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| Number | Title | Issue Date |
| 7418352 | Method of using data binning in the analysis of chromatography/spectrometry data Disclosed herein is a method of analyzing three-dimensional data obtained from a chromatography/spectrometry process, in particular an LC/MS process using a two-dimensional multi-variant statistical analysis. The LC portion permits separation of analytes within a sa... | 08/26/2008 |
| 7072773 | Method of using data binning in the analysis of chromatography/spectrometry data Disclosed herein is a method of analyzing three-dimensional data obtained from a chromatography/spectrometry process, in particular an LC/MS process using a two-dimensional multi-variant statistical analysis. The LC portion permits separation of analytes within a sa... | 07/04/2006 |
| 7041972 | Mass spectrometer An Atmospheric Pressure Chemical Ionisation ion source is disclosed wherein the current applied to a corona needle 2 is repeatedly varied between two or more settings during a single experimental run or acquisition. Two or more separate sets of mass spectral ... | 05/09/2006 |
| 6783705 | Calibration medium for wavelength calibration of U.V. absorbance detectors and methods for calibration The invention features an optical medium for calibrating UV absorbance detectors, methods for making such an optical medium, and methods for calibrating UV absorbance detectors using such a medium. The optical calibration medium includes a gel-sol silica glass monol... | 08/31/2004 |
| 6780315 | Backflow prevention for high pressure gradient systems Gradient performance with high pressure gradient solvent delivery system is optimized by approximation of infinite stroke volume of high pressure pumps by the addition of pulse dampening with backflow prevention to each high pressure pump. The backflow prevention ad... | 08/24/2004 |
| 6758966 | Capillary columns employing monodispersed particles A capillary column comprising monodispersed particles. The capillary is formed using a suitable substrate, wherein two plates are bonded together. At least one of the plates comprises a channel where particle beads are housed. Particle bead positions are of defined ... | 07/06/2004 |
| 6747740 | Approach to short measurement path-length flow cells A photometric measurement flow cell having measurement path-lengths that can be adjusted down to less than 0.1 mm. The measurement path-length is controlled by both a common flow cell body and the dimensional parameters of a stepped sealing optical element. The step... | 06/08/2004 |
| 6684720 | Autosampler syringe with compression sealing A fluid transfer device includes a cylinder and a displacement rod. The cylinder is fabricated rigid enough to minimize distortion of volume yet compliant enough to create a seal between itself and the surface of the displacement rod. The cylinder is cons... | 02/03/2004 |
| 6641736 | Permanently radially compressed column An embodiment of the present invention features a chromatographic device. The chromatographic device comprises a body having a cylindrical wall having an exterior diameter. The cylindrical wall is flexible, expanding and contracting in response to radial ... | 11/04/2003 |
| 6636304 | Laser induced fluorescence capillary interface An optical scheme that substantially eliminates spherical aberration and coma, thereby substantially improving fluorescence excitation and collection efficiency. The optical scheme utilizes a laser beam focused by an optical component through the curved s... | 10/21/2003 |
| 6613224 | Liquid separation column smart cartridge A LC column cartridge comprising a memory component integrally attached to it at the time of its manufacture, as well as a method for producing such a LC column cartridge with an integral memory component is disclosed. The memory component is a semiconduc... | 09/02/2003 |
| 6610201 | High pressure capillary liquid chromatography solvent delivery system High pressure capillary liquid chromatography solvent delivery is effected at substantially low volume and atmospheric pressure. The low volume solvent composition is subsequently pressurized and expelled at high pressure into a receiving device such as a... | 08/26/2003 |
| 6527951 | Chromatographic column A chromatography column with filters having minimal volume. A stamped screen disk is coated with fluorocarbon polymer on both sides, leaving a center area open. The fluorocarbon polymer coating serves as a gasket, providing reliable sealing for pressure u... | 03/04/2003 |
| 6525314 | Compact high-performance mass spectrometer A compact high-performance mass spectrometer includes an ion source, an ion filter, a collision cell, a fragment filter, and an ion detector, along with one or more ion deflectors and one or more gas removal rings. An ion deflector allows a straight ion f... | 02/25/2003 |
| 6526188 | Flow cell, analyte measurement apparatus and methods related thereto A modular flow cell having a high optical throughput, a long optical path length and a small cross-section. The modular flow cell configuration includes remote ports or connections for liquid and light input, and liquid and light output. The flow cell inc... | 02/25/2003 |
| 6456955 | Automated test protocol A method and apparatus for automating the qualification process for chromatographic systems. Automation technology and regression analysis are used for qualifying a chromatography system. The trained operator prepares the chromatography system to ensure t... | 09/24/2002 |
| 6452673 | Multiple input flow cell with single fluid path A chromatographic flow cell having the capacity to handle fluid flow from one or more chromatographic systems, at widely varying flow rates without the need to change flow cells or detectors. The flow cell itself acts as a tee where two or more fluidic in... | 09/17/2002 |
| 6436291 | Permanently radially compressed column A permanently radially compressed chromatographic column having a flexible-walled encasement containing chromatographic media, and a wound element surrounding the encasement for radially compressing the column.... | 08/20/2002 |
| 6423249 | Calibration medium for wavelength calibration of U.V. absorbance detectors and methods for calibration The invention features an optical medium for calibrating UV absorbance detectors, methods for making such an optical medium, and methods for calibrating UV absorbance detectors using such a medium. The optical calibration medium includes a gel-sol silica ... | 07/23/2002 |
| 6404193 | Solvent susceptibility compensation for coupled LC-NMR A method and apparatus in which the limitation upon analysis caused by variation of the magnetic susceptibility of the solvent conveying a sample to an NMR spectrometer can be addressed. The solvent composition which is used to bring about elution of anal... | 06/11/2002 |
