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Assignee: Virginia Commonwealth University


Location: Richmond, VA
No. of patents: 154

1        
NumberTitleIssue Date
8172769Method and apparatus for monitoring intra ocular and intra cranial pressure
A method and apparatus for measuring acoustic energy applied to the head to detect increases in intracranial pressure. Acoustic eye patches are applied to a patient's eye or eyelid, and an ultrasonic sweep generator applies an acoustic signal across the patient's sk...
05/08/2012
8114976genes and gene products for chemotherapeutic, immunoprophylactic and diagnostic applications
Cryptosporidium hominis genes and gene products are provided. The genes and gene products are useful for chemotherapeutic, immunotherapeutic, immunoprophylactic and diagnostic applications. ...
02/14/2012
8111860Recreational bone conduction audio device, system
A waterproof recreational audio device and method that transmits sound via transcutaneous bone conduction provides high fidelity musical signals to a user. The device can be worn on the head of a user and integrated into various types of headgear. The device is tuna...
02/07/2012
8071373Co-culture lymphoid tissue equivalent (LTE) for an artificial immune system (AIS)
The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising T cells, B cells and antigen-primed dendritic cells. The artificial immune system of the present invention can be use...
12/06/2011
8067150In-situ preservation (ISP) bridge method and solution for non-heart beating donors
A method for rapid, in-situ flushing of organs of a non-heart beating donor, and solutions for carrying out the flushing, are provided. The method initiates organ preservation, and the solutions are formulated to counteract basic mechanisms of ischemic cell injury, ...
11/29/2011
8042544Prevention of ventilator associated pneumonia (VAP)
Ventilator associated pneumonia (VAP) may be prevented in a patient, or its occurrence reduced in a population of patients, by disposing in a patient airway an anti-VAP device or an anti-VAP material. By reducing the problem of bacterial-containing secretions that o...
10/25/2011
7947262Use of fullerenes for the treatment of mast cell and basophil-mediated disease
Mast cell (MC) and peripheral blood basophil (PBB)-associated diseases are treated or prevented, or their symptoms are alleviated by the administration of water soluble fullerenes (buckeyballs) to the individual under conditions sufficient to inhibit MC and PBB resp...
05/24/2011
7935298Method of producing fibers by electrospinning at high pressures
A process of making fibers by electrostatic spinning includes the use of a mixing vessel (10), a piston (15) for pressurizing the polymer, carbon dioxide sources (20) for lowering the viscosity of the polymer or pressurizing the collection vesse...
05/03/2011
7888341Combination of glivec (STI571) with a cyclin-dependent kinase inhibitor, especially flavopiridol, in the treatment of cancer
The present invention pertains to a combination for simultaneous, separate or sequential use which comprises (a) a cyclin-dependent kinase inhibitor and (b) 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide and to i...
02/15/2011
7842388Functional polymers via surface modifying agents
Polymers, and particularly conventional commodity bulk polymers, are modified to have a surface activity of interest using a surface modifying polymer that includes a moiety that favors migration to the surface of the bulk polymer together with a moiety provides the...
11/30/2010
7807366Genetic markers for assessing risk of premature birth resulting from preterm premature rupture of membranes
A method to identify women who are at risk for preterm delivery due to premature rupture of membranes (PPROM) is provided. The method entails detecting the presence of SERPINH1 gene variants that express low levels of the gene product, heat shock protein Hsp47. The ...
10/05/2010
7794727Polyvalent chimeric OspC vaccinogen and diagnostic antigen
A chimeric polyvalent recombinant protein for use as a vaccine and diagnostic for Lyme disease is provided. The chimeric protein comprises epitopes of the loop 5 region and/or the alpha helix 5 region of outer surface protein C (OspC) types. The OspC types may be as...
09/14/2010
7781580Stilbene derivatives as new cancer therapeutic agents
Stilbene derivatives exhibit killing and suppression of growth activity against a variety of cancer cells, and are effective at suppressing tumor growth in vivo. The stilbene derivatives may be used in the treatment of diseases characterized by cell hyperproliferati...
