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| Number | Title | Issue Date |
| 8183367 | Methods of preparing polymorphic form A of bazedoxifene acetate The present invention relates to methods of preparing polymorphic Form A of bazedoxifene acetate and polymorphic Form A prepared by such methods. ... | 05/22/2012 |
| 8182817 | Antibodies to human IL-22 The present application provides human antibodies and antigen binding fragments thereof that specifically bind to the human interleukin-22 (IL-22). The antibodies can act as antagonists of IL-22 activity, thereby modulating immune responses in general, and those med... | 05/22/2012 |
| 8178097 | Methods of treatment utilizing binding proteins of the interleukin-21 receptor The present invention provides binding proteins and antigen-binding fragments thereof, including human antibodies, that specifically bind to the human interleukin-21 receptor (IL-21R), and methods of using them. The binding proteins can act as, e.g., antagonists of ... | 05/15/2012 |
| 8173814 | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof The present invention relates to maleate salt forms of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, methods of preparing crystalline maleate salt forms, the associated compounds, and pharmaceutical ... | 05/08/2012 |
| 8173394 | Systems and methods for protein production The invention relates to systems and methods for producing proteins of interest. The invention employs genetically-engineered animal or plant cells that have modified protein folding or processing capacities. In one aspect, the invention features genetically-enginee... | 05/08/2012 |
| 8163884 | Interleukin-21 receptor binding proteins The present invention provides binding proteins and antigen-binding fragments thereof that specifically bind to the human interleukin-21 receptor (IL-21R). The binding proteins can act as, e.g., antagonists of IL-21R activity, thereby modulating immune responses in ... | 04/24/2012 |
| 8143385 | Nucleic acids coding for antibodies against human IL-21 receptor and uses therefor The present application provides human antibodies and antigen binding fragments thereof that specifically bind to the human interleukin-21 receptor (IL-21R). The antibodies can act as antagonists of IL-21R activity, thereby modulating immune responses in general, an... | 03/27/2012 |
| 8129524 | Cyanopyrrole containing cyclic carbamate and thiocarbamate biaryls and methods for preparing the same Methods for preparing cyclic carbamates and thiocarbamates containing cyanopyrrole moieties and of the formula are provided: Z are the same or different and are H, optionally substituted C1 to C6 alkyl... | 03/06/2012 |
| 8129523 | Coupling process for generating reactive boron-containing derivatives of N-substituted pyrrole-2-carbonitriles to produce biaryls A convenient preparation of boron-containing compounds, borate salts, pyrrolecarbonitrile boron-containing compounds, N-substituted-pyrrole-2-carbonitrile boron-containing compounds, and derivatives thereof is provided. The present invention also provides for the us... | 03/06/2012 |
| 8129371 | Thienopyrimidine and pyrazolopyrimidine compounds and their use as mTOR kinase and PI3 kinase inhibitors The invention relates to thienopyrimidine and pyrazolopyrimidine compounds of the Formulas (Ia) and (IIa), or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein compositions ... | 03/06/2012 |
| 8129145 | Production of glycoproteins An improved system for large scale production of glycoproteins in cell culture is provided. In accordance with the present invention, cells expressing a glycoprotein are grown in media that contain manganese at a concentration of between approximately 10 and 600 nM.... | 03/06/2012 |
| 8128928 | Humanized antibodies that recognize beta amyloid peptide The invention provides improved agents and methods for treatment of diseases associated with amyloid deposits of Aβ in the brain of a patient. Preferred agents include humanized antibodies. ... | 03/06/2012 |
| 8124750 | Recombinant protective protein from The present invention discloses amino acid sequences and nucleic acid sequences relating to a Streptococcus pneumoniae surface associated Pneumo Protective Protein (PPP) having a molecular weight of about 20 kilo Daltons (kDa). The PPP exhibits the ability to... | 02/28/2012 |
| 8114869 | Polymorph form II of tanaproget Tanaproget polymorph Form II, processes for preparing tanaproget polymorph Form II, pharmaceutical compositions including tanaproget polymorph Form II, micronized tanaproget polymorph Form II, and processes for converting Form II to tanaproget Form I are provided. A... | 02/14/2012 |
| 8114417 | Recombinant protective protein from The present invention discloses amino acid sequences and nucleic acid sequences relating to a Streptococcus pneumoniae surface associated Pneumo Protective Protein (PPP) having a molecular weight of about 20 kilo Daltons (kDa). The PPP exhibits the ability to... | 02/14/2012 |
| 8110705 | Processes for making hydrazides A method is disclosed for preparing hydrazides from hydrazine and an acyl chloride which comprises the steps of (a) preparing a stirred substantially uniform slurry comprising hydrazine and an inert solvent at low temperature; and (b) adding an acyl chloride continu... | 02/07/2012 |
| 8110198 | Nucleic acid and amino acid sequences relating to for diagnostics and therapeutics The invention provides isolated polypeptide and nucleic acid sequences derived from Staphylococcus epidermidis that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the poly... | 02/07/2012 |
| 8101590 | 9-aminocarbonylsubstituted derivatives of glycylcyclines This invention provides compounds of Formula I having the structure where R1, R2, R3 and A are defined in the specification or a pharmaceutically acceptable salt thereof useful as antibacter... | 01/24/2012 |
| 8101194 | Immunogenic compositions for the prevention and treatment of meningococcal disease The present invention relates to Neisseria ORF2086 proteins, crossreactive immunogenic proteins which can be isolated from nesserial strains or prepared recombinantly, including immunogenic portions thereof, biological equivalents thereof, antibodies that imm... | 01/24/2012 |
