Assignee: Wayne State University

Location: Detroit, MI
No. of patents: 224

Number	Title	Issue Date
8183379	Antitumor agents The invention provides compounds of formula I: wherein Y is F or Br; or a pharmaceutically acceptable salt thereof. The compounds are effective antitumor agents. The invention also provides pharmaceutical compositions compr...	05/22/2012
8178659	Targets for the identification of antibiotics that are not susceptible to antibiotic resistance To identify conserved and variable regions of the 16 S rRNA, an instant evolution experiment was performed on the entire 16 S rRNA. Analysis of these mutants identified regions that are required for function. These conserved sequences may be used as targets for phar...	05/15/2012
8168398	Asbestos exposure, pleural mesothelioma, and osteopontin levels The present invention provides diagnostic methods based on levels of osteopontin. ...	05/01/2012
8163946	Methods and catalysts for making biodiesel from the transesterification and esterification of unrefined oils A method of forming a biodiesel product and a heterogeneous catalyst system used to form said product that has a high tolerance for the presence of water and free fatty acids (FFA) in the oil feedstock is disclosed. This catalyst system may simultaneously catalyze b...	04/24/2012
8148577	Polyamines useful as anti-parasitic and anti-cancer therapeutics and as lysine-specific demethylase inhibitors Polyamine, polyamine/guanidino, and polyamine/biguanide compounds are disclosed. The compounds are useful as anti-cancer and anti-parasitic treatments. The compounds are also useful as inhibitors of the enzyme lysine-specific demethylase-1. ...	04/03/2012
8148564	Compounds for forming metal nitrides Nitride forming precursors are heated to form a metal nitride on a substrate. In some variations, the precursors are contacted with the substrate which has previously been heated to a sufficient temperature to form a nitride film. Precursors to tungsten and molybden...	04/03/2012
8122761	Biosensor based on polymer cantilevers A microcantilever sensor includes a supporting substrate, a cantilever spring element at least partially disposed over the support substrate, a probe layer disposed over the first side of the cantilever spring element, and a piezoresistive transducer attached to the...	02/28/2012
8093287	Inhibitors of matrix metalloproteinases The present invention provides novel compounds of formulas I-IX, as described herein. Also provided are compositions of compounds of formulas I-IX, methods of making compounds of formulas I-IX, and methods of using compounds of formulas I-IX. The compounds of the in...	01/10/2012
8070836	Combined homogeneous and heterogeneous catalytic transesterification process for biodiesel production In one aspect, a process for producing a biofuel comprises reacting a feed material that comprises a glyceride with an alcohol in the presence of a catalytic composition such that at least some of the glyceride in the feed material is converted into a biofuel mixtur...	12/06/2011
8068994	Method for analyzing biological networks Significance of biological pathway in disease state is predicted by (a) providing expression level data for a plurality of biomolecules differentially expressed in a disease state, compared with same biomolecules expressed in a non-diseased state: (b) determining pr...	11/29/2011
8017791	Tri-substituted 2-benzhydryl-5-benzylamino-tetrahydro-pyran-4-ol and 6-benzhydryl-4-benzylamino-tetrahydro-pyran-3-ol analogues, and novel, 3,6-disubstituted pyran derivatives Novel 3,6-disubstituted pyrans, optionally with a further substituent at the 4-position, are monoamine reuptake inhibitors with activity profiles of anti-depressants. ...	09/13/2011
RE42700	Induction of apoptosis in cancer cells The present invention provides compounds that are inducers or inhibitors of apoptosis of apoptosis preceded by cell-cycle arrest. In addition, the present invention provides pharmaceutical compositions and methods for treating mammals with leukemia or other forms of...	09/13/2011
7994602	Titanium dioxide thin film systems A thin-film metal-oxide compound includes a titanium dioxide layer having a thickness of about 100 to 1000 nanometers. The titanium dioxide layer has a single-phase anatase structure. The titanium dioxide layer is directly disposed on a substrate comprised of glass,...	08/09/2011
