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| Number | Title | Issue Date |
| 8183038 | Composition comprising recombinant nucleic acid encoding Sox2, Oct-4, Nanog and Lin28 The present invention relates to methods for reprogramming a somatic cell to pluripotency by administering into the somatic cell at least one or a plurality of potency-determining factors. The invention also relates to pluripotent cell populations obtained using a r... | 05/22/2012 |
| 8179843 | Distributed scheduling method for multi-antenna wireless system A channel allocation system for a beam-forming wireless network selects receivers to enroll in communication from a pool of candidate receivers, by off-loading a determination of the effects of adding each candidate receiver to the candidate receiver itself. In one ... | 05/15/2012 |
| 8178517 | 6-methylvitamin Danalogs and their uses This invention discloses 6-methylvitamin D3 analogs, and specifically 1α,25-dihydroxy-6-methylvitamin D3, and pharmaceutical uses therefor. This compound exhibits vitamin D receptor binding activity and transcription activity as well as activi... | 05/15/2012 |
| 8178331 | Recombinant yeast with improved ethanol tolerance and related methods of use The present invention provides isolated Elo1 and Mig3 nucleic acid sequences capable of conferring increased ethanol tolerance on recombinant yeast and methods of using same in biofuel production, particularly ethanol production. Methods of bioengineering yeast usin... | 05/15/2012 |
| 8175359 | Iterative highly constrained image reconstruction method An image reconstruction method includes reconstructing an initial composite image of a subject using a conventional reconstruction method. The initial composite image employs the best information available regarding the subject of the scan and this information is us... | 05/08/2012 |
| 8173968 | System and method for improved radiation dosimetry A radiation dosimetry quality assurance system is disclosed that includes a three-dimensional (3D) phantom extending along a longitudinal axis to form an exterior surface and an interior volume and a passage formed to extend into the interior volume of the 3D phanto... | 05/08/2012 |
| 8173167 | Micelle composition of polymer and passenger drug Hydrophobic drugs become more practical for treatments by being encapsulated in micelle compositions for increasing solubility. Micelle compositions may include an excipient tocopherol and/or prodrug formulations of the drug. Micelles extend the time period the drug... | 05/08/2012 |
| 8170315 | Localized and highly constrained image reconstruction method An image reconstruction method includes reconstructing a composite image of a subject using a conventional reconstruction method. The composite image employs the best information available regarding the subject of the scan and this information is used to constrain t... | 05/01/2012 |
| 8168133 | Device for performing a high throughput assay A device and method is provided for performing a high throughput assay. The device includes a plate structure having a plate and a plurality of microfluidic structures positioned thereon. Each microfluidic structure defines a channel having an input and an output. A... | 05/01/2012 |
| 8164082 | Spin-bus for information transfer in quantum computing A spin bus quantum computing architecture includes a spin bus formed of multiple strongly coupled and always on qubits that define a string of spin qubits. A plurality of information bearing qubits are disposed adjacent a qubit of the spin bus. Electrodes are formed... | 04/24/2012 |
| 8163900 | Seven-membered heterocyclic carbenes and their metal complexes Disclosed are carbenes of the general formula: and including salts thereof, and metal complexes thereof. The carbenes are useful in any reaction where carbenes and carbene-metal complexes are used. The carbenes disclosed he... | 04/24/2012 |
| 8163325 | Cheese having reintroduced fine particles of cheese Methods of making acid and rennet-based cheeses include processing a previous lot of milk to produce curds and whey from the previous lot of milk, and removing the whey from the curd. For cottage cheeses, curds are washed with a wash water. Whey and wash water (when... | 04/24/2012 |
| 8158614 | Therapeutic treatment of cancer and dysplasia of the cervix or vagina using estrogen antagonists A method for treatment of cervical or vaginal cancer and their associated dysplasia, including the steps of identifying a human cervical or vaginal cancer and/or dysplasia patient, administering an effective amount of an estrogen antagonist therapy to the patient, w... | 04/17/2012 |
