Did You Know...
...that while attempting to develop a super strong glue, 3M employee Spencer Silver accidentally developed a glue that was so weak it would barely hold two pieces of paper together? However, his colleague Art Fry needed the glue. Fry sang with his church choir and marked the pages of his hymnal with small scraps of paper that often fell out. He used Silver's glue to hold the papers in place. Today we call this invention Post-it Notes.
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| Number | Title | Issue Date |
| 6309864 | Process for producing foreign proteins A production method of a heterologous protein, comprising culturing a heterologous protein-producing host prepared by gene manipulation in a medium containing a fatty acid or a salt thereof, and a surfactant and harvesting the heterologous protein from th... | 10/30/2001 |
| 6218410 | Medicines comprising Rho kinase inhibitor A Rho kinase inhibitor is provided as a novel pharmaceutical agent, particularly as a therapeutic agent of hypertension, a therapeutic agent of angina pectoris, a suppressive agent of cerebrovascular contraction, a therapeutic agent of asthma, a therapeut... | 04/17/2001 |
| 6187774 | Fused heterocyclic compounds and pharmaceutical applications thereof The present invention relates to a fused heterocyclic compound of the formula (I) ##STR1## wherein each symbol is as defined in the specification, an optical isomer thereof, a pharmaceutically acceptable salt thereof, a pharmaceutical composition con... | 02/13/2001 |
| 6177059 | GPIb-lipid complex and uses thereof A complex comprising a lipid and a conjugate of GPIb and lipid having a functional group, and use thereof. The GPIb-lipid complex of the present invention is extremely useful as a platelet substitute, a pharmaceutical agent for the prophylaxis and treatme... | 01/23/2001 |
| 6166221 | Production method of optically active imidazole compound, synthetic intermediate therefor and production method thereof The present invention provides a method for producing an optically active 4-[-hydroxy-5-(1-imidazolyl)-2-methylbenzyl]-3,5-dimethylbenzoic acid or a pharmaceutically acceptable salt thereof, which includes subjecting a compound of the formula (I) w... | 12/26/2000 |
| 6159471 | Room temperature storable immunoglobulin preparation for intravenous injection A method for producing an immunoglobulin preparation for intravenous injection, which comprises the steps of: fractionating an immunoglobulin-containing solution with 4 to 10 w/v % of polyethylene glycol having a molecular weight of from 1,000 to 10,000, ... | 12/12/2000 |
| 6156766 | Benzamide compounds and pharmaceutical use thereof Benzamide compounds of the formula ##STR1## wherein each symbol is defined in the specification, isomers thereof and pharmaceutically acceptable acid addition salts thereof. Pharmaceutical compositions comprising a therapeutically effective amount of... | 12/05/2000 |
| 6129925 | Container filled with infusion liquids and infusion preparation An object of the present invention is to provide an infusion preparation set (a container filled with infusion liquids) useful for preparation of an infusion liquid containing sugars, amino acids, electrolytes, a fat emulsion and vitamins. The present inv... | 10/10/2000 |
| 6121329 | Topical administration of 2-amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol An external preparation for topical administration which aims at inhibiting rejection reactions at organ or bone marrow transplantation or treating autoimmune diseases or allergic diseases and contains as the active ingredient 2-amino-2-(2-(4-octylphenyl)... | 09/19/2000 |
| 6090384 | Antiallergic compostion Disclosed is an antiallergic composition comprising, as an active ingredient, a peptide which is capable of binding to human IgE, more specifically the high-affinity immunoglobulin E receptor chain or a soluble fragment, which is capable of bindin... | 07/18/2000 |
| 6068995 | Method for producing protein A method for producing a desired protein, which comprises growing, by a fed-batch culture, a host cell capable of expressing the desired protein, wherein the specific growth rate of the host cell is changed from the initial rate to a predetermined one by ... | 05/30/2000 |
| 6008198 | Porphyrin metal complex-albumin inclusion compound and oxygen carrier composition comprising the same A porphyrin metal complex-albumin inclusion compound wherein a substituted porphyrin metal complex comprising, as a central, coordinated metal, a transitional metal belonging to the fourth or fifth period of the periodic law, is included in the albumin, a... | 12/28/1999 |
