Assignee: Yamasa Corporation

Location: Chiba, JP
No. of patents: 34

Number	Title	Issue Date
8039614	4' -C-substituted-2-haloadenosine derivative The present invention provides a method for producing a 4′-C-substituted-2-haloadenosine derivative represented by the following formula [I], [II], or [III]: wherein X represents a halogen atom, R1 represents a...	10/18/2011
7968521	Stable cystal of protected pseudouridine A stable and high-purity protected pseudouridine in crystal form is provided represented by the following structural formula: wherein M represents a trityl group or a derivative thereof, which is a useful material for produ...	06/28/2011
7955825	Process for producing CMP-N-acetylneuraminic acid The present invention is directed to a process for producing CMP-N-acetylneuraminic acid (CMP-NeuAc), comprising adding to the cultured E. coli cells which has been transformed with both the DNA encoding N-acetylglucosamine-6-phosphate 2-epimerase (GlcNAc-6P ...	06/07/2011
7901912	Method of producing uridine 5′-diphospho--acetylgalactosamine The present invention provides a method for enzymatically producing uridine 5′-diphospho-N-acetylgalactosamine (UDP-GalNAc) (which is an important substrate for oligosaccharide synthesis) from uridine 5′-triphosphate (UTP) and N-acetylgalactosamine 1-phosphate (...	03/08/2011
7790208	Process for producing rich-flavor soy sauce A process of producing a rich-flavor soy sauce, including mixing soy sauce koji and salt water in a tank for preparing moromi mash, adding soy sauce and soy sauce koji at an appropriate point in time during the period of fermentation and aging, and subsequently effe...	09/07/2010
7687231	Method for determining degree of negative effect of macrophages on vertebrate The present invention provides a method for determining the degree of macrophage-associated negative effects on a vertebrate including a human, the method including assaying diacetylpolyamine contained in a sample collected from the vertebrate. According to the meth...	03/30/2010
7625877	4′-c-substituted-2-haloadenosine derivative The present invention provides a 4′-C-substituted-2-haloadenosine derivative represented by the following formula [I], [II], or [III]: wherein X represents a halogen atom, R1 represents an ethynyl group or a cy...	12/01/2009
7339053	4′-C-substituted-2-haloadenosine derivative The present invention provides a 4′-C-substituted-2-haloadenosine derivative represented by the following formula [I], [II], or [III]: (wherein X represents a halogen atom, R1 represents an ethynyl group or a c...	03/04/2008
7132409	Adenosine derivatives and use thereof 2-(6-Cyano-1-hexyn-1-yl)adenosine, 2-(6-cyano-1-hexyn-1-yl)adenosine 5′-monophosphate, or salts thereof; and drugs containing the same as an active ingredient. The compounds have excellent effects of lowering ocular tension, promoting blood flow in retina, and pro...	11/07/2006
7109008	L-glutamate oxidase The present invention provides a novel L-glutamate oxidase, a gene encoding the enzyme, and a method for producing the enzyme. By use of a gene encoding the enzyme, L-glutamate oxidase can be readily prepared at low costs through a recombinant DNA technique. The nov...	09/19/2006
7074773	Pharmaceutical composition for diabetic neuropathy The present invention relates to an agent for the prophylaxis or treatment of diabetic neuropathy, which contains cytidine 5′-diphosphocholine (CDP-choline) as an active ingredient. The agent for the prophylaxis or treatment of diabetic neuropathy of the present i...	07/11/2006
6936596	Adenosine derivatives and use thereof 2-(6-Cyano-1-hexyn-1-yl)adenosine, 2-(6-cyano-1-hexyn-1-yl)adenosine 5′-monophosphate, or salts thereof; and drugs containing the same as an active ingredient. The compounds have excellent effects of lowering ocular tension, promoting blood flow in retina, and pro...	08/30/2005
6924272	Medicinal composition for diabetic neuropathy The present invention relates to an agent for the prophylaxis or treatment of diabetic neuropathy, which contains cytidine 5′-diphosphocholine (CDP-choline) as an active ingredient. The agent for the prophylaxis or treatment of diabetic neuropathy of the present i...	08/02/2005
6890739	Use of uridine diphosphate glucose 4-epimerase The present invention relates to a new use of uridine diphosphate glucose 4-epimerase (also called uridine diphosphate galactose 4-epimerase), and a method of converting uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) to uridine diphosphate N-acetylgalactosamin...	05/10/2005
6780988	Processes for producing P1,P4-diuridine-5′-tetraphosphate The invention describes a process for producing P1,P4-di(uridine-5′-)tetraphosphate (U2P4) or a salt thereof from uridine 5′-monophosphate (UMP); wherein the process comprises at least one of the steps (a) and (b): (a)...	08/24/2004
6617444	Dinucleotide tetraphosphate crystals The present invention is directed to crystals of P1 -(2'-deoxycytidine 5'-)P4 -(uridine 5'-)tetraphosphate (dCP4U) or a salt thereof and to a process for producing the crystals. The present invention also provides a process for produ...	09/09/2003
6458946	Crystals of diuridine tetraphosphate or salt thereof, process for producing the crystals, and process for producing the compounds The invention provides crystals of p1,P4 -di(uridine 5'-) tetraphosphate or a salt thereof; a process for producing the crystals; and a process for producing P1,P4 -di(uridine 5'-) tetraphosphate (U2 ...	10/01/2002
