Assignee: Zeneca Limited

Location: GB
No. of patents: 81

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Number	Title	Issue Date
6423731	Indole derivatives as prodrugs of 5-HT1-like receptor agonists A method for the prophylaxis or treatment of conditions for which 5-HT1 -like agonists are indicated comprising the administration of therapeutically-effective amount of compounds of formula (I) ##STR1## wherein A, W, Z and n are as defined in ...	07/23/2002
6414145	Imidazolyl compounds as inhibitors of farnesyl-protein tranferase ##STR1## The present invention relates to inhibitors of ras farnesylation of Formula (I), wherein T is of Formula (1) or (2) or (3); A is aryl or heteroaryl; B is aryl or heteroaryl; X and Y represent hydrogen, or both X and Y can represent a single bond ...	07/02/2002
6313290	Azolobenzazepine derivatives and compositions and method of use thereof The invention relates to azolobenzazepine derivatives of the formula I: ##STR1## wherein: X is O or S; R1, R2, R3 and R4 are independently hydrogen, perfluorolower-alkyl, halogen, nitro or cyano; and C together ...	11/06/2001
6313148	Aromatic amine compounds that antagnoize the pain enhancing effects of prostaglandins Compounds antagonistic of the pain enhancing effects of prostaglandins are disclosed. The compounds comprise an optionally-substituted A ring with a --CH(R3)N(R2)B--R1 and --OD groups positioned in a 1,2 relationship to on...	11/06/2001
6267806	Dye compositions Disclosed are compositions useful in inks suitable for ink jet printing. The compositions comprising a black dye of specified formula and a dye of the formula (A) or salt thereof: ##STR1## wherein: R1 is C1-4 -alkoxy or C1-4	07/31/2001
6235468	Method for characterising variability in telomere DNA by PCR A method of characterizing a test sample of genomic DNA which method comprises contacting the test sample with type specific primer to prime selectively, within a telomere repeat array, internal repeat units of that type, and extending the type specific p...	05/22/2001
6235757	Substituted heterocycles Compounds of formula I ##STR1## wherein Q1, Q2, Q3, Q4 and Q5 have any of the meanings given in the specification, their N-oxides, and their pharmacuetically acceptable salts are nonpeptide antagonist...	05/22/2001
6232313	Pyridazino quinoline compounds The present invention relates to compounds, pharmaceutical compositions and methods of using compounds having the formula below ##STR1## in the treatment and prevention of certain diseases or conditions. Where the ring designated A is chosen from ortho su...	05/15/2001
6231653	Dye compositions An ink composition comprising: (a) from 0.1 to 50 parts of a dye; (b) from 0.1 to 50 parts of a sugar; (c) from 0.1 to 50 parts of a compound selected from phosphoric acid and a carboxylic acid or a salt thereof; (d) from 0 to 10 parts of a pH buffer; and (e) from ...	05/15/2001
6228811	Solid formulation The formation of undesirable sludge in the course of spraying a solution or dispersion of a water-soluble or water-dispersible solid or a structured gel formulation is reduced by the incorporation in the formulation of a low-density solid particulate mate...	05/08/2001
6214826	Pyridazino quinoline compounds The invention relates to pyridazinoquinoline compounds of the formulas B and B' ##STR1## wherein Ring A is selected from an ortho fused aromatic or heteroaromatic five- or six-membered ring and R1, R3 and R4 are subst...	04/10/2001
6207676	Bicyclic amines A compound of formula (I): ##STR1## wherein R1 represents a group of formula (A) where each of W, X, Y and Z and Z represents either a group CR or the nitrogen atom, provided that not more than two of W, X, Y and Z represent the nitrogen atom a...	03/27/2001
6204223	Packaged agrochemical composition An agrochemical composition packaged in a water soluble or water dispersible sachet is taught. The agrochemical composition is comprised of water-soluble, agrochemically active agent, water and an agent to minimize water loss through the walls of the sach...	03/20/2001
6184392	Process for preparing 3-isochromanone 3-Isochromanome is prepared by reacting an o-xylene-଱,଱'-dihalide with carbon monoxide and water in the presence of a metal catalyst such that the pH of the reaction is maintained between about 7 and 11....	02/06/2001
6184207	Inhibitors of peptide binding to MHC class II proteins The invention concerns pharmacologically useful peptide derivatives of the formula (I): P-AA1 -AA2 -AA3 -AA4 -AA5 -AA6 -AA7 -AA8 -Q, and pharmaceutically acceptable salts t...	02/06/2001
6177442	Bicyclic amine derivatives The invention provides a compound of formula (I): ##STR1## wherein A represents a bidentate group of formula --CH2 --X--CH2 -- (wherein X is methylene, sulfur or oxygen), X'C.dbd.CY or X'WC--CYZ (wherein X', W, Y and Z are independen...	01/23/2001
6169101	Pyridine derivatives as fungicides A fungicidal compound having general formula (I) ##STR1## or a stereoisomer thereof, wherein A is CH or N, B is OCH3 or NHCH3, R1 is H, chloro or methyl and R2 is H, fluoro, chloro or methyl....	01/02/2001
6162916	Process for the preparation of pyrimidine compounds A process for preparing agrochemical intermediates of formula (I), wherein W is (CH3 O)2 CH.CHCO2 CH3 or CH3 O.CH.dbd.CCO2 CH3 ; Z1 is a halogen atom; and R1, ...	12/19/2000
6160117	Chemical process 4,6-Dichloropyrimidine is prepared by treating 4,6-dihydroxypyrimidine with a chlorinating agent of the formula R1 R2 R3 PCl2 wherein R1, R2 and R3 are independently alkyl or aryl, or...	12/12/2000
