Assignee: WASHINGTON UNIVERSITY

Location: St. Louis, MO
No. of patents: 56

Number	Title	Issue Date
8148097	Screening method for identification of compounds with calcium-independent phospholipase Aβ (iPLAβ) modulating activity An in vitro screening method for identifying a compound with iPLA2β modulating activity. ...	04/03/2012
8133493	Regulated attenuation of live vaccines to enhance cross-protective immunogenicity A live attenuated derivative of a pathogenic bacterium intended for use as a vaccine. ...	03/13/2012
8131697	Method and apparatus for approximate matching where programmable logic is used to process data being written to a mass storage medium and process data being read from a mass storage medium A method and device are disclosed for an associative and approximate, analog or digital scanning of databases that allows for the asynchronous accessing of data from a mass storage medium. The invention includes providing dedicated analog and digital circuitry and d...	03/06/2012
8101606	Neurofibromin pathway modulators The present invention encompasses methods for treating neurofibromatosis. ...	01/24/2012
8095508	Intelligent data storage and processing using FPGA devices A data storage and retrieval device and method is disclosed. The device includes at least one magnetic storage medium configured to store target data and at least one re-configurable logic device comprising an FPGA coupled to the at least one magnetic storage medium...	01/10/2012
8069102	Method and apparatus for processing financial information at hardware speeds using FPGA devices A method and apparatus use decision logic deployed on a reconfigurable logic device to process a stream of financial information at hardware speeds. The decision logic can be configured to perform data reduction operations on the financial information stream. Exampl...	11/29/2011
8063268	Transposable elements in rice and methods of use Disclosed are isolated transposable elements, or isolated DNA sequences which encode a transposase protein or a portion of a transposase protein. The isolated transposable elements or the isolated DNA sequences are members of the mPing/Pong family of transposable el...	11/22/2011
8046044	Method and apparatus for acquiring overlapped medical image slices The disclosure describes a technique for medical imaging, referred to herein as the Rapid Interleave Overlap Technique (RIOT), wherein image data is acquired as a plurality of series sequences in a manner that allows for unlimited overlap. RIOT involves interleaving...	10/25/2011
8044350	Miniaturized ultrafine particle sizer and monitor An apparatus for measuring particle size distribution includes a charging device and a precipitator. The charging device includes a corona that generates charged ions in response to a first applied voltage, and a charger body that generates a low energy electrical f...	10/25/2011
8038984	Membrane-permeant peptide complexes for treatment of sepsis Methods and compositions for treating sepsis using cell membrane-permeant peptide conjugate covalent compounds having target cell specificity are provided. ...	10/18/2011
8026099	Lipid profile as a biomarker for early detection of neurological disorders The present invention relates to compositions and methods for the early detection or monitoring of neurodegenerative diseases and neurological disorders including Alzheimer's disease. The invention provides biomarkers based on lipid profiles of biological samples an...	09/27/2011
7991477	Methods for treating central nervous system damage Methods for the treatment of CNS damage are described, and include inducing in a subject in need of such treatment, a therapeutically effective amount of functional electronic stimulation (FES) sufficient to evoke patterned movement in the subject's muscles, the con...	08/02/2011
7985555	Markers for brain damage Methods to identify markers for brain damage using fresh brain tissue and methods and compositions for detecting these markers are disclosed. ...	07/26/2011
7983743	System and method for noninvasive electrocardiographic imaging (ECGI) Noninvasive systems and methods are provided for determining electrical activity for a heart of a living being. A processor is configured to meshlessly compute data that represents heart electrical activity from a set of noninvasively measured body surface electrica...	07/19/2011
7983740	High performance imaging system for diffuse optical tomography and associated method of use A high performance imaging system for diffuse optical tomography is disclosed. A dense grid utilizing sources, e.g., light emitting diodes (“LEDs”), that achieve high performance at high speed with a high dynamic range and low inter-channel crosstalk are complem...	07/19/2011
7981422	Antibodies against West Nile Virus and therapeutic and prophylactic uses thereof The present invention relates to compositions comprising antibodies or fragments thereof that immunospecifically bind to one or more antigens of a flavivirus, particularly of West Nile Virus (WNV), and methods for preventing, treating or ameliorating symptoms associ...	07/19/2011
7954114	Firmware socket module for FPGA-based pipeline processing A firmware socket module is deployed on a reconfigurable logic device, wherein the firmware socket module is configured to provide both commands and target data to an entry point in a data processing pipeline, wherein each command defines a data processing operation...	05/31/2011
7953743	Associative database scanning and information retrieval A method and device are disclosed for an associative and approximate, analog or digital scanning of databases that allows for the asynchronous accessing of data from a mass storage medium. The invention includes providing dedicated analog and digital circuitry and d...	05/31/2011
7949650	Associative database scanning and information retrieval A method and device are disclosed for an associative and approximate, analog or digital scanning of databases that allows for the asynchronous accessing of data from a mass storage medium. The invention includes providing dedicated analog and digital circuitry and d...	05/24/2011
7943168	Nanoparticle delivery systems comprising a hydrophobic core and a lipid/surfactant layer comprising a membrane-lytic peptide Compositions which comprise emulsions of nanoparticles for delivery of membrane-integrating peptides are described. The nanoparticles comprise a liquid hydrophobic core coated with a lipid/surfactant layer which contains the membrane-integrating peptides. Methods to...	05/17/2011
