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"I watched his countenance closely, to see if he was not deranged ... and I was assured by other senators after he left the room that they had no confidence in it."
U.S. Senator Smith of Indiana ; After seeing Samuel Morse demonstrate the telegraph.
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| Number | Title | Issue Date |
| 7534605 | CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases An isolated polypeptide is provided. The isolated polypeptide comprising an antigen recognition domain capable of specifically binding a CD44 polypeptide as set forth in SEQ ID NO: 2 and incapable of binding a CD44 polypeptide selected from the group consisting of: ... | 05/19/2009 |
| 7528947 | Nanoparticles functionalized probes and methods for preparing such probes The present invention provides probes functionalized with nanoparticles, methods for binding nanoparticles to the probes and the use of such probes in nanometer scale imaging techniques. More specifically, the present invention provides a tip device having at least ... | 05/05/2009 |
| 7528227 | Histone H2A peptide derivatives and uses thereof Peptides derived from a segment of human histone H2A, the segment corresponding to amino acid residues 36-44 of human histone H2A, are capable of reducing or ameliorating the extent of injury induced by noxious stimuli when administered to animals. Pharmaceutical co... | 05/05/2009 |
| 7504384 | Use of lipid conjugates in the treatment of infection This invention provides compounds and methods of use thereof in suppressing, inhibiting, preventing, or treating a pathogenic effect on a cell, including, inter alia, infection with intracellular pathogens. Also provided are compounds and methods of use thereof in s... | 03/17/2009 |
| 7504099 | Methods of inducing or enhancing connective tissue repair This invention provides method for repairing, regenerating, treating, or inducing the repair of an injury, a defect or a condition of a connective tissue of a subject. This invention provides a method of regenerating, enhancing, inducing repair and/or development of... | 03/17/2009 |
| 7456154 | Antisense oligonucleotide against human acetylcholinesterase (AChE) and uses thereof The invention relates to an antisense oligonucleotide targeted to the coding region of the human acetylcholinesterase (AChE), which selectively suppresses the AChE-R isoform of the enzyme. The antisense oligonucleotide is intended for use in the treatment and/or pre... | 11/25/2008 |
| 7425322 | Responsive biomedical composites A responsive polymeric system including a responsive polymeric component capable of undergoing a transition that results in a sharp increase in viscosity in response to a triggering effected at a predetermined body site. The system includes a solid non-ceramic reinf... | 09/16/2008 |
| 7407753 | Methods, kits and pharmaceutical compositions for diagnosing, delaying onset of, preventing and/or treating osteoporosis The present invention uncovers a highly significant association of SNPs in the CNR2 locus, encoding the cannabinoid receptor 2 protein, with osteoporosis. Methods and kits for determining predisposition to osteoporosis, improving diagnosis in individuals suspected o... | 08/05/2008 |
| 7393938 | Use of lipid conjugates in the treatment of diseases This invention provides compounds represented by the structure of the general formula (A): wherein L is a lipid or a phospholipid, Z is either nothing, ethanolamine, serine, inositol, choline, or glycerol, Y is either nothi... | 07/01/2008 |
| 7378438 | Beta-agonist compounds comprising nitric oxide donor groups and reactive oxygen species scavenger groups and their use in the treatment of respiratory disorders The present invention relates to multifunctional β-agonist compounds comprising a reactive oxygen species scavenger group and a nitric oxide donor, and their use for the treatment of respiratory diseases involving airway obstruction, such as asthma and chronic bron... | 05/27/2008 |
| 7365247 | Method of large scale mutagenesis in tomato plants The present invention relates to a rapid and large-scale production of tomato mutants by utilizing a miniature tomato plant which can be crossed with tomato commercial plants. Mutations are induced in the miniature tomato cultivars and desired mutants are subsequent... | 04/29/2008 |
| 7351527 | Immunizing fish against viral infection The present invention provides the isolated causative agent of the disease affecting Cyprinus carpino and a method for its isolation. The invention further provides avirulent forms, e.g., live-attenuated form, inactivated form and genetically modified forms o... | 04/01/2008 |
| 7345033 | Carbamoyl-and thiocarbamoyl-phosphonates and pharmaceutical compositions comprising them The present invention provides a compound of the following formula I: R3—NH—C(═X)—P(═O)OR1OR2 including pharmaceutically acceptable salts, solvates, hydrates and polymorphs of the compounds of formula I... | 03/18/2008 |