| 8092798 | Method of increasing trabecular bone density in a patient in need thereof by an antibody against GDF-8 The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative d... | 01/10/2012 |
| 8071112 | Compositions and methods of use of ORF-1358 from beta-hemolytic streptococcal strains The present invention relates to polynucleotides encoding Streptococcus group C and G polypeptides and their use in immunogenic compositions. The invention also relates to immunogenic compositions comprising polypeptides encoded by those polynucleotides. In a... | 12/06/2011 |
| 8067182 | Method of weak partitioning chromatography This invention relates to methods of using weak partitioning chromatography for the purification of a product from a load fluid containing one or more impurities. Further, the invention relates to methods of weak partitioning chromatography defined by operating cond... | 11/29/2011 |
| 8067013 | Multivalent avian influenza vaccines A vaccine composition and method which is effective in preventing or ameliorating Avian Influenza Virus infection is set forth herein. The vaccine contains at least two inactivated strains of avian influenza virus, wherein the combined haemoagglutinin (HA) total is ... | 11/29/2011 |
| 8063053 | 1-(arylsulfonyl)-4-(piperazin-1-yl)-1H-benzimidazoles as 5-hydroxytryptamine-6 ligands The invention relates to 1-(arylsulfonyl)-4-(piperazin-1-yl)-1H-benzimidazole compounds of the Formula I: or a tautomer, stereoisomer, or pharmaceutically acceptable salt thereof, wherein the constituent variables are as de... | 11/22/2011 |
| 8063041 | Polymorphic Form D of bazedoxifene acetate and methods of preparing same The present disclosure relates to polymorphic Form D of bazedoxifene acetate, pharmaceutical compositions and methods of treatment using the same, and methods of preparing the same. ... | 11/22/2011 |
| 8058407 | Purification of acidic proteins using ceramic hydroxyapatite chromatography The present invention provides a method of removing product-related inactive or partially active species, high molecular weight aggregates, as well as other process-related impurities from preparations of acidic proteins by using ceramic hydroxyapatite chromatograph... | 11/15/2011 |
| 8044178 | Anti-5T4 antibodies and uses thereof Anti-5T4 antibodies, anti-5T4 antibody/drug conjugates, and methods for preparing and using the same. ... | 10/25/2011 |
| 8039469 | Triazine compounds as PI3 kinase and mTOR inhibitors Compounds of formula I wherein: R1 is and R2, R4, and R6-9 are... | 10/18/2011 |
| 8039231 | Methods for enhanced production of bone morphogenetic proteins Methods and processes for improved recombinant protein production are provided. The methods are useful for production of growth factors, particularly those of the TGF-β superfamily, including bone morphogenetic proteins (BMPs), such as BMP-2. Suitable host cells ar... | 10/18/2011 |
| 8030325 | Biosynthetic gene cluster for the production of a complex polyketide A polyketide synthase complex composed of polyketide synthase with 15 total modules, a non-ribosomal peptide synthetase with 1 module, and a cytochrome P450 hydroxylase is described. Also provided are novel Streptomyces species and methods of modified Stre... | 10/04/2011 |
| 8026276 | Parenteral CCI-779 formulations containing cosolvents, an antioxidant, and a surfactant Parenteral formulations of rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl) -2-methylpropionic acid (CCI-779) are provided. One parenteral formulation contains CCI-779, an alcoholic co-solvent, and an antioxidant. Another parenteral formulation contains CCI-779, ... | 09/27/2011 |
| 8022216 | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof The present invention relates to maleate salt forms of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, methods of preparing crystalline maleate salt forms, the associated compounds, and pharmaceutical ... | 09/20/2011 |
| 8003784 | Cyanopyrrole containing cyclic carbamate and thiocarbamate biaryls and methods for preparing the same Methods for preparing cyclic carbamates and thiocarbamates containing cyanopyrrole moieties and of the formula are provided. Z are the same or different and are H, optionally substituted C1 to C6 alkyl... | 08/23/2011 |
| 8003133 | Calcium phosphate delivery vehicles for osteoinductive proteins A composition for delivery of osteogenic proteins is disclosed. The composition comprises an osteogenic protein, a calcium phosphate material as a carrier, and an effective amount of an effervescent agent. Methods of making the compositions and methods of using the ... | 08/23/2011 |
| 8003097 | Treatment of cerebral amyloid angiopathy The invention provides improved agents and methods for treatment of cerebral amyloid angiopathy (CAA) and methods to effect prophylaxis of CAA. The methods can treat CAA concurrently with Alzheimer's disease or separately. The methods can effect prophylaxis of CAA c... | 08/23/2011 |
| 8002721 | Thermal covering The present invention is directed to a thermal covering that delivers consistent therapy to a portion of a user's hand-wrist area, is easy to use and apply to the body, and is securely positionable on the body. The thermal covering can be entirely disposable after o... | 08/23/2011 |
| 7998965 | Glutamate aggrecanase inhibitors The present invention relates to modulators of metalloproteinase activity. ... | 08/16/2011 |
| 7994333 | Methods and compositions for selectin inhibition The present invention relates to the field of anti-inflammatory substances, and more particularly to novel compounds that act as antagonists of the mammalian adhesion proteins known as selectins. In some embodiments, methods for treating selectin mediated disorders ... | 08/09/2011 |
| 7982043 | Protein tyrosine kinase enzyme inhibitors This invention provides compounds of formula 1, having the structure wherein R1, R2, R3, R4, and R5 are described within the specification. ... | 07/19/2011 |
| 7981912 | Indole acetic acids exhibiting CRTH2 receptor antagonism and uses thereof The invention relates to indole acetic acid compounds which function as antagonists of the CRTH2 receptor. The invention also relates to the use of these compounds to inhibit the binding of prostaglandin D2 and its metabolites or certain thromboxane metab... | 07/19/2011 |