6403568	4'-C-ethynyl pyrimidine nucleosides and pharmaceutical compositions thereof The invention provides 4'-C-ethynyl pyrimidine nucleosides (other than 4'-C-ethynylthymidine) represented by formula [I]: ##STR1## wherein B represents a base selected from the group consisting of pyrimidine and derivatives thereof; X represents a hydroge...	06/11/2002
6387889	Medicinal compositions for treating eye diseases Medicinal compositions for treating eye diseases which contain as the active ingredient 2-alkynyladenosine derivatives having an acetylene union at the 2-position of adenine base. Having a long-lasting and remarkable effect of lowering ocular tension, the...	05/14/2002
6333315	4'-C-ethynyl purine nucleoside compounds The invention provides 4'-C-ethynyl purine nucleosides represented by formula [I]: ##STR1## wherein B represents a base selected from the group consisting of purine and derivatives thereof; X represents a hydrogen atom or a hydroxyl group; and R repr...	12/25/2001
6291670	4'-C-ethynyl pyrimidine nucleoside compounds and pharmaceutical compositions The invention provides 4'-C-ethynyl pyrimidine nucleosides (other than 4'-C-ethynylthymidine) represented by formula [I]: ##STR1## wherein B represents a base selected from the group consisting of pyrimidine and derivatives thereof; X represents a hydroge...	09/18/2001
6287819	Process for producing uridine diphosphate-n-acetylglucosamine A process for producing uridine diphosphate-N-acetylglucosamine (UDPAG) from uridylic acid (UMP) and N-acetylglucosamine by use of microorganism cells, characterized by adding N-acetylglucosamine kinase thereto. According to the present invention, UDPAG c...	09/11/2001
6270744	Diagnostic agent for angiopathic diseases A diagnostic agent for angiopathic diseases containing a monoclonal antibody against human smooth muscle myosin or active fragments of the antibody labeled with a radioactive isotope; a kit thereof; and a method of diagnostic imaging for angiopathic disea...	08/07/2001
6040158	Process for preparing sugar nucleotide A process for preparing a sugar nucleotide from a nucleotide by using a yeast cell, characterized in that both a nucleoside diphosphate-sugar pyrophosphorylase and a sugar 1-phosphate are present in the reaction system. According to this process, various ...	03/21/2000
6022713	Process for producing nucleoside 5'-triphosphates and application of the same The present invention relates to a process for producing nucleoside 5'-triphosphates (NTP) from nucleoside 5'-diphosphates (NDP) other than adenosine 5'-diphosphate (ADP), characterized by using a polyphosphate kinase as an enzyme and polyphosphate as the...	02/08/2000
5998223	Method of assaying autoimmune anticardiolipin antibody and kit therefor In a method for assaying an anticardiolipin antibody in a sample utilizing 댢-glycoprotein I, a polypeptide having the same amino acid sequence as domain IV of 댢-glycoprotein I or a polypeptide partially different therefrom but functionally e...	12/07/1999
5990118	Purine compounds and xanthine oxidase inhibitors Purine or triazolopurine compounds are disclosed represented by formula (I) or (II): ##STR1## wherein R1 and R4 represent each hydrogen, halogeno, hydroxy, mercapto, or amino; R2 represents alkyl or aryl; and R3	11/23/1999
5968783	Process for the preparation of sugar nucleotides The present invention relates to a process for preparing sugar nucleotides from nucleotides and sugar derivatives by the use of yeast, characterized in that the reactions are conducted at 20° C. or below. According to this process, even when the preparat...	10/19/1999
5908757	Antibody reagent for detecting dissecting aortic aneurysm and uses thereof By measuring smooth muscle myosin heavy chain in the blood of a patient using an antibody to the smooth muscle myosin heavy chain, dissecting aortic aneurysm can be diagnosed very easily and rapidly without any special equipment....	06/01/1999
5817639	Purine 4'-thioarabinonucleosides The present invention provides a novel purine 4'-thioarabinonucleoside represented by the following formula 1!: ##STR1## wherein B represents a purine base other than adenine. Also disclosed are a method for preparing the purine 4'-thioarabinonucle...	10/06/1998
5696097	Antineoplastic 5'-diacylglycerylphosphatidyl-2-deoxy-2'-methylenylcytidines and method of making Novel 2'-methylidenenucleotide compounds of the formula (I) ##STR1## wherein R is a hydrogen or a halogen, R1 and R2 are the same or different and each is a fatty acid residue or a hydrocarbon residue, and R3 and R	12/09/1997
5670328	Monoclonal antibodies to human pulmonary surfactant apoprotein D and use thereof A monoclonal antibody which is capable of specifically binding with human pulmonary surfactant apoprotein D has been successfully obtained. Using the monoclonal antibody, human pulmonary surfactant apoprotein D can be specifically detected and assayed, wh...	09/23/1997
5472883	Solid phase reagent and assay method for measuring antibodies specific to antiphospholipid syndrome A solid phase reagent is provided which comprises a carrier having a surface onto which functional groups containing a negative charge or a lone pair of electrons and/or free radicals containing a negative charge or a lone pair of electrons have been intr...	12/05/1995
5412089	2'-deoxy-2'-methylidenecytidine dihydrate, methods for its production and compositions Novel stable, non-hygroscopic 2'-deoxy-2'-methylidenecytidine dihydrate and its methods for production, and compositions with improved solubility containing same and saccharide(s)....	05/02/1995

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Assignee: Yamasa Corporation