Assignee: Yale University

Location: New Haven, CT
No. of patents: 205

Number	Title	Issue Date
8185320	Systems and methods for automated analysis of cells and tissues Systems and methods for rapidly analyzing cell containing samples, for example to identify morphology or to localize and quantitate biomarkers are disclosed. ...	05/22/2012
8182814	Methods of treating inflammatory airway conditions by inhibition of IL-11 activity The present invention provides a method for the treatment or prophylaxis of T-helper type 2 (Th2)-mediated disorders using antagonists of IL-11. ...	05/22/2012
8181653	Intrauterine fallopian tube occlusion device An intrauterine device for occluding orifices of fallopian tubes includes a resilient body having an elongated member with a first end and a second end. The elongated member further includes a first leg ending with the first end of the elongated member, a second leg...	05/22/2012
8165684	Wireless system for epilepsy monitoring and measurement A wireless system for monitoring a patient's brain tissue including (1) a plurality of electrodes abutting brain tissue, (2) main circuitry outside the patient's body to transmit power at radio frequencies and send/receive data using infrared energy, and (3) subcuta...	04/24/2012
8153596	Use of SH2 STAT3/STAT1 peptidomimetics as anticancer drugs The subject invention concerns compositions and methods for blocking cancer cell growth or proliferation and/or inducing cancer cell death. Compositions of the present invention are peptidomimetics that inhibit STAT function. Peptidomimetics of the invention display...	04/10/2012
8121794	Systems and methods for automated analysis of cells and tissues Systems and methods for rapidly analyzing cell containing samples, for example to identify morphology or to localize and quantitate biomarkers are disclosed. ...	02/21/2012
8109816	Method and apparatus for measurement and analysis of a golf swing A method for analyzing at least one golf swing parameter using a plurality of accelerometers located proximate the distal ends of a golf club, a signal processing and display system utilizing a double pendulum model of a golf club swing, said model for describing sw...	02/07/2012
8093299	Methods of treating bowel disorders The present invention relates to methods for treating bowel disorders using calcimimetics. ...	01/10/2012
8084471	Proteomimetic compounds as inhibitors of the interaction of nuclear receptor with coactivator peptides The present invention relates to compounds, pharmaceutical compositions and methods which inhibit the binding of coactivator proteins in nuclear receptors, including estrogen receptors (alpha and/or beta), androgen receptors, thyroid receptors and peroxisome prolife...	12/27/2011
8084258	Manipulation of tissue of organ type using the notch pathway The present invention is directed to methods for altering the fate of a cell, tissue or organ type by altering Notch pathway function in the cell. The invention is further directed to methods for altering the fate of a cell, tissue or organ type by simultaneously ch...	12/27/2011
8084228	Nogo-B receptor antagonists Nogo-B receptors bind to Nogo-B and mediate its biological function. We have discovered that Nogo-B receptor is a component of endothelial cells, and is highly expressed in intact blood vessels. The present invention provides compositions comprising the Nogo-B recep...	12/27/2011
8076451	Selective delivery of molecules into cells or marking of cells in diseased tissue regions using environmentally sensitive transmembrane peptide A polypeptide with a predominantly hydrophobic sequence long enough to span a membrane lipid bilayer as a transmembrane helix (TM) and comprising one or more dissociable groups inserts across a membrane spontaneously in a pH-dependant fashion placing one terminus in...	12/13/2011
8076347	Compounds and methods for the treatment of cancer (−)-(2S,4S)-1-(2-Hydroxymethyl-1,3-dioxolan-4-yl)cytosine (also referred to as (−)-OddC) or its derivative and its use to treat cancer in animals, including humans. ...	12/13/2011
8071104	Neovascular-targeted immunoconjugates Immunoconjugates for treating diseases associated with neovascularization such as cancer, rheumatoid arthritis, the exudative form of macular degeneration, and atherosclerosis are described. The immunoconjugates typically consist of the Fc region of a human IgG1 imm...	12/06/2011
8058477	Process for the synthesis of arylamines from the reaction of an aromatic compound with ammonia or a metal amide A catalytic process for the synthesis of aromatic primary amines, reagent compositions for effecting the process, and transition metal complexes useful in the process, are provided. ...	11/15/2011
8058314	Conductance of improperly folded proteins through the secretory pathway and related methods for treating disease This invention provides the methodology and agents for treating any disease or clinical condition which is at least partly the result of endoplasmic reticulum-associated retention of proteins. Thus, the methods and agents of the present invention provide for the rel...	11/15/2011
8036833	Systems and methods for automated analysis of cells and tissues Systems and methods for rapidly analyzing cell containing samples, for example to identify morphology or to localize and quantitate biomarkers are disclosed. ...	10/11/2011
8035387	Methods and apparatus for compensating field inhomogeneities in magnetic resonance studies One aspect of the present disclosure relates to a method or determining location(s) at which at least one magnetic article is to be positioned during a magnetic resonance imaging procedure of at least one subject. A magnetic field Bo is applied to a region that incl...	10/11/2011
8034070	Varicose vein dissector and removal apparatus A varicose vein dissector and removal apparatus includes a handle having a first end and a second end, a dissector extending from the first end of the handle and a hook extending from the second end of the handle, and a blade positioned within the dissector for move...	10/11/2011
8030456	Nogo receptor antagonists Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are compositions comprising, and methods for...	10/04/2011