| 6004565 | Compositions and methods of using compositions with accelerated lymphocyte homing immunosuppressive properties The methods and compositions of the invention and the compounds used in the invention involve a novel immunosuppression mechanism, accelerated lymphocyte homing immunosuppression (ALH-immunosuppression). For example, the compound FTY720 specifically direc... | 12/21/1999 |
| 5993863 | Alimentative infusion liquids for administration through peripheral vein The present invention aims at providing an alimentative infusion liquid which has improved stability and preservability and can be administered through a peripheral vein. The infusion liquid contains sugars, amino acids, electrolytes and a fat emulsion at... | 11/30/1999 |
| 5989593 | Method for producing antithrombin-III, method for purifying it, and preparation containing it A method for producing antithrombin-III from an antithrombin-III-containing aqueous solution, comprising at least one of the following steps (a) and (b): (a) heating the antithrombin-III-containing aqueous solution in the presence of a stabilizing agent s... | 11/23/1999 |
| 5965557 | Method for prophylaxis and treatment of irritable bowel syndrome A method for the prophylaxis and treatment of irritable bowel syndrome, which comprises administering a pharmaceutically effective amount of at least one compound selected from the group consisting of (&#b1;)-2-(4-chlorophenyl)-5,6-dihydro-[1]benzothiepin... | 10/12/1999 |
| 5958944 | Benzamide compounds and pharmaceutical use thereof Benzamide compounds of the formula ##STR1## wherein each symbol is as defined in the specification, isomers thereof and pharmaceutically acceptable acid addition salts thereof. Pharmaceutical compositions comprising a therapeutically effective amount... | 09/28/1999 |
| 5952316 | 2-amino-1,3-propanediol compound and immunosuppressant 2-Amino-1,3-propanediol compounds of the formula (I) ##STR1## wherein R is an optionally substituted straight- or branched carbon chain, an optionally substituted aryl, an optionally substituted cycloalkyl or the like, and R2, R3 | 09/14/1999 |
| 5948820 | Benzene compound and pharmaceutical use thereof A benzene compound of the formula ##STR1## wherein each symbol is as defined in the specification; an optically active isomer or salt thereof, a medicinal composition containing the same, and an immunosuppressant containing the same as the active ... | 09/07/1999 |
| 5929299 | Helicobacter pylori-colonized mongolian gerbils, method for preparation thereof, and method for screening anti-Helicobacter pylori substance using them Helicobacter pylori-colonized Mongolian gerbils prepared by oral inoculation of a broth culture obtained from a liquid culture of Helicobacter pylori, to the Mongolian gerbils for intragastric colonization of Helicobacter pylori. These Mongolian gerbil mo... | 07/27/1999 |
| 5889030 | Method for stabilizing pranoprofen and stable liquid preparation of pranaprofen A method for stabilizing pranoprofen, comprising placing an aqueous solution of pranoprofen in coexistence with an antioxidant, or placing an aqueous solution of pranoprofen under the conditions of limited supply of oxygen, and a stable aqueous preparatio... | 03/30/1999 |
| 5871778 | Sustained release microsphere preparation containing antipsychotic drug A sustained release microsphere preparation which is produced by including a hydrophobic antipsychotic drug such as bromperidol, haloperidol or the like into a base composed of a high molecular weight polymer having in vivo histocompatibility such as poly... | 02/16/1999 |
| 5856345 | Method for stabilizing pranoprofen and stable liquid preparation of pranoprofen A method for stabilizing pranoprofen, comprising placing an aqueous solution of pranoprofen in coexistence with an antioxidant, or placing an aqueous solution of pranoprofen under the conditions of limited supply of oxygen, and a stable aqueous preparatio... | 01/05/1999 |
| 5776488 | Liposome preparation A liposome preparation comprising a water-soluble 2'-deoxy-2'methylidenecytidine compound encapsulated therein and a compound which positively charges the surface of lipid membrane. This liposome preparation is not only expected to decrease toxicity to my... | 07/07/1998 |
| 5760032 | Thienylazole compound and thienotriazolodiazepine compound Thienylazole compounds (I) and thienotriazolodiazepine compounds (II) of the formulas ##STR1## wherein R1 and R2 are hydrogen, halogen, C1 -C5 alkyl and the like; --A.dbd.B-- is --N.dbd.N-- and the like; R | 06/02/1998 |
