Assignee: Whitehead Institute for Biomedical Research

Location: Cambridge, MA
No. of patents: 148

Browse patents
Browse applications

Number	Title	Issue Date
8143480	Compositions and methods for efficient gene silencing in plants This invention relates to methods for knock-down of a target gene in plants, particularly efficient and specific methods for knock-down of a target gene in plants. This invention also relates to methods for silencing endogenous plant genes or plant pathogen genes. I...	03/27/2012
8133679	Methods of identifying agents that diminish cellular toxicity associated with an α-synuclein polypeptide of Parkinson's disease in yeast Methods of screening candidate agents to identify lead compounds for the development of therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease and methods for identifying a mutation in, or changes in...	03/13/2012
8124365	Identification of genotype-selective anti-tumor agents The present invention relate to methods of identifying a genotype-selective agent. In certain embodiments, the invention relates to agents that are selectively toxic to engineered human tumorigenic cells. ...	02/28/2012
8106180	Methods and products for expression of micro RNAs The invention relates to microRNAs, methods of producing microRNAs and methods for using microRNAs. ...	01/31/2012
8071369	Compositions for reprogramming somatic cells The invention provides methods for reprogramming somatic cells to generate multipotent or pluripotent cells. Such methods are useful for a variety of purposes, including treating or preventing a medical condition in an individual. The invention further provides meth...	12/06/2011
8058515	Plant cells and plants overexpressing vacuolar proton pyrophosphatases The present invention relates to a transgenic plant, comprising one or more plant cells transformed with exogenous nucleic acid which increases expression of vacuolar pyrophosphatase in the plant. Also encompassed by the present invention are transgenic progeny and ...	11/15/2011
8058012	Five-helix protein Five-Helix protein, which comprises the three N-helices and at least two, but not three, of the three C-helices of the trimer-of-hairpin structure of HIV gp41, separated by linkers, such as amino acid residue linkers, is disclosed. Six-Helix protein, which includes ...	11/15/2011
8003852	Transgenic plants overexpressing a plant vacuolar pyrophosphatase Transgenic plants are described which are engineered to overexpress vacuolar H+-PPase. Plants such as tobacco and petunia transformed with A. Thaliana AVP-1 are shown to have increased meristematic activity resulting in larger leaves, stem, flower,...	08/23/2011
7960504	Inhibitors of HIV membrane fusion Inhibitors of HIV membrane fusion and a method of identifying drugs or agents which inhibit binding of the N-helix coiled-coil and the C helix of HIV gp41 envelope protein. ...	06/14/2011
7906308	Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex In certain aspects, the invention relates to methods for identifying compounds which modulate Akt activity mediated by the rictor-mTOR complex and methods for treating or preventing a disorder that is associated with aberrant Akt activity. ...	03/15/2011
7811578	Soluble chimeric peptide inhibitors of HIV entry comprising an IZ trimeric coiled-coil peptide and HIV gp41 N-helix coiled-coil peptide Described herein are chimeric peptides comprising a soluble trimeric coiled-coil and all or a portion of the N-peptide region of HIV gp41. These molecules are stable, trimeric coiled-coils that inhibit HIV entry into cells, such as human cells. Such peptides can be ...	10/12/2010
7807464	Methods for expansion and analysis of cultured hematopoietic stem cells Methods and kits for propagating hematopoietic stem cells are provided. The methods comprise culturing cells in medium comprising one or more angiopoietin-like proteins, under conditions sufficient for expansion of HSCs. Angiopoietin-like proteins include angiopoiet...	10/05/2010
7767453	Cultured hematopoietic stem cells and method for expansion and analysis thereof Hematopoietic stem cells and methods for ex vivo expansion of hematopoietic stem cells are provided. The methods comprise culturing the cells in a media containing an effective amount insulin-like growth factor (IGF), fibroblast growth factor (FGF), thrombopoietin (...	08/03/2010