8026065	Assessment of oocyte competence Methods are provided for evaluating an oocyte for fertilization and implantation. For example, methods are provided for determining whether an oocyte expresses, or does not express, one or more of a group of markers identified as differently expressed between chromo...	09/27/2011
8017726	Anti-inflammatory compounds and uses thereof The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inh...	09/13/2011
8008262	β-peptides β-peptide regions of polypeptides can serve as structural mimics of α-helices in wild type proteins. Because α-helices of one protein often bind to a target protein in a biological pathway, a polypeptide that contains a helical β-peptide region can be used to di...	08/30/2011
8002989	Osmotic desalination process An energy efficient desalination process that does not produce waste products involves the extraction of water from a first solution, such as seawater, by using a second concentrated solution to draw the water from the first solution across a semi-permeable membrane...	08/23/2011
7988951	Method for inducing selectively suppressed immune response to transplanted tissue or cells Transimmunization methods incorporating skin immunologic challenges are described for either selectively suppressing the immune response of recipients of transplanted tissue or cells or monitoring induced anti-cancer immunity. In one embodiment, skin from the transp...	08/02/2011
7988707	Dynamic spine stabilizer A dynamic spine stabilizer moves under the control of spinal motion providing increased mechanical support within a central zone corresponding substantially to the neutral zone of the injured spine. The dynamic spine stabilizer includes a support assembly and a resi...	08/02/2011
7985583	Chlamydomonas intraflagellar transport 88 (IFT-88) The invention relates to various intraflagellar transport (IFT) polypeptides and the nucleic acids that encode them. The new IFT particle polypeptides and nucleic acids can be used in a variety, of diagnostic, screening, and therapeutic methods. ...	07/26/2011
7985538	Drug resistance and methods of reversing Described herein is a cellular marker, MyD88, useful for assessing an individual's (patient's) sensitivity (or resistance) to chemotherapy, particularly sensitivity (or resistance) to chemotherapeutic drugs, such as plant alkaloids (e.g., a taxane, such as paclitaxe...	07/26/2011
7951788	Method of treating cancer and other conditions or disease states using L-cytosine nucleoside analogs The present invention relates to the use of the compound according to formula (I) Where S is (A) or (B); X is H or F; R1 is H, an acyl group, a C1-C20 alkyl or ether group, a phosphate, diphosphate, triphosphate or a phosphodiester g...	05/31/2011
7943130	Methods and compositions relating to CCR5 antagonist, IFN-γ and IL-13 induced inflammation The present invention includes compositions and methods for the treatment of Th1 and/or Th2 medicated inflammatory diseases, relating to inhibiting CCR5. This is because the present invention demonstrates, for the first time, that expression of IFN-γ, IL-13, and CC...	05/17/2011
7935496	Diagnosis of preeclampsia The present invention provides methods and compositions related to the detection and/or monitoring of the levels of angiogenic factors, specifically VEGF, PlGF and sFlt-1, in urine samples obtained from pregnant women and the effects of such levels on the risk of de...	05/03/2011
7932067	Detection, isolation and uses of renalase (monoamine oxidase C) The present invention provides for the identification, isolation and uses of mammalian Monoamine Oxidase C (MAO-C), also known as renalase. ...	04/26/2011
7931675	Dynamic stabilization device including overhanging stabilizing member Spine stabilization devices, systems and methods are provided in which a single resilient member or spring is disposed on an elongate element that spans two attachment members attached to different spinal vertebrae. The elongate element passes through at least one o...	04/26/2011
7928216	Nuclease resistant external guide sequences for treating inflammatory and viral related respiratory diseases External Guide Sequence (EGS) are described that target proteins required for generation and modification of the immunoglobulin and T-cell repertoire that are useful for treatment or prevention of inflammatory or related diseases. Formulations suitable for administr...	04/19/2011
7893034	Regulation of oncogenes by microRNAs Naturally occurring miRNAs that regulate human oncogenes and methods of use therof are described. Suitable nucleic acids for use in the methods and compositions described herein include, but are not limited to, pri-miRNA, pre-miRNA, mature miRNA or fragments of vari...	02/22/2011
7893032	NgR variants and compositions thereof for suppressing axonal growth inhibition The invention provides compositions and methods for interfering with Nogo-receptor mediated signaling and mediating axonal growth. The invention also provides methods for treating central nervous system diseases, disorders or injuries. ...	02/22/2011
7888089	eNOS mutations useful for gene therapy and therapeutic screening The present invention relates to new NOS variants or mutants which contain structural alterations in the site of Akt dependent phosphorylation. The altered NOS proteins or peptides, especially the human eNOS proteins or peptides, Akt proteins or polypeptides and the...	02/15/2011
7887809	Neovascular-targeted immunoconjugates Immunoconjugates for treating diseases associated with neovascularization such as cancer, rheumatoid arthritis, the exudative form of macular degeneration, and atherosclerosis are described. The immunoconjugates typically consist of the Fc region of a human IgG1 imm...	02/15/2011
7884450	Growth of boron nanostructures with controlled diameter A process for growth of boron-based nanostructures, such as nanotubes and nanowires, with a controlled diameter and with controlled chemical (such as composition, doping) as well as physical (such as electrical and superconducting) properties is described. The boron...	02/08/2011
7879816	Methods of treating cancer and other conditions or disease states using LFMAU and LDT The present invention relates to the use of the compound according to formula (I), below for the treatment of tumors, cancer and hyperproliferative diseases, among other conditions or disease states: Where X is H or F; R1 and R2 are independent...	02/01/2011

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Assignee: Yale University