08/24/2010
7771825Functional polymers via surface modifying agents
Polymers, and particularly conventional commodity bulk polymers, are modified to have a surface activity of interest using a surface modifying polymer that includes a moiety that favors migration to the surface of the bulk polymer together with a moiety provides the...
08/10/2010
7771793Functional polymers via surface modifying agents, and methods for polymeric surface modification
Polymers, and particularly conventional commodity bulk polymers, are modified to have a surface activity of interest using a surface modifying polymer that includes a moiety that favors migration to the surface of the bulk polymer together with a moiety provides the...
08/10/2010
7727558Polymeric delivery agents and delivery agent compounds
Polymeric delivery agents, delivery agent compounds and compositions comprising them which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well. ...
06/01/2010
7709257Models for vaccine assessment
The present invention is directed to methods for constructing and using in vivo and in vitro models of aspects of human immunity and, in particular, construction of a human immune system model for the testing of, for example, vaccines, adjuvants, immunotherapy candi...
05/04/2010
7616771Acoustic coupler for skin contact hearing enhancement devices
There is provided hearing device improvements using modulation techniques adapted to the characteristics of auditory and vestibular hearing. One embodiment provides for extending hearing to the infrasonic range by extracting sounds from the high ambient noise in thi...
11/10/2009
7610153Multi-drug titration and evaluation
Titration of a combination of drugs or treatment modalities within individual subjects is carried out using an evolutionary operation (EVOP) direct-search procedure such as the Nelder-Mead simplex. Desirability functions are incorporated to define the main response ...
10/27/2009
7579373Targeted bisplatinum polyamines as pro-drugs: selective release of platinum
Pro-drug forms of linear polyamine-bridged platinum compounds and methods for their production and use are provided. The polyamine-bridge portion of the compounds is based on spermine or spermidine, and the central amines of the polyamine-bridge are chemically bonde...
08/25/2009
7468067One hand tourniquet with locking mechanism
Provided is a tourniquet having two opposing and pivotally movable plates. The plates comprise a clamp that pinches an elastomeric cord. The plates are pivotally biased together by a spring. The cord is attached to a back end of the clamp. A free end of the cord is ...
12/23/2008
7442754Molecular imprinting of small particles, and production of small particles from solid state reactants
Small particles of polymeric material are produced by expansion of a mixture of monomers and a propellant. The size and shape of the particles can be precisely tailored by materials selection and expansion conditions. Particles of 10 nanometers to 100 microns can be...
10/28/2008
7402594Sulfated bis-cyclic agents
Sulfated bis-cyclic compounds that are potent anticoagulants and methods for their manufacture are provided. The sulfated compounds are bis-cyclic moieties comprised of an isoquinoline ring joined to a phenyl ring with the general chemical structure formula (I) wher...
07/22/2008
7396590Soft block with repeat units that favor migration to a surface and repeat units with an activity of interest, and polymeric articles or coatings using same
Polymers, and particularly conventional commodity bulk polymers, are modified to have a surface activity of interest using a surface modifying polymer that includes a moiety that favors migration to the surface of the bulk polymer together with a moiety provides the...
07/08/2008
7310427Recreational bone conduction audio device, system
A waterproof recreational audio device and method that transmits sound via transcutaneous bone conduction provides high fidelity musical signals to a user. The device can be worn on the head of a user and integrated into various types of headgear. The device is tuna...
12/18/2007
7285687Cannabinoids
Compounds of the formula: wherein R, R1 and R4 are defined in the specification, and pharmaceutically acceptable salts, esters and tautomers thereof, having activity at peripheral cannabinoid receptors, commonly designated the CB2 receptor class. The compounds are u...
10/23/2007
7279555Advanced antigen presentation platform
The present invention provides particles for the presentation of haptens for the purpose of eliciting an immune response. The amino acid sequences of the monomers which make up the particles are derived from duck hepatitis B virus core protein. The particles may als...
