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| Number | Title | Issue Date |
| 6730735 | Conjugate of polyethylene glycol and chitosan PEG-chitosan conjugates comprising chitosan and polyethylene glycol moieties or derivatives thereof which are bonded together and their use in medicine is described. In one embodiment, the conjugate comprises a chitosan moiety or a derivative thereof and a polyethyl... | 05/04/2004 |
| 6635254 | Surface modification of lamellar particles Lamellar particles are provided comprising a biodegradable and biocompatible polymer and carrying a cationic charge on their surface. These particles are prepared by mixing a preformed negatively charged lamellar particle with a positively charged materia... | 10/21/2003 |
| 6534065 | Influenza vaccine composition with chitosan adjuvant A vaccine composition adapted for mucosal administration is provided. The composition includes one or more influenza vaccine antigens and an effective adjuvant amount of an acid addition salt of a chitosan wherein the chitosan is a deacetylated chitin whi... | 03/18/2003 |
| 6432440 | Pectin compositions and methods of use for improved delivery of drugs to mucosal surfaces Liquid pharmaceutical compositions for administration to a mucosal surface, comprising a therapeutic agent and a pectin with a low degree of esterification are described. Such compositions gel, or can be adapted to gel, at the site of application in the a... | 08/13/2002 |
| 6413941 | Polymer composition for delivering a nucleic acid or derivative thereof A composition for delivering a biologically active polyanionic molecule comprising a linear polymer with a backbone comprising amido and tertiary amino groups arranged regularly on the backbone and biologically active polyanionic molecule bound to the pol... | 07/02/2002 |
| 6391318 | Vaccine compositions including chitosan for intranasal administration and use thereof A variety of different types of nasal vaccine systems have been described including cholera toxin, microspheres, nanoparticles, liposomes, attenuated virus, and outer membrane proteins (proteosomes). The present invention is directed toward a novel nasal ... | 05/21/2002 |
| 6387917 | Salts of opioid analgesics, particularly morphine, and methods of using same The methane sulphonate salt of morphine and compositions thereof have medicinal uses, particularly in the treatment of pain. Compositions comprising a methane sulphonate salt of an opioid analgesic also have medicinal uses, adapted for nasal delivery.... | 05/14/2002 |
| 6383513 | Compositions comprising cannabinoids There is provided a composition for the nasal delivery of a cannabinoid which comprises a cannabinoid in a biphasic delivery system or a cannabinoid in a microsphere delivery system.... | 05/07/2002 |
| 6355276 | Adhesive drug delivery composition Adhesive material from the fimbriae (esp. Type 1) of bacteria or synthetic analogues or fragments thereof is combined with a drug to provide for attachment to the gut of a mammal, thereby prolonging the transit time of the drug through the gut. The 28 kDa... | 03/12/2002 |
| 6342251 | Compositions for nasal administration There is provided a composition for the nasal delivery of a drug suitable for the treatment of erectile dysfunction to a mammal wherein the composition is adapted to provide an initial rise in plasma level followed by a sustained plasma level of the drug.... | 01/29/2002 |
| 6310089 | Composition for the administration of a D1-agonists A composition for intranasal administration comprising a full or partial D1-agonist of the dopamine receptor.... | 10/30/2001 |
| 6228396 | Colonic drug delivery composition A colonic drug delivery composition is provided and comprises a starch capsule containing a drug, the starch capsule being provided with a coating such that the drug will only be released from the capsule in the colon. The coating may be a pH sensitive ma... | 05/08/2001 |
| 6207197 | Gastroretentive controlled release microspheres for improved drug delivery There is provided a drug delivery composition for the controlled release of an active agent in the stomach environment over a prolonged period of time, which comprises a microsphere comprising an active ingredient in the inner core of the microsphere and ... | 03/27/2001 |
| 6200602 | Composition for enhanced uptake of polar drugs from the colon The invention provides a drug delivery composition for colonic delivery comprising a polar drug, an absorption promoter which (a) comprises a mixture of a fatty acid having 6 to 16 carbon atoms or a salt thereof and a dispersing agent, or (b) comprises a ... | 03/13/2001 |