| 8158424 | Primate pluripotent stem cells cultured in medium containing gamma-aminobutyric acid, pipecolic acid and lithium Previous methods for culturing primate pluripotent stem cells have required either fibroblast feeder cells or a medium which was exposed to fibroblast feeder cells to maintain the stem cells in an undifferentiated state. It has now been found that high levels of fib... | 04/17/2012 |
| 8158422 | Erythroid cells producing adult-type β-hemoglobin generated from human embryonic stem cells Methods and compositions of erythroid cells that produce adult β-hemoglobin, generated by culturing CD31+, CD31+/CD34+ or CD34+ cells from embryonic stem cells under serum-free culture conditions. ... | 04/17/2012 |
| 8158371 | Assay for antibodies to A method of detecting an immune response to a paratuberculosis-specific antigen, comprising incubating a sample from a subject with the paratuberculosis-specific antigen and detecting the presence of an antibody in the sample as an indication of an immune response t... | 04/17/2012 |
| 8158117 | Methods and compositions for phosphate binding The present invention provides improved methods and compositions for therapeutically controlling and/or reducing serum phosphate levels in animals and mammalian patients. The methods comprise administering to the patient an amount of a dendrimer composition effectiv... | 04/17/2012 |
| 8154001 | Ion radiation therapy system with variable beam resolution An ion radiation therapy machine provides a steerable beam for treating a tumor within the patient where the exposure spot of the beam is controlled in width and/or length to effect a flexible trade-off between treatment speed, accuracy, and uniformity. ... | 04/10/2012 |
| 8153698 | Method for producing bio-fuel that integrates heat from carbon-carbon bond-forming reactions to drive biomass gasification reactions A low-temperature catalytic process for converting biomass (preferably glycerol recovered from the fabrication of bio-diesel) to synthesis gas (i.e., H2/CO gas mixture) in an endothermic gasification reaction is described. The synthesis gas is used in exo... | 04/10/2012 |
| 8153424 | Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells A method of differentiating embryonic stem cells into ventral spinal progenitor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and ar... | 04/10/2012 |
| 8153383 | Mycobacterial culture screening test for complex bacteria A method of antigen-capture assays that uses the detection of antigens secreted into liquid culture is provided. Also provided are antibodies to Mycobacterium avium complex-specific antigens, and diagnostic kits and systems for the detection of the presence o... | 04/10/2012 |
| 8152999 | Membrane cascade-based separation The present invention provides counter flow cascade separation systems useful to separate solute/solute pairs present in a solvent. The separation systems include a series of interconnected stages with each stage comprising a diafilter preferentially permeable for o... | 04/10/2012 |
| 8152784 | Method for treating or preventing steroid-induced glaucoma An integrin antagonist reduces the occurrence of cross-linked actin network (CLAN) structures in cells of the trabecular meshwork. CLAN structures are associated with steroid-induced glaucoma. Reduction in CLAN structures is associated with increased aqueous humor o... | 04/10/2012 |
| 8150795 | Methods and devices for analysis of clustered data, in particular action potentials (i.e. neuron firing signals in the brain) Methods for clustering of multi-dimensional data allow unsupervised grouping of multi-dimensional data points into clusters having like characteristics. The methods may be usefully applied to extracellular action potentials (neuronal spikes) measured from the brain,... | 04/03/2012 |
| 8149415 | Background-free absorption spectroscopy using spectral differentiator An absorption spectrometer provides improved rejection of background radiation signal by employing a frequency-swept laser signal without frequency dithering and performing an effective differentiation of output light from a test cell to eliminate these constant or ... | 04/03/2012 |
| 8148984 | Method for magnitude constrained phase contrast magnetic resonance imaging A method for magnitude constrained phase contrast magnetic resonance imaging (MRI) is provided. The method utilizes an assumption that the image magnitude is shared across a series of images reconstructed from a set of phase contrast enhanced k-space data. In this m... | 04/03/2012 |
| 8148553 | Catalytic conversion of cellulose to liquid hydrocarbon fuels by progressive removal of oxygen to facilitate separation processes and achieve high selectivities Described is a method to make liquid chemicals, such as functional intermediates, solvents, and liquid fuels from biomass-derived cellulose. The method is cascading; the product stream from an upstream reaction can be used as the feedstock in the next downstream rea... | 04/03/2012 |