| 7303760 | Method for treating multi-drug resistant tumors Methods for administering mitomycin C to a multi-drug resistant cell and for reducing the toxicity of the compound are described. In the methods, mitoymic C is provided in the form of a prodrug conjugate, where the drug is linked to a hydrophobic moiety, such as a l... | 12/04/2007 |
| 7305144 | System and method for compressing the dynamic range of an image A gradient domain compression system generates, from an input image having a high luminance dynamic range, an output image having a lower luminance dynamic range. The system comprises a gradient image generator module, a gradient compression module, and an output im... | 12/04/2007 |
| 7297540 | Methods of generating tissue using devitalized, acellular scaffold matrices derived from micro-organs Methods of generating, and isolating adult stem cells and utilizing such cells and/or embryonic stem cells in generating tissue of a specific function and micro-architecture are provided. ... | 11/20/2007 |
| 7253341 | Denaturant stable and/or protease resistant, chaperone-like oligomeric proteins, polynucleotides encoding same, their uses and methods of increasing a specific activity thereof Novel denaturant-stable, protease resistant, homo-oligomeric proteins, also referred to herein as stable proteins (SPs), having chaperone-like activity; methods of production and purification of SPs; nucleic acids encoding SPs; methods of isolating nucleic acids enc... | 08/07/2007 |
| 7238656 | Protective factors against inflammation, burns and noxious stimuli Peptide factors isolated from skin following exposure to chemical or thermal injury and treatment with iodine preparations are capable of reducing or ameliorating the extent of injury when administered to other animals. Specific peptides, including fragments of hist... | 07/03/2007 |
| 7232929 | Amide derivatives of 2,2,3,3-tetramethylcyclopropane carboxylic acid The invention relates to new 2,2,3,3-tetramethylcyclopropane carboxamide derivative compounds, pharmaceutical compositions thereof and uses thereof for treating psychotic disorders, neurodegenerative diseases, epilepsy and pain. ... | 06/19/2007 |
| 7223389 | Compositions and methods for treatment of cancer The present invention discloses lentogenic viral strains useful in the treatment of cancer. A preferred viral strain of Newcastle Disease Virus (NDV) is specifically characterized in terms of biological activities. The present invention further discloses treatment o... | 05/29/2007 |
| 7223902 | Method of producing recombinant β-glucosidase and an aroma spreading plant The invention provides a method of producing a recombinant polypeptide having β-glucosidase enzymatic activity, a polynucleotide encoding the polypeptide, nucleic acid constructs carrying the polynucleotide, transformed cells, such as yeast cells, and transgenic or... | 05/29/2007 |
| RE39616 | Aminoindan derivatives This invention is directed to compounds of the following formula: wherein when a is 0, b is 1 or 2; when a is 1, b is 1, m is from 0-3, X is O or S, Y is halogeno, R1 is hydrogen C1-4 alkyl, R2 is... | 05/08/2007 |
| 7200318 | Near infra-red composite polymer-nanocrystal materials and electro-optical devices produced therefrom The invention comprises a composite material comprising a host material in which are incorporated semiconductor nanocrystals. The host material is light-transmissive and/or light-emissive and is electrical chargetransporting thus permitting electrical charge transpo... | 04/03/2007 |
| 7189692 | Synthetic peptides and pseudopeptides having osteogenic activity and pharmaceutical compositions containing the same Cyclic to Synthetic pseudopeptide derivatives of osteogenic growth polypeptide (OGP) and OGP(10-14) which are capable of enhancing bone cell proliferation and bone formation. Pharmaceutical composition comprising as active ingredient at least one pseudopeptide deriv... | 03/13/2007 |
| 7189398 | Broad spectrum pyrogenic exotoxins antagonists and vaccines The invention relates to peptides having an amino acid sequence substantially homologous to an amino sequence of a domain of a pyrogenic exotoxin, which domain forms a central turn in the exotoxin starting within β-strand 7 and connecting the β-strand 7, via short... | 03/13/2007 |
| 7189414 | Controlled release oral drug delivery system The invention relates to synchronous drug delivery composition comprising a polymeric matrix which comprises hydrogel blended with a hydrophobic polymer, so as to form an erodible matrix, a drug, and, optionally, an agent which enhances intestinal drug absorption an... | 03/13/2007 |
