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| Number | Title | Issue Date |
| 8180435 | Method and apparatus for determining target depth, brightness and size within a body region A method of investigating the location and size of a light-emitting source in a subject is disclosed. In practicing the method, one first obtains a light intensity profile by measuring, from a first perspective with a photodetector device, photons which (i) originat... | 05/15/2012 |
| 8044996 | Surface construction using combined photographic and structured light information The invention relates to topographic construction that combines photographic and structured light information. The dual modality construction acquires structured light information for an object and photographic images from multiple views about the object. Topographi... | 10/25/2011 |
| 7949383 | Imaging apparatus with selectable moveable stage An imaging box assembly is provided for capturing an image of a sample. The imaging box assembly includes a body having an interior cavity for receiving the sample, and having a front portion defining an opening into the cavity. The body further includes a view port... | 05/24/2011 |
| 7881773 | Multi-mode internal imaging The invention described herein provides systems and methods for multi-modal imaging with light and a second form of imaging. Light imaging involves the capture of low intensity light from a light-emitting object. A camera obtains a two-dimensional spatial distributi... | 02/01/2011 |
| 7860549 | Method and apparatus for 3-D imaging of internal light sources The present invention provides systems and methods for obtaining a three-dimensional (3D) representation of one or more light sources inside a sample, such as a mammal. Mammalian tissue is a turbid medium, meaning that photons are both absorbed and scattered as they... | 12/28/2010 |
| 7813782 | Imaging system including an object handling system The invention described herein provides systems and methods for handling objects within an imaging system, such as a multi-modal imaging system. An object handling system operates to position an object to be imaged in an interior cavity of a light imaging system, an... | 10/12/2010 |
| 7806082 | Living specimen induction chamber The invention described herein provides an induction chamber used to sedate one or more living specimens. The induction chamber comprises at least one gas inlet through which anesthesia gas and oxygen are supplied. To minimize escape of anesthetizing gas is into the... | 10/05/2010 |
| 7797034 | 3-D in-vivo imaging and topography using structured light The present invention provides systems and methods for obtaining a three-dimensional (3D) representation of one or more light sources inside a sample, such as a mammal. Mammalian tissue is a turbid medium, meaning that photons are both absorbed and scattered as they... | 09/14/2010 |
| 7765487 | Graphical user interface for in-vivo imaging A graphical user interface is provided which allows the user to perform numerous operations suitable for analysis of in-vivo images within a single display screen or a single window. Using the in-vivo GUI, the user may create and manipulate analysis tools such as re... | 07/27/2010 |
| 7764986 | Method and apparatus for determining target depth, brightness and size within a body region A method of investigating the location and size of a light-emitting source in a subject is disclosed. In practicing the method, one first obtains a light intensity profile by measuring, from a first perspective with a photodetector device, photons which (i) originat... | 07/27/2010 |
| 7663664 | Absolute intensity determination for a fluorescent light source in low level light imaging systems The invention describes systems and methods to obtain and present imaging data in absolute units. The systems and methods convert relative image data produced by a camera to absolute light intensity data using a compensation factor. The compensation factor accommoda... | 02/16/2010 |
| 7649185 | Fluorescent phantom device Described herein is a phantom device that simplifies usage, testing, and development of light imaging systems. The phantom device includes a body and a fluorescent light source internal to the body. The body comprises an optical material designed to at least partial... | 01/19/2010 |
| 7629573 | Tissue phantom calibration device for low level light imaging systems The present invention relates to a phantom device that simplifies usage and testing of a low intensity light imaging system. The phantom device includes a body and a light source internal to the body. The body comprises an optically selective material designed to at... | 12/08/2009 |
| 7616985 | Method and apparatus for 3-D imaging of internal light sources The present invention provides systems and methods for obtaining a three-dimensional (3D) representation of one or more light sources inside a sample, such as a mammal. Mammalian tissue is a turbid medium, meaning that photons are both absorbed and scattered as they... | 11/10/2009 |
| 7603167 | Method and apparatus for 3-D imaging of internal light sources The present invention provides systems and methods for obtaining a three-dimensional (3D) representation of one or more light sources inside a sample, such as a mammal. Mammalian tissue is a turbid medium, meaning that photons are both absorbed and scattered as they... | 10/13/2009 |
| 7599731 | Fluorescent light tomography Described herein are systems and methods for obtaining a three-dimensional (3D) representation of the distribution of fluorescent probes inside a sample, such as a mammal. Using a) fluorescent light emission data from one or more images, b) a surface representation ... | 10/06/2009 |
| 7595838 | Multi-view imaging apparatus Systems and methods are provided for taking images of a sample. The sample is placed in an imaging box comprising a moveable stage that allows images of the sample to be taken from various positions and angles within the imaging box. The images are taken by a camera... | 09/29/2009 |
| 7589786 | Multi-view imaging of a sample in a box Systems and methods are provided for taking images of a sample. The sample is placed in an imaging box comprising a moveable stage that allows images of the sample to be taken from various positions and angles within the imaging box. The images are taken by a camera... | 09/15/2009 |
| 7581191 | Graphical user interface for 3-D in-vivo imaging The present invention provides a computer system and user interface that allows a user to readily view and analyze two-dimensional and three-dimensional in vivo images and imaging data. The user interface is well-suited for one or more of the following actions perti... | 08/25/2009 |
| 7555334 | Small animal light intensity monitor Disclosed are methods and apparatus for collecting light emitted from an animal, where a luminescent reporter has been injected into the animal is disclosed. The apparatus includes a chamber for receiving the animal, wherein the chamber is light tight preventing a s... | 06/30/2009 |