7918847	Method and associated system for the interventional treatment of atrial fibrillation A method for treatment of atrial fibrillation includes utilizing mathematical analysis, e.g., logistic regression, on a collection of variables selected from the group including effective refractory period, wavelength, tissue area, tissue weight, maximum tissue widt...	04/05/2011
7917312	Photoacoustic doppler flow sensing and imaging A method for measuring a fluid flow includes employing small light-absorbing particles as tracers that flow at the same speed as the fluid, measuring the photoacoustic Doppler shifts of the photoacoustic signals produced by these tracer particles, and determining, f...	03/29/2011
7917299	Method and apparatus for performing similarity searching on a data stream with respect to a query string An apparatus and method for performing similarity searching on a data stream with respect to a query string are disclosed, where the data stream comprises a plurality of data substrings, and where the query string comprises a plurality of query substrings. A program...	03/29/2011
7915417	Amino methylated 2-pyridinones Novel amino methylated 2-pyridinones, precursors, intermediates, and derivatives; the methods for the preparation of the same; uses of the same for inhibiting pili formation in bacteria; and pharmaceutical compositions comprising these compounds are described in thi...	03/29/2011
7893266	Detection of cancer cells in vitro using sigma-2 receptor ligands as radiotracers Methods for detection of cancer cells and for determining the proliferative status of cells in a tissue sample in vitro are disclosed. These methods comprise contacting a tissue sample with a radiolabeled compound or salt thereof of Formula	02/22/2011
7892545	Humanized antibodies that sequester amyloid beta peptide A method to treat conditions characterized by formation of amyloid plaques both prophylactically and therapeutically is described. The method employs humanized antibodies which sequester soluble Aβ peptide from human biological fluids or which preferably specifical...	02/22/2011
7883860	Human protein acyl transferases and methods of uses therefor The present invention provides the identification of human Ras palmitoyl acyl transfersase complexes, and nucleic acids coding therefor. In addition, methods of screening for modulators of human Ras palmitoyl acyl transfersase, including high throughput yeast screen...	02/08/2011
7871604	Recombinant bacterial vaccine system with environmentally limited viability Disclosed is an Environmentally Limited Viability System (ELVS) for microorganisms based on temperature differences between permissive and non-permissive environments. Viability of the microorganisms are limited to the permissive environment by specifically expressi...	01/18/2011
7855174	Methods of treating vasodilatory shock The invention encompasses methods of decreasing the lumenal diameter of a blood vessel by contacting the vessel with a myosin light chain phosphatase inhibitor. ...	12/21/2010
7851436	Inhibition of migration and induction of cell death by the type II collagen amino propeptides The present invention provides combinations and methods for inducing cell death, inhibiting angiogenesis, and inhibiting cell migration. In particular, the present invention provides methods for inducing cell death in a cell expressing an αvβ3 and/or an αvβ5 int...	12/14/2010
7807345	Kits for detection of segmented negative strand RNA viruses The present invention provides compositions and methods for the detection of the presence, absence, or quantity of a segmented negative strand RNA virus such as an influenza virus. A genetically engineered vertebrate cell comprising an artificial segment comprising ...	10/05/2010
7803351	Blood brain barrier permeation peptides Novel blood-brain barrier permeant amyloid-targeting peptides and peptide conjugates are described. The peptide conjugates include a radioisotope or other label in a stable complex that translocates across brain capillary endothelial cell monolayers. The labeled pep...	09/28/2010
7794942	Cell lines permissive for HCV replication HCV variants are described. The variants include polynucleotides comprising non-naturally occurring HCV sequences and HCV variants that have a transfection efficiency and ability to survive subpassage greater than HCV that have wild-type polyprotein coding regions. ...	09/14/2010
7781421	Neuroactive 13, 24-cyclo-18, 21-dinorcholanes and structurally related pentacyclic steriods Novel pentacyclic steroids and pentacyclic D-homosteroids comprising: (i) the tetracyclic steroid ring system or tetracyclic D-homosteroid ring system, respectively; (ii) a C(3) substituent selected from the group consisting of (a) a hydroxyl or carboxyl in the α-c...	08/24/2010
7771722	Assay method for alzheimer's disease A diagnostic test for preclinical and clinical Alzheimer's disease is based on plasma levels of Aβ40, Aβ42, their ratio, or their rate of entry following administration of antibodies that sequester Aβ. Alterations of any of these parameters ...	08/10/2010
7737158	Processes for regulating blood glucose in a mammal The present invention relates to processes for regulating the blood glucose concentration of a mammal. ...	06/15/2010
7680790	Method and apparatus for approximate matching of DNA sequences A method and device are disclosed for an associative and approximate, analog or digital scanning of databases that allows for the asynchronous accessing of data from a mass storage medium. The invention includes providing dedicated analog and digital circuitry and d...	03/16/2010
7670794	Managing glycemia status in diabetic patients Methods for monitoring and managing glycemia status in a diabetic patient are disclosed. The methods comprise measuring in a diabetic patient, serum concentrations of HbA1c, glucose and inorganic phosphate and comparing the measured concentrations with reference con...	03/02/2010
7659400	Radiolabelled benzamide analogues, their synthesis and use in diagnostic imaging Fluoroalkoxybenzamide compounds which selectively bind Sigma-2 receptors are disclosed. These compounds, when labelled with 18F, can be used as radiotracers for imaging of tumors by positron emission tomography (PET). In addition, these compounds, when la...	02/09/2010
7649082	Persephin specific antibodies A novel growth factor, persephin, which belongs to the GDNF/neurturin family of growth factors, is disclosed. The human, mouse and rat amino acid sequences have been identified. Human, mouse and rat persephin genomic DNA sequences have been cloned and sequenced and ...	01/19/2010

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Assignee: WASHINGTON UNIVERSITY