitors of LTA4H (leukotriene A4 hydrolase) useful for the treatment and prevention and prophylaxis of inflammatory diseases and disorders. The compounds have general formula Ψ: | 07/22/2008 |
| 7384736 | Methods for predicting drug sensitivity in patients afflicted with an inflammatory disease Methods are disclosed for predicting the efficacy of a drug for treating an inflammatory disease in a human patient, including: obtaining a sample of cells from the patient; obtaining a gene expression profile of the sample in the absence and presence of in vitro mo... | 06/10/2008 |
| 7244571 | Methods for producing Ex vivo models for inflammatory disease and uses thereof The invention relates to methods for inducing a pro-asthma/pro-inflammatory like state in a resident tissue cell, comprising contacting the cell with one or more cytokines, e.g., IL-1β, TNFα or both. Methods are also disclosed for identifying genes that regulate r... | 07/17/2007 |
| 7146375 | Inference control method in a data cube A system for editing the dimension structure associated with a data cube is revealed. The editing may be used to enforce given criteria on the cube. This includes modifying the cube in order to satisfy regulations requiring researchers to protect information about i... | 12/05/2006 |
| 7016910 | Indexing, rewriting and efficient querying of relations referencing semistructured data The invention discloses methods and apparatus that facilitate efficient querying of tables referencing semistructured data such as digraphs and other domains with complex grouping structure. The invention methods enable meaningful indexing of the tables as well as r... | 03/21/2006 |
| 6970874 | Populating data cubes using calculated relations The current invention discloses methods for transforming a set of relations into multidimensional data cubes. A syntheses process is disclosed that dynamically and with minimal user input eliminates ambiguities when populating a data cube by introducing table-like v... | 11/29/2005 |
| 6897027 | Method for desalting nucleic acids The present invention relates to a method for desalting nucleic acid samples. The method involves contacting a liquid sample comprising a nucleic acid and an ionic salt with an ion exchanger comprising an insoluble phosphate salt, removing said liquid, and eluting s... | 05/24/2005 |
| 6893828 | Methods for producing ex vivo models for inflammatory disease and uses thereof The present invention relates to methods for inducing a pro-asthma/pro-inflammatory like state in a resident tissue cell, comprising contacting the cell with IL-1β, TNFα or both. Methods are also disclosed for identifying genes that regulate responses to anti-infl... | 05/17/2005 |
| 6630304 | Human osteoporosis gene A role of the human BMP2 gene in osteoporosis is disclosed. Methods for diagnosis, prediction of clinical course and treatment for osteoporosis using polymorphisms in the BMP2 gene are also disclosed.... | 10/07/2003 |
| 6410712 | Human narcolepsy gene The gene for hypocretin (orexin) receptor 2 (HCRTR2), which is associated with narcolepsy, is disclosed. Also described are methods of diagnosis of narcolepsy, pharmaceutical compositions comprising nucleic acids comprising the HCRTR2 gene, as well as met... | 06/25/2002 |
| 6356900 | Online modifications of relations in multidimensional processing A method/operator is disclosed that adjusts measurements during processing in a multidimensional data cube. The online "depth-of-field" operator disclosed varies the density of points in a representation of the multidimensional cube. The operator may be a... | 03/12/2002 |
| 6319710 | Human narcolepsy gene The gene for hypocretin (orexin) receptor 1 (HCRTR1), which is associated with narcolepsy, is disclosed. Also described are methods of diagnosis of narcolepsy, pharmaceutical compositions comprising nucleic acids comprising the HCRTR1 gene, as well as met... | 11/20/2001 |