| 7555332 | Fluorescent light tomography Described herein are systems and methods for obtaining a three-dimensional (3D) representation of the distribution of fluorescent probes inside a sample, such as a mammal. Using a) fluorescent light emission data from one or more images, b) a surface representation ... | 06/30/2009 |
| 7503323 | Multiple output anesthesia system The present invention provides improved anesthesia delivery systems that consistently and reliably deliver anesthesia gas to multiple gas outlets. The systems are particularly useful for anesthetizing multiple mammals and living specimens to be imaged by a low-light... | 03/17/2009 |
| 7474399 | Dual illumination system for an imaging apparatus and method A dual illumination system is disclosed for use with an imaging apparatus. The imaging apparatus defines a light-tight imaging compartment with an interior wall having a view port extending into the imaging compartment. This view port enables data acquisition of a b... | 01/06/2009 |
| 7474398 | Illumination system for an imaging apparatus with low profile output device A fluorescence illumination system is provided for use with an imaging apparatus that defines a light-tight imaging compartment. The fluorescence illumination system includes a trans-illumination component configured to direct excitation light into a first surface o... | 01/06/2009 |
| 7466418 | Fluorescence illumination assembly for an imaging apparatus and method A macroscopic fluorescence illumination assembly is provided for use with an imaging apparatus with a light-tight imaging compartment. The imaging apparatus includes an interior wall defining a view port extending into the imaging compartment to enable viewing of a ... | 12/16/2008 |
| 7464707 | Anesthesia delivery device for use in a light imaging system The present invention provides improved anesthesia delivery systems that consistently and reliably deliver anesthesia gas to multiple gas outlets. The systems are particularly useful for anesthetizing multiple mammals and living specimens to be imaged by a low-light... | 12/16/2008 |
| 7461652 | Imaging system with anesthesia system The present invention provides improved anesthesia delivery systems that consistently and reliably deliver anesthesia gas to multiple gas outlets. The systems are particularly useful for anesthetizing multiple mammals and living specimens to be imaged by a low-light... | 12/09/2008 |
| 7449615 | Non-invasive evaluation of physiological response in a transgenic mouse The present invention relates to panels of reporter expression cassettes and the generation of transgenic non-human animals, wherein said reporter expression cassettes have selected control elements operable linked to reporter genes. The invention includes methods o... | 11/11/2008 |
| 7449567 | Isolation and identification of mouse and human transcription control elements associated with cytochrome expression The present invention relates to transcription control elements derived from mouse and human genes associated with cytochrome expression, e.g., Cyp3A11 and CYP3A4, respectively. Isolated polynucleotides, expression cassettes, vectors, recombinant cells, and transgen... | 11/11/2008 |
| 7403812 | Method and apparatus for determining target depth, brightness and size within a body region A method of investigating the location and size of a light-emitting source in a subject is disclosed. In practicing the method, one first obtains a light intensity profile by measuring, from a first perspective with a photodetector device, photons which (i) originat... | 07/22/2008 |
| 7383078 | Imaging apparatus with heating element An improved imaging apparatus is disclosed that allows a user to perform numerous imaging operations. The imaging apparatus may include one or more improvements to imaging box design to improve illumination control within the imaging box, such as improved door seal ... | 06/03/2008 |
| 7331341 | Living specimen induction chamber The invention described herein provides an induction chamber used to sedate one or more living specimens. The induction chamber comprises at least one gas inlet through which anesthesia gas and oxygen are supplied. To minimize escape of anesthetizing gas is into the... | 02/19/2008 |
| 7299420 | Graphical user interface for imaging A graphical user interface is provided which allows the user to perform numerous operations suitable for analysis of in-vivo images within a single display screen or a single window. Using the the-vivo GUI, the user may create and manipulate analysis tools such as r... | 11/20/2007 |
| 7298415 | Structured light imaging apparatus The present invention integrates a structured light source into an imaging system for reconstructing surface topography of an object being imaged. The structured light source includes a mechanism for transmitting a set of lines onto the object from an angle. The lin... | 11/20/2007 |
| 7196190 | Methods and compositions for screening for angiogenesis modulating compounds The present invention relates to novel transcription control elements, including promoters, derived from angiogenesis-related genes, particularly the mouse VEGF gene, the mouse VEGFR-2 receptor gene, and the mouse Tie2 gene. Also disclosed are isolated polynucleotid... | 03/27/2007 |
| 7190991 | Multi-mode internal imaging The invention described herein provides systems and methods for multi-modal imaging with light and a second form of imaging. Light imaging involves the capture of low intensity light from a light-emitting object. A camera obtains a two-dimensional spatial distributi... | 03/13/2007 |
| 7177024 | Bottom fluorescence illumination assembly for an imaging apparatus A macroscopic fluorescence illumination assembly is provided for use with an a imaging apparatus with a light-tight imaging compartment. The imaging apparatus includes an interior wall defining a view port extending into the imaging compartment to enable viewing of ... | 02/13/2007 |
| 7116354 | Absolute intensity determination for a light source in low level light imaging systems The invention describes systems and methods to obtain and present imaging data in absolute units. The systems and methods convert relative image data produced by a camera to absolute light intensity data using a compensation factor. The compensation factor accommoda... | 10/03/2006 |
| 7115793 | Isolation and identification of transcription control elements associated with mouse eosinophil peroxidase expression The present invention relates to novel transcription control elements derived from a mouse eosinophil peroxidase gene. Such transcription control elements may comprise isolated polynucleotides, expression cassettes, vectors, recombinant cells, and transgenic animals... | 10/03/2006 |
| 7113217 | Multi-view imaging apparatus Systems and methods are provided for taking images of a sample. The sample is placed in an imaging box comprising a moveable stage that allows images of the sample to be taken from various positions and angles within the imaging box. The images are taken by a camera... | 09/26/2006 |