| 6396057 | Electrospray and other LC/MS interfaces An improved method and apparatus for performing Mass spectrometry, in particular, Liquid chromatography/Mass spectrometry (LC/MS) is disclosed. Controlled generation of individual charged droplets enables the subsequent steps of trapping, desolvation and ... | 05/28/2002 |
| 6376044 | Enhanced resolution matrix-laser desorption and ionization TOF-MS sample surface A thin layer for sample analysis by matrix-assisted laser desorption mass spectrometry, comprising a matrix material in a supported dispersion wherein the support is a solid or is formed from a solid. The invention is also directed to a method of making a... | 04/23/2002 |
| 6367847 | Coupler for placing two or more fluid streams in communication One embodiment of the present coupler comprises two or more conduits for transporting fluid. Each of the two or more conduits has at least one end defining an opening in said conduit, and each of the conduits has an axis running parallel to the flow of fl... | 04/09/2002 |
| 6364623 | Bubble detection and recovery in a liquid pumping system A serial, dual piston high pressure fluid pumping system that overcomes the difficulties of gas in the fluid stream without the need for added mechanical valves or fluid paths. A bubble detection and recovery mechanism monitors compression and decompressi... | 04/02/2002 |
| 6348150 | Permanently radially compressed column An embodiment of the present invention features a chromatographic device. The chromatographic device comprises a body having a cylindrical wall having an exterior diameter. The cylindrical wall is flexible, expanding and contracting in response to radial ... | 02/19/2002 |
| 6342948 | Dual pathlength system for light absorbance detection A flow cell for absorbance detection with at least two different optical path lengths. It increases the range of analyte concentrations which can be measured compared with a conventional single path flow cell. Light from the two paths is combined onto the... | 01/29/2002 |
| 6322695 | Ion exchange porous resins for solid phase extraction and chromatography Embodiments of the present invention are directed to porous resins for solid phase extractions. The resins feature at least one hydrophobic component, at least one hydrophilic component and at least one ion exchange functional group. The resins exhibit su... | 11/27/2001 |
| 6312575 | Methods and devices for chromatographic pattern analysis employing chromatographic variability characterizations Method and devices for performing chromatographic pattern analysis determine chromatographic variability due to a plurality of sources without requiring identification or characterization of peaks or other chromatographic features, receives data indicativ... | 11/06/2001 |
| 6299767 | High pressure capillary liquid chromatography solvent delivery system High pressure capillary liquid chromatography solvent delivery is effected at substantially low volume and atmospheric pressure. The low volume solvent composition is subsequently pressurized and expelled at high pressure into a receiving device such as a... | 10/09/2001 |
| 6276195 | Three capillary flow-through viscometer A method and apparatus for measuring the viscosity of a sample solution which comprises an input tube for transporting a sample solution flow towards a splitter for diverting input flow into two distinct flow streams where three capillary tubes are locate... | 08/21/2001 |
| 6278111 | Electrospray for chemical analysis An improved electrospray (ES) apparatus has a low pressure ES chamber coupled to a desolvation chamber. The desolvation chamber desolvates the incoming analyte ions of the cone-jet with non-conductive energy. The apparatus stabilizes cone-jet formation in... | 08/21/2001 |
| 6239871 | Laser induced fluorescence capillary interface An optical scheme that substantially eliminates spherical aberration and coma, thereby substantially improving fluorescence excitation and collection efficiency. The optical scheme utilizes a laser beam focused by an optical component through the curved s... | 05/29/2001 |
| 6188813 | Flow cell, analyte measurement apparatus and methods related thereto A modular flow cell having a high optical throughput, a long optical path length and a small cross-section. The modular flow cell configuration includes remote ports or connections for liquid and light input, and liquid and light output. The flow cell inc... | 02/13/2001 |
| 6187595 | Method for detecting polymers in a solution, detector system and chromatography apparatus containing such a detector system A method of quantitatively detecting a polymer in a solution of the polymer in a solvent is provided, which method comprises the steps of (a) adding to the solution a non-solvent for said polymer in a sufficient amount to make the resulting liquid turbid ... | 02/13/2001 |
| 6161442 | Autosampler syringe with compression sealing A fluid transfer device includes a cylinder and a displacement rod. The cylinder is fabricated rigid enough to minimize distortion of volume yet compliant enough to create a seal between itself and the surface of the displacement rod. The cylinder is cons... | 12/19/2000 |
| 6158271 | Three capillary flow-through viscometer A method and apparatus for measuring the viscosity of a sample solution which comprises an input tube for transporting a sample solution flow towards a splitter for diverting input flow into two distinct flow streams where three capillary tubes are locate... | 12/12/2000 |
| 6140640 | Electrospray device A non-reactive electrospray needle structure that can be used with relatively low electrical potential introduced externally at a selectable location along the length of the needle structure. The electrospray device or apparatus includes a non-conductive ... | 10/31/2000 |
| 6137641 | Multi-channel plane grating monochromator Selective adjustment of astigmatism is provided by a spherical mirror bent to simultaneously increase radius of curvature in one plane and decrease radius of curvature in the plane at right angles thereto. In one implementation the mirror disposed in a mo... | 10/24/2000 |
| 6106238 | Bubble detection and recovery in a liquid pumping system A serial, dual piston high pressure fluid pumping system that overcomes the difficulties of gas in the fluid stream without the need for added mechanical valves or fluid paths. A bubble detection and recovery mechanism monitors compression and decompressi... | 08/22/2000 |
| 6099724 | Active pump phasing to enhance chromatographic reproducibility A fluid delivery method and apparatus implementing active phasing to actively restore the substantially exact mechanical positions of driven components in a delivery system in order to precisely reproduce the mechanical signature and hydraulic characteris... | 08/08/2000 |