6149843	Microcapsules containing suspensions of biologically active compounds and ultraviolet protectant Microcapsules containing a biologically active material which is sensitive to ultraviolet light are prepared which contain an ultraviolet light protectant selected from titanium dioxide, zinc oxide and mixtures thereof, suspended and thoroughly dispersed ...	11/21/2000
6147083	Azospiro compounds as NK1 or NK2 antagonists Compounds of formula I: ##STR1## wherein Q1, Q2, Q3, Q4, and Q5 have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide ant...	11/14/2000
6143899	Chemical process A process for the preparation of 2-hydroxy-6-trifluoromethylpyridine which comprises reacting 2-fluoro-6-trifluomethylpyridine or a mixture of 2-fluoro-6-trifluoromethylpyridine and 2-chloro-6-trifluoromethylpyridine with an alkali metal hydroxide at a te...	11/07/2000
6136567	Production of proteins, plasmids coding therefor and organisms containing such plasmids Plasmids which comprise: (1) an origin of replication; (2) an additional sequence required for plasmid replication or preferably a gene giving a selective advantage; and (3) two expression cassettes each of which are located between (1) and (2) but are se...	10/24/2000
6124356	Fungicides A fungicidal compound of formula (I): or a stereoisomer thereof, wherein A is CH or N, B is OCH3 or NHCH3, E is --NR1 --C(CH3).dbd.N-- or --N.dbd.C(CH3)--NR1 --, R1 is H, C1...	09/26/2000
6124279	Therapeutic heterocycles Compounds of formula I ##STR1## wherein G, J, L, M, m and D have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of ...	09/26/2000
6124281	Azolobenzazepine derivatives as neurologically active agents The invention relates to azolobenzazepine derivatives of formula (I), wherein: X is O or S; R1, R2, R3 and R4 are independently hydrogen, perfluorolower-alkyl, halogen, nitro or cyano; and C together with the ca...	09/26/2000
6110729	Enzymatic process for stereoselective preparation of a tertiary alcohol by hydrolysis of corresponding acid A stereoselective method for making compounds of Formula VIII ##STR1## wherein A and * are as defined in the specification. Enzymic processes and intermediates useful for preparing compound of Formula VIII are disclosed....	08/29/2000
6103721	Heteroaryl-substituted pyridazino quinoline compounds The present invention concerns compounds according to the following formula, ##STR1## wherein: R1 is (CH2)n,L where n is an integer in the range 0 to 6, and L is a carbon-linked five-membered heteroaryl ring having an...	08/15/2000
6100258	Aromatic amine compounds that antagonize the pain enhancing effects of prostaglandins Compounds antagonistic of the pain enhancing effects of prostaglandins are disclosed. The compounds comprise an optionally-substituted A ring with a --CH(R3)N(R2)B--R1 and --OD groups positioned in a 1,2 relationship to on...	08/08/2000
6096892	Chemical process A process for preparing 4,6-dihydroxypyrimidine comprising the steps: a) contacting formamide, an alkoxide of formula ROM and a malonate of formula CH2 (CO2 R)2 in a solvent of formula ROH; b) adding water to the product of step (a)...	08/01/2000
6090824	Therapeutic neurokinin receptor antagonist compounds Compounds of formula I ##STR1## wherein Q1, Q2, Q3, and Q4 have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists Substan...	07/18/2000
6087306	Granule composition A granule suitable for aqueous spray application after tank mix dispersion or dissolution comprises an active ingredient or auxiliary agent, an inert filler and a water-swellable material wherein the water-swellable material is incorporated into the granu...	07/11/2000
6083951	Aryl-substituted pyrimidine sulphonamide compounds as endothelin antagonists Pyrimidine sulphonamide compounds of the following formula, ##STR1## wherein Q is a naphthyl or biphenyl group either unsubstituted or substituted with A1, and where A1, R1 and R2 are a variety of alkyl, ar...	07/04/2000
6075131	Monoazocompounds with an indanyl moiety Compounds of Formula (1) have utility as dyes for ink-jet printing where Formula (1) comprises: Tq --W Formula (1) which includes all acceptable forms of such compounds selected from one or more of the ...	06/13/2000
6060475	Substituted pyrazin-2-yl-sulphonamide-(3-pyridyl) compounds and uses thereof The invention concerns pharmaceutically useful compounds of the formula I, in which A1, A2, A3, A4, B1, m, Ar, W, X, Y, Z and R1 have any of the meanings defined herein, and their pharmaceu...	05/09/2000
6057345	Substituted aryl and heteroaryl compounds as E-type prostaglandin antagonists Compounds of the formula, ##STR1## and pharmaceutically-acceptable salts thereof, which are useful as antagonists of the pain-enhancing effects of E-type prostaglandins, processes for the preparation of such compounds, pharmaceutical composition...	05/02/2000
6054593	Proline derivatives The present invention relates to particular forms of a novel 1-substituted-N-[2-methyl-1-(trifluoroacetyl)propyl]pyrrolidine-2-carboxam ide which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them u...	04/25/2000
6054613	Process for the production of sulphonamides A process for the preparation of a sulfonamide of formula: RSO2 NR1 R2 wherein R represents C1 -C10 alkyl; and R1 and R2 independently represent hydrogen, C1 -C10 alk...	04/25/2000
6048889	Proline derivatives The present invention relates to particular forms of a novel 1-substituted-N-[2-methyl-1-(trifluoroacetyl)propyl]pyrrolidine-2-carboxam ide which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them u...	04/11/2000
6048998	One-step process for preparing methyl 2-(halomethyl)phenylacetate from 3-isochromanone Methyl 2-(chloro- or bromomethyl)phenylacetate is prepared by treating 3-isochromanone with thionyl chloride or thionyl bromide in the presence of methanol....	04/11/2000

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Assignee: Zeneca Limited