| 7176498 | Terahertz radiating device based on semiconductor coupled quantum wells A semiconductor device and method of its fabrication are provided to enable the device operation in a THz spectral range. The device comprises a heterostructure including at least first and second semiconductor layers. The first and second layers are made of materia... | 02/13/2007 |
| 7174459 | Imprinting an identification certificate A system and method for using imprinting as part of a security function that involves a user, for a security and/or identification mechanism. Imprinting is preferably used for cryptographic primitives, for determining a one-way function that operates at least partia... | 02/06/2007 |
| 7172749 | Radiolabeled irreversible inhibitors of epidermal growth factor receptor tyrosine kinase and their use in radioimaging and radiotherapy Radiolabeled epidermal growth factor receptor tyrosine kinase (EGFR-TK) irreversible inhibitors and their use as biomarkers for medicinal radioimaging such as Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) and as radiopharm... | 02/06/2007 |
| 7141552 | Use of lipid conjugates in the treatment of diseases The invention provides a method for treating a subject suffering from an intestinal disease, including, inter alia, Crohn's disease, ulcerative colitis, immuno-inflammatory intestinal injury, drug-induced enteropathy and ischemia-induced intestinal injury. This inve... | 11/28/2006 |
| 7135295 | Detection of small molecules by use of a piezoelectric sensor A protein comprising an antigen-binding portion formed by two cooperating peptide sequences of FIGS. 3A and 3B of the application. The protein may alternatively comprise an altered antigen-binding portion where at least one of the peptide sequences is ... | 11/14/2006 |
| 7122668 | Platinum complexes and their use in therapy The present invention concerns novel platinum complexes in which at least one of the amine ligand is a non-planar heterocyclic aliphatic amine. The platinum complexes may be in a trans or cis configuration and were found to posses therapeutic activites. Thus, the pr... | 10/17/2006 |
| 7115161 | Ink-jet ink compositions based on oil-in-water microemulsion forming nanoparticles upon application on a surface An Ink-jet ink composition for piezoelectric in-jet printing comprising: (a) a hydrophobic dye; (b) an oil-in-water microemulsion including: (i) a volatile oil; (ii) water; (iii) a co-solvent; (iv) at least one surfactant; and (v) a binder, wherein upon application ... | 10/03/2006 |
| 7109993 | Method and system for the automatic computerized audio visual dubbing of movies A method for automated computerized audio visual dubbing of a movie comprises (i) generating a three-dimensional head model of an actor in a movie, the head model being representative of specific facial features of the actor, and (ii) generating a three-dimensional ... | 09/19/2006 |
| 7101864 | Compositions comprising oxophosphonate-based metalloproteinase inhibitors The present invention relates to compositions useful for treating or controlling disease states or conditions associated with zinc containing proteinases, especially metalloproteinases. The active ingredient in these compositions is an alpha-oxo- or alpha-thixophosp... | 09/05/2006 |
| 7101859 | Use of lipid conjugates in the treatment of diseases The invention provides novel methods for treating disease based upon the medicinal use of lipids and phospholipids covalently bound to physiologically acceptable monomers or polymers. Phosphatidylethanolamine moieties conjugated to physiologically acceptable monomer... | 09/05/2006 |
| 7101839 | Methods of and compositions for inhibiting the proliferation of mammalian cells A method of preventing, inhibiting and/or reversing proliferation, colonization, differentiation and/or development of abnormally proliferating cells in a subject is disclosed. The method is effected by administering to the subject a therapeutically effective amount... | 09/05/2006 |
| 7090995 | Molecules and methods using same for measuring non-transferrin bound iron A molecule suitable for use as an indicator of free iron levels in a biological sample, the molecule including an iron binding moeity and a signal generating moeity, wherein an intensity of the signal generated by the signal generating moeity is related to an amount... | 08/15/2006 |
| 7074915 | Antisense oligonucleotide against human acetylcholinesterase (AChE) and uses thereof The invention relates to an antisense oligonucleotide targeted to the coding region of the human acetylcholinesterase (AChE), which selectively suppresses the AChE-R isoform of the enzyme. The antisense oligonucleotide is intended for use in the treatment and/or pre... | 07/11/2006 |
| 7067486 | Acetylcholinesterase-derived peptides and uses thereof The invention relates to a cell growth and/or differentiation regulatory peptide comprising a sequence of about 9 to about 150 amino acids derived from acetylcholinesterase amino acid sequence, preferably from the C-terminal region of acetylcholinesterase. The inven... | 06/27/2006 |