7994123	Hybrid proteins with ErbB4 extracellular domain and neuregulin heparin-binding domain for targeting Polypeptides of the neuregulin (NRG) heparin binding domain (N-HBD) and nucleic acids coding therefor are disclosed. In particular, fusion polypeptides are produced that comprise, as a targeting structure, a N-HBD polypeptide, fragment, homologue or functional deriv...	08/09/2011
7964536	Neoepitope detection of disease using protein arrays A biosensor for use in detecting the presence of diseases, the biosensor comprising a detector for detecting a presence of at least one marker indicative of a specific disease. A method of determining efficacy of a pharmaceutical for treating a disease or staging di...	06/21/2011
7928127	Inhibitors of matrix metallaproteinases The present invention provides novel compounds of formulas I-IX, as described herein. Also provided are compositions of compounds of formulas I-IX, methods of making compounds of formulas I-IX, and methods of using compounds of formulas I-IX. The compounds of the in...	04/19/2011
7915433	Tri-substituted 2-benzhydryl 5-benzlamino-tetrahydro-pyran-4-OL and 6-benzhydryl-4-benzylamino-tetrahydro-pyran-3-OL analogues, and novel 3,6 disubstituted pyran derivatives Novel 3,6-disubstituted pyrans, optionally with a further substituent at the 4-position, are monoamine reuptake inhibitors with activity profiles of anti-depressants. ...	03/29/2011
7901896	Asbestos exposure, pleural mesothelioma, and osteopontin levels The present invention provides diagnostic methods based on the levels of osteopontin. ...	03/08/2011
7901656	Metal oxide-containing nanoparticles The present invention provides a copper oxide-containing composition that includes copper oxide nanoparticles and one or more heteroatom donor ligands bonded to the surface of the nanoparticles, where x and y are numbers having a ratio that is equal to the ratio of ...	03/08/2011
7888330	Phosphoramidate derivatives of FAU The present invention provides phosphoramidate derivatives of a furanosyluracil analog, FAU, that can effectively deliver FAU monophosphate, or a derivative thereof, intracellularly. FAU-Phosphoramidate diesters can bypass the first step of phosphorylation and be ac...	02/15/2011
7863004	Neoepitope detection of disease using protein arrays There is provided a diagnostic tool for use in diagnosing diseases, the tool having a detector for detecting the presence of an array of markers indicative of disease. Also provided is a combination of markers for disease, the combination including at least two mark...	01/04/2011
7837944	Device for separating and concentrating microfluidic particles A flow unit for microfluidic particles separation and concentration is disclosed. The unit comprises a nozzle segment, a turn segment, and a diffuser segment. The nozzle segment is defined by a first member and a second member, and has an opening through which fluid...	11/23/2010
7799707	Method of forming gated, self-aligned micro-structures and nano structures Methods of forming a gated, self-aligned nano-structures for electron extraction are disclosed. One method of forming the nano-structure comprises irradiating a first surface of a thermally conductive laminate to melt an area across the first surface of the laminate...	09/21/2010
7759482	Aminoglycosides as antibiotics The present invention provides aminoglycosides and pharmaceutical compositions that include the aminoglycosides. The aminoglycosides are useful to treat or prevent infectious diseases (e.g., bacterial infections) in a mammal (e.g., human). ...	07/20/2010
7728007	Therapeutic amides The invention provides compounds of the formula: wherein X, Y, and Z are as defined in the specification. The compounds are effective anti-tumor agents. The invention also provides pharmaceutical compositions comprising a c...	06/01/2010
7723519	Hybrid 2-aminoterailin and aryl-substituted piperazine compounds and their use in altering CNS activity Hybrid compounds containing an aminotetralin moiety or a heterocyclic and/or open chain analog thereof linked through an alkylene group to an aryl ring system-substituted piperidiene moiety exhibit high levels of CNS activity, in some cases exhibiting especially hig...	05/25/2010
7709196	Methods and compositions for the identification of antibiotics that are not susceptible to antibiotic resistance Compositions and methods are provided to identify functional mutant ribosomes that may be used as drug targets. The compositions and methods allow isolation and analysis of mutations that would normally be lethal and allow direct selection of rRNA mutants with prede...	05/04/2010