| 8144966 | Use of endogenous fluorescence to identify invading metastatic breast tumor cells The present invention broadly provides methods and systems for detecting, identifying, and characterizing conditions, including diseases and other disorders in human or other animal subjects, by analyzing fluorescence from endogenous flavin adenine dinucleotide (FAD... | 03/27/2012 |
| 8143238 | Methods of increasing epidermal skin thickness by topical administration of a 19-nor containing vitamin D compound Methods of increasing the thickness of the epidermal layer in the skin of a human comprising topically administering a therapeutically effective dose of an active pharmaceutical ingredient comprising a vitamin D analog including 2-methylene-19-nor-20(S)-1α-hydroxy-... | 03/27/2012 |
| 8142708 | Micro fluidic system for single molecule imaging Laminar flow of a carrier liquid and polymeric molecules through micro-channels is used to straighten the polymeric molecules and attach the straightened molecules to a wall of the micro-channel for subsequent treatment and analysis. Micro-channels can be manufactur... | 03/27/2012 |
| 8140292 | Method and system for controlling a voltage waveform A method of automating a process for controlling a voltage waveform applied to an object is provided. A first waveform for applying to the object is received. A first FFT of the first waveform is calculated. A second waveform for input to the waveform generator is d... | 03/20/2012 |
| 8137924 | Method and compositions for detecting botulinum neurotoxin A molecular construct capable of fluorescent resonance energy transfer (FRET), comprising a linker peptide, a donor fluorophore moiety and an acceptor fluorophore moiety, wherein the linker peptide is a substrate of a botulinum neurotoxin selected from the group con... | 03/20/2012 |
| 8133732 | Method of forming myeloid precursor cells from human embryonic stem cells This invention relates to the culture of dendritic cells from human embryonic stem (ES) cells. Human ES cells are first cultured into hematopoietic cells by co-culture with stromal cells. The cells now differentiated into the hematopoietic lineage are then cultured ... | 03/13/2012 |
| 8133731 | Production of primate neural stem cells through expression of pax6 A transcription factor both necessary and sufficient for human neuroectoderm specification, Pax6, as well as applications thereof, is disclosed. ... | 03/13/2012 |
| 8133680 | Using liquid crystals to detect affinity microcontact printed biomolecules The present invention provides methods, devices and kits for detecting a ligand. The methods involve capturing a ligand from a sample with an affinity substrate that includes a receptor for a ligand, transferring captured ligand to a detection surface and detecting ... | 03/13/2012 |
| 8133534 | Methods and compositions for forming patterns with isolated or discrete features using block copolymer materials Methods of directing the self assembly of block copolymers on chemically patterned surfaces to pattern discrete or isolated features needed for applications including patterning integrated circuit layouts are described. According to various embodiments, these featur... | 03/13/2012 |
| 8133341 | Molecular transfer printing using block copolymers Methods of creating and transferring chemical patterns and physical patterns of deposited materials or molecules using block copolymers are provided. The methods involve providing block copolymer materials blended with one or more transfer molecules or inks. The dif... | 03/13/2012 |
| 8129499 | Antiviral peptides against influenza virus The present disclosure generally relates to peptides having antiviral properties. More particularly, the invention relates to peptides exhibiting activity against influenza viruses, to pharmaceutical compositions comprising the peptides, and to methods of using the ... | 03/06/2012 |
| 8125640 | Automated analysis system for detection and quantification of biomolecules by measurement of changes in liquid crystal orientation The present invention provides systems and methods for data acquisition and image analysis that utilize twisted nematic liquid crystals (“TNLCs”) to create maps of bio/chemical functionality patterned on surfaces. The method involves the acquisition of a series ... | 02/28/2012 |
| 8124410 | Methods of finding, selecting and studying cells in heterogeneous co-cultures Co-cultures of heterogeneous cell populations in a diffusion-constrained microenvironment and methods for co-culturing are disclosed. ... | 02/28/2012 |