7682828	Methods for reprogramming somatic cells The invention provides methods for reprogramming somatic cells to generate multipotent or pluripotent cells. Such methods are useful for a variety of purposes, including treating or preventing a medical condition in an individual. The invention further provides meth...	03/23/2010
7615554	Erastin and erastin binding proteins, and uses thereof The invention relates to methods of screening for binding partners, especially binding partners essential for the biological activity of erastin (e.g. VDACs such as VDAC3). The invention also provides reagents and methods for effective killing of cancer cells with e...	11/10/2009
7611838	Biologically-active DNA-binding sites and related methods The invention relates to the identification of biologically-active DNA-binding sites to which a protein of interest binds in a cell. The invention also relates to the identification of agents and conditions which alter the biologically-active DNA-binding sites to wh...	11/03/2009
7575869	Genome wide location and function of DNA binding proteins The present invention relates to a method of identifying a region (one or more) of a genome of a cell to which a protein of interest binds. In the methods described herein, DNA binding protein of a cell is linked (e.g., covalently crosslinked) to genomic DNA of a ce...	08/18/2009
7572575	SIR2 activity This invention relates to methods of screening compounds that modulate cellular and organismal processes by modification of the activity of SIR2 and/or transcription factors, e.g., p53, particularly methods of screening for compounds that modify lifespan and/or meta...	08/11/2009
7556921	Methods for mapping signal transduction pathways to gene expression programs The invention relates to improved methods of identifying the gene expression programs that are regulated by a signal transduction pathway. The invention also provides methods of identifying agents which modulate signal transduction pathway. The invention also provid...	07/07/2009
7534933	Transgenic plants overexpressing a plant vacuolar H + -ATPase Transgenic plants are described which are engineered to overexpress vacuolar H+-PPase. Plants such as tobacco and petunia transformed with A. Thaliana AVP-1 are shown to have increased meristematic activity resulting in larger leaves, stem, flower,...	05/19/2009
7504224	Five-Helix protein Five-Helix protein, which comprises the three N-helices and at least two, but not three, of the three C-helices of the trimer-of-hairpin structure of HIV gp41, separated by linkers, such as amino acid residue linkers, is disclosed. Six-Helix protein, which includes ...	03/17/2009
7501248	Prostate cancer diagnosis and outcome prediction by expression analysis Methods identifying prostate cancer, methods for prognosing and diagnosing prostate cancer, methods for identifying a compound that modulates prostate cancer development, methods for determining the efficacy of a prostate cancer therapy, and oligonucleotide microarr...	03/10/2009
7501234	Stress proteins and uses therefor The present invention relates to stress proteins and methods of modulating an individual's immune response. In particular, it relates to the use of such stress proteins in immune therapy and prophylaxis, which results in an induction or enhancement of an individual'...	03/10/2009
7501125	Vivo CTL elicitation by heat shock protein fusion proteins maps to a discrete domain and is CD4+ T cell-independent The present invention relates to a method of inducing a CD8+ CTL response to a molecule in an individual deficient in CD4+ T cells comprising administering to the individual an hsp or a portion of an ATP binding domain of an hsp joined to the m...	03/10/2009
7491943	Method and apparatus for UV imaging A method and apparatus for illuminating a subject with deep UV light and detecting 2-dimensional image information, e.g., a transmission image, fluorescence image, reflected light image, etc. The subject may be illuminated with a light pulse having a duration of 2 s...	02/17/2009
7491530	Fusion partner cells and uses thereof The present invention provides in one aspect novel fusion partner cells that ectopically express one or more genes that alter the phenotype of a hybrid cell made from a fusion of the fusion partner cell and a fusion cell, hybrid cell lines produced using the fusion ...	02/17/2009
7470507	Genome-wide location and function of DNA binding proteins The present invention relates to a method of identifying a region (one or more) of a genome of a cell to which a protein of interest binds. In the methods described herein, DNA binding protein of a cell is linked (e.g., covalently crosslinked) to genomic DNA of a ce...	12/30/2008