| 5753649 | Therapeutic agent for osteoporosis and diazepine compound A therapeutic agent for osteoporosis, comprising an azepine compound of the formula ##STR1## wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof as an active ingredient, a method for treating ost... | 05/19/1998 |
| 5721231 | Thienotriazolodiazepine compound and pharmaceutical use thereof N-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno 3,2-f!1,2,4!triazolo4,3-a!1,4!diazepin-6-yl )-N'- (2-methoxyphenyl)urea, optical isomers thereof and pharmaceutically acceptable salts thereof. The compounds of the present invention strongly an... | 02/24/1998 |
| 5719176 | 2-amino-1,3-propanediol compound and immunosuppressant A 2-amino-1,3-propanediol compound represented by general formula (I) or a pharmaceutically acceptable salt thereof, and an immunosuppressant containing the same as the active ingredient. In said formula R represents optionally substituted linear or branc... | 02/17/1998 |
| 5712274 | Thienotriazolodiazepine compounds and their pharmaceutical use Thienotriazolodiazepine compounds of the formula (1) ##STR1## wherein each symbol is as defined in the specification, pharmaceutically acceptable salts thereof, and pharmaceutical use thereof. The compounds of the present invention are useful as prev... | 01/27/1998 |
| 5705630 | 2'-methylidenepyrimidine nucleoside compounds 2'-Methylidenepyrimidine nucleoside compounds of the general formula: ##STR1## wherein R1 stands for amino or hydroxy group; R2 stands for a halogen or a lower alkyl when R1 is amino or R2 stands for an alk... | 01/06/1998 |
| 5703150 | Phosphonite or phosphonate compounds and use thereof Phosphonite and phosphonate compounds ##STR1## wherein X1, X2, X3 and X4 are each independently a group of the formula ##STR2## wherein R is a hydrogen atom or a methyl group, p is 0 or 1, q is in... | 12/30/1997 |
| 5691330 | Condensed thiophene compound and pharmaceutical use thereof A condensed thiophene compound represented by general formula: ##STR1## or a pharmaceutically acceptable salt thereof, wherein ring S represents a thiophene ring; R1 represents hydrogen, halogen, alkyl, etc.; R2 represents hydro... | 11/25/1997 |
| 5686479 | Immunosuppressive drug An immunosuppressive drug, an autoimmune disease treating drug, an immunosuppression enhancing drug and a cell adhesion inhibitor, each containing a thienotriazolodiazepine compound wherein the 2-position of its diazepine ring is alkylated as an active in... | 11/11/1997 |
| 5677316 | 8-methoxy-quinolonecarboxylic acid derivatives 8-Methoxy-quinolonecarboxylic acid derivatives of the formula ##STR1## wherein R1 is a hydrogen atom, a lower alkyl, a phenylalkyl or an ester residue hydrolyzable in the living body, R2 is a hydrogen atom or methyl and n is an ... | 10/14/1997 |
| 5665711 | Antitumor composition for oral administration An antitumor composition for oral administration, comprising a 2'-deoxy-2'-methylidenecytidine compound of the formula ##STR1## wherein R is a hydrogen or a halogen, and R1 and R2 are the same or different and each is a hydrogen... | 09/09/1997 |
| 5661100 | Urea (thiourea) derivative and thermal recording sheet using the same A thermal recording sheet wherein a compound of Formula (I) or (II) is contained in a thermal color developing layer including a basic colorless dye and an organic color developer as main ingredients: ##STR1## (wherein A denotes hydrogen atom, an alk... | 08/26/1997 |
| 5656299 | Sustained release microsphere preparation containing antipsychotic drug and production process thereof A sustained release microsphere preparation which is produced by including a hydrophobic antipsychotic drug such as bromperidol, haloperidol or the like into a base composed of a high molecular weight polymer having in vivo histocompatibility such as poly... | 08/12/1997 |
| 5637322 | Method for producing composition for solid medicine In producing a composition for solid medicine, comprising, as an active ingredient, a potassium channel activator and a pharmaceutically acceptable water-insoluble cellulose polymer, a method for producing a composition for solid medicine, which is charac... | 06/10/1997 |
| 5604229 | 2-amino-1,3-propanediol compound and immunosuppressant 2-Amino-1,3-propanediol compounds of the formula (I) ##STR1## wherein R is an optionally substituted straight- or branched carbon chain, an optionally substituted aryl, an optionally substituted cycloalkyl or the like, and R2, R3 | 02/18/1997 |
| 5597918 | Fused pyridazine compound A fused pyridazine compound of the formula ##STR1## wherein each symbol is as defined in the description. The compounds of the present invention are useful as anxiolytic agents which selectively act on anxiety because of having less side effects (e.g... | 01/28/1997 |
