Did You Know...
...that several people are credited with the invention of the flush toilet? Most people have heard of Thomas Crapper (1837-1910), the sanitary engineer who invented the valve-and-siphon arrangement that made the modern toilet possible. Another claimant to "the throne" was British inventor Alexander Cumming who patented a toilet in 1775. Then there's a nameless Minoan (a native of ancient Crete) who lived 4,000 years ago who supposedly was ahead of his time and created the first flush toilet!
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| Number | Title | Issue Date |
| 8106087 | Spiro-oxindole compounds and their uses as therapeutic agents This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R | 01/31/2012 |
| 8101647 | Spiro-oxindole compounds and their use as therapeutic agents This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases ... | 01/24/2012 |
| 8080651 | Juvenile hemochromatosis gene (HFE2A), expression products and uses thereof Polynucleotide and polypeptide sequences for HFE2A, as well as mutations associated with juvenile hemochromatosis, and methods of utilizing these for the screening and identification of agents for the treatment of diseases of iron metabolism, including small organic... | 12/20/2011 |
| 8071603 | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I) where x, y, J, K, W, V, R3, R4, R5 | 12/06/2011 |
| 8067219 | Polynucleotide encoding an ATP binding cassette transporter 1 (ABC1) polypeptide The invention features ABC1 nucleic acids and polypeptides for the diagnosis and treatment of abnormal cholesterol regulation. The invention also features methods for identifying compounds for modulating cholesterol levels in an animal (e.g., a human). ... | 11/29/2011 |
| 7893206 | Juvenile hemochromatosis gene (HFE2A) cleavage products and uses thereof Isolated fragments of the HFE2A protein able to bind and modulate HFE2A and other proteins, such as hepcidin, involved in the iron metabolism pathway are disclosed, such fragments being of molecular weight of approximately 7 kDa to 43 kDa. Also disclosed are corresp... | 02/22/2011 |
| 7816075 | Methods and compositions using stearoyl-CoA desaturase to identify triglyceride reducing therapeutic agents The use of screening assays based on the role of human stearoyl-CoA desaturase-1 (“hSCD1”) in human diseases, disorders or conditions relating to serum levels of triglyceride, VLDL, HDL, LDL, total cholesterol, or production of secretions from mucous membranes, ... | 10/19/2010 |
| 7435559 | Methods and compositions employing a novel stearoyl-CoA desaturase-hSCD5 A cDNA encoding a novel human stearoy-CoA desaturase (dubbed “hSCD5”) as well as vectors and cells comprising such polynucleotide are disclosed. Also described are assay methods for determining the ability of small molecules and other chemical agents to increase... | 10/14/2008 |
| 7390813 | Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents Novel compounds useful in the treatment of, prevention of or protection against diseases and/or conditions related to metabolic syndrome and lipid metabolism, especially diseases of fatty acid and cholesterol metabolism, such as those mediated by stearoyl-CoA desatu... | 06/24/2008 |
| 7294480 | High throughput screening assays using fatty acid synthetic enzymes High throughput screening assays for the identification of potential therapeutic agents able to modulate the activity of enzymes of fatty acid biosynthesis, especially desaturases and/or elongases, are disclosed along with therapeutic uses of the agents identified b... | 11/13/2007 |
| 7232662 | Methods and compositions employing a novel stearoyl-CoA desaturase-hSCD5 A cDNA encoding a novel human stearoy-CoA desaturase (dubbed “hSCD5”) as well as vectors and cells comprising such polynucleotide are disclosed. Also described are assay methods for determining the ability of small molecules and other chemical agents to increase... | 06/19/2007 |