7709054	Particle-rod nano structures and method of forming same by spin coating A method of forming a particle-rod nanostructure is disclosed. The method comprises preparing a mixture comprising an inorganic nanoparticle and an organic molecule in a solvent. The method further comprises spin-coating the mixture to nucleate a crystal growth of t...	05/04/2010
7632761	Method of making thin film anatase titanium dioxide A method for producing a thin film titanium dioxide is disclosed. The disclosed method for producing the thin film titanium dioxide includes performing a magnetron reactive sputtering process to vaporize at least portions of a titanium source in a sputtering chamber...	12/15/2009
7601366	Promotion of peroxisomal catalase function in cells The molecular mechanisms of peroxisome biogenesis have begun to emerge: in contrast, relatively little is known about how the organelle functions as cells age. The present inventors characterized age-related changes in peroxisomes of human cells and showed that agin...	10/13/2009
7595331	N-and O-substituted 4-[2-(diphenylmethoxy)-ethyl]-1-[(phenyl)methyl]piperidine analogs and methods of treating CNS disorders therewith N- and O-substituted 4[2-diaromaticmethoxy and methylamino)alkyl]piperidines exhibit high CNS activity with respect to the dopamine transporter (DAT) and serotonin transporter (SERT). Preferred compounds exhibit highly differential behavior as between the DAT and SE...	09/29/2009
7585863	Therapeutic amides The invention provides compounds of the formula: wherein A, X, Y, and Z are as defined in the specification. The compounds are effective anti-tumor agents. The invention also provides pharmaceutical compositions comprising ...	09/08/2009
7566310	System for diagnosing and treating sleep apnea Two programs measure upper airway resistance using Resistance=Pressure/Flow. Raw flow and pressure data is divided into breaths and time adjusted so each breath starts with the value zero. Each breath is graphed as flow in the y-axis and time in the x-axis. The slop...	07/28/2009
7544816	(−)-Epigallocatechin gallate derivatives for inhibiting proteasome (−)-EGCG, the most abundant catechin, was found to be chemopreventive and anticancer agent. However, (−)-EGCG has at least one limitation: it gives poor bioavailability. This invention provides compounds of generally formula 10, wherein R1 is selected...	06/09/2009
7534996	Velocity imaging tandem mass spectrometer A mass spectrometer that employs ion velocity mapping. The mass spectrometer includes velocity mapping ion optics that focus the ions based on their velocity. The focused ions are then directed into a deflection region between two deflection plates. A pulse is appli...	05/19/2009
7527794	Hybrid proteins with neuregulin heparin-binding domain for targeting to heparan sulfate proteoglycans Polypeptides of the neuregulin (NRG) heparin binding domain (N-HBD) and nucleic acids coding therefor are disclosed. In particular, fusion polypeptides are produced that comprise, as a targeting structure, a N-HBD polypeptide, fragment, homologue or functional deriv...	05/05/2009
7524669	Transgenic and method for bioremediation An isolated and purified transgenic Saccharomyces cerevisiae yeast cell comprising a disrupted ACR3 gene and an isolated DNA sequence comprising a promoter operably linked to a nucleic acid molecule encoding yeast cadmium factor resistance protein Ycf1p, is p...	04/28/2009
7507749	Antitumor agents The invention provides compounds of formula I: wherein Y is F, Cl, Br, methyl or methoxy; and pharmaceutically acceptable salts thereof. The compounds are effective antitumor agent. The invention also provides pharmaceutica...	03/24/2009
7470788	Antitumor agents The invention provides compounds of formula I: wherein Y is F, Cl or Br; or a pharmaceutically acceptable salt thereof. The compounds are effective antitumor agents. The invention also provides pharmaceutical compositions c...	12/30/2008
7402445	Method of forming micro-structures and nano-structures Methods of forming a nano-structure for electron extraction are disclosed. One method of forming a nano-structure comprises irradiating an area on a first surface of a thermal conductive film to melt the area across the film. The film is insulated on a second surfac...	07/22/2008

«First «Previous1 2 3 4 5 6 Next»Last»

PatentStorm

Did You Know...

PatentStorm News

Assignee: Wayne State University