10/09/2007
7279500Sulfonamide cannabinoid agonists and antagonists
Cannabinoid agonists and antagonists are provided for use in the treatment of disorders such as acute and chronic pain, inflammation, loss of appetite, convulsions, multiple sclerosis, nausea and vomiting. The cannabinoid agonists and antagonists contain a sulfonami...
10/09/2007
7262030Multiple sequencible and ligatible structures for genomic analysis
High throughput methods and kits for single nucleotide polymorphism (SNP) genotyping are provided. The methods involve utilizing nested PCR amplification reactions which produce sequencible and ligatible structures. An outer PCR primer set amplifies the SNP, and an ...
08/28/2007
7192995Homogenous compositions of polymers and crystalline solids or cross-linking agents and methods of making the same
Elastomeric polymers are combined with chemical agents in the presence of supercritical fluids such as supercritical carbon dioxide by swelling the polymer with the supercritical fluid, and impregnating the swollen polymer with the chemical agent. The process can be...
03/20/2007
7179800Cannabinoids
Compounds of the formula: wherein R, R1 and R4 are defined in the specification, and pharmaceutically acceptable salts, esters and tautomers thereof, having activity at peripheral cannabi...
02/20/2007
7169857Homogenous compositions of fluoropolymers and crystalline solids or cross-linking agents and methods of making the same
Fluoroelastomers are combined with chemical agents in the presence of supercritical carbon dioxide by swelling the fluoroelastomer with the carbon dioxide, and impregnating the swollen fluorelastomer with the chemical agent. The process can be conducted at relativel...
01/30/2007
7135134Method for forming microscopic polymer interconnections
Polymer fiber interconnects are produced between microscale features on substrate using only electrostatic forces. In one embodiment, electric field driven directed growth of fibers is achieved between microscale droplets of a concentrated polymer solution deposited...
11/14/2006
7119208Anti-sickling agents
Compounds for the treatment of sickle-cell disease, and methods for their use are provided. The compounds have a dual mode of action. First, binding of the compounds to hemoglobin increases the oxygen affinity of both normal and sickle hemoglobin. Secondly, binding ...
10/10/2006
7118534Methods for monitoring and optimizing central venous pressure and intravascular volume
Central Venous Pressure (CVP) is non-invasively determined with accuracy comparable to invasive measurement techniques. To do so, curves are plotted based on non-invasively determined patient information obtained by applying a controllable variable (pressure) to a v...
10/10/2006
7115685Fluoropolymer-carbon dioxide compositions and methods of processing fluoropolymers
Fluoropolymer materials containing tetrafluoroethylene monomers, such as PTFE, are significantly swollen by supercritical carbon dioxide at high temperatures and pressures. The swollen fluoropolymer is processable by molding, extrusion, and other techniques. In addi...
10/03/2006
7113814Tissue interrogation spectroscopy
In an emergency medicine patient, accurate measurement of change or lack thereof from non-shock, non-ischemic, non-inflammation, non-tissue injury, non-immune dysfunction conditions is important and is provided, as practical, real-time approaches for accurately char...
09/26/2006
7091207Method of treating myocardial infarction with PDE-5 inhibitors
A method is provided for the prevention of ischemia/reperfusion injury, for example, in patients undergoing heart surgery, and involves the administration of a phosphodiesterase-5 (PDE-5) inhibitor such as sildenafil. The method may also be used during or after a he...
08/15/2006
6960633Fluoropolymer-carbon dioxide compositions and methods of processing fluoropolymers
Fluoropolymer materials containing tetrafluoroethylene monomers, such as PTFE, are significantly swollen by supercritical carbon dioxide at high temperatures and pressures. The swollen fluoropolymer is processable by molding, extrusion, and other techniques. In addi...
11/01/2005
6911437Saccharide derivatives especially useful in wound dressings
Sequestrants and inhibitors of protease are applied to the wound site through the use of wound dressing based carrier systems to which they may be optionally ionically or covalently bound for the purpose of the initiation or enhancement of healing associated with ch...
06/28/2005
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