7452670	Methods of identifying agents that diminish cellular toxicity associated with an α-synuclein polypeptide of Parkinson's disease in yeast Methods of screening candidate agents to identify lead compounds for the development of therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease and methods for identifying a mutation in, or changes in...	11/18/2008
7402659	Thymic stromal lymphopoietin receptor molecules and uses thereof The present invention provides Thymic Stromal Lymphopoietin Receptor (TSLPR) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing TSLPR polypeptides. The inven...	07/22/2008
7402396	Core structure of gp41 from the HIV envelope glycoprotein Described are the crystal structure of the α-helical domain of the gp41 component of HIV-1 envelope glycoprotein which represents the core of fusion-active gp41, methods of identifying and designing drugs which inhibit gp41 function and drugs which do so. ...	07/22/2008
7358262	Identification of genotype-selective anti-tumor agents The present invention relate to methods of identifying a genotype-selective agent. In certain embodiments, the invention relates to agents that are selectively toxic to engineered human tumorigenic cells. ...	04/15/2008
7335874	Method and apparatus for generating a circularly polarized illumination beam A method and apparatus for illuminating a subject with deep UV light and detecting 2-dimensional image information, e.g., a transmission image, fluorescence image, reflected light image, etc. The subject may be illuminated with a light pulse having a duration of 2 s...	02/26/2008
7324926	Methods for predicting chemosensitivity or chemoresistance Methods and apparatus for classifying or predicting the classes for samples based on gene expression are described. Also described are methods and apparatus for ascertaining or discovering new, previously unknown classes based on gene expression. Methods, computer s...	01/29/2008
7239986	Methods for classifying samples and ascertaining previously unknown classes Methods and apparatus for classifying or predicting the classes for samples based on gene expression are described. Also described are methods and apparatus for ascertaining or discovering new, previously unknown classes based on gene expression. ...	07/03/2007
7226598	Peptide inhibitors of HIV entry Described herein are chimeric peptides comprising a soluble trimeric coiled-coil and all or a portion of the N-peptide region of HIV gp41. These molecules are stable, trimeric coiled-coils that inhibit HIV entry into cells, such as human cells. Such peptides can be ...	06/05/2007
7105293	Genetic markers for tumors Sets of genetic markers for specific tumor classes are described, as well as methods of identifying a biological sample based on these markers. Also described are diagnostic, prognostic, and therapeutic screening uses for these markers, as well as oligonucleotide ar...	09/12/2006
7101879	Treatments for neurotoxicity in Alzheimer's Disease The invention involves identification of a mechanism of β-amyloid peptide cytotoxicity, which enables treatment of conditions caused by β-amyloid peptide aggregates by administration of compounds which antagonize the mechanism of cytotoxicity. The invention includ...	09/05/2006
7052870	mTOR kinase-associated proteins The invention describes isolated mTOR-associated proteins (“mTOR-APs”) as well as isolated variants and fragments thereof and the isolated nucleic acids encoding them. The invention also describes vectors and host cells containing nucleic acid encoding an mTOR-A...	05/30/2006
7053179	Five-Helix protein Five-Helix protein, which comprises the three N-helices and at least two, but not three, of the three C-helices of the trimer-of-hairpin structure of HIV gp41, separated by linkers, such as amino acid residue linkers, is disclosed. Six-Helix protein, which includes ...	05/30/2006
7033772	Methods of identifying inhibitors of fatty acid transport proteins (FATP) A family of fatty acid transport proteins (FATPs) mediate transport of long chain fatty acids (LCFAs) across cell membranes into cells. These proteins exhibit different expression patterns among the organs of mammals. Nucleic acids encoding FATPs of this family, vec...	04/25/2006

«First «Previous1 2 3 4 Next»Last»

PatentStorm

Bizarre Patents

PatentStorm News

Assignee: Whitehead Institute for Biomedical Research